Morphometric stability of the corneal subbasal nerve plexus in healthy individuals: A 3-year longitudinal study using corneal confocal microscopy

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 5, 2014, Pages 3195-3199

  Dehghani, Cirous ^a   Pritchard, Nicola ^a   Edwards, Katie ^a   Vagenas, Dimitrios ^a   Russell, Anthony W ^b,c   Malik, Rayaz A ^d   Efron, Nathan ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Age; Corneal confocal microscopy; Natural history; Subbasal nerve plexus

Indexed keywords

HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; AGE; ARTICLE; BLOOD ANALYSIS; BLOOD PRESSURE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CONFOCAL MICROSCOPY; CORNEAL CONFOCAL MICROSCOPY; CORNEAL NERVE FIBER LENGTH; EYE EXAMINATION; FEMALE; HUMAN; IMAGE ANALYSIS; INTRAOCULAR PRESSURE; LONGITUDINAL STUDY; MALE; MIDDLE AGED; NERVE FIBER; NERVE PLEXUS; NORMAL HUMAN; PRIORITY JOURNAL; SUBBASAL NERVE PLEXUS; VISUAL ACUITY;

AGE; CORNEAL CONFOCAL MICROSCOPY; NATURAL HISTORY; SUBBASAL NERVE PLEXUS;

CORNEA; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; NERVE FIBERS; OPHTHALMIC NERVE; REFERENCE VALUES; ROC CURVE; TIME FACTORS;

EID: 84901452735     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-13959     Document Type: Article

References (35)

