Development, characterization and application of in situ gel systems for intranasal delivery of tacrine

International Journal of Pharmaceutics

Volumn 468, Issue 1-2, 2014, Pages 272-282

  Qian, Shuai ^a   Wong, Yin Cheong ^a   Zuo, Zhong ^a  

^a Prince of Wales Hospital   (Hong Kong)

Author keywords

In situ gel; Intranasal; Keywords; Pharmacokinetics; Pluronic F 127; Tacrine

Indexed keywords

MACROGOL 8000; POLOXAMER; TACRINE; CHITOSAN; CHOLINESTERASE INHIBITOR; DRUG CARRIER; GEL; MACROGOL DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG TRANSPORT; DRUG UPTAKE; GEL; GELATION; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; MUCOCILIARY TRANSPORT; NONHUMAN; NOSE CAVITY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; TRANSITION TEMPERATURE; ANIMAL; BIOAVAILABILITY; BLOOD; CHEMISTRY; COMPARATIVE STUDY; FLOW KINETICS; INTRANASAL DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; METABOLISM; MUCOCILIARY CLEARANCE; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PHASE TRANSITION; PROCEDURES; SOLUBILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; CHOLINESTERASE INHIBITORS; DRUG CARRIERS; GELS; MALE; MUCOCILIARY CLEARANCE; NASAL CAVITY; PHASE TRANSITION; POLOXAMER; POLYETHYLENE GLYCOLS; RATS, SPRAGUE-DAWLEY; RHEOLOGY; SOLUBILITY; TACRINE; TECHNOLOGY, PHARMACEUTICAL; TRANSITION TEMPERATURE;

EID: 84901593892     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.04.015     Document Type: Article

References (69)

