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Volumn 14, Issue 6, 2014, Pages

The negative effects of obesity and poor glycemic control on cognitive function: A proposed model for possible mechanisms

Author keywords

Brain mechanisms; Cognitive function; Glycemic control; Obesity; Type 2 diabetes mellitus

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; GHRELIN; LEPTIN; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

EID: 84901581586     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-014-0495-z     Document Type: Article
Times cited : (26)

References (102)
  • 1
    • 84872091789 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2013 update: A report from the American Heart Association
    • Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics - 2013 update: a report from the American Heart Association. Circulation. 2013;127:e6-e245.
    • (2013) Circulation , vol.127
    • Go, A.S.1    Mozaffarian, D.2    Roger, V.L.3
  • 3
    • 71049116356 scopus 로고    scopus 로고
    • The morbidity and mortality associated with overweight and obesity in adulthood
    • Lenz M, Richter T, Muhlhauser I. The morbidity and mortality associated with overweight and obesity in adulthood. Dtsch Arztebl Int. 2009;106:641-8.
    • (2009) Dtsch Arztebl Int , vol.106 , pp. 641-648
    • Lenz, M.1    Richter, T.2    Muhlhauser, I.3
  • 4
    • 62449223532 scopus 로고    scopus 로고
    • Midlife and late-life obesity and the risk of dementia: Cardiovascular health study
    • This study shows that mid-life obesity is associated with increased risk for dementia
    • .•• Luchsinger JA. Midlife and late-life obesity and the risk of dementia: cardiovascular health study. Arch Neurol. 2009;66:336-42. This study shows that mid-life obesity is associated with increased risk for dementia.
    • (2009) Arch Neurol , vol.66 , pp. 336-342
    • Luchsinger, J.A.1
  • 5
    • 84889652068 scopus 로고    scopus 로고
    • Obesity is associated with white matter atrophy: A combined diffusion tensor imaging and voxel-based morphometric study
    • Karlsson HK, Tuulari JJ, Hirvonen J, et al. Obesity is associated with white matter atrophy: a combined diffusion tensor imaging and voxel-based morphometric study. Obesity. 2013;21:2530-7.
    • (2013) Obesity , vol.21 , pp. 2530-2537
    • Karlsson, H.K.1    Tuulari, J.J.2    Hirvonen, J.3
  • 6
    • 84881311223 scopus 로고    scopus 로고
    • Obesity interacts with cerebral hypoperfusion to exacerbate cognitive impairment in older adults with heart failure
    • Alosco ML, Spitznagel MB, Raz N, et al. Obesity interacts with cerebral hypoperfusion to exacerbate cognitive impairment in older adults with heart failure. Cerebrovasc Dis Extra. 2012;2:88-98.
    • (2012) Cerebrovasc Dis Extra , vol.2 , pp. 88-98
    • Alosco, M.L.1    Spitznagel, M.B.2    Raz, N.3
  • 7
    • 79960594533 scopus 로고    scopus 로고
    • Improved memory function 12weeks after bariatric surgery
    • The results from this study show that bariatric surgery patients exhibit significant cognitive impairments that improved 12-weeks postoperatively relative to obese controls
    • .• Gunstad J, Strain G, Devlin MJ, et al. Improved memory function 12weeks after bariatric surgery. Surg Obes Relat Dis. 2011;7:465-72. The results from this study show that bariatric surgery patients exhibit significant cognitive impairments that improved 12-weeks postoperatively relative to obese controls.
    • (2011) Surg Obes Relat Dis , vol.7 , pp. 465-472
    • Gunstad, J.1    Strain, G.2    Devlin, M.J.3
  • 8
    • 84877680047 scopus 로고    scopus 로고
    • Obesity and impaired cognitive functioning in the elderly: A population-based cross-sectional study (NEDICES)
    • This study documents the adverse effects of obesity on cognitive function in >1500 persons
    • .•• Benito-Leon J, Mitchell AJ, Hernandez-Gallego J, et al. Obesity and impaired cognitive functioning in the elderly: a population-based cross-sectional study (NEDICES). Eur J Neurol. 2013;20:899-906. This study documents the adverse effects of obesity on cognitive function in >1500 persons.
    • (2013) Eur J Neurol , vol.20 , pp. 899-906
    • Benito-Leon, J.1    Mitchell, A.J.2    Hernandez-Gallego, J.3
  • 9
    • 34250851356 scopus 로고    scopus 로고
    • Associations between obesity and developmental functioning in pre-school children: A population-based study
    • DOI 10.1038/sj.ijo.0803644, PII 0803644
    • Mond JM, Stich H, Hay PJ. Associations between obesity and development functioning in pre-school children: a population-based study. Int J Obes. 2007;31:1068-73. (Pubitemid 46987778)
    • (2007) International Journal of Obesity , vol.31 , Issue.7 , pp. 1068-1073
    • Mond, J.M.1    Stich, H.2    Hay, P.J.3    Kraemer, A.4    Baune, B.T.5
  • 10
    • 70249093603 scopus 로고    scopus 로고
    • Evidence of executive dysfunction in extremely obese adolescents: A pilot study
    • Lokken KL, Boeka AG, Austin AM, et al. Evidence of executive dysfunction in extremely obese adolescents: a pilot study. Surg Obes Relat Dis. 2009;5:547-52.
