-
1
-
-
67349245787
-
New insights into the aetiology of colorectal cancer from genome-wide association studies
-
Tenesa A and Dunlop MG: New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat Rev Genet 10: 353-358, 2009.
-
(2009)
Nat Rev Genet
, vol.10
, pp. 353-358
-
-
Tenesa, A.1
Dunlop, M.G.2
-
2
-
-
84865326680
-
MicroRNA-93 inhibits tumor growth and early relapse of human colorectal cancer by affecting genes involved in the cell cycle
-
Yang IP, Tsai HL, Hou MF, et al: MicroRNA-93 inhibits tumor growth and early relapse of human colorectal cancer by affecting genes involved in the cell cycle. Carcinogenesis 33: 1522-1530, 2012.
-
(2012)
Carcinogenesis
, vol.33
, pp. 1522-1530
-
-
Yang, I.P.1
Tsai, H.L.2
Hou, M.F.3
-
3
-
-
67650999875
-
The basics of epithelial-mesenchymal transition
-
Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.
-
(2009)
J Clin Invest
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
-
4
-
-
33244463813
-
Complex networks orchestrate epithelial-mesenchymal transitions
-
DOI 10.1038/nrm1835, PII NRM1835
-
Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142, 2006. (Pubitemid 43278296)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.2
, pp. 131-142
-
-
Thiery, J.P.1
Sleeman, J.P.2
-
5
-
-
70349165716
-
Epithelial-mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic
-
Voulgari A and Pintzas A: Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta 1796: 75-90, 2009.
-
(2009)
Biochim Biophys Acta
, vol.1796
, pp. 75-90
-
-
Voulgari, A.1
Pintzas, A.2
-
6
-
-
78049284317
-
Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail
-
Du C, Zhang C, Hassan S, et al: Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail. Cancer Res 70: 7810-7819, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 7810-7819
-
-
Du, C.1
Zhang, C.2
Hassan, S.3
-
7
-
-
33748116186
-
A Transient, EMT-Linked Loss of Basement Membranes Indicates Metastasis and Poor Survival in Colorectal Cancer
-
DOI 10.1053/j.gastro.2006.06.016, PII S0016508506012868
-
Spaderna S, Schmalhofer O, Hlubek F, et al: A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology 131: 830-840, 2006. (Pubitemid 44307069)
-
(2006)
Gastroenterology
, vol.131
, Issue.3
, pp. 830-840
-
-
Spaderna, S.1
Schmalhofer, O.2
Hlubek, F.3
Berx, G.4
Eger, A.5
Merkel, S.6
Jung, A.7
Kirchner, T.8
Brabletz, T.9
-
8
-
-
84055216938
-
Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formation
-
Yao D, Dai C and Peng S: Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formation. Mol Cancer Res 9: 1608-1620, 2011.
-
(2011)
Mol Cancer Res
, vol.9
, pp. 1608-1620
-
-
Yao, D.1
Dai, C.2
Peng, S.3
-
9
-
-
0037009364
-
MicroRNA maturation: Stepwise processing and subcellular localization
-
DOI 10.1093/emboj/cdf476
-
Lee Y, Jeon K, Lee JT, et al: MicroRNA maturation: stepwise processing and subcellular localization. EMBO J 21: 4663-4670, 2002. (Pubitemid 34984353)
-
(2002)
EMBO Journal
, vol.21
, Issue.17
, pp. 4663-4670
-
-
Lee, Y.1
Jeon, K.2
Lee, J.-T.3
Kim, S.4
Kim, V.N.5
-
10
-
-
0141843656
-
The nuclear RNase III Drosha initiates microRNA processing
-
DOI 10.1038/nature01957
-
Lee Y, Ahn C, Han J, et al: The nuclear RNase III Drosha initiates microRNA processing. Nature 425: 415-419, 2003. (Pubitemid 37187272)
-
(2003)
Nature
, vol.425
, Issue.6956
, pp. 415-419
-
-
Lee, Y.1
Ahn, C.2
Han, J.3
Choi, H.4
Kim, J.5
Yim, J.6
Lee, J.7
Provost, P.8
Radmark, O.9
Kim, S.10
Kim, V.N.11
-
11
-
-
0347988235
-
Nuclear Export of MicroRNA Precursors
-
DOI 10.1126/science.1090599
-
Lund E, Güttinger S, Calado A, et al: Nuclear export of microRNA precursors. Science 303: 95-98, 2004. (Pubitemid 38055779)
-
(2004)
Science
, vol.303
, Issue.5654
, pp. 95-98
-
-
Lund, E.1
Guttinger, S.2
Calado, A.3
Dahlberg, J.E.4
Kutay, U.5
-
12
-
-
33645294070
-
Oncomirs - microRNAs with a role in cancer
-
Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269, 2006.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 259-269
-
-
Esquela-Kerscher, A.1
Slack, F.J.2
-
13
-
-
84868193774
-
Comparative profiling of miRNA expression of lung adenocarcinoma cells in two-dimensional and three-dimensional cultures
-
Li C, Nguyen HT, Zhuang Y, et al: Comparative profiling of miRNA expression of lung adenocarcinoma cells in two-dimensional and three-dimensional cultures. Gene 511: 143-150, 2012.