1. B.C. Anderson, N.K. Pandit, and S.K. Mallapragada Understanding drug release from poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) gels Journal of Controlled Release 70 2001 157 167 (Pubitemid 32144800)
2. E. Baloglu, S.Y. Karavana, Z.A. Senyigit, S. Hilmioglu-Polat, D.Y. Metin, O. Zekioglu, T. Guneri, and D.S. Jones In-situ gel formulations of econazole nitrate: preparation and in-vitro and in-vivo evaluation Journal of Pharmacy and Pharmacology 63 2011 1274 1282
3. A.K. Bandyopadhyay, and S. Basu Development and characterization of mucoadhesive in situ nasal gel of midazolam prepared with Ficus carica mucilage AAPS PharmSciTech 11 2010 1223 1231
4. C.R. Behl, H.K. Pimplaskar, A.P. Sileno, J. deMeireles, and V.D. Romeo Effects of physicochemical properties and other factors on systemic nasal drug delivery Advanced Drug Delivery Reviews 29 1998 89 116 (Pubitemid 28044088)
5. J.M. Bermudez, A.F. Jimenez-Kairuz, M.E. Olivera, D.A. Allemandi, and R.H. Manzo A ciprofloxacin extended release tablet based on swellable drug polyelectrolyte matrices AAPS PharmSciTech 9 2008 924 930
6. A.V. Bhalerao, S.L. Lonkar, S.S. Deshkar, S.V. Shirolkar, and A.D. Deshpande Nasal mucoadhesive in situ gel of ondansetron hydrochloride Indian Journal of Pharmaceutical Sciences 71 2009 711 713
7. M. Bhandwalkar, and A. Avachat Thermoreversible nasal in situ gel of venlafaxine hydrochloride: formulation, characterization, and pharmacodynamic evaluation AAPS PharmSciTech 14 2013 101 110
8. T. Bouziani, and A. Benmounah Correlation between v-funnel and mini-slump test results with viscosity KSCE Journal of Civil Engineering 17 2013 173 178
9. H.E. Burroughs, and S.J. Hansen The thermal enviroment: a internal habitat Chapter 6 H.E. Burroughs, S.J. Hansen, Managing Indoor Air Quality fifth ed. 2011 Fairmont Press Lilburn, GA, USA 147 164
10. C. Callens, J. Ceulemans, A. Ludwig, P. Foreman, and J.P. Remon Rheological study on mucoadhesivity of some nasal powder formulations European Journal of Pharmaceutics and Biopharmaceutics 55 2003 323 328 (Pubitemid 36561559)
11. E. Chen, J. Chen, S.L. Cao, Q.Z. Zhang, and X.G. Jiang Preparation of nasal temperature-sensitive in situ gel of Radix Bupleuri and evaluation of the febrile response mechanism Drug Development and Industrial Pharmacy 36 2010 490 496
12. H.J. Cho, P. Balakrishnan, E.K. Park, K.W. Song, S.S. Hong, T.Y. Jang, K.S. Kim, S.J. Chung, C.K. Shim, and D.D. Kim Poloxamer/cyclodextrin/chitosan- based thermoreversible gel for intranasal delivery of fexofenadine hydrochloride Journal of Pharmaceutical Sciences 100 2011 681 691
13. N.E. Cooke, and C. Chen A contribution to a mathematical theory for polymer-based controlled release devices International Journal of Pharmaceutics 115 1995 17 27
14. G.M. Corbo, A. Foresi, P. Bonfitto, A. Mugnano, N. Agabiti, and P.J. Cole Measurement of nasal mucociliary clearance Archives of Disease in Childhood 64 1989 546 550 (Pubitemid 19104114)
15. P. Costa, and J.M. Sousa Lobo Modeling and comparison of dissolution profiles European Journal of Pharmaceutical Sciences 13 2001 123 133 (Pubitemid 32288781)
16. H.R. Costantino, L. Illum, G. Brandt, P.H. Johnson, and S.C. Quay Intranasal delivery: physicochemical and therapeutic aspects International Journal of Pharmaceutics 337 2007 1 24 (Pubitemid 46756063)
17. S.V. Dhuria, L.R. Hanson, and W.H. Frey 2nd Intranasal delivery to the central nervous system: mechanisms and experimental considerations Journal of Pharmaceutical Sciences 99 2010 1654 1673
18. P. Dondeti, H. Zia, and T.E. Needham Bioadhesive and formulation parameters affecting nasal absorption International Journal of Pharmaceutics 127 1996 115 133 (Pubitemid 26092131)
19. M.D. Donovan, and M.P. Zhou Drug effects on in vivo nasal clearance in rats International Journal of Pharmaceutics 116 1995 77 86
20. K. Edsman, J. Carlfors, and R. Petersson Rheological evaluation of poloxamer as an in situ gel for ophthalmic use European Journal of Pharmaceutical Sciences 6 1998 105 112 (Pubitemid 28164280)
21. J.J. Escobar-Chavez, M. Lopez-Cervantes, A. Naik, Y.N. Kalia, D. Quintanar-Guerrero, and A. Ganem-Quintanar Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations Journal of Pharmacy and Pharmaceutical Sciences 9 2006 339 358 (Pubitemid 46655458)
22. J.C. Gilbert, J. Hadgraft, A. Bye, and L.G. Brookes Drug release from Pluronic F-127 gels International Journal of Pharmaceutics 32 1986 223 228 (Pubitemid 16015303)
