Variables associated with corneal confocal microscopy parameters in healthy volunteers: Implications for diabetic neuropathy screening

Diabetic Medicine

Volumn 29, Issue 9, 2012, Pages

  Wu, T ^a   Ahmed, A ^a   Bril, V ^a   Orszag, A ^a   Ng, E ^a   Nwe, P ^a   Perkins, B A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Corneal confocal microscopy; Corneal nerve fibre length; Healthy volunteers

Indexed keywords

HEMOGLOBIN A1C;

ADULT; AGE; ARTICLE; CONFOCAL MICROSCOPY; CONTACT LENS; CORNEA; CORNEAL CONFOCAL MICROSCOPY; DIABETIC NEUROPATHY; ELECTROPHYSIOLOGY; EYE EXAMINATION; FEMALE; HUMAN; HUMAN EXPERIMENT; LINEAR REGRESSION ANALYSIS; MALE; NERVE FIBER; NORMAL HUMAN; RISK FACTOR; SCREENING;

ADULT; BIOLOGICAL MARKERS; CORNEA; CROSS-SECTIONAL STUDIES; DIABETIC NEUROPATHIES; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; MASS SCREENING; MICROSCOPY, CONFOCAL; MIDDLE AGED; NERVE FIBERS; REGRESSION ANALYSIS;

EID: 84865134778     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2012.03678.x     Document Type: Article

References (30)

1. Vinik AI, Holland MT, Le Beau JM, Liuzzi FJ, Stansberry KB, Colen LB. Diabetic neuropathies. Diabetes Care 1992; 15: 1926-1975.
2. England JD, Gronseth GS, Franklin G, Carter GT, Kinsella LJ, Cohen JA et al. Practice Parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, and American Academy of Physical Medicine and Rehabilitation. Neurology 2009; 72: 177-184.
3. Malik RA, Kallinikos P, Abbott CA, van Schie CH, Morgan P, Efron N et al. Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients. Diabetologia 2003; 46(5): 683-688.
4. Hossain P, Sachdev A, Malik RA. Early detection of diabetic peripheral neuropathy with corneal confocal microscopy. Lancet 2005; 366: 1340-1343.
5. Tavakoli M, Quattrini C, Abbott C, Kallinikos P, Marshall A, Finnigan J et al. Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Diabetes Care 2010; 33: 1792-1797.
6. Quattrini C, Tavakoli M, Jeziorska M, Kallinikos P, Tesfaye S, Finnigan J et al. Surrogate markers of small fiber damage in human diabetic neuropathy. Diabetes 2007; 56: 2148-2154.
7. Efron N, Edwards K, Roper N, Pritchard N, Sampson GP, Shahidi AM et al. Repeatability of measuring corneal subbasal nerve fiber length in individuals with type 2 diabetes. Eye Contact Lens 2010; 36: 245-248.
8. Hertz P, Bril V, Orszag A, Ahmed A, Ng E, Nwe P et al. Reproducibility of in vivo corneal confocal microscopy as a novel screening test for early diabetic sensorimotor polyneuropathy. Diabet Med 2011; 28: 1253-1260.
9. Erie JC, McLaren JW, Hodge DO, Bourne WM. The effect of age on the corneal subbasal nerve plexus. Cornea 2005; 24: 705-709.
10. Patel DV, Tavakoli M, Craig JP, Efron N, McGhee CN. Corneal sensitivity and slit scanning in vivo confocal microscopy of the subbasal nerve plexus of the normal central and peripheral human cornea. Cornea 2009; 28: 735-740.
11. Niederer RL, Perumal D, Sherwin T, McGhee CN. Age-related differences in the normal human cornea: a laser scanning in vivo confocal microscopy study. Br J Ophthalmol 2007; 91: 1165-1169.
12. Darwish T, Brahma A, O'Donnell C, Efron N. Subbasal nerve fiber regeneration after LASIK and LASEK assessed by noncontact esthesiometry and in vivo confocal microscopy: prospective study. J Cataract Refract Surg 2007; 33: 1515-1521.
13. Erie JC, McLaren JW, Hodge DO, Bourne WM. Recovery of corneal subbasal nerve density after PRK and LASIK. Am J Ophthalmol 2005; 140: 1059-1064.
14. Oliveira-Soto L, Efron N. Morphology of corneal nerves in soft contact lens wear. A comparative study using confocal microscopy. Ophthalmic Physiol Opt 2003; 23: 163-174.
15. Efron N, Mutalib HA, Perez-Gomez I, Koh HH. Confocal microscopic observations of the human cornea following overnight contact lens wear. Clin Exp Optom 2002; 85: 149-155.
16. Efron N, Perez-Gomez I, Morgan PB. Confocal microscopic observations of stromal keratocytes during extended contact lens wear. Clin Exp Optom 2002; 85: 156-160.
17. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2011; 34(Suppl 1): S62-S69.
18. Bril V., Perkins B.A. Validation of the Toronto Clinical Scoring System for diabetic polyneuropathy. Diabetes Care 2002; 25: 2048-2052.
19. Tavakoli M, Malik RA. Corneal confocal microscopy: a novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies. J Vis Exp 2011 (47). pii: 2194
20. Kallinikos P, Berhanu M, O'Donnell C, Boulton AJ, Efron N, Malik RA. Corneal nerve tortuosity in diabetic patients with neuropathy. Invest Ophthalmol Vis Sci 2004; 45: 418-422.
21. England JD, Gronseth GS, Franklin G, Miller RG, Asbury AK, Carter GT et al. Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology 2005; 64: 199-207.
22. Oh SJ. 'Normal values for common nerve conduction tests'. Clinical Electromyography: Nerve Conduction Studies, 3rd edn. Baltimore: Lippincott Williams & Wilkins, 2002.
23. Grupcheva CN, Wong T, Riley AF, McGhee CN. Assessing the sub-basal nerve plexus of the living healthy human cornea by in vivo confocal microscopy. Clin Experiment Ophthalmol 2002; 30: 187-190.
24. Tesfaye S., Chaturvedi N, Eaton SE, Ward JD, Manes C, Ionescu-Tirgoviste C et al. Vascular risk factors and diabetic neuropathy. N Engl J Med 2005; 352: 341-350.
25. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977-986.
26. Papanas N, Vinik AI, Ziegler D. Neuropathy in prediabetes: does the clock start ticking early? Nat Rev Endocrinol 2011; 7(11): 682-690.
27. Sumner CJ, Sheth S, Griffin JW, Cornblath DR, Polydefkis M. The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology 2003; 60: 108-111.
28. Singleton JR, Smith AG, Russell JW, Feldman EL. Microvascular complications of impaired glucose tolerance. Diabetes 2003; 52: 2867-2873.
29. Messmer EM, Schmid-Tannwald C, Zapp D, Kampik A. In vivo confocal microscopy of corneal small fiber damage in diabetes mellitus. Graefes Arch Clin Exp Ophthalmol 2010; 248: 1307-1312.
30. Tavakoli M, Kallinikos P, Iqbal A, Herbert A, Fadavi H, Efron N et al. Corneal confocal microscopy detects improvement in corneal nerve morphology with an improvement in risk factors for diabetic neuropathy. Diabet Med 2011; 28: 1261-1267.