Variations in potassium channel genes are associated with breast pain in women prior to breast cancer surgery

Journal of Neurogenetics

Volumn 28, Issue 1-2, 2014, Pages 122-135

  Langford, Dale J ^a   West, Claudia ^a   Elboim, Charles ^c   Cooper, Bruce A ^a   Abrams, Gary ^b   Paul, Steven M ^a   Schmidt, Brian L ^d   Levine, Jon D ^b   Merriman, John D ^a   Dhruva, Anand ^b   Neuhaus, John ^b   Leutwyler, Heather ^a   Baggott, Christina ^a   Sullivan, Carmen Ward ^a   Aouizerat, Bradley E ^a   Miaskowski, Christine ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Redwood Regional Medical Group   (United States)

^d NEW YORK UNIVERSITY   (United States)

Author keywords

Breast cancer; Breast pain; Candidate genes; Potassium channel genes; Preoperative pain

Indexed keywords

POTASSIUM CHANNEL;

ADULT; ARTICLE; BREAST CANCER; BREAST SURGERY; CANCER SURGERY; FEMALE; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MASTALGIA; PRIORITY JOURNAL; SENSORY NERVE CELL; SINGLE NUCLEOTIDE POLYMORPHISM; YOUNG ADULT; AGED; BREAST TUMOR; COMPLICATION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MIDDLE AGED; PAIN; REGRESSION ANALYSIS;

ADULT; AGED; BREAST NEOPLASMS; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MIDDLE AGED; PAIN; POLYMORPHISM, SINGLE NUCLEOTIDE; POTASSIUM CHANNELS; REGRESSION ANALYSIS; YOUNG ADULT;

EID: 84901418920     PISSN: 01677063     EISSN: 15635260     Source Type: Journal    
DOI: 10.3109/01677063.2013.856430     Document Type: Article

References (55)

