Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Krohn, Jon ^a   Speed, Doug ^b   Palme, Rupert ^c   Touma, Chadi ^d   Mott, Richard ^a   Flint, Jonathan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^d MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BAYES THEOREM; CONTROLLED STUDY; EPISTASIS; FEMALE; GENE INTERACTION; GENETIC TRAIT; HERITABILITY; MALE; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; QUANTITATIVE TRAIT LOCUS; QUANTITATIVE TRAIT LOCUS MAPPING; SEX ROLE; SPARSE PARTITIONING; ANIMAL; CHROMOSOME MAP; GENETIC VARIABILITY; PHENOTYPE; QUANTITATIVE TRAIT; SEX DIFFERENCE;

ANIMALS; BAYES THEOREM; CHROMOSOME MAPPING; FEMALE; GENETIC VARIATION; MALE; MICE; PHENOTYPE; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE; SEX FACTORS;

EID: 84901481778     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096450     Document Type: Article

References (22)

1. Zuk O, Hechter S, Sunyaev SR, Lander ES (2012) Genetic interactions create phantom heritability. Proc Natl Acad Sci U S A 109: 1193-1198.
2. Mackay T (2004) The genetic architecture of quantitative traits: lessons from Drosophila. Curr Opin Genet Dev 14: 253-257.
3. Peirce J, Derr R, Shendure J, Kolata T, LM S (1998) A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice. Mamm Genome 9: 942-948. (Pubitemid 29030893)
4. Mattson D, Dwinell M, Greene A, Kwitek A, Roman R, et al. (2007) Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. Am J Physiol Renal Physiol 293: F1905-1914. (Pubitemid 350179615)
5. Weiss L, Pan L, Abney M, Ober C (2006) The sex-specific genetic architecture of quantitative traits in humans. Nat Genet 38: 218-222. (Pubitemid 43177237)
6. Brockmann G, Haley C, Renne U, Knott S, Schwerin M (1998) Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth. Genetics 150: 369-381. (Pubitemid 28415530)
7. Brockmann G, Karatayli E, Haley C, Renne U, Rottmann O, et al. (2004) QTLs for pre- and postweaning body weight and body composition in selected mice. Mamm Genome 15: 593-609. (Pubitemid 39050022)
8. Taylor B, Tarantino L, Phillips S (1999) Gender-influenced obesity QTLs identified in a cross involving the KK type II diabetes-prone mouse strain. Mamm Genome 10: 963-968. (Pubitemid 29470936)
9. Wanstrat A, Wakeland E (2001) The genetics of complex autoimmune diseases: non-MHC susceptibility genes. Nat Immunol 2: 802-809.
10. Fijneman R, de Vries S, Jansen R, Demant P (1996) Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse. Nat Genet 14: 465-467. (Pubitemid 26414592)
11. van Wezel T, Ruivenkamp C, Stassen A, Moen C, Demant P (1999) Four new colon cancer susceptibility loci, Scc6 to Scc9 in the mouse. Cancer Res 59: 4216-4218. (Pubitemid 29418729)
12. Demarest K, McCaughran JJ, Mahjubi E, Cipp L, Hitzemann R (1999) Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. J Neurosci 19: 549-561. (Pubitemid 29036006)
13. Valdar W, Solberg L, Gauguier D, Burnett S, Klenerman P, et al. (2006) Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet 38: 879-887. (Pubitemid 44141655)
14. Speed D, Tavare S (2011) Sparse partitioning: nonlinear regression with binary or tertiary predictors, with application to association studies. The Annals of Applied Statistics 5: 873-893.
15. Atwell S, Huang Y, Vilhjalmsson B, Willems G, Horton M, et al. (2010) Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature 465: 627-631.
16. Mott R, Talbot C, Turri M, Collins A, Flint J (2000) A method for fine mapping quantitative trait loci in outbred animal stocks. Proc Natl Acad Sci U S A 97: 12649-12654.
17. Astle W, Balding D (2009) Population structure and cryptic relatedness in genetic association studies. Statist Sci 24: 387-576.
18. Speed D, Hemani G, Johnson M, Balding D (2012) Improved heritability estimation from genome-wide SNPs. Am J Hum Genet 91: 1011-1021.
19. Corbeil R, Searle S (1976) Restricted maximum likelihood (REML) estimation of variance components in the mixed model. Technometrics 18: 31-38.
20. Patsopoulos N, Tatsioni A, Ioannidis J (2007) Claims of sex differences: an empirical assessment in genetic associations. J Am Med Assoc 298: 880-893. (Pubitemid 47311294)
21. Kendler K, Gardner C, Neale M, Prescott C (2001) Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? Psychol Med 31: 605-616. (Pubitemid 32421962)
22. Kendler K, Gatz M, Gardner C, Pedersen N (2006) A Swedish national twin study of lifetime major depression. Am J Psychiatry 163: 109-114. (Pubitemid 43050111)