    • (2009) Surg Obes Relat Dis , vol.5 , pp. 547-552
    • Lokken, K.L.1    Boeka, A.G.2    Austin, A.M.3
  • 11
    • 84877287697 scopus 로고    scopus 로고
    • Higher BMI is associated with reduced cognitive performance in division I athletes
    • Fedor A, Gunstad J. Higher BMI is associated with reduced cognitive performance in division I athletes. Obes Facts. 2013;6: 185-92.
    • (2013) Obes Facts , vol.6 , pp. 185-192
    • Fedor, A.1    Gunstad, J.2
  • 12
    • 37849185832 scopus 로고    scopus 로고
    • Elevated body mass index is associated with executive dysfunction in otherwise healthy adults
    • DOI 10.1016/j.comppsych.2006.05.001, PII S0010440X06000654
    • Gunstad J, Paul RH, Cohen RA, et al. Elevated bodymass index is associated with executive dysfunction in otherwise healthy adults. Compr Psychiatry. 2007;48:57-61. (Pubitemid 44826976)
    • (2007) Comprehensive Psychiatry , vol.48 , Issue.1 , pp. 57-61
    • Gunstad, J.1    Paul, R.H.2    Cohen, R.A.3    Tate, D.F.4    Spitznagel, M.B.5    Gordon, E.6
  • 14
    • 33749861878 scopus 로고    scopus 로고
    • Relation between body mass index and cognitive function in healthy middle-aged men and women
    • DOI 10.1212/01.wnl.0000238082.13860.50, PII 0000611420061010000021
    • Cournot M, Marqui JC, Ansiau D, et al. Relation between body mass index and cognitive function in healthy middle-aged men and women. Neurology. 2006;67:1208-14. (Pubitemid 44563829)
    • (2006) Neurology , vol.67 , Issue.7 , pp. 1208-1214
    • Cournot, M.1    Marquie, J.C.2    Ansiau, D.3    Martinaud, C.4    Fonds, H.5    Ferrieres, J.6    Ruidavets, J.B.7
  • 16
    • 0032764016 scopus 로고    scopus 로고
    • Diabetes mellitus and the risk of dementia. The Rotterdam Study
    • Ott A, Stolk RP, van Harksamp F, et al. Diabetes mellitus and the risk of dementia. The Rotterdam Study. Neurology. 1999;53:1937.
    • (1999) Neurology , vol.53 , pp. 1937
    • Ott, A.1    Stolk, R.P.2    Van Harksamp, F.3
  • 17
    • 79955471687 scopus 로고    scopus 로고
    • Elevated BMI is associated with decreased blood flow in the prefrontal cortex using SPECT imaging in healthy adults
    • Willeumier K, Taylor D, Amen D. Elevated BMI is associated with decreased blood flow in the prefrontal cortex using SPECT imaging in healthy adults. Obesity. 2011;19:1095-7.
    • (2011) Obesity , vol.19 , pp. 1095-1097
    • Willeumier, K.1    Taylor, D.2    Amen, D.3
  • 18
    • 84861460193 scopus 로고    scopus 로고
    • Central obesity in the elderly is related to late-onset Alzheimer disease
    • Luchsinger JA, Cheng D, Tang MX, et al. Central obesity in the elderly is related to late-onset Alzheimer disease. Alzheimer Dis Assoc Disord. 2012;26:101-5.
    • (2012) Alzheimer Dis Assoc Disord , vol.26 , pp. 101-105
    • Luchsinger, J.A.1    Cheng, D.2    Tang, M.X.3
  • 19
    • 33646417625 scopus 로고    scopus 로고
    • Heart failure and risk of dementia and Alzheimer disease: A population-based cohort study
    • Qiu C, Winblad B, Marengoni A, et al. Heart failure and risk of dementia and Alzheimer disease: a population-based cohort study. Arch Intern Med. 2006;166:1003-8.
    • (2006) Arch Intern Med , vol.166 , pp. 1003-1008
    • Qiu, C.1    Winblad, B.2    Marengoni, A.3
  • 21
    • 84881317403 scopus 로고    scopus 로고
    • Cerebral perfusion is associated with whitematter hyperintensities in older adults with heart failure
    • Alosco ML, Brickman AM, Spitznagel MB, et al. Cerebral perfusion is associated with whitematter hyperintensities in older adults with heart failure. Congest Heart Fail. 2013;19:E29-34.
    • (2013) Congest Heart Fail , vol.19
    • Alosco, M.L.1    Brickman, A.M.2    Spitznagel, M.B.3
  • 22
    • 62849098571 scopus 로고    scopus 로고
    • Alzheimer-type neuropathological changes in morbidly obese individuals
    • Mrak RE. Alzheimer-type neuropathological changes in morbidly obese individuals. Clin Neuropathol. 2009;28:40-5.
