Evaluation of Agaricus blazei in vivo for antigenotoxic, anticarcinogenic, phagocytic and immunomodulatory activities

Regulatory Toxicology and Pharmacology

Volumn 59, Issue 3, 2011, Pages 412-422

  Ishii, Priscila Lumi ^a,c   Prado, Carolina Kato ^a   Mauro, Mariana de Oliveira ^a,c   Carreira, Clísia Mara ^b   Mantovani, Mário Sérgio ^b   Ribeiro, Lúcia Regina ^c   Dichi, Jane Bandeira ^b   Oliveira, Rodrigo Juliano ^b,c,d  

^a Centro Univ Filadélfia   (Brazil)

^b STATE UNIVERSITY OF LONDRINA   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^d FEDERAL UNIVERSITY OF MATO GROSSO DO SUL   (Brazil)

Author keywords

Agaricus blazei; Anticarcinogenicity; Antigenotoxicity; Immunomodulation

Indexed keywords

AGARICUS BLAZEI EXTRACT; DNA;

ABERRANT CRYPT FOCUS; AGARICUS BLAZEI; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD CELL COUNT; CARCINOGENESIS; CELL COUNT; CELL PROLIFERATION; COMET ASSAY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA DAMAGE; FUNCTIONAL FOOD; GENOTOXICITY; IMMUNOMODULATION; IN VIVO STUDY; INTESTINE MUCOSA; MALE; MONOCYTE; MOUSE; MUSHROOM; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SPLEEN CELL;

AGARICUS; ANIMALS; ANTIMUTAGENIC AGENTS; ANTINEOPLASTIC AGENTS; COMET ASSAY; DNA DAMAGE; IMMUNOLOGIC FACTORS; MALE; MICE; PHAGOCYTOSIS; PLANT EXTRACTS;

AGARICUS BLAZEI; BASIDIOMYCOTA;

EID: 79952696151     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.01.004     Document Type: Article

References (80)