1. Alloui, A., Zimmermann, K., Mamet, J., Duprat, F., Noel, J., Chemin, J., et al. (2006). TREK-1, a K-channel involved in polymodal pain perception. EMBO J, 25, 2368-2376. (Pubitemid 44012220)
2. Blednov, Y. A., Stoffel, M., Alva, H., & Harris, R. A. (2003). A pervasive mechanism for analgesia: Activation of GIRK2 channels. Proc Natl Acad Sci U S A, 100, 277-282. (Pubitemid 36078065)
3. Brunner, F., Bachmann, L. M., Weber, U., Kessels, A. G., Perez, R. S., Marinus, J., et al. (2008). Complex regional pain syndrome 1 - The Swiss cohort study. BMC Musculoskelet Disord, 9, 92.
4. Conde, L., Vaquerizas, J. M., Dopazo, H., Arbiza, L., Reumers, J., Rousseau, F., et al. (2006). PupaSuite: Finding functional single nucleotide polymorphisms for large-scale genotyping purposes. Nucleic Acids Res, 34, W621-W625. (Pubitemid 44529845)
5. Corry, D. C. (1952). Pain in carcinoma of the breast. Lancet, 1, 274-276.
6. Costigan, M., Belfer, I., Griffi n, R. S., Dai, F., Barrett, L. B., Coppola, G., et al. (2010). Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain, 133, 2519-2527.
7. Dodson, P. D., & Forsythe, I. D. (2004). Presynaptic K-channels: Electrifying regulators of synaptic terminal excitability. Trends Neurosci, 27, 210-217. (Pubitemid 38376408)
8. Dunn, L. B., Aouizerat, B. E., Cooper, B. A., Dodd, M., Lee, K., West, C., et al. (2012). Trajectories of anxiety in oncology patients and family caregivers during and after radiation therapy. Eur J Oncol Nurs, 16, 1-9.
9. Dunn, L. B., Aouizerat, B. E., Langford, D. J., Cooper, B. A., Dhruva, A., Cataldo, J. K., et al. (2013). Cytokine gene variation is associated with depressive symptom trajectories in oncology patients and family caregivers. Eur J Oncol Nurs, 17, 346-353.
10. Feske, S., Skolnik, E. Y., & Prakriya, M. (2012). Ion channels and transporters in lymphocyte function and immunity. Nat Rev Immunol, 12, 532-547.
11. Fields, H. L., Heinricher, M. M., & Mason, P. (1991). Neurotransmitters in nociceptive modulatory circuits. Annu Rev Neurosci, 14, 219-245.
12. Fillingim, R. B. (2005). Individual differences in pain responses. Curr Rheumatol Rep, 7, 342-347.
13. Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., et al. (2002). The structure of haplotype blocks in the human genome. Science, 296, 2225-2229. (Pubitemid 34680308)
14. Gibson, S. J., & Helme, R. D. (2001). Age-related differences in pain perception and report. Clin Geriatr Med, 17, 433-456. (Pubitemid 32783029)
15. Halder, I., Shriver, M., Thomas, M., Fernandez, J. R., & Frudakis, T. (2008). A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four continents: Utility and applications. Hum Mutat, 29, 648-658. (Pubitemid 351614589)
16. Hattersley, A. T., & McCarthy, M. I. (2005). What makes a good genetic association study? Lancet, 366, 1315-1323. (Pubitemid 41416588)
17. Hoggart, C. J., Parra, E. J., Shriver, M. D., Bonilla, C., Kittles, R. A., Clayton, D. G., et al. (2003). Control of confounding of genetic associations in stratifi ed populations. Am J Hum Genet, 72, 1492-1504. (Pubitemid 36628388)
18. Illi, J., Miaskowski, C., Cooper, B., Levine, J. D., Dunn, L., West, C., et al. (2012). Association between pro-and anti-infl ammatory cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression. Cytokine, 58, 437-447.
19. Ioannidis, J. P., Ntzani, E. E., Trikalinos, T. A., & Contopoulos-Ioannidis, D. G. (2001). Replication validity of genetic association studies. Nat Genet, 29, 306-309. (Pubitemid 33096456)
20. Jensen, M. P., Gammaitoni, A. R., Olaleye, D. O., Oleka, N., Nalamachu, S. R., & Galer, B. S. (2006). The pain quality assessment scale: Assessment of pain quality in carpal tunnel syndrome. J Pain, 7, 823-832. (Pubitemid 44740532)
21. Jo, H. Y., Kim, S. Y., Lee, S., Jeong, S., Kim, S. J., Kang, T. M., et al. (2011). Kir3. 1 channel is functionally involved in TLR4-mediated signaling. Biochem Biophys Res Commun, 407, 687-691.
22. Karnofsky, D. (1977). Performance Scale. New York: Plenum Press.
23. Karnofsky, D., Abelmann, W. H., Craver, L. V., & Burchenal, J. H. (1948). The use of nitrogen mustards in the palliative treatment of carcinoma. Cancer, 1, 634-656.
24. Kyranou, M., Paul, S. M., Dunn, L. B., Puntillo, K., Aouizerat, B. E., Abrams, G., et al. (2013). Differences in depression, anxiety, and quality of life between women with and without breast pain prior to breast cancer surgery. Eur J Oncol Nurs, 17, 190-195.
25. Lacroix-Fralish, M. L., Ledoux, J. B., & Mogil, J. S. (2007). The Pain Genes Database: An interactive web browser of painrelated transgenic knockout studies. Pain, 131, 3. e1-3. e4.
26. Lane-Claypon, J. E. (1926). A further report on cancer of the breast with special reference to its associated antecedent conditions. Reports on Public Health and Medical Subjects. London: Ministry of Health.
27. Lesage, F. (2003). Pharmacology of neuronal background potassium channels. Neuropharmacology, 44, 1-7. (Pubitemid 36135836)
