Changes in glycemic control are associated with changes in cognition in non-diabetic elderly

Journal of Alzheimer's Disease

Volumn 30, Issue 2, 2012, Pages 299-309

  Ravona Springer, Ramit ^a   Moshier, Erin ^b   Schmeidler, James ^b   Godbold, James ^b   Akrivos, Jimmy ^b   Rapp, Michael ^c   Grossman, Hillel T ^b,d   Wysocki, Michael ^b   Silverman, Jeremy M ^b,d   Haroutunian, Vahram ^b,d   Beeri, Michal Schnaider ^b  

^a SHEBA MEDICAL CENTER   (Israel)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c HUMBOLDT UNIVERSITY   (Germany)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cognition; elderly; glucose control; HbA1c; non diabetic

Indexed keywords

APOLIPOPROTEIN E4; CHOLESTEROL; GLUCOSE; HEMOGLOBIN A1C; TRIACYLGLYCEROL;

AGED; ARTICLE; ATTENTION; CHOLESTEROL BLOOD LEVEL; COGNITION; EDUCATION; FEMALE; FOLLOW UP; GENDER; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPERTENSION; LANGUAGE; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MENTAL DETERIORATION; MINI MENTAL STATE EXAMINATION; ORIENTATION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RECALL; SMOKING; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84861520613     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120106     Document Type: Article

References (47)

