High fitness costs and instability of gene duplications reduce rates of evolution of new genes by duplication-divergence mechanisms

Molecular Biology and Evolution

Volumn 31, Issue 6, 2014, Pages 1526-1535

  Adler, Marlen ^a   Anjum, Mehreen ^a,b   Berg, Otto G ^a   Andersson, Dan I ^a   Sandegren, Linus ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF THE PUNJAB   (Pakistan)

Author keywords

Escherichia coli; evolution of new genes; fitness cost; gene amplification

Indexed keywords

ANTIBIOTIC AGENT; DNA; ANTIINFECTIVE AGENT; BETA LACTAMASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BASE PAIRING; CONTROLLED STUDY; COPY NUMBER VARIATION; EVOLUTION; FITNESS COST; GENE AMPLIFICATION; GENE DOSAGE; GENE DUPLICATION; GENETIC PARAMETERS; GENETIC VARIABILITY; GENOMIC INSTABILITY; MATHEMATICAL MODEL; NONHUMAN; PLASMID; BACTERIA; BACTERIAL GENE; BIOLOGICAL MODEL; DRUG EFFECTS; GENE FREQUENCY; GENETIC SELECTION; GENETICS; MOLECULAR EVOLUTION; REPRODUCTIVE FITNESS;

ANTI-BACTERIAL AGENTS; BACTERIA; BETA-LACTAMASES; DNA COPY NUMBER VARIATIONS; EVOLUTION, MOLECULAR; GENE AMPLIFICATION; GENE DUPLICATION; GENE FREQUENCY; GENES, BACTERIAL; GENETIC FITNESS; MODELS, GENETIC; PLASMIDS; SELECTION, GENETIC;

EID: 84901468529     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msu111     Document Type: Article

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