-
(2012)
Gene
, vol.511
, pp. 143-150
-
-
Li, C.1
Nguyen, H.T.2
Zhuang, Y.3
-
14
-
-
66849124564
-
MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance
-
Moriyama T, Ohuchida K, Mizumoto K, et al: MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance. Mol Cancer Ther 8: 1067-1074, 2009.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1067-1074
-
-
Moriyama, T.1
Ohuchida, K.2
Mizumoto, K.3
-
15
-
-
52149102044
-
Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells
-
Bhaumik D, Scott GK, Schokrpur S, et al: Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene 27: 5643-5647, 2008.
-
(2008)
Oncogene
, vol.27
, pp. 5643-5647
-
-
Bhaumik, D.1
Scott, G.K.2
Schokrpur, S.3
-
16
-
-
84880266798
-
Clinical significance of miR-22 expression in patients with colorectal cancer
-
Zhang G, Xia S, Tian H, et al: Clinical significance of miR-22 expression in patients with colorectal cancer. Med Oncol 29: 3108-3812, 2012.
-
(2012)
Med Oncol
, vol.29
, pp. 3108-3812
-
-
Zhang, G.1
Xia, S.2
Tian, H.3
-
17
-
-
84873488599
-
Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression
-
Paterson EL, Kazenwadel J, Bert AG, et al: Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression. Neoplasia 15: 180-191, 2013.
-
(2013)
Neoplasia
, vol.15
, pp. 180-191
-
-
Paterson, E.L.1
Kazenwadel, J.2
Bert, A.G.3
-
18
-
-
84876391985
-
Upregulation of microRNA-155 promotes the migration and invasion of colorectal cancer cells through the regulation of claudin-1 expression
-
Zhang GJ, Xiao HX, Tian HP, et al: Upregulation of microRNA-155 promotes the migration and invasion of colorectal cancer cells through the regulation of claudin-1 expression. Int J Mol Med 31: 1375-1380, 2013.
-
(2013)
Int J Mol Med
, vol.31
, pp. 1375-1380
-
-
Zhang, G.J.1
Xiao, H.X.2
Tian, H.P.3
-
19
-
-
84876184639
-
Decrease expression of microRNA-20a promotes cancer cell proliferation and predicts poor survival of hepatocellular carcinoma
-
Fan MQ, Huang CB, Gu Y, et al: Decrease expression of microRNA-20a promotes cancer cell proliferation and predicts poor survival of hepatocellular carcinoma. J Exp Clin Cancer Res 32: 21, 2013.
-
(2013)
J Exp Clin Cancer Res
, vol.32
, pp. 21
-
-
Fan, M.Q.1
Huang, C.B.2
Gu, Y.3
-
20
-
-
84882832773
-
MiR-20a triggers metastasis of gall-bladder carcinoma
-
Chang Y, Liu C, Yang J, et al: MiR-20a triggers metastasis of gall-bladder carcinoma. J Hepatol 59: 518-527, 2013.