23. J.C. Gilbert, J.L. Richardson, M.C. Davies, and K.J. Palin The effect of solutes and polymers on the gelation properties of pluronic F-127 solutions for controlled drug delivery Journal of Controlled Release 5 1987 113 118
24. R.G. Green, and R.G. Griskey Rheological behavior of dilatant (shear-thickening) fluids. Part I. Experimental and data Journal of Rheology 12 1968 13 25
25. P. Hartvig, H. Askmark, S.M. Aquilonius, L. Wiklund, and B. Lindstrom Clinical pharmacokinetics of intravenous and oral 9-amino-1,2,3,4- tetrahydroacridine, tacrine European Journal of Clinical Pharmacology 38 1990 259 263 (Pubitemid 20137478)
26. W.A. Hyman Rheology of power law fluids Industrial and Engineering Chemistry Fundamentals 15 1976 215 218
27. L. Illum Nasal drug delivery - possibilities, problems and solutions Journal of Controlled Release 87 2003 187 198 (Pubitemid 36255456)
28. L. Illum, N.F. Farraj, and S.S. Davis Chitosan as a novel nasal delivery system for peptide drugs Pharmaceutical Research 11 1994 1186 1189 (Pubitemid 24259861)
29. L. Illum, P. Watts, A.N. Fisher, M. Hinchcliffe, H. Norbury, I. Jabbal-Gill, R. Nankervis, and S.S. Davis Intranasal delivery of morphine Journal of Pharmacology and Experimental Therapeutics 301 2002 391 400 (Pubitemid 34250318)
30. J.P. Jacky Barometric measurement of tidal volume: effects of pattern and nasal temperature Journal of Applied Physiology 49 1980 319 325 (Pubitemid 10043206)
31. B.R. Jasti, V.P. Marasanapalle, J.R. Crison, J.W. Ma, and X.L. Li Investigation of some factors contributing to negative food effects Biopharmaceutics and Drug Disposition 30 2009 71 80
32. B. Jeong, S.W. Kim, and Y.H. Bae Thermosensitive sol-gel reversible hydrogels Advanced Drug Delivery Reviews 54 2002 37 51 (Pubitemid 34075313)
33. V.S. Jitendra, K.M. Kailas, J.D. Remeth, D.H. Vijay, and S.M. Niranjan In situ mucoadhesive nasal gels of metoclopramide hydrochloride: preformulation and formulation studies Journal of Pharmaceutical Research 1 2008 88 96
34. V.V. Jogani, P.J. Shah, P. Mishra, A.K. Mishra, and A.R. Misra Intranasal mucoadhesive microemulsion of tacrine to improve brain targeting Alzheimer Disease and Associated Disorders 22 2008 116 124
35. Z. Li, and J. Guan Thermosensitive hydrogels for drug delivery Expert Opinion on Drug Delivery 8 2011 991 1007
36. H.R. Lin, and K.C. Sung Carbopol/pluronic phase change solutions for ophthalmic drug delivery Journal of Controlled Release 69 2000 379 388
37. S. Madden, V. Spaldin, and B.K. Park Clinical pharmacokinetics of tacrine Clinical Pharmacokinetics 28 1995 449 457
38. S. Madden, T.F. Woolf, W.F. Pool, and B.K. Park An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes Biochemical Pharmacology 46 1993 13 20 (Pubitemid 23218576)
39. R.J. Majithiya, P.K. Ghosh, M.L. Umrethia, and R.S. Murthy Thermoreversible-mucoadhesive gel for nasal delivery of sumatriptan AAPS PharmSciTech 7 2006 67
40. W.P. McNally, W.F. Pool, M.W. Sinz, P. Dehart, D.F. Ortwine, C.C. Huang, T. Chang, and T.F. Woolf Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue Drug Metabolism and Disposition 24 1996 628 633 (Pubitemid 26170713)
41. ® F127 gel dissolution: drug release in stirred systems Journal of Controlled Release 67 2000 191 202 (Pubitemid 30303834)
42. J.T. O'Brien, S. Eagger, and R. Levy Effects of tetrahydroaminoacridine on liver function in patients with Alzheimer's disease Age and Ageing 20 1991 129 131
43. F. Ojima, T. Ido, J. Hatazawa, M. Itoh, H. Shinohara, S. Watanuki, S. Seo, H. Kai, K. Takahama, T. Ishii, Y. Nakagawa, and T. Miyata Development of a new method for simultaneously evaluating mucociliary clearance and pulmonary epithelial permeability in rabbit experiments by means of18FDG, three-dimensional positron emission tomography and rectilinear scan Annals of Nuclear Medicine 12 1998 231 235 (Pubitemid 28549739)
44. B.K.M. Park, Stephen, Spaldin, Vanessa, Woolf, F. Thomas, Pool, and F. William Tacrine transaminitis: potential mechanisms Alzheimer Disease and Associated Disorders 8 1994 S39 S49
45. J. Patocka, D. Jun, and K. Kuca Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease Current Drug Metabolism 9 2008 332 335 (Pubitemid 351836422)
46. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates sixth ed. 2007 Elsevier London, UK