1. Akramiene D., Kondrotas A., Didziapetrien J., Kevelatis E. Effects of β-glucans on the immune system. Medicine (Kaunas) 2007, 43:597-606.
2. Alves de Lima, P.L., 2006. Lentiluns edodes (Berk.) Singer: Mecanismo de modulação da mutagênese química in vivo e alterações de efeito durante a estocagem. 46p. Tese -Doutorado em Patologia. Faculdade de Medicina- UNESP- Botucatu- São Paulo- Brasil.
3. Angeli J.P.F., Ribeiro L.R., Bellini M.F., Mantovani M.S. ,-Glucan extracted from the medicinal mushroom Agaricus blazei prevents the genotoxic effects of benzo[a]pyrene in the human hepatoma cell line HepG2. Arch. Toxicol. 2008, 83:81-86.
4. Antunes L.M.G., Araújo M.C.P. Mutagenicidade e antimutagenicidade dos principais corantes para alimentos. Rev. Nutr. 2000, 13:81-88.
5. Bain B.J. Células Sangüíneas: Um guia prático 2007, Artmed, Porto Alegre: Artmed, p. 288. 4th ed.
6. Banerjee A., Quirke P., Path F.R.C. Experimental models of colorectal cancer. Dis. Colon Rectum 1998, 41:490-505.
7. Bellini M.F., Giacomini N.L., Eira A.F., Ribeiro L.R., Mantovani M.S. Anticlastogenic effect of aqueous extracts of Agaricus blazei on CHO-k1 cells, studying different developmental phases of the mushroom. Toxicol. in Vitro 2003, 17:465-469.
8. Bellini M.F., Angeli J.P.F., Matuo R., Terezan A.P., Ribeiro L.R., Mantovani M.S. Antigenotoxicity of Agaricus blazei mushroom organic and aqueous extracts in chromosomal aberration and cytokinesis block micronucleus assays in CHO-K1 and HTC cells. Toxicol. in Vitro 2006, 20:355-360.
9. Bird R.P. Observation and qualification of aberrant crypt in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett. 1987, 37:147-151.
10. Bird R.P. Role of aberrant crypt loci in under standing the pathogenesis of colon cancer. Cancer Lett. 1995, 93:55-71.
11. Bobek P., Galbavy S. Effect of pleuran (beta-glucan from Pleurotus ostreatus) on the antioxidant status of the organism and on dimethylhydrazine-induced precancerous lesions in rat colon. Br. J. Biomed. Sci. 2001, 58:164-168.
12. Bobek P., Galbavy S., Ozdin L. Effect of oyster mushroom (Pleurotus ostreatus) on pathological changes in dimethylhydrazine-induced rat colon cancer. Oncol. Rep. 1998, 5:727-730.
13. Bobek P., Nosál'ová V., Cerná S. Effect of pleuran (beta-glucan from Pleurotus ostreatus) in diet or drinking fluid on colitis in rats. Nahrung 2001, 45:360-363.
14. Chan Y., Chang T., Chan C.H., Yeh Y.C., Chen C.W., Shieh B., Li C. Immunomodulatory effects of Agaricus blazei Murril inb Balb/cByJ mice. J. Microbiol. Imuunol. Infect. 2007, 40:201-208.
15. Chorvatovicová D., Machová E., Sandula J. Effect of ultrasonicated carboxymethilglucan on cyclophosphamide induced mutagenicity. Mutat. Res. 1996, 371:115-120.
16. Chorvatovicová D., Machová E., Sandula J. Ultrasonication: the way to achieve antimutagenic effect of carboxymethyl-chitin-glucan by oral administration. Mutat. Res. 1999, 412:83-89.
17. COBEA, Colégio Brasileiro de Experimentação Animal. 2004. Manual sobre cuidados e usos de animais de laboratório. Available in: Acess: ago 2006.
18. De Flora S., Ferguson L.R. Overview of mechanismas of câncer chemopreventive agentes. Mutat. Res. 2005, 591:8-15.
19. Delmanto R.D., De Lima P.L.A., Suguia M.M., Salvadori D.M.F., Eira A.F., Speit G., Ribeiro L.R. Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide. Mutat. Res. 2001, 496:15-21.
20. Demleitner S., Kraus J., Franz G. Synthesis and antitumor activity of sulfoalkyl derivates of curdlan and lichenan. Carbohydr. Res. 1992, 226:247-252.
21. Deschner E.E. Early proliferative defects induced by six weekly injections of 1, 2-dimethylhydrazine in epithelial cells of mouse distal colon. Z. Krebsforsch 1978, 91:205-216.
