Mutagenicity and antimutagenicity of teas used in popular medicine in the salmonella/microsome assay

Toxicology in Vitro

Volumn 22, Issue 4, 2008, Pages 1043-1049

  Horn, Rubem Cesar ^a   Vargas, Vera Maria Ferrão ^a  

^a Divisao de Biologia   (Brazil)

Author keywords

Antimutagenicity; Co mutagenesis; Mutagenicity; Plant extracts; Salmonella microsome assay

Indexed keywords

2 FLUORENYLAMINE; GOCHNATIA CORDATA EXTRACT; GOCHNATIA POLYMORPHA EXTRACT; MUTAGENIC AGENT; NITROQUINOLINE DERIVATIVE; PLANT EXTRACT; SODIUM AZIDE; UNCLASSIFIED DRUG; VITEX MONTEVIDENSIS EXTRACT;

ANGIOSPERM; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASTERACEAE; FRAMESHIFT MUTATION; GOCHNATIA CORDATA; GOCHNATIA POLYMORPHA; LIVER METABOLISM; MEDICINAL PLANT; MICROSOME; MUTAGENESIS; MUTAGENICITY; NONHUMAN; RAT; SALMONELLA; TEA; VITEX MONTEVIDENSIS;

ANTIMUTAGENIC AGENTS; ASTERACEAE; BEVERAGES; BRAZIL; FLAVONOIDS; MICROSOMES; MUTAGENICITY TESTS; MUTAGENS; PLANT EXTRACTS; SALMONELLA; TANNINS; VITEX;

ASTERACEAE; GOCHNATIA; GOCHNATIA POLYMORPHA; LAMIACEAE; RATTUS; VITEX;

EID: 41949110408     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.12.014     Document Type: Article

References (36)

