Gochnatia polymorpha ssp. floccosa: Bioprospecting of an anti-inflammatory phytotherapy for use during pregnancy

Journal of Ethnopharmacology

Volumn 154, Issue 2, 2014, Pages 370-379

  De David, Natan ^a   De Oliveira Mauro, Mariana ^a   Gonçalves, Caroline Amélia ^a   Pesarini, João Renato ^a   Strapasson, Regiane Lauriano Batista ^b   Kassuya, Cândida Aparecida Leite ^c   Stefanello, Maria Élida Alves ^b   Cunha Laura, Andréa Luiza ^a   Monreal, Antônio Carlos Duenhas ^a   Oliveira, Rodrigo Juliano ^a  

^a FEDERAL UNIVERSITY OF MATO GROSSO DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^c UNIVERSIDADE FEDERAL DA GRANDE DOURADOS   (Brazil)

Author keywords

Asteraceae; Chronic inflammation; Immunomodulation; Micronucleus; Teratogenesis

Indexed keywords

GOCHNATIA POLYMORPHA ETHANOL EXTRACT; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIRTH DEFECT; CONTROLLED STUDY; EMBRYO DEVELOPMENT; EOSINOPHIL COUNT; FEMALE; FETUS DEVELOPMENT; GESTATION PERIOD; GOCHNATIA POLYMORPHA; IMMUNOSTIMULATION; LOW DRUG DOSE; LYMPHOCYTE COUNT; MALE; MATING; MEDICINAL PLANT; MOUSE; MUTAGENICITY; NEUTROPHIL COUNT; NONHUMAN; ORGANOGENESIS; PHYTOTHERAPY; PREGNANCY; REPRODUCTIVE SUCCESS; SPONTANEOUS ABORTION; TERATOGENESIS; ANIMAL; ASTERACEAE; BLOOD CELL COUNT; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EDEMA; ENVIRONMENTAL EXPOSURE; ETHNOPHARMACOLOGY; ISOLATION AND PURIFICATION; MICRONUCLEUS TEST; ORGAN SIZE; PHAGOCYTOSIS; SPLEEN; TOXICITY;

ASTERACEAE; GOCHNATIA POLYMORPHA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTERACEAE; BLOOD CELL COUNT; EDEMA; EMBRYONIC DEVELOPMENT; ETHNOPHARMACOLOGY; FEMALE; FETAL DEVELOPMENT; MALE; MATERNAL EXPOSURE; MICE; MICRONUCLEUS TESTS; ORGAN SIZE; ORGANOGENESIS; PHAGOCYTOSIS; PLANT EXTRACTS; PREGNANCY; SPLEEN;

EID: 84901587347     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.04.005     Document Type: Article

References (65)

