Steroidal saponin of Trillium tschonoskii. Reverses multidrug resistance of hepatocellular carcinoma

Phytomedicine

Volumn 20, Issue 11, 2013, Pages 985-991

  Wang, Hui ^a   Zhai, Zhenbo ^b   Li, Nanlin ^a   Jin, Haifeng ^a   Chen, Jianghao ^a   Yuan, Shifang ^a   Wang, Ling ^a   Zhang, Juliang ^a   Li, Yongping ^a   Yun, Jun ^a   Fan, Jing ^a   Yi, Jun ^a   Ling, Rui ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Tumor Hospital   (China)

Author keywords

Chemotherapy; Hepatocellular carcinoma; Multidrug resistance; Saponin; Trillium tschonoskii

Indexed keywords

DOXORUBICIN; FLUOROURACIL; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 5; PLANT EXTRACT; SAPONIN; TRILLIUM TSCHONOSKII EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL SURVIVAL; CHEMOSENSITIZATION; COLONY FORMATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; IC 50; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER CELL CARCINOMA; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; TRILLIUM; TRILLIUM TSCHONOSKII; TUMOR XENOGRAFT; WESTERN BLOTTING;

CHEMOTHERAPY; HEPATOCELLULAR CARCINOMA; MULTIDRUG RESISTANCE; SAPONIN; TRILLIUM TSCHONOSKII;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HETEROGRAFTS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED BALB C; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PHYTOTHERAPY; PLANT EXTRACTS; SAPONINS; STEROIDS; TRILLIUM;

MUS; TRILLIUM TSCHONOSKII;

EID: 84880805730     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.04.014     Document Type: Article

References (30)