22. Di Luzio N.R., Williams D.L., Mcnamee R.B., Edwards B.F., Kitahama A. Comparative tumor-innhibitory and anty-bacterial activity of soluble and particulate glucana. Int. J. Cancer 1979, 24:773-779.
23. Druckrey, H., Preussman, R., Matzkies, F., 1978. Selektive Erzeugung von Darmkaebs bei Ratten durch 1,2-Dimethylhydrazin. In: Barkla D.H., Tutton P.J. (Eds.), Ultrastructure of 1,2-dimethylhydrazine-induced adenocar-cinomas in rat colon. J. Natl. Cancer Inst., vol. 61, pp. 1291-1299.
24. Ferguson L.R. Antimutagens as cancer chemopreventive agents in the diet. Mutat. Res. 1994, 307:395-410.
25. Firenzuoli F., Gori L., Lombardo G. The medicinal Agaricus blazei Murril: review of literature and pharmaco-toxicological problems. Evid. Based Complement Alternat. Med. 2007, 5:3-15.
26. Flagg E.W., Coates R.J., Greenberg R.S. Epidemiologic studies of antioxidants and cancer in humans. J. Am. Coll. Nutr. 1995, 14:419-427.
27. Human colonic bacteria. Role in physiology, pathology and nutrition 1995, 61-73. CRC Press, Boca Raton.
28. Goldin B.R., Gorbach S.L. Effect of Lactobacillus acidophilus dietary supplements on 1, 2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats. J. Natl. Cancer Inst. 1980, 64:263-265.
29. Green C.J., Van hoeij K.A., Bindels J.G. Short chain fatty acid (SCFA) and gas production of incividual fiber sources and a mix typical to a normal diet using an in vitro technique. J. Pediatr. Gastroenterol. Nutr. 1998, 26:591.
30. Grüter A., Friederich U., Würgler F.E. The mutagenicity of edible mushrooms in a histone-independent bacterial test system. Food Chem. Toxicol. 1991, 29:159-165.
31. Gurr E. The rational use of dyes in biology 1965, Leonard Hill, London, p. 422.
32. Gurr E. Synthetic dyes in biology medicine and chemistry 1971, Academic Press, London, p. 806.
33. Guterres Z.R., Mantovani M.S., Ferreira da Eira A., Ribeiro L.R., Jordão B.Q. Genotoxic and antigenotoxic effects of organic extracts of mushroom Agaricus blazei Murrill on V79 cells. Genet. Mol. Biol. 2005, 28:458-463.
34. Guterrez Z.R., Mantovani M.S., Eira A.F., Ribeiro L.R., Jordão B.Q. Variation of the antimutagenicity effects of water extracts of Agaricus blazei Murrill in vitro. Toxicol. in Vitro 2004, 18:301-309.
35. Hague A., Manning A.M., Hanlon K.A., Huschtscha L., Hart D., Paraskev A.C. Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. Int. J. Cancer 1993, 55:498-505.
36. Hauly M.C., Moscatto J.A. Inulin and Oligofructosis: a review about functional properties, prebiotic effects an importanc for food industry. Semina: Ciencias Exatas e Tecnologia 2002, 23:105-118.
37. Hayashi M., Morita T., Kodama Y., Sofuni T., Ishidate M. The micronucleus assay with mouse peripheral blood reticulocytes using acrideine arange-coated slides. Mutat. Res. 1990, 245:245-249.
38. Hesketh J., Wybranska I., Dommels Y., Elliot R., Pico C., Keijer J. Nutrient-gene interactions in benefit-risk analysis. Br. J. Nutr. 2006, 95:1232-1236.
39. Hornstra G., Barth C.A., Galli C., Mensink R.C., Mutanen M., Riemersma R.A., Roberfroid M., Salminen K., Vansant G., Verschuren P.M. Functional food and cardiovascular system. Br. J. Nutr. 1998, 1:113-146.
40. Instituto Nacional do Câncer (INCA). Estimativa, 2008. Disponível em: Acess: 30 de mar. 2008. http://www.inca.gov.br/estimativa.
41. Junqueira L.C.U., Carneiro J. Histologia Básica 2008, Guanabara Koogan, Rio de Janeiro, p. 524. 11th ed.
42. Kada T. Environmental and biological factors suppressing induction of mutagens. Toxicol. Forum 1983, 6:580-589.
43. Kawamura M., Kasai H., He L., Deng X., Yamashita A., Terunuma A., Houriuchi I., Tanabe F., Ito M. Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells. Immunology 2005, 114:397-409.
44. Kishida E., Sone Y., Misaki A. Effects of branch distribution and chemical modiffications of antitumor (1, 3)-β-d-glucan. Carbohydr. Polym. 1992, 17:89-95.