    • (2009) Clin Neuropathol , vol.28 , pp. 40-45
    • Mrak, R.E.1
  • 23
    • 77954030767 scopus 로고    scopus 로고
    • Obesity is linked with lower brain volume in 700 AD and MCI patients
    • Ho AJ, Raji CA, Becker JT, et al. Obesity is linked with lower brain volume in 700 AD and MCI patients. Neurobiol Aging. 2010;31: 1326-39.
    • (2010) Neurobiol Aging , vol.31 , pp. 1326-1339
    • Ho, A.J.1    Raji, C.A.2    Becker, J.T.3
  • 24
    • 84860707186 scopus 로고    scopus 로고
    • Relation of regional gray and white matter volumes to current BMI and future increases in BMI: A prospective MRI study
    • Yokum S,Ng J, Stice E. Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study. Int J Obes. 2012;36:656-64.
    • (2012) Int J Obes , vol.36 , pp. 656-664
    • Yokum, S.1    Ng, J.2    Stice, E.3
  • 25
    • 53949089074 scopus 로고    scopus 로고
    • Relationship between body mass index and brain volume in healthy adults
    • Gunstad J, Paul RH, Cohen RA, et al. Relationship between body mass index and brain volume in healthy adults. Int J Neurosci. 2008;118:1582-93.
    • (2008) Int J Neurosci , vol.118 , pp. 1582-1593
    • Gunstad, J.1    Paul, R.H.2    Cohen, R.A.3
  • 26
    • 7444240744 scopus 로고    scopus 로고
    • Body mass index and white matter lesions in elderly women. An 18-year longitudinal study
    • DOI 10.1017/S1041610204000353
    • Gustafson DR, Steen B, Skoog I. Body mass index and white matter lesions in elderly women. An 18-year longitudinal study. Int Psychogeriatr. 2004;16:327-36. (Pubitemid 39441496)
    • (2004) International Psychogeriatrics , vol.16 , Issue.3 , pp. 327-336
    • Gustafson, D.R.1    Steen, B.2    Skoog, I.3
  • 27
    • 26444458863 scopus 로고    scopus 로고
    • Central obesity and the aging brain
    • DOI 10.1001/archneur.62.10.1545
    • Jagust W, Harvey D, Mungas D, et al. Central obesity and the aging brain. Arch Neurol. 2005;62:1545-8. (Pubitemid 41434559)
    • (2005) Archives of Neurology , vol.62 , Issue.10 , pp. 1545-1548
    • Jagust, W.1    Harvey, D.2    Mungas, D.3    Haan, M.4
  • 28
    • 84879221649 scopus 로고    scopus 로고
    • Relationships between gray matter, body mass index, and waist circumference in healthy adults
    • Kurth F, Levitt JG, Phillips OR, et al. Relationships between gray matter, body mass index, and waist circumference in healthy adults. Hum Brain Mapp 2013;34:1737-46
    • (2013) Hum Brain Mapp , vol.34 , pp. 1737-1746
    • Kurth, F.1    Levitt, J.G.2    Phillips, O.R.3
  • 29
    • 77955360281 scopus 로고    scopus 로고
    • The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: Systematic review and meta-analysis
    • Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ. 2010;341:c3666.
    • (2010) BMJ , vol.341
    • Debette, S.1    Markus, H.S.2
  • 30
    • 79952006211 scopus 로고    scopus 로고
    • Obesity is associated with reduced white matter integrity in otherwise healthy adults
    • Stanek KM, Grieve SM, Brickman AM, et al. Obesity is associated with reduced white matter integrity in otherwise healthy adults. Obesity. 2011;19:500-4.
    • (2011) Obesity , vol.19 , pp. 500-504
    • Stanek, K.M.1    Grieve, S.M.2    Brickman, A.M.3
  • 31
    • 78149373656 scopus 로고    scopus 로고
    • Projection of the year 2050 burden of diabetes in the U.S. adult population: Dynamic modeling of incidence, mortality, and prediabetes prevalence
    • Boyle JP, Thompson TJ, Gregg EW, et al. Projection of the year 2050 burden of diabetes in the U.S. adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Popul Health Metrics. 2010;8:29.
    • (2010) Popul Health Metrics , vol.8 , pp. 29
    • Boyle, J.P.1    Thompson, T.J.2    Gregg, E.W.3
  • 32
    • 0024026298 scopus 로고
    • The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo RA. Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM [review]. Diabetes. 1988;37:667-87. (Pubitemid 19043172)
    • (1988) Diabetes , vol.37 , Issue.6 , pp. 667-687
    • DeFronzo, R.A.1
  • 33
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest. 2000;106:171-6. (Pubitemid 30483118)
    • (2000) Journal of Clinical Investigation , vol.106 , Issue.2 , pp. 171-176
    • Shulman, G.I.1
  • 34
    • 0027966932 scopus 로고
    • Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men
    • Chan JM, Rimm EB, Colditz GA, et al. Obesity., fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care. 1994;17:961-9. (Pubitemid 24268605)
    • (1994) Diabetes Care , vol.17 , Issue.9 , pp. 961-969
    • Chan, J.M.1    Rimm, E.B.2    Colditz, G.A.3    Stampfer, M.J.4    Willett, W.C.5
  • 36
    • 61849170118 scopus 로고    scopus 로고
    • Full accounting of diabetes and prediabetes in the U.S. population in 1988-1994 and 2005-2006
    • Cowie CC, Rust KF, Ford ES, et al. Full accounting of diabetes and prediabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care. 2011;32:287-94.