1. M.P. Adam, J.E. Polifka, and J.M. Friedman Evolving knowledge of the teratogenicity of medications in human pregnancy American Journal of Medical Genetics Part C: Seminars in Medical Genetics 157 2011 175 182
2. M.H. Amorim, R.M. Gil da Costa, C. Lopes, and M.M. Bastos Sesquiterpene lactones: adverse health effects and toxicity mechanisms Critical Reviews in Toxicology 43 2013 559 579
3. M. Arambarri, S.E. Freire, M.N. Colares, N.D. Bayon, M.C. Novoa, C. Monti, and S.A. Sten-Glein Leaf anatomy of medicinal shrubs and trees from misiones Forest of the Paranaense Province (Argentina). Part2 Boletín de la Sociedad Argentina de Botánica 43 2008 31 36
4. S.A. Auharek, M. Do Carmo Vieira, C.A.L. Cardoso, R.J. Oliveira, and A.L. Cunha-Laura Reproductive toxicity of Campomanesia xanthocarpa (Berg.) in female Wistar rats Journal of Ethnopharmacology 148 2013 341 343
5. M.V. Barrow, and W.J. Taylor A rapid method for detecting malformations in rat fetuses Journal of Morphology 127 1969 291 305
6. F. Bohlmann, C. Zdero, G. Schmeda-Hirschmann, J. Jakupovic, X.A. Dominguez, R.M. King, and H. Robinson Dimeric guainolides and other constituents from Gochnatia species Phytochemistry 44 1986 1175 1178
7. R. Bueno, R.O. Castilho, R.B. Costa, A. Pott, V.J. Pott, G.N. Scheidt, and M.S. Batista Medicinal plants used by the Kaiowá and Guarani indigenous populations in the Caarapó reserve, Mato Grosso do Sul, Brazil Acta Botanica Brasilica 19 2005 39 44
8. G.D. Cappon, J.C. Cook, and M.E. Hurtt Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure Birth Defects Research (Part B) 68 2003 47 56
9. C.A.N. Catalan, S.A. Borkosky, and P.J. Nathan The secondary metabolite chemistry of the subtribe Gochnatiinae (Tribe Mutisieae, Family Compositae) Biochemical Systematics and Ecology 24 1996 659 718
10. C.A.N. Catalan, M.I. Vega, M.E. Lopez, M.R. Cuenca, T.E. Gedris, and W. Herz Coumarins and a kaurane from Gochnatia polymorpha ssp. Polymorpha from Paraguay Biochemical Systematics and Ecology 31 2003 417 422
11. J.C. Cox, and A.R. Coulter Adjuvants - a classification and review of the modes of action Vaccine 15 1997 248 256
12. D.C. Damasceno, W.G. Kempinas, G.T. Volpato, M. Consoni, M.V.C. Rudge, and F.J.R. Paumgartten Anomalias Congênitas: Estudos Experimentais first ed. 2008 Coopmed Editora Médica Belo Horizonte
13. J.R. Daw, G.E. Hanley, D.L. Greyson, and S.G. Morgan Prescription drug use during pregnancy in developed countries: a systematic review Pharmacoepidemiology and Drug Safety 20 2011 895 902
14. D.R.V. Edwards, and K.E. Hartmann Racial differences in risk of spontaneous abortions associated with periconceptional over-the-counter nonsteroidal anti-inflammatory drug exposure Annals of Epidemiology 24 2013 111 115 10.1016/j.annepidem.2013.11.001
15. M.A. Elovitz Anti-inflammatory interventions in pregnancy: now and the future Seminars in Fetal and Neonatal Medicine 11 2006 327 332
16. U.J. Eriksson, and L. Jansson Diabetes in pregnancy: decreased placental blood flow and disturbed fetal developmental in the rat International Pediatric Research 18 1984 735 738
17. A.C.M. Farias, J.R. Da Silva, and T.C.B. Tomassini Constituents of Mochinea polymorpha Journal of Natural Products 47 1984 363 364
18. T.M.B. Garlet, and B.E. Irgang Medicinal plants used by rural women workers in Cruz Alta, Rio Grande do Sul Brazilian Journal of Medicinal Plants 4 2001 9 18
19. C.A. Gonçalves, N.L. Silva, M.O. Mauro, N. David, A.L. Cunha-Laura, S.A. Auharek, A.C.D. Monreal, M.C. Vieira, D.B. Silva, F.J.L. Santos, J.M. Siqueira, and R.J. Oliveira Evaluation of mutagenic, teratogenic and immunomodulatory effects of Annona nutans hydromethanolic fraction on pregnant mice Genetics and Molecular Research 2014 (in press)
20. C.A. Gonçalves, J.M. Siqueira, C.A. Carollo, M.O. Mauro, N. David, A.L. Cunha-Laura, A.C.D. Monreal, A.H. Castro, L. Fernandes, R.R. Chagas, S.A. Auharek, and R.J. Oliveira Gestational exposure to Byrsonima verbascifolia: teratogenicity, mutagenicity and immunomodulation evaluation in female Swiss mice Journal of Ethnopharmacology 150 2013 843 850
21. F. Stils Harold Jr. Adjuvants and antibody production: dispelling the myths associated with freund's complete and other adjuvants ILAR Journal 46 2005 280 293
22. M. Hayashi, T. Morita, Y. Kodama, T. Sofuni, and M. Ishidate Jr. The micronucleus assay with mouse peripheral blood reticulocytes using acrideine arange-coated slides Mutation Research 245 1990 245 249