45. Kobayashi H., Sugiyama C., Morikawa Y., Hayashi M., Sofuni T.A. Comparison between manual microscopic analysis and computerized image analysis in the single cell gel electrophoresis assay. MMS Commun. 1995, 3:103-115.
46. Koo M., Rao A.V. Long-term effect of Bifidobacteria and neosugar on precursor lesions of colonic cancer in CFI mice. Nuts: Cancer 1991, 16:249-257.
47. Krutovskikh V.A., Turosov V.S. Tumors of intestines. Pathology of tumors in laboratory animals, 2nd ed. 1994, Vol. II:195-211. Yarc, Lyon.
48. Lin H., She Y.H., Cassileth B.R., Sirotnak F. Cunningham rundles, S. Maitake beta-glucan MD fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro. Int. Immunopharmacol. 2004, 4:91-99.
49. Liu Y., Fukuwatari Y., Okumura K., Takeda K., Ishibashi K., Furukawa M., Ohno N., Mori K., Gao M., Motoi M. Immunomodulating activity of Agaricus brasiliensis KA21 in mice and in human volunteers. Evid. based complement Alternat. Med. 2008, 5:205-219.
50. Lohman P.H.M., Gentileb J.M., Ferguson L.R. Antimutagenesis/anticarcinogenesis: screening, methods and biomarkers. Mutat. Res. 2001, 496:1-4.
51. López-Varela S., Gonzalez-Gross M., Marcos A. Functional foods and the immune system: a review. Eur. J. Nutr. 2002, 56:29-33.
52. Luiz R.C., Jordão B.Q., Eira A.F., Ribeiro L.R., Mantovani M.S. Mechanism of anticlastogenicity of Agaricus blazei Murrill mushroom organic extracts in wild type CHO(k1) and repair deficient (xrs5) cells by chromosome aberration and sister chromatid exchange assays. Mutat. Res. 2003, 528:75-79.
53. Machado M.P., Rodrigues Filho E., Terezan A.P., Ribeiro L.R., Mantovani M.S. Cytotoxicity, genotoxicity and antimutagenicity of hexane extracts of Agaricus blazei determined in vitro by the comet assay and CHO/HGPRT gene mutation assay. Toxicol. in Vitro 2005, 19:533-539.
54. Menoli R.C.N., Mantovani M.S., Ribeiro L.R., Gunter S., Jordão B.Q. Antimutagenic effects of the mushroom Agaricus blazei Murrill extracts on V79 cells. Mutat. Res. 2001, 496:5-13.
55. Mizuno T. Bioactive biomolecules of mushrooms - food, function and medicinal effect of mushroom fungi. Food Res. Int. 1995, 11:7-21.
56. Mizuno M., Morimoto M., Minato K., Tsuchida H. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets mice. Biosci. Biotechnol. Biochem. 1998, 62:434-437.
57. Morita K., Hara M., Kada T. Studies on natural desmutagens: screening for vegetable and fruit factors active in inactivation of mutagenic pyrolysis produts from amino acids. Agric. Biol. Chem. J. 1978, 42:1235-1238.
58. Murakawa K., Fukunaga K., Tanouchi M., Hopsokawa M., Hossain Z., Takahashi K. Therapy of myeloma in vivo using marine phospholipid in combination with Agaricus blazei murril as an immune respond activator. J. Oleo Sci. 2007, 56:179-188.
59. Nosál'ová V., Bobek P., Cerná S., Galbavý S., Stvyrtina S. Effects of Pleuran (β-glucan Isolated from Pleurotus ostreatus) on experimental colitis in rats. Physiol. Res. 2001, 50:575-581.
60. Ohno N., Uchiyama M., Tsuzuki A., Tokunaga K., Miura N.N., Adachi Y., Aizawa M.W., Tamura H., Tanaka S., Yadomae T. Solubilization of yeast cell-wall beta-(1→3)-d-glucan by sodium hypoclorite oxidation and dimethyl sulfoxide extraction. Carboydr. Res. 1999, 316:161-172.
61. Oliveira J.M., Jordão B.Q., Ribeiro L.R., Eira A.F., Mantovani M.S. Anti-genotoxic effect of aqueous extracts of sun mushroom (Agaricus blazei Murill lineage 99/26) in mammalian cells in vitro. Food Chem. Toxicol. 2002, 40:15-20.
62. Oliveira R.J., Ribeiro L.R., Silva A.F., Matuo R., Mantovani M.S. Evaluation of antimutagenic activity and mechanisms of action of β-glucan from barley, in CHO-k1 and HTC cell lines using the micronucleus test. Toxicol. in Vitro 2006, 20:1225-1233.