-
(2013)
J Hepatol
, vol.59
, pp. 518-527
-
-
Chang, Y.1
Liu, C.2
Yang, J.3
-
21
-
-
77951838369
-
miR-20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells
-
Fan X, Liu Y, Jiang J, et al: miR-20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells. Acta Biochim Biophys Sin (Shanghai) 42: 318-324, 2010.
-
(2010)
Acta Biochim Biophys Sin (Shanghai)
, vol.42
, pp. 318-324
-
-
Fan, X.1
Liu, Y.2
Jiang, J.3
-
22
-
-
84863121672
-
miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression
-
Huang G, Nishimoto K, Zhou Z, et al: miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. Cancer Res 72: 908-916, 2012.
-
(2012)
Cancer Res
, vol.72
, pp. 908-916
-
-
Huang, G.1
Nishimoto, K.2
Zhou, Z.3
-
23
-
-
84872687799
-
Differential distribution of miR-20a and miR-20b may underly metastatic heterogeneity of breast cancers
-
Li JY, Zhang Y, Zhang WH, et al: Differential distribution of miR-20a and miR-20b may underly metastatic heterogeneity of breast cancers. Asian Pac J Cancer Prev 13: 1901-1906, 2012.
-
(2012)
Asian Pac J Cancer Prev
, vol.13
, pp. 1901-1906
-
-
Li, J.Y.1
Zhang, Y.2
Zhang, W.H.3
-
24
-
-
78650096337
-
MicroRNA-20a overexpression inhibited proliferation and metastasis of pancreatic carcinoma cells
-
Yan H, Wu J, Liu W, et al: MicroRNA-20a overexpression inhibited proliferation and metastasis of pancreatic carcinoma cells. Hum Gene Ther 21: 1723-1734, 2010.
-
(2010)
Hum Gene Ther
, vol.21
, pp. 1723-1734
-
-
Yan, H.1
Wu, J.2
Liu, W.3
-
25
-
-
79951881614
-
miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines
-
Chai H, Liu M, Tian R, et al: miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines. Acta Biochim Biophys Sin (Shanghai) 43: 217-225, 2011.
-
(2011)
Acta Biochim Biophys Sin (Shanghai)
, vol.43
, pp. 217-225
-
-
Chai, H.1
Liu, M.2
Tian, R.3
-
26
-
-
84861607077
-
Prognostic values of the miR-17-92 cluster and its paralogs in colon cancer
-
Yu G, Tang JQ, Tian ML, et al: Prognostic values of the miR-17-92 cluster and its paralogs in colon cancer. J Surg Oncol 106: 232-237, 2012.
-
(2012)
J Surg Oncol
, vol.106
, pp. 232-237
-
-
Yu, G.1
Tang, J.Q.2
Tian, M.L.3
-
27
-
-
67649425233
-
Over- and under-expressed microRNAs in human colorectal cancer
-
Motoyama K, Inoue H, Takatsuno Y, et al: Over- and under-expressed microRNAs in human colorectal cancer. Int J Oncol 34: 1069-1075, 2009.
-
(2009)
Int J Oncol
, vol.34
, pp. 1069-1075
-
-
Motoyama, K.1
Inoue, H.2
Takatsuno, Y.3
-
28
-
-
0034654497
-
Controlling TGF-beta signaling
-
Massagué J and Chen YG: Controlling TGF-beta signaling. Genes Dev 14: 627-644, 2000.