1. Alice C.B., Vargas V.M.F., Silva G.A.A.B., Siqueira N.C.S., Schapoval E.E.S., Gleye J., Henriques J.A.P., and Henriques A.T. Screening of plants used in south Brazilian folk medicine. Journal of Ethnopharmacology 35 (1991) 165-171
2. Beudot C., De Méo M.P., Dauzonne D., Elias R., Laget M., Guiraud H., Balasard G., and Duménil G. Evaluation of the mutagenicity and antimutagenicity of forty-two 3-substituted flavones in the Ames test. Mutation Research 417 (1998) 141-153
3. Buening M.K., Chang R.L., Huang M.-T., Fortner J.G., Wood A.W., and Conney A.H. Activation and inhibition of benzo[a]pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occuring flavonoids. Cancer Research 41 (1981) 67-72
4. Campesato V.R., Graf U., Reguly M.L., and Andrade H.H. Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. Environmental Molecular Mutagenesis 29 1 (1997) 91-97
5. Chung K.-T., Wei C.-I., and Johnson M.G. Are tannins a double-edged sword in biology and health. Trends in Food Science and Technology 9 (1998) 168-175
6. Czeczot H., Tudek B., Kusztelak J., Szymczyk T., Dobrowolska B., Glinkowska G., Malinowski J., and Strzelecka H. Isolation and studies of the mutagenic activity in the Ames test of flavonoids naturally occuring in medical herbs. Mutation Research 240 (1990) 209-216
7. De Bruyne T., Pieters L., Deelstra H., and Vlietinck A. Condensed vegetable tannins: biodiversity in structure and biological activities. Biochemical Systematics and Ecology 27 (1999) 445-459
8. Edenharder R., van Petersdorf I., and Rauscher R. Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazol [4-5-f] quinoline (IQ) and other heterocyclic amine mutagens from cooked food. Mutation Research 287 (1993) 261-274
9. Fernandes J.B.F., and Vargas V.M.F. Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa. Phytotherapy Research 17 3 (2003) 269-273
10. Ferreira I.C.F.S., and Vargas V.M.F. Mutagenicity of medicinal plant extracts in Salmonella/microsome assay. Phytotherapy Research 13 (1999) 397-400
11. Horn R.C., and Vargas V.M.F. Antimutagenic activity of extracts of natural substances in the Salmonella/microsome assay. Mutagenesis 18 2 (2003) 113-118
12. Imanishi H., Sasaki Y.F., Ohta T., Watanabe M., Kato T., and Shirasu Y. Tea tannin components modify the induction of sister-chiromatid exchanges and chromosome aberration in mutagen-treated cultured mammalian cells and mice. Mutation Research 259 (1991) 79-88
13. Kada T., Kaneko K., Matsuzaki T., and Hara Y. Detection and chemical identification of natural bio-antimutagens. Mutation Research 150 (1985) 127-132
14. Kappus H. Overview of enzyme systems involved in bioreduction of drugs and in redox cycling. Biochemical Pharmacology 35 (1986) 1-6
15. Khan N.S., Ahmad A., and Hadi S.M. Anti-oxidant, pro-oxidant properties of tannic acid and its binding to DNA. Chemico-Biological Interactions 125 (2000) 177-189
16. MacGregor J.T. Genetic toxicology of dietary flavonoids. In: Knudser I. (Ed). Genetic Toxicology of the Diet (1986), Alan R. Liss, New York 33-43
17. MacGregor J.T., and Wilson R.E. Flavone mutagenicity in Salmonella typhimurium: dependence on the pKM101 plasmid and excision-repair deficiency. Environmental Molecular Mutagenesis 11 (1988) 315-322
18. Maron D.M., and Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutation Research 113 (1983) 173-215
19. Mortelmans K., and Zeiger E. The Ames Salmonella/microsome mutagenicity assay. Mutation Research 455 (2000) 29-60
20. Myers L.A., Kier L., Rao T., Shaw B., and Williams L. Microcomputer software for data management and statistical analyses of the Ames/Salmonella test. In: Krewski D. (Ed). Statistical Methods in Toxicological Research (1991), Gordon and Brech, New York 65-279
21. Nozaka T., Watanabe F., Tadaki S., Ishino M., Morimoto I., Kunitomo J., Ishii H., and Natori S. Mutagenicity of isoquinoline alkaloids, especially of the aporphine type. Food and Chemical Toxicology 30 8 (1992) 689-694
22. Okuda T. Systematics and health effects of chemically distinct tannins in medicinal plants. Phytochemistry 66 (2005) 2012-2031
23. Okuda T., Kimura Y., Yoshida T., Hatano T., Okuda H., and Arichi S. Inhibitory effects of tannins on lipid peroxidation in mitochondria and microsomes of liver. Chemical and Pharmaceutical Bulletin 31 (1983) 1625-1631
24. Parke D.V., Ioannides C., and Lewis D.F.V. The 1990 pharmaceutical manufactures association of Canada keynote lecture. The role of the cytochromes P450 in the detoxication and activation of drugs and others chemicals. Canadian Journal of Physiology and Pharmacology 69 (1991) 537-549
25. Paula-Ramos A.L.L., Querol C.B., Marques E.K., and Henriques J.A.P. Cytotoxic activation of pyrrolizidine alkaloid integerrimine in yeast Saccharomyces is caused by repairable DNA damage. Revista Brasileira de Genética 14 (1991) 897-912
26. Ravanel P., Leclercq M.A., and Mariotte M. La génotocixité des flavonoides. Plants médicinales et Phytérapie XXI (1987) 63-78
27. Ruan C., Liang Y., Liu J., Tu W., and Liu Z. Antimutagenic effects of eight natural foods in a high liver cancer incidence area. Mutation Research 279 (1992) 35-40
28. Sakai Y., Nagase H., Ose Y., Kito U., Sato T., Kamai M., and Mizuno M. Inhibitory action of paeony root extract on the mutagenicity of benzo(a)pyrene. Mutation Research 244 (1990) 129-134
29. Saxena J. "In vitro" test systems for mutagenicity screening of environmental chemicals. Revista Microbiológica 15 1 (1984) 1-16
30. Spjotovoll E., and Stoline M.R. An extension of the T-method of multiple comparison to include the cases with unequal sample sizes. Journal of the American Statistical Association 68 (1973) 976-978
31. Vargas V.M.F., Motta V.E.P., and Henriques J.A.P. Mutagenic activity detected by the Ames test in river water under the influence of petrochemical industries. Mutation Research 319 (1993) 31-45
32. Vargas V.M.F., Motta V.E.P., Alice C.B., Guidobono R.R., and Henriques J.A.P. Mutagenic activity of plant extracts used in popular medicine. Revista Brasileira de Farmácia 70 (1989) 65-67
33. Vargas V.M.F., Motta V.E.P., and Henriques J.A.P. Analysis of mutagenicity of waters under the influence of petrochemical industrial complexes by the Ames test (Salmonella/microsome). Revista Brasileira de Genética 11 (1988) 505-518
34. World Health Organization - WHO, 2006. .
35. World Health Organization, 1999. WHO monographs on selected medicinal plants, vol. 1. Geneva, World Health Organization, 295 p.
36. Yen G.C., and Chen H.Y. Relationship between antimutagenic activity and major components of various teas. Mutagenesis 11 (1996) 37-41