1. Ravona-Springer R, Luo X, Schmeidler J, Wysocki M, Lesser G, Rapp M, Dahlman K, Grossman H, Haroutunian V, Schnaider BM (2010) Diabetes is associated with increased rate of cognitive decline in questionably demented elderly. Dement Geriatr Cogn Disord 29, 68-74.
2. Roberts RO, Geda YE, Knopman DS, Christianson TJ, Pankratz VS, Boeve BF, Vella A, Rocca WA, Petersen RC (2008) Association of duration and severity of diabetes mellitus with mild cognitive impairment. Arch Neurol 65, 1066-1073.
3. Schnaider BM, Goldbourt U, Silverman JM, Noy S, Schmeidler J, Ravona-Springer R, Sverdlick A, Davidson M (2004) Diabetes mellitus in midlife and the risk of dementia three decades later. Neurology 63, 1902-1907. (Pubitemid 39532388)
4. Xu W, Qiu C, Gatz M, Pedersen NL, Johansson B, Fratiglioni L (2009) Mid-and late-life diabetes in relation to the risk of dementia:A population-based twin study. Diabetes58, 71-77.
5. Yaffe K, Blackwell T, Whitmer RA, Krueger K, Barrett CE (2006) Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women. J Nutr Health Aging 10, 293-295.
6. Rasgon NL, Kenna HA, Wroolie TE, Kelley R, Silverman D, Brooks J, Williams KE, Powers BN, Hallmayer J, Reiss A (2011) Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease. Neurobiol Aging 32, 1942-1948.
7. Beeri MS, Schmeidler J, Sano M, Wang J, Lally R, Grossman H, Silverman JM (2006) Age, gender, and education norms on the CERAD neuropsychological battery in the oldest old. Neurology 67, 1006-1010. (Pubitemid 44454594)
8. Morris JC (1993) The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology 43, 2412-2414. (Pubitemid 23346995)
9. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
10. Goldstein DE, Little RR, Lorenz RA, Malone JI, Nathan DM, Peterson CM (2004) Tests of glycemia in diabetes. Diabetes Care 27 (Suppl 1), S91-S93.
11. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ (2003) The seventh report of the joint national committee onprevention, detection, evaluation, and treatment of high blood pressure: The JNC 7 report. JAMA 289, 2560-2572. (Pubitemid 37430158)
12. American Diabetes A (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33 (Suppl 1), S62-S69.
13. Rodriguez C, Pablos-Mendez A, Palmas W, Lantigua R, Mayeux M, Berglund L (2010) Comparison of modifiable determinants of lipids and lipoprotein levels among African-Americans, Hispanics, and Non-Hispanic Caucasians >65 years of age living in New York city. Am J Cardiol 89, 178-183.
14. Rebeck GW, Reiter JS, Strickland DK, Hyman BT (1993) Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron 11, 575-580. (Pubitemid 23321768)
15. Twisk J, Rijmen F (2009) Longitudinal tobit regression: A new approach to analyze outcome variables with floor or ceiling effects. J Clin Epidemiol 62, 953-958.
16. Qiu C, Kivipelto M, von SE (2009) Epidemiology of Alzheimer's disease: Occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 11, 111-128.
17. Beeri MS, Ravona-Springer R, Silverman JM, Haroutunian V (2009) The effects of cardiovascular risk factors on cognitive compromise. Dialogues Clin Neurosci 11, 201-212.
18. Fratiglioni L, Paillard-Borg S, Winblad B (2004) An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol 3, 343-353. (Pubitemid 38648855)
19. Pani LN, Korenda L, Meigs JB, Driver C, Chamany S, Fox CS, Sullivan L, D'Agostino RB, Nathan DM (2008) Effect of agingonA1C levelsinindividuals without diabetes: Evidence from the framingham offspring study and the national health and nutrition examination survey 2001-2004. Diabetes Care 31, 1991-1996.
20. Hashimoto Y, Futamura A, Ikushima M (1995) Effectofaging on HbA1c in a working male Japanese population. Diabetes Care 18, 1337-1340.
21. Drachman DA (2006) Aging of the brain, entropy, and Alzheimer disease. Neurology 67, 1340-1352. (Pubitemid 44632055)
22. Selvin E, Zhu H, Brancati FL (2009) Elevated A1C in Adults Without a History of Diabetes in the U. S. Diabetes Care 32, 828-833.
23. Hilborn JV, Strauss E, Hultsch DF, Hunter MA (2009) Intrain-dividual variability across cognitive domains: Investigation of dispersion levels and performance profiles in older adults. J Clin Exp Neuropsychol 31, 412-424.
24. Convit A, Wolf OT, Tarshish C, de Leon MJ (2003) Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proc Natl Acad Sci USA 100, 2019-2022. (Pubitemid 36254566)
25. Enzinger C, Fazekas F, Matthews PM, Ropele S, Schmidt H, Smith S, Schmidt R (2005) Risk factors for progression of brain atrophy in aging: Six-year follow-up of normal subjects. Neurology 64, 1704-1711. (Pubitemid 40695802)
26. Park S, Barrett-Connor E, Wingard DL, Shan J, Edelstein S (1996) GHbisabetter predictorof cardiovascular disease than fasting or postchallenge plasma glucose in women without diabetes. The Rancho Bernardo Study. Diabetes Care 19, 450-456.
27. de Vegt F, Dekker JM, Ruhe HG, Stehouwer CD, Nijpels G, Bouter LM, Heine RJ (1999) Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: The Hoorn Study. Diabetologia 42, 926-931. (Pubitemid 29369599)
28. Khaw KT, Wareham N, Luben R, Bingham S, Oakes S, Welch A, Day N (2001) Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of european prospective investigation of cancer and nutrition (EPIC-Norfolk). BMJ 322, 15-18. (Pubitemid 32066250)
29. Jorgensen L, Jenssen T, Joakimsen O, Heuch I, Ingebret-sen OC, Jacobsen BK (2004) Glycated hemoglobin level is strongly related to the prevalence of carotid artery plaques with high echogenicity in nondiabetic individuals: The Tromso study. Circulation 110, 466-470. (Pubitemid 38993858)
30. Schneider JA, Bennett DA (2010) Where vascular meets neu-rodegenerative disease. Stroke 41, S144-S146.
31. Duckrow RB, Beard DC, Brennan RW (1987) Regional cerebral blood flow decreases during chronic and acute hyper-glycemia. Stroke 18, 52-58. (Pubitemid 17016685)
32. Mattson MP, Guthrie PB, Kater SB (1989) Intrinsic factors in the selective vulnerabilityofhippocampal pyramidal neurons. Prog Clin Biol Res 317, 333-351.
33. Cervos-Navarro J, Diemer NH (1991) Selective vulnerability in brain hypoxia. Crit Rev Neurobiol 6, 149-182.
34. McNay EC, Fries TM, Gold PE (2000) Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task. Proc Natl Acad Sci USA 97, 2881-2885. (Pubitemid 30159266)
35. Yaffe K, Blackwell T, Whitmer RA, Krueger K, Barrett Connor E (2006) Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women. J Nutr Health Aging 10, 293-295.
36. Population Division USCB (2008) NP2008 D1: Projected populationbysingle yearofage, sex, race, and Hispanic origin for the United States: July 1, 2000 to July 1, 2050.
37. Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas CH (2010) Dementia incidence continues to increase with age in the oldest old: The 90+ study. Ann Neurol 67, 114-121.
38. Wilson RS, Schneider JA, Arnold SE, Bienias JL, Bennett DA (2007) Conscientiousness and the incidenceof Alzheimer disease and mild cognitive impairment. Arch Gen Psychiatry 64, 1204-1212. (Pubitemid 47529345)
39. Kravitz BA, Corrada MM, Kawas CH (2009) High levels of serum C-reactive protein are associated with greater risk of all-causemortality, but not dementia, intheoldest-old: Results from The 90+ Study. J Am Geriatr Soc 57, 641-646.
40. Hensel A, Angermeyer MC, Riedel-Heller SG (2007) Measuring cognitive change in older adults: Reliable change indices for the Mini-Mental State Examination. J Neurol Neurosurg Psychiatry 78, 1298-1303. (Pubitemid 350221406)
41. Unger JM, van Belle G, Heyman A (1999) Cross-sectional versus longitudinal estimates of cognitive change in non-demented older people: A CERAD study. Consortium to establish a registry for Alzheimer's disease. J Am Geriatr Soc 47, 559-563. (Pubitemid 29215584)
42. American Psychiatric A ed. (2010) Diagnostic and Statistical Manual of Mental Disorders IV, American Psychiatric Association, Washington, DC, pp. 133-155.
43. Gold DA (2012) An examination of instrumental activities of daily living assessment in older adults and mild cognitive impairment. J Clin Exp Neuropsychol 34, 11-34.
44. Brown PJ, Devanand DP, Liu X, Caccappolo E, Initiative ftAsDN (2011) Functional impairmentinelderly patients with mild cognitive impairment and mild Alzheimer disease. Arch Gen Psychiatry 68, 617-626.
45. Okura T, Heisler M, Langa KM (2009) Association between cognitive function and social support with glycemic control in adults with diabetes mellitus. J Am Geriatr Soc 57, 1816-1824.
46. Scherer T, O'Hare J, Diggs-Andrews K, Schweiger M, Cheng B, Lindtner C, Zielinski E, Vempati P, Su K, Dighe S, Mil-som T, Puchowicz M, Scheja L, Zechner R, Fisher SJ, Previs SF, Buettner C (2011) Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metab 13, 183-194.
47. Beeri MS, Schmeidler J, Silverman JM, Gandy S, Wysocki M, Hannigan CM, Purohit DP, Lesser G, Grossman HT, Haroutu-nian V (2008) Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology 71, 750-757.