-
(2000)
Genes Dev
, vol.14
, pp. 627-644
-
-
Massagué, J.1
Chen, Y.G.2
-
29
-
-
33846326893
-
Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression
-
DOI 10.1158/1078-0432.CCR-06-1467
-
Wang LH, Kim SH, Lee JH, et al: Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression. Clin Cancer Res 13: 102-110, 2007. (Pubitemid 46121858)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.1
, pp. 102-110
-
-
Wang, L.-H.1
Kim, S.-H.2
Lee, J.H.3
Choi, Y.-L.4
Kim, Y.C.5
Park, T.S.6
Hong, Y.-C.7
Wu, C.-F.8
Shin, Y.K.9
-
30
-
-
0030775491
-
Inactivation of Smad4 in gastric carcinomas
-
Powell SM, Harper JC, Hamilton SR, et al: Inactivation of Smad4 in gastric carcinomas. Cancer Res 57: 4221-4224, 1997. (Pubitemid 27413428)
-
(1997)
Cancer Research
, vol.57
, Issue.19
, pp. 4221-4224
-
-
Powell, S.M.1
Harper, J.C.2
Hamilton, S.R.3
Robinson, C.R.4
Cummings, O.W.5
-
31
-
-
0033587156
-
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
-
DOI 10.1038/sj.onc.1202642
-
Miyaki M, Iijima T, Konishi M, et al: Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene 18: 3098-3103, 1999. (Pubitemid 29261230)
-
(1999)
Oncogene
, vol.18
, Issue.20
, pp. 3098-3103
-
-
Miyaki, M.1
Iijima, T.2
Konishi, M.3
Sakai, K.4
Ishii, A.5
Yasuno, M.6
Hishima, T.7
Koike, M.8
Shitara, N.9
Iwama, T.10
Utsunomiya, J.11
Kuroki, T.12
Mori, T.13
-
32
-
-
0033814963
-
Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease
-
Maitra A, Molberg K, Albores-Saavedra J and Lindberg G: Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease. Am J Pathol 157: 1105-1111, 2000.
-
(2000)
Am J Pathol
, vol.157
, pp. 1105-1111
-
-
Maitra, A.1
Molberg, K.2
Albores-Saavedra, J.3
Lindberg, G.4
-
33
-
-
0030848192
-
Frequency of Smad gene mutations in human cancers
-
Riggins GJ, Kinzler KW, Vogelstein B and Thiagalingam S: Frequency of Smad gene mutations in human cancers. Cancer Res 57: 2578-2580, 1997. (Pubitemid 27283760)
-
(1997)
Cancer Research
, vol.57
, Issue.13
, pp. 2578-2580
-
-
Riggins, G.J.1
Kinzler, K.W.2
Vogelstein, B.3
Thiagalingam, S.4
-
34
-
-
33644534795
-
The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
-
Deckers M, van Dinther M, Buijs J, et al: The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res 66: 2202-2209, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 2202-2209
-
-
Deckers, M.1
Van Dinther, M.2
Buijs, J.3
-
35
-
-
16344378397
-
TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
-
DOI 10.1091/mbc.E04-08-0658
-
Valcourt U, Kowanetz M, Niimi H, et al: TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell 16: 1987-2002, 2005. (Pubitemid 40471965)
-
(2005)
Molecular Biology of the Cell
, vol.16
, Issue.4
, pp. 1987-2002
-
-
Valcourt, U.1
Kowanetz, M.2
Niimi, H.3
Heldin, C.-H.4
Moustakas, A.5
-
36
-
-
24344483878
-
Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses
-
DOI 10.1128/MCB.25.18.8108-8125.2005
-
Levy L and Hill CS. Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol 25: 8108-8125, 2005. (Pubitemid 41263004)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.18
, pp. 8108-8125
-
-
Levy, L.1
Hill, C.S.2
-
37
-
-
0037026605
-
Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells
-
Müller N, Reinacher-Schick A, Baldus S, et al: Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells. Oncogene 21: 6049-6058, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 6049-6058
-
-
Müller, N.1
Reinacher-Schick, A.2
Baldus, S.3
-
38
-
-
77955785880
-
SMAD4 mediates mesenchymal-epithelial reversion in SW480 colon carcinoma cells
-
Pohl M, Radacz Y, Pawlik N, et al: SMAD4 mediates mesenchymal-epithelial reversion in SW480 colon carcinoma cells. Anticancer Res 30: 2603-2613, 2010.
-
(2010)
Anticancer Res
, vol.30
, pp. 2603-2613
-
-
Pohl, M.1
Radacz, Y.2
Pawlik, N.3
|