    • (2011) Diabetes Care , vol.32 , pp. 287-294
    • Cowie, C.C.1    Rust, K.F.2    Ford, E.S.3
  • 37
    • 77949445462 scopus 로고    scopus 로고
    • Diabetes risk reduction behaviors among U.S. adults with prediabetes
    • Geiss LS, James C, Gregg EW, et al. Diabetes risk reduction behaviors among U.S. adults with prediabetes. Am J Prev Med. 2010;38:403-9.
    • (2010) Am J Prev Med , vol.38 , pp. 403-409
    • Geiss, L.S.1    James, C.2    Gregg, E.W.3
  • 38
    • 78049274928 scopus 로고    scopus 로고
    • Accelerated progression from mild cognitive impairment to dementia in people with diabetes
    • Xu W, Caracciolo B, Wang HX, et al. Accelerated progression from mild cognitive impairment to dementia in people with diabetes. Diabetes. 2010;59:2928-35.
    • (2010) Diabetes , vol.59 , pp. 2928-2935
    • Xu, W.1    Caracciolo, B.2    Wang, H.X.3
  • 39
    • 9644291424 scopus 로고    scopus 로고
    • The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function
    • DOI 10.1080/13803390490514875
    • Awad N, Gagnon M, Messier C. The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function. J Clin Exp Neuropsychol. 2004;26:1044-80. (Pubitemid 39577337)
    • (2004) Journal of Clinical and Experimental Neuropsychology , vol.26 , Issue.8 , pp. 1044-1080
    • Awad, N.1    Gagnon, M.2    Messier, C.3
  • 41
    • 77957689072 scopus 로고    scopus 로고
    • Preliminary evidence for brain complications in obese adolescents with type 2 diabetes mellitus
    • Yau PL, Javier DC, Ryan CM, et al. Preliminary evidence for brain complications in obese adolescents with type 2 diabetes mellitus. Diabetologia. 2010;53:2298-306.
    • (2010) Diabetologia , vol.53 , pp. 2298-2306
    • Yau, P.L.1    Javier, D.C.2    Ryan, C.M.3
  • 42
    • 84862999162 scopus 로고    scopus 로고
    • Type 2 diabetes and cognitive impairment: Linking mechanisms
    • This is a recent review paper highlighting the common mechanisms of cognitive impairment in type 2 diabetes mellitus
    • .• Luchsinger JA. Type 2 diabetes and cognitive impairment: linking mechanisms. J Alzheimers Dis. 2012;30:S185-98. This is a recent review paper highlighting the common mechanisms of cognitive impairment in type 2 diabetes mellitus.
    • (2012) J Alzheimers Dis , vol.30
    • Luchsinger, J.A.1
  • 44
    • 0036227542 scopus 로고    scopus 로고
    • Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study
    • Peila R, Rodriguez BL, Launer LJ. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu- Asia Aging Study. Diabetes. 2002;51:1256-62. (Pubitemid 34438377)
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 1256-1262
    • Peila, R.1    Rodriguez, B.L.2    Launer, L.J.3
  • 45
    • 0037118940 scopus 로고    scopus 로고
    • Hippocampal neuronal apoptosis in type 1 diabetes
    • DOI 10.1016/S0006-8993(02)02887-1, PII S0006899302028871
    • Li ZG, Zhang W, Grunberger G, et al. Hippocampal neuronal apoptosis in type 1 diabetes. Brain Res. 2002;946:221-31. (Pubitemid 34876334)
    • (2002) Brain Research , vol.946 , Issue.2 , pp. 221-231
    • Li, Z.-G.1    Zhang, W.2    Grunberger, G.3    Sima, A.A.F.4
  • 47
    • 84886086583 scopus 로고    scopus 로고
    • Altered baseline brain activity in type 2 diabetes: A resting-state fMRI study
    • Xia W, Wang S, Sun Z, et al. Altered baseline brain activity in type 2 diabetes: a resting-state fMRI study. Psychoneuroendocrinology. 2013;38:2493-501.
    • (2013) Psychoneuroendocrinology , vol.38 , pp. 2493-2501
    • Xia, W.1    Wang, S.2    Sun, Z.3
  • 48
    • 84455196307 scopus 로고    scopus 로고
    • Obese adolescents with type 2 diabetes mellitus have hippocampal and frontal lobe volume reductions
    • Bruehl H, Sweat V, Tirsi A, Shah B, et al. Obese adolescents with type 2 diabetes mellitus have hippocampal and frontal lobe volume reductions. Neurosci Med. 2011;2:34-42.
    • (2011) Neurosci Med , vol.2 , pp. 34-42
    • Bruehl, H.1    Sweat, V.2    Tirsi, A.3    Shah, B.4
  • 49
    • 84856468202 scopus 로고    scopus 로고
    • Age-related changes in endothelial function and blood flow regulation
    • Toda N. Age-related changes in endothelial function and blood flow regulation. Pharmacol Ther. 2012;133:159-76.