23. R.C. Horn, and V.M. Vargas Mutagenicity and antimutagenicity of teas used in popular medicine in the salmonella/microsome assay Toxicology In Vitro 22 2008 1043 1049
24. P.L. Ishii, C.K. Prado, M.O. Mauro, C.M. Carreira, M.S. Mantovani, L.R. Ribeiro, J.B. Dichi, and R.J. Oliveira Evaluation of Agaricus blazei in vivo for antigenotoxic, anticarcinogenic, phagocytic and immunomodulatory activities Regulatory Toxicology and Pharmacology 59 2011 412 422
25. J.A. Keifer, D.C. Guttridge, B.P. Ashburner, and A.S. Baldwin Jr. Inhibition of NF-kB activity by thalidomide through suppression of IkB kinase activity Journal of Biological Chemistry 276 2001 22382 22387
26. C.A. Kimmel, and J.G. Wilson Skeletal deviations in rats: malformations or variations? Teratology 1 1973 38 44
27. N. Kretschmer, B. Rinner, N. Stuendl, H. Kaltenegger, E. Wolf, O. Kunert, H. Boechzelt, A. Leithner, R. Bauer, and B. Lohberger Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells Planta Medica 78 2012 1749 1756
28. M.E. Maggi, A. Mangeaud, M.C. Carpinella, C.G. Ferrayoli, G.R. Valladares, and S.M. Palacios Laboratory evaluation of Artemisia annua L. extract and artemisinin activity against Epilachna paenulata and Spodoptera eridania Journal of Chemical Ecology 31 2005 1527 1536
29. J.M. Manson, H. Zenick, and R.D. Costlow Teratology test methods for laboratory animals A.W. Hayes, Principles and Methods of Toxicology 1982 Raven Press New York 141 184
30. J.M. Manson, and Y.J. Kang Test methods for assessing female reproductive and developmental toxicology A.W. Hayes, Principles and Methods of Toxicology 1994 Raven Press New York 989 1038
31. M.L. Martinez-Frias, E. Rodriguez-Pinilla, and L. Prieto Prenatal exposure to salicylates and gastroschisis: a case-control study Teratology 56 1997 241 243
32. V.B. Mathema, Y.S. Koh, B.C. Thakuri, and M. Sillanpää Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities Inflammation 35 2012 560 565
33. M.H. Moghadam, H. Hajimehdipoor, S. Saeidnia, A. Atoofi, R. Shahrestani, R.W. Read, and M. Mosaddegh Anti-proliferative activity and apoptotic potential of britannin, a sesquiterpene lactone from Inula aucheriana Natural Product Communications 7 2012 979 980
34. A.S. Moreira, V. Spitzer, E.E. Schapoval, and E.P. Schenkel Antiinflammatory activity of extracts and fractions from the leaves of Gochnatia polymorpha Phytotherapy Research. 14 2000 638 640
35. W.B. Mors, C.T. Rizzini, and N.A. Pereira Medicinal Plants of Brazil 2000 Reference Publications Inc Michigan
36. H.R. Nakhai-Pour, P. Broy, O. Sheehy, and A. Bérard Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion Canadian Medical Association Journal 183 2011 1713 1720
37. B. Ofori, D. Oraichi, L. Blais, E. Rey, and A. Bérard Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: a nested case-control study Birth Defects Research (Part B) 77 2006 268 279
38. C. Olesen, F.H. Steffensen, G.L. Nielsen, L. de Jong-van den Berg, J. Olsen, and H.T. Sorensen Drug use in first pregnancy and lactation: a population-based survey among Danish women. The EUROMAP group European Journal of Clinical Pharmacology 55 1999 139 144
39. R.J. Oliveira, S.U. Oliva, G.A. Daroz, and E.M. Rubio Fertility assessment and possible external structural defects on progeny from male rats chronically exposed to arsenic Revista Brasileira de Toxicologia 18 2005 57 61
40. R.J. Oliveira, M.J. Salles, A.F. da Silva, T.Y. Kanno, A.C. Lourenço, G.A. Freiria, H.J. Matiazi, L.R. Ribeiro, and M.S. Mantovani Effect of the polyssacharide β-glucon on clastogenicity and teratogenicity caused by acute exposure to cyclophosphamide in mice Regulatory Toxicology and Pharmacology 53 2009 164 173
41. R.J. Oliveira, E. Baise, M. de O. Mauro, J.R. Pesarini, R. Matuo, A.F. Silva, L.R. Ribeiro, and M.S. Mantovani Evaluation of chemopreventive activity of glutamine by the comet and the micronucleus assay in mice's peripheral blood Environmental Toxicology and Pharmacology 28 2009 120 124
42. R.J. Oliveira, J.R. Pesarini, M.O. Mauro, L.S. Fronza, S.G. Victorelli, W.B. Cantero, and A.C.M.B. Antoniolli Effects of phenylalanine on reproductive performance and teratogenesis in mice Genetics and Molecular Research 2014 (in press)
43. R.R. Piornedo, P. Souza, M.E.A. Stefanello, R.L.B. Strapasson, A.R. Zampronio, and C.A.L. Kassuya Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice Journal of Ethnopharmacology 133 2011 1077 1084