63. Oliveira R.J., Matuo R., Siva A.F., Matiazi H.J., Mantovani M.S., Ribeiro L.S. Protective effect of β-glucan extracted from Saccharomyces cerevisiae against SNS damage and cytotoxicity in wild-type (k1) and repair-deficient (xrs5) CHO cells. Toxicol. in Vitro 2007, 21:41-52.
64. Oliveira R.J., Salles M.J., Silva A.F., Kanno T.Y., Lourenço A.C., Freiria G.A., Matiazi H.J., Ribeiro L.R., Mantovani M.S. Effects of the polysaccharide beta-glucan on clastogenicity and teratogenicity caused by acute exposure to cyclophosphamide in mice. Regul. Toxicol. Pharmacol. 2009, 53:164-173.
65. Peridgon G., Waldez J.C., Rachid M. Antitumor activity of yogurt: study of possible immune mechanisms. J. Dairy Res. 1998, 65:129-138.
66. Pierre F., Perrin R., Champ M., Bornet F., Meflah K., Menanteau J. Short-chain in fructooligosaccharides reduce the occurrence of colon tumor and develop gut-associated lymphoid tissue in Min mice. Cancer Res. 1997, 57:225-228.
67. Pool-Zobel B.L., Bertram B., Knoll M., Lambertz R., Neudecker C., Schillinger U., Schmezer P., Holzapfel W.H. Antigenotoxic properties of lactic acid bacteria in vivo in the gastrointestinal tract of rats. Nutr. Cancer 1993, 20:271-281.
68. Reddy B.S., Rivenson A. Inhibitory effect of Bifidobacterium longum on colon mammary, and liver carcinogenesis induced by 2-amino-3-methylimidazol(4, 5f)quinoline, a food mutagen. Cancer Res. 1993, 53:3914-3918.
69. Richards T.C. Early changes in the dynamics of crypt cell populations in mouse colon following administration of 1, 2- dimethylhydrazine. Cancer Res. 1977, 37:1680-1685.
70. Rodrigues S.B., Jabor I.A.S., Silva G.G.M., Rocha C.L.M.S.C. Avaliação do potencial antimutagênico do Cogumelo do Sol (Agaricus blazei) no sistema methG1 em Aspergillus (= Emericella) nidulans. Acta Scientiarium Agron. 2003, 25:513-517.
71. Saitô H., Yoshioka Y., Ushara N., Aketagawa J., Tanaka S., Shibata Y. Relationship between conformation and biological response for (163)-β-d-glucans in the activation of coagulation Factor G from limulus amebocyte lysate and host-mediated antitumor. Demonstration of single-helix conformation as a stimulant. Carbohydr. Res. 1991, 217:181-190.
72. Scheppach W., Bartram H.P., Richter F. Role of short-chain fatty acids in the prevention of colorectal cancer. Eur. J. Cancer 1995, 31:1077-1080.
73. Silva, L.A.G., 1999. Criptas aberrantes como biomarcador da ontogênese do cólon: análise comparativa entre testes de curta e média duração em modelo de carcinogênese pela DMH no rato. 95p. Dissertação de mestrado- Faculdade de Medicina- UNESP- Botucatu- São Paulo- Brasil.
74. Singh N.P., Mccoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
75. Slamenová D., Lábaj J., Krizková L., Kogan G., Sandula J., Bresgen N., Eckl P. Protective effects of fungal (1>3)-β-d-glucan derivatives against oxidative DNA lesions in V79 hamster lung cells. Cancer Lett. 2003, 198:153-160.
76. Talcott J.A., Clark J.A., Lee I.P. Measuring pereceived effects of drinking of extracts of basidiomycetes Agaricus balzei murril: a survey of japanese consumers with cancer. BCM Complement. Alternat. Med. 2007, 7:1-8.
77. Tice R.R. The single cell gel/Comet assay: a microgel eletrophoretic technique for the detection of DNA damage and repair in individual cells. Environ. Mutagen 1995, 315-339. Bios Scientific Publishers, Oxford. D.H. Phillips, S. Venitt (Eds.).
78. Tohamy A.A., El-ghor A.A., El-nahas S.M., Noshy M.M. ,-Glucan inhibits the genotoxicity of cyclophosphamide, adramycin and cisplatin. Mutat. Res. 2003, 541:45-53.
79. Wargovich M.J., Goldberg M., Newmark H., Bruce W. Nuclear aberrations as a short term for genotoxicity to the colon: evaluation of nineteen agents in mice. J. Nat. Cancer Inst. 1983, 71:133-137.
80. Wiebecke B., Krey B., Löhrs U. Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice. Virchows Arch. A. 1973, 360:179-193.