    • (2012) Pharmacol Ther , vol.133 , pp. 159-176
    • Toda, N.1
  • 51
    • 20444480549 scopus 로고    scopus 로고
    • Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6
    • DOI 10.1016/j.diabres.2004.11.007, PII S0168822704003742
    • Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Prac. 2005;69:29-35. (Pubitemid 40813409)
    • (2005) Diabetes Research and Clinical Practice , vol.69 , Issue.1 , pp. 29-35
    • Park, H.S.1    Park, J.Y.2    Yu, R.3
  • 52
    • 0037072285 scopus 로고    scopus 로고
    • Interleukin-6 and risk of cognitive decline: Macarthur studies of successful aging
    • Weaver JD, Huang MH, Albert M, et al. Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging. Neurology. 2002;59:371-8. (Pubitemid 34857929)
    • (2002) Neurology , vol.59 , Issue.3 , pp. 371-378
    • Weaver, J.D.1    Huang, M.-H.2    Albert, M.3    Harris, T.4    Rowe, J.W.5    Seeman, T.E.6
  • 55
    • 0034985014 scopus 로고    scopus 로고
    • Advanced glycation: An important pathological event in diabetic and age related ocular disease
    • DOI 10.1136/bjo.85.6.746
    • Stitt AW. Advanced glycation: an important pathological event in diabetic and age related ocular disease. Br J Ophthalmol. 2001;85: 746-53. (Pubitemid 32554256)
    • (2001) British Journal of Ophthalmology , vol.85 , Issue.6 , pp. 746-753
    • Stitt, A.W.1
  • 56
    • 0028908348 scopus 로고
    • Advanced protein glycosylation in diabetes and aging
    • Brownlee M. Advanced protein glycosylation in diabetes and aging. Annu Rev Med. 1995;46:223-34.
    • (1995) Annu Rev Med , vol.46 , pp. 223-234
    • Brownlee, M.1
  • 58
    • 0032951044 scopus 로고    scopus 로고
    • Differential regional dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer's disease
    • DOI 10.1002/1531-8249(199904)45:4<466::AID-ANA8>
    • Small SA, Perera GM, DeLaPaz R, et al. Differential regional dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer's disease. Ann Neurol. 1999;45:466-72. (Pubitemid 29165813)
    • (1999) Annals of Neurology , vol.45 , Issue.4 , pp. 466-472
    • Small, S.A.1    Perera, G.M.2    DeLaPaz, R.3    Mayeux, R.4    Stern, Y.5
  • 59
    • 0031797832 scopus 로고    scopus 로고
    • Glucose intolerance, cognitive impairment and Alzheimer's disease
    • DOI 10.1097/00019052-199812000-00011
    • Vanhanen M, Soininen H. Glucose intolerance, cognitive impairment and Alzheimer 's disease. Curr Opin Neurol. 1998;11: 673-7. (Pubitemid 28561204)
    • (1998) Current Opinion in Neurology , vol.11 , Issue.6 , pp. 673-677
    • Vanhanen, M.1    Soininen, H.2
  • 60
    • 34147173277 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer's disease pathogenesis: Potential mechanisms and implications for treatment
    • DOI 10.2174/156720507780362137
    • Craft S. Insulin resistance and Alzheimer 's disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res. 2007;4:147-52. (Pubitemid 46557503)
    • (2007) Current Alzheimer Research , vol.4 , Issue.2 , pp. 147-152
    • Craft, S.1
  • 61
    • 0025504552 scopus 로고
    • Reduced regional cerebral blood flowin aged noninsulin-dependent diabetic patients with not history of cerebrovascular disease: Evaluation by N-isopropyl-123I-p-iodoamphetamine with single-photon emission computed tomography
    • Wakisaka M, Nagamachi S, Inoue K, et al. Reduced regional cerebral blood flowin aged noninsulin-dependent diabetic patients with not history of cerebrovascular disease: evaluation by N-isopropyl-123I-p-iodoamphetamine with single-photon emission computed tomography. J Diabet Complicat. 1990;4:170-4.
    • (1990) J Diabet Complicat , vol.4 , pp. 170-174
    • Wakisaka, M.1    Nagamachi, S.2    Inoue, K.3
  • 62
    • 0025363792 scopus 로고
    • Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats
    • Jakobsen J, Nedergaard M, Aarsle-jensen M, et al. Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats. Diabetes. 1990;39:437-40. (Pubitemid 20111424)
    • (1990) Diabetes , vol.39 , Issue.4 , pp. 437-440
    • Jakobsen, J.1    Nedergaard, M.2    Aarslew-Jensen, M.3    Diemer, N.H.4
  • 63
    • 84862298982 scopus 로고    scopus 로고
    • The role of insulin and insulin-like growth factor-1/FoxO-Mediated transcription for the pathogenesis of obesity-associated dementia
    • Moll L, Schubert M. The role of insulin and insulin-like growth factor-1/FoxO-Mediated transcription for the pathogenesis of obesity-associated dementia. Curr Gerontol Geriatr Res. 2012;2012:384094.