1. T.A. Abere, P.E. Okoto, and F.O. Agoreyo Antidiarrhoea and toxicological evaluation of the leaf extract of Dissotis rotundifolia Triana (Melastomataceae) BMC Complementary and Alternative Medicine 10 2010 71
2. C.M. Collins, P.G. Murray, S. Denman, J.P. Morrissey, L. Byrnes, T.T. Teeri, and M.G. Tuohy Molecular cloning and expression analysis of two distinct beta-glucosidase genes, bg1 and aven1, with very different biological roles from the thermophilic, saprophytic fungus Talaromyces emersonii Mycological Research 111 Pt7 2007 840 849 (Pubitemid 47187672)
3. D. Cui, Q. Xu, K. Wang, and X. Che Gli1 is a potential target for alleviating multidrug resistance of gliomas Journal of the Neurological Sciences 288 2010 156 166
4. K. Dredge, E. Hammond, P. Handley, T.J. Gonda, M.T. Smith, C. Vincent, R. Brandt, V. Ferro, and I. Bytheway PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models British Journal of Cancer 104 2011 635 642
5. L. Fu Plant Red Book of China: Rare Threatened Plant 1992 Science Publishing House Press Beijing
6. P.Y. Hayes, R. Lehmann, K. Penman, W. Kitching, and J.J. De Voss Steroidal saponins from the roots of Trillium erectum (Beth root) Phytochemistry 70 2009 105 113
7. X.J. He, W.R. Wang, Y. Zhang, and Q. Yang The effect of radixin knockdown on the expression and efflux function of MRP2 in SGC-7901 cells European Journal of Pharmaceutical Sciences 46 2012 426 434
8. M. Huan, B. Zhang, Z. Teng, H. Cui, J. Wang, X. Liu, H. Xia, S. Zhou, and Q. Mei In vitro and in vivo antitumor activity of a novel pH-activated polymeric drug delivery system for doxorubicin PLoS ONE 7 2012 e44116
9. H.Y. Huang, J.L. Niu, L.M. Zhao, and Y.H. Lu Reversal effect of 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone on multi-drug resistance in resistant human hepatocellular carcinoma cell line BEL-7402/5-FU Phytomedicine 18 2011 1086 1092
10. K. Kamimura, T. Suda, Y. Tamura, M. Takamura, T. Yokoo, M. Igarashi, H. Kawai, S. Yamagiwa, M. Nomoto, and Y. Aoyagi Phase I study of miriplatin combined with transarterial chemotherapy using CDDP powder in patients with hepatocellular carcinoma BMC Gastroenterology 12 2012 127
11. H. Kusakabe, H. Iwasaki, and K. Sano Expression of lung resistance protein in epithelioid sarcoma in vitro and in vivo Archives for Dermatological Research Archiv fur Dermatologische Forschung 292 2000 292 300 (Pubitemid 30386439)
12. L. Milane, Z. Duan, and M. Amiji Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer PLoS ONE 6 2011 e24075
13. Z.J. Ming, Y. Hu, Y.H. Qiu, L. Cao, and X.G. Zhang Synergistic effects of aescin and 5-fluorouracil in human hepatocellular carcinoma SMMC-7721 cells Phytomedicine 17 2010 575 580
14. M. Ono, F. Sugita, and S. Shigematsu Three new steroid glycosides from the underground parts of Trillium kamtschaticum Chemical and Pharmaceutical Bulletin 55 2007 1093 1096 (Pubitemid 47026554)
15. D.M. Parkin, F. Bray, and J. Ferlay Global cancer statistics CA: A Cancer Journal for Clinicians 55 1999 74 108
16. P. Ray, K.L. Rialon-Guevara, E. Veras, B.A. Sullenger, and R.R. White Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker Journal of Clinical Investigation 122 2012 1734 1741
17. D.T. Rein, A. Volkmer, G. Bauerschmitz, I.M. Beyer, W. Janni, M.C. Fleisch, A.K. Welter, D. Bauerschlag, T. Schöndorf, and M. Breidenbach Combination of a MDR1-targeted replicative adenovirus and chemotherapy for the therapy of pretreated ovarian cancer Journal of Cancer Research and Clinical Oncology 138 2012 603 610
18. U. Stein, K. Jürchott, M. Schläfke, and P. Hohenberger Expression of multidrug resistance genes MVP, MDR1, and MRP1 determined sequentially before, during, and after hyperthermic isolated limb perfusion of soft tissue sarcoma and melanoma patients Journal of Clinical Oncology 20 2002 3282 3292 (Pubitemid 34831527)
19. J. Sun, C.A. Yeung, N.N. Co, T.Y. Tsang, E. Yau, K. Luo, P. Wu, J.C. Wa, K.P. Fung, T.T. Kwok, and F. Liu Clitocine reversal of P-gp associated multi-drug resistance through down-regulation of transcription factor NF-κB in R-HepG2 cell line PLoS ONE 7 2012 e40720
20. G. Szakács, J.K. Paterson, J.A. Ludwig, C. Booth-Genthe, and M.M. Gottesman Targeting multidrug resistance in cancer Nature Reviews Drug Discovery 5 2006 219 234 (Pubitemid 43336035)
21. B. Tan, W.D. Piwnica, and L. Ratner Multidrug resistance transporters and modulation Current Opinion in Oncology 12 2000 450 458 (Pubitemid 32268882)
22. P.M. Tang, J.Y. Chan, D.M. Zhang, S.W. Au, W.P. Fong, S.K. Kong, S.K. Tsui, M.M. Waye, T.C. Mak, and K.P. Fung Pheophorbide a, an active component in Scutellaria barbata, reverses P-gp-mediated multidrug resistance on a human hepatoma cell line R-HepG2 Cancer Biology and Therapy 6 2007 504 509 (Pubitemid 47328323)
23. W. Xin, L. Zhang, F. Sun, N. Jiang, H. Fan, T. Wang, Z. Li, J. He, and F. Fu Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro Phytomedicine 18 2011 272 277
24. H. Wagner Synergy research: approaching a new generation of phytopharmaceuticals Fitoterapia 82 2011 34 37
25. J. Wang, K. Zou, Y. Zhang, C. Liu, J. Wu, Y. Zhou, F. Dan, and Y. Zhang An 18-norspirostanol saponin with inhibitory action against COX-2 production from the underground part of Trillium tschonoskii Chemical and Pharmaceutical Bulletin 55 2007 679 681 (Pubitemid 46570855)
26. Z. Wang, H. Jin, R. Xu, Q. Mei, and D. Fan Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression Experimental and Molecular Medicine 41 2009 717 727
27. Z. Wang, L. Liu, M. Wang, M. Shen, J. Li, J. Liu, C. Li, C. Xin, S. Zhu, Q. Mei, and Y. Wang NOTCH1 regulates migration and invasion of skin cancer cells by E-cadherin repression Molecular and Cellular Biochemistry 362 2012 35 41
28. O. Wesołowska, J. Wiśniewski, K. Sroda, A. Krawczenko, A. Bielawska-Pohl, M. Paprocka, D. Duś, and K. Michalak 8-Prenylnaringenin is an inhibitor of multidrug resistance-associated transporters, P-glycoprotein and MRP1 European Journal of Pharmacology 644 2010 32 40
29. C.Y. Yang, J. Wang, Y. Zhao, L. Shen, X. Jiang, Z.G. Xie, N. Liang, L. Zhang, and Z.H. Chen Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components Journal of Ethnopharmacology 130 2010 231 236
30. A. Yokosuka, and Y. Mimaki Steroidal glycosides from the underground parts of Trillium erectum and their cytotoxic activity Phytochemistry 69 2008 2724 2730