44. V. Popović, A. Heyerick, S. Petrović, S. Van Calenbergh, I. Karalić, M. Niketić, and D. Deforce Sesquiterpene lactones from the extracts of two Balkan endemic Laserpitium species and their cytotoxic activity Phytochemistry 87 2013 102 111
45. Y. Ren, U.M. Acuña, F. Jiménez, R. García, M. Mejía, H. Chai, J.C. Gallucci, N.R. Farnsworth, D.D. Soejarto, E.J. Carcache de Blanco, and A.D. Kinghorn Cytotoxic and NF-κB inhibitory sesquiterpene lactones from Piptocoma rufescens Tetrahedron 68 2012 2671 2678
46. D.M. Rothwarf, and M. Karin The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus Science's Signal Transduction Knowledge Environment 1999 10.1126/stke.1999.5.re1
47. A.C.B. Sacilotto, W. Vichnewski, and W. Herz Ent-kaurene diterpenes from Gochnatia polymorpha var. polymorpha Phytochemistry 44 1997 659 661
48. E. Salewski Färbemethode zum makroskopischen Nachweis von implantations-stellen am Uterus der Ratte Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie 247 1964 367
49. A. Salminen, M. Lehtonen, T. Suuronen, K. Kaarniranta, and J. Huuskonen Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential Cellular and Molecular Life Sciences 65 2008 2979 2999
50. Sancho, G., Roque, N., 2013. Gochnatia: Lista de espécies da flora do Brasil. Jardim Botânico do Rio de Janeiro. 〈http://floradobrasil. jbrj.gov.br/jabot/floradobrasil/FB5317〉 (accessed 09.01.14.).
51. L.B. Silva, R.L.B. Strapasson, D. Riva, M.J. Salvador, and M.E.A. Stefanello Triterpenes from the flowers of Gochnatia polymorpha ssp. floccosa (Asteraceae) Brazilian Journal of Pharmacognosy 21 2011 556 559
52. R.E. Staples, and V.L. Schnell Refinements in rapid clearing technic in the KOH-alizarin red S method for fetal loc Stain Technology 39 1964 61 63
53. M.E.A. Stefanello, A.C. Cervi, J.R.A. Wisniewski, and E.L. Simionatto Óleo essencial de Gochnatia polymorpha (LESS) CABR. ssp. floccosa CABR Química Nova 29 2006 999 1002
54. M.E.A. Stefanello, M.J. Salvador, I.Y. Ito, and P.A.T. Macari Avaliação da atividade antimicrobiana e citotóxica de extratos de Gochnatia polymorpha ssp. floccosa Brazilian Journal of Pharmacognosy 16 2006 525 530
55. R.L.B. Strapasson Estudo Químico e Farmacológico das Cascas do Tronco de Gochnatia polymorpha ssp. floccosa (Asteraceae) (Master's thesis) 2010 Department of Chemistry, Federal University of Paraná Curitiba, PR, Brazil
56. R.L.B. Strapasson, A.C. Cervi, J.E. Carvalho, A.L.T.G. Ruiz, M.J. Salvador, and M.E.A. Stefanello Bioactivity-guided isolation of cytotoxic sesquiterpene lactones of Gochnatia polymorpha ssp. floccosa Phytotherapy Research 26 2012 1053 1056
57. V.R. Suarez, L.L. Thompson, V. Jain, G.L. Olson, G.D. Hankins, M.A. Belfort, and G.R. Saade The effect of in utero exposure to indomethacin on the need for surgical closure of a patent ductus arteriosus in the neonate American Journal of Obstetrics and Gynecology 187 2002 886 888
58. K.T. Szabo Congenital Malformations in Laboratory and Farm Animals 1989 Academic Press San Diego
59. K. Takeda, O. Takeuchi, T. Tsujimura, S. Itami, O. Adachi, T. Kawai, H. Sanjo, K. Yoshikawa, N. Terada, and S. Akira Limb and skin abnormalities in mice lacking IKKa Science 284 1999 313 316
60. P. Taylor Practical Teratology 1986 Academic Press New York
61. H. Wang, T. Wu, M. Yan, G. Liu, P. Li, X.Q. Zhang, W.C. Ye, and L.Y. Zhang Sesquiterpenes from Ainsliaea fragrans and their inhibitory activities against cyclooxygenases-1 and 2 Chemical and Pharmaceutical Bulletin (Tokyo) 57 2009 597 599
62. J.G. Wilson Methods for administering agents and detecting malformations in experimental animals J.G. Wilson, J. Warkany, Teratology: Principles and Techniques 1965 The University of Chicago Press Chicago 262 277
63. E.T. Wong, and V. Tergaonkar Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential Clinical Science (Lond) 116 2009 451 465
64. Z. Zelinkova, C. van der Ent, K.F. Bruin, O. van Baalen, H.G. Vermeulen, H.J. Smalbraak, R.J. Ouwendijk, A.C. Hoek, S.D. van der Werf, E.J. Kuipers, and C.J. van der Woude Effects of discontinuing anti-tumor necrosis factor therapy during pregnancy on the course of inflammatory bowel disease and neonatal exposure Clinical Gastroenterology and Hepatology 11 2013 318 321
65. S. Zhang, Y.K. Won, C.N. Ong, and H.M. Shen Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms Current Medicinal Chemistry Anti-cancer Agents 5 2005 239 249