    • (2012) Curr Gerontol Geriatr Res , vol.2012 , pp. 384094
    • Moll, L.1    Schubert, M.2
  • 65
    • 84861520613 scopus 로고    scopus 로고
    • Changes in glycemic control are associated with changes in cognition in nondiabetic elderly
    • Ravona-Springer R,Moshier E, et al. Changes in glycemic control are associated with changes in cognition in nondiabetic elderly. J Alzheimers Dis. 2012;30:299-309.
    • (2012) J Alzheimers Dis , vol.30 , pp. 299-309
    • Ravona-Springer, R.1    Moshier, E.2
  • 66
    • 33748475644 scopus 로고    scopus 로고
    • Glycosated hemoglobin level and development of mild cognitive impairment or dementia in older women
    • Yaffe K, Blackwell T,Whitmer RA, et al. Glycosated hemoglobin level and development of mild cognitive impairment or dementia in older women. J Nutr Health Aging. 2006;10:293-5.
    • (2006) J Nutr Health Aging , vol.10 , pp. 293-295
    • Yaffe, K.1    Blackwell, T.2    Whitmer, R.A.3
  • 67
    • 3342964204 scopus 로고    scopus 로고
    • Glycated hemoglobin level is strongly related to the prevalence of carotid artery plaques with high echogenicity in nondiabetic individuals: The Tromso study
    • DOI 10.1161/01.CIR.0000136809.55141.3B
    • Jorgensen L, Jenssen T, Joakimsen O, et al. Glycated hemoglobin level is strongly related to the prevalence of carotid artery plaques with high echogenicity in nondiabetic individuals: the Tromoso study. Circulation. 2004;110:466-70. (Pubitemid 38993858)
    • (2004) Circulation , vol.110 , Issue.4 , pp. 466-470
    • Jorgensen, L.1    Jenssen, T.2    Joakimsen, O.3    Heuch, I.4    Ingebretsen, O.C.5    Jacobsen, B.K.6
  • 68
    • 0023118941 scopus 로고
    • Regional cerebral blood flow decreases during chronic and acute hyperglycemia
    • Duckrow RB, Beard DC, Brennan RW. Regional cerebral blood flow decreases during chronic and acute hyperglycemia. Stroke. 1987;18:52-8. (Pubitemid 17016685)
    • (1987) Stroke , vol.18 , Issue.1 , pp. 52-58
    • Duckrow, R.B.1    Beard, D.C.2    Brennan, R.W.3
  • 69
    • 18844445577 scopus 로고    scopus 로고
    • Risk factors for progression of brain atrophy in aging: Six-year follow-up of normal subjects
    • DOI 10.1212/01.WNL.0000161871.83614.BB
    • Enzinger C, Fazekas F, Matthews PM, et al. Risk factors for progression of brain atrophy in aging: 6 year follow-up of normal subjects. Neurology. 2005;64:1704-11. (Pubitemid 40695802)
    • (2005) Neurology , vol.64 , Issue.10 , pp. 1704-1711
    • Enzinger, C.1    Fazekas, F.2    Matthews, P.M.3    Ropele, S.4    Schmidt, H.5    Smith, S.6    Schmidt, R.7
  • 71
    • 77649217019 scopus 로고    scopus 로고
    • Overweight, obesity, and depression: A systematic review and meta-analysis of longitudinal studies
    • Luppino FS, de Wit LM, Bouvy PF, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010;67:220-9.
    • (2010) Arch Gen Psychiatry , vol.67 , pp. 220-229
    • Luppino, F.S.1    De Wit, L.M.2    Bouvy, P.F.3
  • 73
    • 84871659929 scopus 로고    scopus 로고
    • Physical activity, brain plasticity, and Alzheimer's disease
    • Erickson KI, Weinstein AM, Lopez OL. Physical activity, brain plasticity, and Alzheimer's disease. Arch Med Res. 2012;43:615-21.
    • (2012) Arch Med Res , vol.43 , pp. 615-621
    • Erickson, K.I.1    Weinstein, A.M.2    Lopez, O.L.3
  • 74
    • 84883761124 scopus 로고    scopus 로고
    • The interactive effects of cerebral perfusion and depression on cognitive function in older adults with heart failure
    • Alosco ML, Spitznagel MB, Raz N, et al. The interactive effects of cerebral perfusion and depression on cognitive function in older adults with heart failure. Psychosom Med. 2013;75:632-9.
    • (2013) Psychosom Med , vol.75 , pp. 632-639
    • Alosco, M.L.1    Spitznagel, M.B.2    Raz, N.3
  • 75
    • 34147101131 scopus 로고    scopus 로고
    • Relation of obesity to cognitive function: Importance of central obesity and synergistic influence of concomitant hypertension. The Framingham heart study
    • DOI 10.2174/156720507780362263
    • Wolf PA, Beiser A, Elias MF, et al. Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study. Curr Alzheimer Res. 2007;4:111-6. (Pubitemid 46557497)
    • (2007) Current Alzheimer Research , vol.4 , Issue.2 , pp. 111-116
    • Wolf, P.A.1    Beiser, A.2    Elias, M.F.3    Au, R.4    Vasan, R.S.5    Seshadri, S.6
  • 76
    • 81055138880 scopus 로고    scopus 로고
    • Aerobic fitness and obesity: Relationship to cerebral white matter integrity in the brain of active and sedentary older adults
    • Marks BL, Katz LM, Styner M, et al. Aerobic fitness and obesity: relationship to cerebral white matter integrity in the brain of active and sedentary older adults. Br J Sport Med. 2011;45:1208-15.