28. Linden, W., Vodermaier, A., Mackenzie, R., & Greig, D. (2012). Anxiety and depression after cancer diagnosis: Prevalence rates by cancer type, gender, and age. J Affect Disord, 141, 343-351.
29. Luscher, C., & Slesinger, P. A. (2010). Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nat Rev Neurosci, 11, 301-315.
30. Marker, C. L., Stoffel, M., & Wickman, K. (2004). Spinal G-protein-gated K-channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia. J Neurosci, 24, 2806-2812. (Pubitemid 38380958)
31. Marsh, B., Acosta, C., Djouhri, L., & Lawson, S. N. (2012). Leak K(-) channel mRNAs in dorsal root ganglia: Relation to infl ammation and spontaneous pain behaviour. Mol Cell Neurosci, 49, 375-386.
32. McCann, B., Miaskowski, C., Koetters, T., Baggott, C., West, C., Levine, J. D., et al. (2012). Associations between pro-and anti-infl ammatory cytokine genes and breast pain in women prior to breast cancer surgery. J Pain, 13, 425-437.
33. Miaskowski, C., Cooper, B. A., Dhruva, A., Dunn, L. B., Langford, D. J., Cataldo, J. K., et al. (2012a). Evidence of associations between cytokine genes and subjective reports of sleep disturbance in oncology patients and their family caregivers. PLoS ONE, 7, e40560.
34. Miaskowski, C., Cooper, B., Paul, S. M., West, C., Langford, D., Levine, J. D., et al. (2012b). Identifi cation of patient subgroups and risk factors for persistent breast pain following breast cancer surgery. J Pain, 13, 1172-1187.
35. Miaskowski, C., Dodd, M., Paul, S. M., West, C., Hamolsky, D., Abrams, G., et al. (2013). Lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery. PLoS ONE, 8, e60164.
36. Miller, C. (2000). An overview of the potassium channel family. Genome Biol, 1, 1-5.
37. Nishizawa, D., Nagashima, M., Katoh, R., Satoh, Y., Tagami, M., Kasai, S., et al. (2009). Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery. PLoS ONE, 4, e7060.
38. Poleshuck, E. L., Katz, J., Andrus, C. H., Hogan, L. A., Jung, B. F., Kulick, D. I., et al. (2006). Risk factors for chronic pain following breast cancer surgery: A prospective study. J Pain, 7, 626-634. (Pubitemid 44291598)
39. Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006). Principal components analysis corrects for stratifi cation in genome-wide association studies. Nat Genet, 38, 904-909. (Pubitemid 44141658)
40. Rau, K. K., Cooper, B. Y., & Johnson, R. D. (2006). Expression of TWIK-related acid sensitive K-channels in capsaicin sensitive and insensitive cells of rat dorsal root ganglia. Neuroscience, 141, 955-963. (Pubitemid 44066666)
41. Richardson, F. C., & Kaczmarek, L. K. (2000). Modifi cation of delayed rectifi er potassium currents by the Kv9. 1 potassium channel subunit. Hear Res, 147, 21-30. (Pubitemid 30658051)
42. Rothman, K. J. (1990). No adjustments are needed for multiple comparisons. Epidemiology, 1, 43-46. (Pubitemid 20255621)
43. Sangha, O., Stucki, G., Liang, M. H., Fossel, A. H., & Katz, J. N. (2003). The Self-Administered Comorbidity Questionnaire: A new method to assess comorbidity for clinical and health services research. Arthritis Rheum, 49, 156-163. (Pubitemid 36418272)
44. SPSS. (2010). IBM SPSS for Windows (version 19). Chicago, IL: SPSS, Inc.
45. StataCorp. (2005). Stata Statistical Software (release 9). College Station, TX: Stata Corporation.
46. Stephens, M., Smith, N. J., & Donnelly, P. (2001). A new statistical method for haplotype reconstruction from population data. Am J Hum Genet, 68, 978-989. (Pubitemid 32289743)
47. Takeda, M., Tsuboi, Y., Kitagawa, J., Nakagawa, K., Iwata, K., & Matsumoto, S. (2011). Potassium channels as a potential therapeutic target for trigeminal neuropathic and infl ammatory pain. Mol Pain, 7, 5.
48. Talley, E. M., Lei, Q., Sirois, J. E., & Bayliss, D. A. (2000). TASK-1, a two-pore domain K-channel, is modulated by multiple neurotransmitters in motoneurons. Neuron, 25, 399-410.
49. Talley, E. M., Sirois, J. E., Lei, Q., & Bayliss, D. A. (2003). Two-pore-Domain (KCNK) potassium channels: Dynamic roles in neuronal function. Neuroscientist, 9, 46-56. (Pubitemid 36139578)
50. Tasmuth, T., von Smitten, K., & Kalso, E. (1996). Pain and other symptoms during the fi rst year after radical and conservative surgery for breast cancer. Br J Cancer, 74, 2024-2031. (Pubitemid 27007153)
51. Tian, C., Gregersen, P. K., & Seldin, M. F. (2008). Accounting for ancestry: Population substructure and genome-wide association studies. Hum Mol Genet, 17, R143-R150.
52. Tsantoulas, C., Zhu, L., Shaifta, Y., Grist, J., Ward, J. P., Raouf, R., et al. (2012). Sensory neuron downregulation of the Kv9. 1 potassium channel subunit mediates neuropathic pain following nerve injury. J Neurosci, 32, 17502-17513.
53. Ulens, C., Daenens, P., & Tytgat, J. (1999). The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands. Eur J Pharmacol, 385, 239-245.
54. Wickenden, A. (2002). K(-) channels as therapeutic drug targets. Pharmacol Ther, 94, 157-182.
55. Xie, W. (2007). Ion channels in pain transmission. Int Anesthesiol Clin, 45, 107-120. (Pubitemid 46624190)