Antitumor effects of artesunate on human breast carcinoma MCF-7 cells and IGF-IR expression in nude mice xenografts

Chinese Journal of Cancer Research

Volumn 26, Issue 2, 2014, Pages 200-207

  Dong, Hai Ying ^a   Wang, Zhi Fei ^a  

^a Pharmacy Department of Zhejiang   (China)

Author keywords

Anticancer effect; Artesunate (ART); Cell apoptosis; Nude mice

Indexed keywords

ARTESUNATE; CASPASE 3; CYCLOPHOSPHAMIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SOMATOMEDIN C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG MECHANISM; DRUG MEGADOSE; ELECTRON MICROSCOPY; FEMALE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LOW DRUG DOSE; MCF 7 CELL LINE; MOUSE; NONHUMAN; NUDE MOUSE; PROTEIN EXPRESSION; TUMOR XENOGRAFT; WESTERN BLOTTING;

EID: 84901455217     PISSN: 10009604     EISSN: 19930631     Source Type: Journal    
DOI: 10.3978/j.issn.1000-9604.2014.04.07     Document Type: Article

References (18)

1. White NJ. Qinghaosu (artemisinin): the price of success. Science 2008;320:330-4. (Pubitemid 351555649)
2. Efferth T, Dunstan H, Sauerbrey A, et al. The anti-malarial artesunate is also active against cancer. Int J Oncol 2001;18:767-73.
3. Efferth T, Sauerbrey A, Olbrich A, et al. Molecular modes of action of artesunate in tumor cell lines. Mol Pharmacol 2003;64:382-94. (Pubitemid 36910002)
4. Lai H, Sasaki T, Singh NP, et al. Effects of artemisinin-tagged holotransferrin on cancer cells. Life Sci 2005;76:1267-79. (Pubitemid 40092141)
5. Singh NP, Lai HC. Artemisinin induces apoptosis in human cancer cells. Anticancer Res 2004;24:2277-80. (Pubitemid 39166306)
6. Lu JJ, Meng LH, Cai YJ, et al. Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species. Cancer Biol Ther 2008;7:1017-23.
7. Jiao Y, Ge CM, Meng QH, et al. Dihydroartemisinin is an inhibitor of ovarian cancer cell growth. Acta Pharmacol Sin 2007;28:1045-56. (Pubitemid 47020494)
8. Chen T, Li M, Zhang R, et al. Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy. J Cell Mol Med 2009;13:1358-70.
9. Li LN, Zhang HD, Yuan SJ, et al. Artesunate attenuates the growth of human colorectal carcinoma and inhibits hyperactive Wnt/beta-catenin pathway. Int J Cancer 2007;121:1360-5.
10. Dong HY, Song WH, Sun JP, et al. Effect of artemisinin on the growth of Hela. Journal of Harbin Medical University 2002;36:423-4.
11. Dong HY, Wang ZF, Song WH, et al. Apoptosis induced by artemisinin in K562 cells. Bulletin of China Cancer 2003:12:473-5.
12. Lai H, Singh NP. Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin. Cancer Lett 1995;91:41-6.
13. Efferth T, Olbrich A, Bauer R. mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether. Biochem Pharmacol 2002;64:617-23.
14. Li Y, Shan F, Wu JM, et al. Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle. Bioorg Med Chem Lett 2001;11:5-8. (Pubitemid 32006112)
15. Chen HH, Zhou HJ, Fang X. Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro. Pharmacol Res 2003;48:231-6. (Pubitemid 36818928)
16. Reed JC. Apoptosis-targeted therapies for cancer. Cancer Cell 2003;3:17-22. (Pubitemid 37443888)
17. Zhang X, Yang X, Pan Q. Artesunate's effect of anticancer and apoptosis induction in human liver tumor (BEL-7402). Chinese Traditional and Herbal Drugs 1998;29:467-9.
18. Efferth T, Benakis A, Romero MR, et al. Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. Free Radic Biol Med 2004;37:998-1009. (Pubitemid 39164582)