    • (2011) Br J Sport Med , vol.45 , pp. 1208-1215
    • Marks, B.L.1    Katz, L.M.2    Styner, M.3
  • 77
    • 79958076981 scopus 로고    scopus 로고
    • FTO gene polymorphisms and obesity risk: A meta-analysis
    • Peng S, Zhu Y, Xu F, et al. FTO gene polymorphisms and obesity risk: a meta-analysis. BMC Med. 2011;9:71.
    • (2011) BMC Med , vol.9 , pp. 71
    • Peng, S.1    Zhu, Y.2    Xu, F.3
  • 78
    • 77952340870 scopus 로고    scopus 로고
    • A commonly carried allele of the obesity-related gene is associated with reduced brain volume in the healthy elderly
    • Ho AJ, Stein JL, Hua X, et al. A commonly carried allele of the obesity-related gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A. 2010;107:8404-9.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 8404-8409
    • Ho, A.J.1    Stein, J.L.2    Hua, X.3
  • 79
    • 80052827558 scopus 로고    scopus 로고
    • Interaction between vascular factors and the APOE ε4 allele in predicting rate of progression in Alzheimer's disease
    • Mielke MM, Leoutsakos JM, Tschanz JT, et al. Interaction between vascular factors and the APOE ε4 allele in predicting rate of progression in Alzheimer's disease. J Alzheimer Dis. 2011;26: 127-34.
    • (2011) J Alzheimer Dis , vol.26 , pp. 127-134
    • Mielke, M.M.1    Leoutsakos, J.M.2    Tschanz, J.T.3
  • 83
    • 71849089826 scopus 로고    scopus 로고
    • Plasma Amyloid-beta peptide levels correlate with adipocyte amyloid precursor protein gene expression in obese individuals
    • Lee Y, Martin JM, Maple RL, et al. Plasma Amyloid-beta peptide levels correlate with adipocyte amyloid precursor protein gene expression in obese individuals. Neuroendocrinology. 2009;90:383-90.
    • (2009) Neuroendocrinology , vol.90 , pp. 383-390
    • Lee, Y.1    Martin, J.M.2    Maple, R.L.3
  • 85
    • 34147096369 scopus 로고    scopus 로고
    • Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: A position paper
    • DOI 10.2174/156720507780362254
    • Finch CE, Morgan TE. Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position Paper. Curr Alzheimer Res. 2007;4:185-9. (Pubitemid 46562393)
    • (2007) Current Alzheimer Research , vol.4 , Issue.2 , pp. 185-189
    • Finch, C.E.1    Morgan, T.E.2
  • 86
    • 84255175411 scopus 로고    scopus 로고
    • Obesity, leptin, and Alzheimer's disease
    • Lee EB. Obesity, leptin, and Alzheimer's disease. Ann N YAcad Sci. 2011;1243:15-29.
    • (2011) Ann N YAcad Sci , vol.1243 , pp. 15-29
    • Lee, E.B.1
  • 88
    • 84855904096 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and Alzheimer 's disease: Physiopathology and beyond
    • Diniz BS, Teizeira AL. Brain-derived neurotrophic factor and Alzheimer 's disease: physiopathology and beyond. Neuromol Med. 2011;13:217-22.
    • (2011) Neuromol Med , vol.13 , pp. 217-222
    • Diniz, B.S.1    Teizeira, A.L.2
  • 89
    • 54049157378 scopus 로고    scopus 로고
    • Serum leptin levels are associated with cognitive function in older adults
    • Gunstad J, Spitznagel M, Keary T, et al. Serum leptin levels are associated with cognitive function in older adults. Brain Res. 2008;1230:233-6.
    • (2008) Brain Res , vol.1230 , pp. 233-236
    • Gunstad, J.1    Spitznagel, M.2    Keary, T.3
  • 90
    • 84863597741 scopus 로고    scopus 로고
    • Reduction in inflammation and the expression of amyloid precursor protein and other proteins related to Alzheimer's disease following gastric bypass surgery
    • Ghanim H, Monte SV, Sia CL, et al. Reduction in inflammation and the expression of amyloid precursor protein and other proteins related to Alzheimer's disease following gastric bypass surgery. J Clin Endocrinol Metab. 2012;97:E1197-201.
    • (2012) J Clin Endocrinol Metab , vol.97
    • Ghanim, H.1    Monte, S.V.2    Sia, C.L.3
  • 91
    • 84896315510 scopus 로고    scopus 로고
    • Adaptation of leptin, ghrelin or insulin during weight loss as predictors weight regain: A review of current literature
    • Strohacker K, McCaffery JM, Maclean PS, et al. Adaptation of leptin, ghrelin or insulin during weight loss as predictors weight regain: a review of current literature. Int J Obes (London) 2014;38: 388-96.
