A plasma concentration of α-ketoglutarate influences the kinetic interaction of ligands with organic anion transporter 1

Molecular Pharmacology

Volumn 86, Issue 1, 2014, Pages 86-95

  Ingraham, Leslie ^a   Li, Mansong ^a   Renfro, J Larry ^b   Parker, Sonda ^b   Vapurcuyan, Arpine ^c   Hanna, Imad ^c   Pelis, Ryan M ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; 4 AMINOHIPPURIC ACID; BUMETANIDE; CEFALOTIN; CEFTRIAXONE; CIDOFOVIR; FUROSEMIDE; IBUPROFEN; INDOMETACIN; LIGAND; NAPROXEN; ORGANIC ANION TRANSPORTER 1; PLASMA PROTEIN; PROBENECID; TELMISARTAN; VALSARTAN; ALPHA-KETOGLUTARIC ACID; CYTOSINE; ORGANIC ANION TRANSPORTER; PHOSPHONIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; CHO CELL LINE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG INHIBITION; DRUG POTENCY; DRUG UPTAKE; EQUILIBRIUM DIALYSIS; FEMALE; HUMAN; IC 50; KIDNEY PROXIMAL TUBULE; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; ADULT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CELL LINE; CRICETULUS; KINETICS; METABOLISM; MIDDLE AGED; PHYSIOLOGY; SWINE; TRANSPORT AT THE CELLULAR LEVEL;

ADULT; ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CHO CELLS; CRICETULUS; CYTOSINE; HUMANS; KETOGLUTARIC ACIDS; KINETICS; LIGANDS; MIDDLE AGED; ORGANIC ANION TRANSPORTERS; ORGANOPHOSPHONATES; P-AMINOHIPPURIC ACID; SWINE;

EID: 84901434770     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.114.091777     Document Type: Article

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