1. Lagali N, Peebo BB, Germundsson J, et al. Laser-scanning in vivo confocal microscopy of the cornea: Imaging and analysis methods for preclinical and clinical applications. In: Confocal Laser Microscopy - Principles and Applications in Medicine, Biology, and the Food Sciences. Rijeka, Croatia: InTech; 2013: 51-75.
2. Zhang XB, Chen Q, Chen W, et al. Tear dynamics and corneal confocal microscopy of subjects with mild self-reported office dry eye. Ophthalmology. 2011;118:902-907.
3. Labbé A, Alalwani H, Van Went C, et al. The relationship between subbasal nerve morphology and corneal sensation in ocular surface disease. Invest Ophthalmol Vis Sci. 2012;53: 4926-4931.
4. Benitez-del-Castillo JM, Acosta MC, Wassfi MA, et al. Relation between corneal innervation with confocal microscopy and corneal sensitivity with noncontact esthesiometry in patients with dry eye. Invest Ophthalmol Vis Sci. 2007;48:173-181.
5. Villani E, Mantelli F, Nucci P. In-vivo confocal microscopy of the ocular surface: ocular allergy and dry eye. Curr Opin Allergy Clin Immunol. 2013;13:569-576.
6. Efron N, Hollingsworth JG. New perspectives on keratoconus as revealed by corneal confocal microscopy. Clin Exp Optom. 2008;91:34-55.
7. Patel DV, Ku JYF, Johnson R, et al. Laser scanning in vivo confocal microscopy and quantitative aesthesiometry reveal decreased corneal innervation and sensation in keratoconus. Eye. 2009;23:586-592.
8. Hollingsworth JG, Efron N. Confocal microscopy of the corneas of long-term rigid contact lens wearers. Cont Lens Anterior Eye. 2004;27:57-64.
9. Efron N, Mutalib HA, Perez-Gomez I, et al. Confocal microscopic observations of the human cornea following overnight contact lens wear. Clin Exp Optom. 2002;85:149-155.
10. Darwish T, Brahma A, Efron N, et al. Subbasal nerve regeneration after penetrating keratoplasty. Cornea. 2007;26: 935-940.
11. Darwish T, Brahma A, O'Donnell C, et al. Subbasal nerve fiber regeneration after LASIK and LASEK assessed by noncontact esthesiometry and in vivo confocal microscopy: prospective study. J Cataract Refract Surg. 2007;33:1515-1521.
12. Erie JC, McLaren JW, Hodge DO, et al. Recovery of corneal subbasal nerve density after PRK and LASIK. Am J Ophthal-mol. 2005;140:1059-1064.
13. Tavakoli M, Quattrini C, Abbott C, et al. Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Diabetes Care. 2010;33:1792-1797.
14. Edwards K, Pritchard N, Vagenas D, et al. Utility of corneal confocal microscopy for assessing mild diabetic neuropathy: baseline findings of the LANDMark study. Clin Exp Optom. 2012;95:348-354.
15. Tavakoli M, Marshall A, Thompson L, et al. Corneal confocal microscopy: a novel noninvasive means to diagnose neuropathy in patients with Fabry disease. Muscle Nerve. 2009;40: 976-984.
16. Tavakoli M, Marshall A, Pitceathly R, et al. Corneal confocal microscopy: a novel means to detect nerve fibre damage in idiopathic small fibre neuropathy. Exp Neurol. 2010;223:245-250.
17. Ferrari G, Nalassamy N, Downs H, et al. Corneal innervation as a window to peripheral neuropathies. Exp Eye Res. 2013;113; 148-150.
18. Marfurt CF, Cox J, Deek S, et al. Anatomy of the human corneal innervation. Exp Eye Res. 2010;90:478-492.
19. Patel DV, Tavakoli M, Craig JP, et al. Corneal sensitivity and slit scanning in vivo confocal microscopy of the subbasal nerve plexus of the normal central and peripheral human cornea. Cornea. 2009;28:735-740.
20. Erie JC, McLaren JW, Hodge DO, et al. The effect of age on the corneal subbasal nerve plexus. Cornea. 2005;24:705-709.
21. He JC, Bazan NG, Bazan HEP. Mapping the entire human corneal nerve architecture. Exp Eye Res. 2010;91:513-523.
22. Niederer RL, Perumal D, Sherwin T, et al. Age-related differences in the normal human cornea: a laser scanning in vivo confocal microscopy study. Br J Ophthalmol. 2007;91: 1165-1169.
23. Parissi M, Karanis G, Randjelovic S, et al. Standardized baseline human corneal subbasal nerve density for clinical investigations with laser-scanning in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 2013;54:7091-7102.
24. Oliveira-Soto L, Efron N. Morphology of corneal nerves in soft contact lens wear. A comparative study using confocal microscopy. Ophthalmic Physiol Opt. 2003;23:163-174.
25. Patel SV, McLaren JW, Hodge DO, et al. Confocal microscopy in vivo in corneas of long-term contact lens wearers. Invest Ophthalmol Vis Sci. 2002;43:995-1003.
26. Wu T, Ahmed A, Bril V, et al. Variables associated with corneal confocal microscopy parameters in healthy volunteers: implications for diabetic neuropathy screening. Diabet Med. 2012;29:e297-e303.
27. Vagenas D, Pritchard N, Edwards K, et al. Optimal image sample size for corneal nerve morphometry. Optom Vis Sci. 2012;89:812-817.
28. Dabbah MA, Graham J, Petropoulos IN, et al. Automatic analysis of diabetic peripheral neuropathy using multi-scale quantitative morphology of nerve fibres in corneal confocal microscopy imaging. Med Image Anal. 2011;15:738-747.
29. Grupcheva CN, Wong T, Riley AF, et al. Assessing the sub-basal nerve plexus of the living healthy human cornea by in vivo confocal microscopy. Clin Experiment Ophthalmol. 2002;30: 187-190.
30. Zhivov A, Winter K, Hovakimyan M, et al. Imaging and quantification of subbasal nerve plexus in healthy volunteers and diabetic patients with or without retinopathy. PLoS One. 2013;8:e52157.
31. Niederer RL, Perumal D, Sherwin T, et al. Laser scanning in vivo confocal microscopy reveals reduced innervation and reduction in cell density in all layers of the keratoconic cornea. Invest Ophthalmol Vis Sci. 2008;49:2964-2970.
32. Castren E, Hen R. Neuronal plasticity and antidepressant actions. Trends Neurosci. 2013;36:259-267.
33. Baudry A, Mouillet-Richard S, Launay JM, et al. New views on antidepressant action. Curr Opin Neurobiol. 2011;21:858-865.
34. Edwards K, Pritchard N, Gosschalk K, et al. Wide-field assessment of the human corneal subbasal nerve plexus in diabetic neuropathy using a novel mapping technique. Cornea. 2012;31:1078-1082.
35. Patel DV, McGhee CNJ. Mapping of the normal human corneal sub-basal nerve plexus by in vivo laser scanning confocal microscopy. Invest Ophthalmol Vis Sci. 2005;46:4485-4488.