    • (2014) Int J Obes (London) , vol.38 , pp. 388-396
    • Strohacker, K.1    McCaffery, J.M.2    Maclean, P.S.3
  • 92
    • 84892446002 scopus 로고    scopus 로고
    • Potential benefits of weight loss in coronary heart disease
    • Ades PA, Savage PD. Potential benefits of weight loss in coronary heart disease. Prog Cardiovasc Dis. 2014;56:448-56.
    • (2014) Prog Cardiovasc Dis , vol.56 , pp. 448-456
    • Ades, P.A.1    Savage, P.D.2
  • 93
    • 84885477386 scopus 로고    scopus 로고
    • Long-term changes in leptin, chemerin, and Ghrelin levels following different bariatric surgery procedures: Roux-en-Y Gastric bypass and sleeve gastrectomy
    • Terra X, Auguet T, Guiu-Jurado E, et al. Long-term changes in leptin, chemerin, and Ghrelin levels following different bariatric surgery procedures: Roux-en-Y Gastric bypass and sleeve gastrectomy. Obes Surg. 2013;23:1790-8.
    • (2013) Obes Surg , vol.23 , pp. 1790-1798
    • Terra, X.1    Auguet, T.2    Guiu-Jurado, E.3
  • 94
    • 79960116360 scopus 로고    scopus 로고
    • Improved diabetes control in the elderly delays global cognitive decline
    • Luchsinger JA, Palmas W, Teresi JA, et al. Improved diabetes control in the elderly delays global cognitive decline. J Nutr Health Aging. 2011;15:445-9.
    • (2011) J Nutr Health Aging , vol.15 , pp. 445-449
    • Luchsinger, J.A.1    Palmas, W.2    Teresi, J.A.3
  • 95
    • 80054748660 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): A randomized open-label substudy
    • Launer LJ, Miller ME, Williamson JD, et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomized open-label substudy. Lancet Neurol. 2011;10:969-77.
    • (2011) Lancet Neurol , vol.10 , pp. 969-977
    • Launer, L.J.1    Miller, M.E.2    Williamson, J.D.3
  • 96
    • 84904464017 scopus 로고    scopus 로고
    • Epigenomic approach in understanding Alzheimer's disease and type 2 diabetes mellitus
    • Shaik MM, Hua GS, Kamal MA. Epigenomic approach in understanding Alzheimer's disease and type 2 diabetes mellitus. CNS Neurol Disord Drug Targets. 2014;13(2):283-9.
    • (2014) CNS Neurol Disord Drug Targets , vol.13 , Issue.2 , pp. 283-289
    • Shaik, M.M.1    Hua, G.S.2    Kamal, M.A.3
  • 97
    • 77949507782 scopus 로고    scopus 로고
    • The impact of cognitive function on medication management: Three studies
    • Stilley CS, Bender CM, Dunbar-Jacob J, et al. The impact of cognitive function on medication management: three studies. Health Psychol. 2010;29:50-5.
    • (2010) Health Psychol , vol.29 , pp. 50-55
    • Stilley, C.S.1    Bender, C.M.2    Dunbar-Jacob, J.3
  • 98
    • 84870248837 scopus 로고    scopus 로고
    • Cognitive function and treatment adherence in older adults with heart failure
    • Alosco ML, Spitznagel MB, van Dulmen M, et al. Cognitive function and treatment adherence in older adults with heart failure. Psychosom Med. 2012;74:965-73.
    • (2012) Psychosom Med , vol.74 , pp. 965-973
    • Alosco, M.L.1    Spitznagel, M.B.2    Van Dulmen, M.3
  • 99
    • 84881186111 scopus 로고    scopus 로고
    • Cognitive function is linked to adherence to bariatric postoperative guidelines
    • Spitznagel MB, Galioto R, Limbach K, et al. Cognitive function is linked to adherence to bariatric postoperative guidelines. Surg Obes Relat Dis. 2013;9:580-5.
    • (2013) Surg Obes Relat Dis , vol.9 , pp. 580-585
    • Spitznagel, M.B.1    Galioto, R.2    Limbach, K.3
  • 100
  • 101
    • 84884496377 scopus 로고    scopus 로고
    • Can diabetes be surgically cured? Long-term metabolic effects of bariatric surgery in obese patients with type 2 diabetes mellitus
    • Bariatric surgery with sustainable remission and improvement in T2DM
    • .•• Brethauer SA, Aminian A, Romera-Talamas H, et al. Can diabetes be surgically cured? Long-term metabolic effects of bariatric surgery in obese patients with type 2 diabetes mellitus. Ann Surg. 2013;258:628-37. Bariatric surgery with sustainable remission and improvement in T2DM.
    • (2013) Ann Surg , vol.258 , pp. 628-637
    • Brethauer, S.A.1    Aminian, A.2    Romera-Talamas, H.3
  • 102
    • 84869161483 scopus 로고    scopus 로고
    • Effects of intentional weight loss on physical and cognitive function in middleaged and older obese participants: A pilot study
    • Siervo M, Nasti G, Stephan BC, et al. Effects of intentional weight loss on physical and cognitive function in middleaged and older obese participants: a pilot study. J Am Coll Nutr. 2012;31:79 - 86.
    • (2012) J Am Coll Nutr , vol.31 , pp. 79-86
    • Siervo, M.1    Nasti, G.2    Stephan, B.C.3


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