47. G.G. Pereira, F.A. Dimer, S.S. Guterres, C.P. Kechinski, J.E. Granada, and N.S.M. Cardozo Formulation and characterization of poloxamer 407: Thermoreversible gel containing polymeric microparticles and hyaluronic acid Quimica Nova 36 2013 1121 1125
48. D.F. Proctor, I. Andersen, and G.R. Lundqvist Human nasal mucosal function at controlled temperatures Respiration Physiology 30 1977 109 124 (Pubitemid 8095123)
49. S. Qian, M. Mak, L. He, C.Y. Ho, Y. Han, and Z. Zuo In vitro anti-antiacetylcholinesterase activities and permeabilities of novel potential anti-Alzheimer's agents 9th International Society for the Study of Xenobiotics (ISSX) Meeting, September 04-08 Istanbul, Turkey 2010
50. S. Qian, S.K. Wo, and Z. Zuo Pharmacokinetics and brain dispositions of tacrine and its major bioactive monohydroxylated metabolites in rats Journal of Pharmaceutical and Biomedical Analysis 61 2012 57 63
51. N. Qizilbash, A. Whitehead, J. Higgins, G. Wilcock, L. Schneider, and M. Farlow Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. Dementia Trialists' Collaboration JAMA 280 1998 1777 1782 (Pubitemid 28536880)
52. E. Ruel-Gariépy, and J.-C. Leroux In situ-forming hydrogels - review of temperature-sensitive systems European Journal of Pharmaceutics and Biopharmaceutics 58 2004 409 426 (Pubitemid 39037244)
53. J. Rutland, and P.J. Cole Nasal mucociliary clearance and ciliary beat frequency in cystic fibrosis compared with sinusitis and bronchiectasis Thorax 36 1981 654 658 (Pubitemid 12217360)
54. I.R. Schmolka Artificial skin I. Preparation and properties of pluronic F-127 gels for treatment of burns Journal of Biomedical Materials Research 6 1972 571 582
55. V. Spaldin, S. Madden, W.F. Pool, T.F. Woolf, and B.K. Park The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes British Journal of Clinical Pharmacology 38 1994 15 22 (Pubitemid 24222831)
56. W.K. Summers Tacrine (THA, Cognex (R)) Journal of Alzheimer's Disease 2 2000 85 93
57. W.K. Summers Tacrine, and Alzheimer's treatments Journal of Alzheimer's Disease 9 2006 439 445 (Pubitemid 44253338)
58. D.M. Suzuki, K. Alagiakrishnan, K.H. Masaki, A. Okada, and M. Carethers Patient acceptance of intranasal cobalamin gel for vitamin B12 replacement therapy Hawaii Medical Journal 65 2006 311 314
59. J. Varshosaz, M. Tabbakhian, and Z. Salmani Designing of a thermosensitive chitosan/poloxamer in situ gel for ocular delivery of ciprofloxacin The Open Drug Delivery Journal 2 2008 61 70
60. V.D. Wagh, K.H. Deshmukh, and K.V. Wagh Formulation and evaluation of in situ gel drug delivery system of Sesbania grandiflora flower extract for the treatment of bacterial conjunctivitis Journal of Pharmaceutical Sciences and Research 4 2012 1880 1884
61. X. Wang, G. Liu, J. Ma, S. Guo, L. Gao, Y. Jia, X. Li, and Q. Zhang In situ gel-forming system: an attractive alternative for nasal drug delivery Critical Reviews in Therapeutic Drug Carrier Systems 30 2013 411 434
62. P. Watts, and A. Smith PecSys: in situ gelling system for optimised nasal drug delivery Expert Opinion on Drug Delivery 6 2009 543 552
63. Y. Wong, and Z. Zuo Brain disposition and catalepsy after intranasal delivery of loxapine: role of metabolism in PK/PD of intranasal CNS drugs Pharmaceutical Research 30 2013 2368 2384
64. Y.C. Wong, S. Qian, and Z. Zuo Regioselective biotransformation of CNS drugs and its clinical impact on adverse drug reactions Expert Opinion on Drug Metabolism & Toxicology 8 2012 833 854
65. Y.C. Wong, and Z. Zuo Intranasal delivery - modification of drug metabolism and brain disposition Pharmaceutical Research 27 2010 1208 1223
66. M.-O. Yun, H.-G. Choi, J.-H. Jung, and C.-K. Kim Development of a thermo-reversible insulin liquid suppository with bioavailability enhancement International Journal of Pharmaceutics 189 1999 137 145 (Pubitemid 29481749)
67. N.M. Zaki, G.A. Awad, N.D. Mortada, and S.S. Abd ElHady Enhanced bioavailability of metoclopramide HCl by intranasal administration of a mucoadhesive in situ gel with modulated rheological and mucociliary transport properties European Journal of Pharmaceutical Sciences 32 2007 296 307 (Pubitemid 350064481)
68. Y. Zhang, M. Huo, J. Zhou, A. Zou, W. Li, C. Yao, and S. Xie DDSolver: an add-in program for modeling and comparison of drug dissolution profiles The AAPS Journal 12 2010 263 271
69. Y.J. Zhang, C.H. Ma, W.L. Lu, X. Zhang, X.L. Wang, J.N. Sun, and Q. Zhang Permeation-enhancing effects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo Acta Pharmacologica Sinica 26 2005 1402 1408 (Pubitemid 41607015)