Nanosilver particles in medical applications: Synthesis, performance, and toxicity

International Journal of Nanomedicine

Volumn 9, Issue 1, 2014, Pages 2399-2407

  Ge, Liangpeng ^a,b,c,d,e   Li, Qingtao ^b,c,f   Wang, Meng ^b,c   Ouyang, Jun ^f   Li, Xiaojian ^g   Xing, Malcolm M Q ^b,c  

^a Chongqing Academy of Animal Science   (China)

^b UNIVERSITY OF MANITOBA   (Canada)

^c MANITOBA INSTITUTE OF CHILD HEALTH   (Canada)

^d AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

^e Chongqing Key Laboratory of Pig Industry Sciences   (China)

^f SOUTHERN MEDICAL UNIVERSITY   (China)

^g FIRST MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Biomedical application; Nanosilver particles; Synthesis; Toxicity

Indexed keywords

AMOXICILLIN; BONE CEMENT; SILVER NANOPARTICLE; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; METAL NANOPARTICLE; SILVER;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIVIRAL ACTIVITY; BACTERIAL CLEARANCE; BIOSENSOR; BIOSYNTHESIS; CARDIAC IMPLANT; CATHETER; CENTRAL VENOUS CATHETER; HIGH TEMPERATURE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MATERIAL COATING; MATERIAL STATE; NEUROSURGICAL CATHETER; NONHUMAN; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; REVIEW; SURFACE PROPERTY; SYNTHESIS; TOOTH IMPLANT; TOXICITY TESTING; WOUND DRESSING; ANIMAL; CHEMISTRY; TOXICITY;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; HUMANS; METAL NANOPARTICLES; SILVER;

EID: 84901391283     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S55015     Document Type: Review

References (88)

1. Chen J, Ouyang J, Kong J, Zhong W, Xing MM. Photo-cross-linked and pH-sensitive biodegradable micelles for doxorubicin delivery. ACS Appl Mater Interfaces. 2013;5(8):3108-3117.
2. Mohamed A, Xing MM. Nanomaterials and nanotechnology for skin tissue engineering. Int J Burns Trauma. 2012;2(1):29-41.
3. Tian Y, Chen J, Zahtabi F, Keijzer R, Xing M. Nanomedicine as an innovative therapeutic strategy for pediatric lung diseases. Pediatric Pulmonol. 2013;48(11):1098-1111.
4. Xing M, Zhong W, Xu X, Thomson D. Adhesion force studies of nanofibers and nanoparticles. Langmuir. 2010;26(14):11809-11814.
5. El-Badawy A, Feldhake D, Venkatapathy R. State of the Science Literature Review: Everything Nanosilver and More. Washington, DC: US Environmental Protection Agency; 2010.
6. Zhong W, Xing MM, Maibach HI. Nanofibrous materials for wound care. Cutan Ocul Toxicol. 2010;29(3):143-152.
7. Uchihara T. Silver diagnosis in neuropathology: principles, practice and revised interpretation. Acta Neuropathol. 2007;113(5):483-499.
8. Sibbald RG, Contreras-Ruiz J, Coutts P, Fierheller M, Rothman A, Woo K. Bacteriology, inflammation, and healing: a study of nanocrystalline silver dressings in chronic venous leg ulcers. Adv Skin Wound Care. 2007;20(10):549-558.
9. Skirtach AG, Muñoz Javier A, Kreft O, et al. Laser-induced release of encapsulated materials inside living cells. Angew Chem Int Ed Engl. 2006;45(28):4612-4617.
10. Galiano K, Pleifer C, Engelhardt K, et al. Silver segregation and bacterial growth of intraventricular catheters impregnated with silver nanoparticles in cerebrospinal fluid drainages. Neurol Res. 2008;30(3):285-287.
11. Moore K. A new silver dressing for wounds with delayed healing. Wounds UK. 2006;2(2):70-78.
12. Vigneshwaran N, Kathe AA, Varadarajan PV, Nachane RP, Balasubramanya RH. Functional finishing of cotton fabrics using silver nanoparticles. J Nanosci Nanotechnol. 2007;7(6):1893-1897.
13. Chen X, Schluesener HJ. Nanosilver: a nanoproduct in medical application. Toxicol Lett. 2008;176(1):1-12.
14. Jung JH, Oh HC, Noh HS, Ji JH, Kim SS. Metal nanoparticle generation using a small ceramic heater with a local heating area. J Aerosol Sci. 2006;37(12):1662-1670.
15. Tsuji T, Iryo K, Watanabe N, Tsuji M. Preparation of silver nanoparticles by laser ablation in solution: influence of laser wavelength on particle size. Appl Surf Sci. 2002;202(1-2):80-85.
16. Abid JP, Wark AW, Brevet PF, Girault HH. Preparation of silver nanoparticles in solution from a silver salt by laser irradiation. Chem Commun (Camb). 2002;(7):792-793.
17. Tien DC, Liao CY, Huang JC, et al. Novel technique for preparing a nano-silver water suspension by the arc-discharge method. Reviews on Advanced Materials Science. 2008;18:750-756.
18. Evanoff DD Jr, Chumanov G. Synthesis and optical properties of silver nanoparticles and arrays. Chemphyschem. 2005;6(7):1221-1231.
19. Pyatenko A, Yamaguchi M, Suzuki M. Synthesis of spherical silver nanoparticles with controllable sizes in aqueous solutions. J Phys Chem C. 2007;111(22):7910-7917.
20. Blanco-Andujar C, Tung LD, Thanh NTK. Synthesis of nanoparticles for biomedical applications. Annual Reports Section "A" (Inorganic Chemistry). 2010;106:553-568.
21. Naik RR, Stringer SJ, Agarwal G, Jones SE, Stone MO. Biomimetic synthesis and patterning of silver nanoparticles. Nat Mater. 2002;1(3): 169-172.
22. Nam KT, Lee YJ, Krauland EM, Kottmann ST, Belcher AM. Peptide-mediated reduction of silver ions on engineered biological scaffolds. ACS Nano. 2008;2(7):1480-1486.
23. Anisha BS, Biswas R, Chennazhi KP, Jayakumar R. Chitosan-hyaluronic acid/nano silver composite sponges for drug resistant bacteria infected diabetic wounds. Int J Biol Macromol. 2013;62:310-320.
24. Sintubin L, De Windt W, Dick J, et al. Lactic acid bacteria as reducing and capping agent for the fast and efficient production of silver nanoparticles. Appl Microbiol Biotechnol. 2009;84(4): 741-749.
25. Balaji DS, Basavaraja S, Deshpande R, Mahesh DB, Prabhakar BK, Venkataraman A. Extracellular biosynthesis of functionalized silver nanoparticles by strains of Cladosporium cladosporioides fungus. Colloids Surf B Biointerfaces. 2009;68(1):88-92.
26. Sintubin L, Verstraete W, Boon N. Biologically produced nanosilver: current state and future perspectives. Biotechnol Bioeng. 2012;109(10): 2422-2436.
27. Shankar SS, Ahmad A, Sastry M. Geranium leaf assisted biosynthesis of silver nanoparticles. Biotechnol Prog. 2003;19(6):1627-1631.
28. Thomas V, Yallapu MM, Sreedhar B, Bajpai SK. Fabrication, characterization of chitosan/nanosilver film and its potential antibacterial application. J Biomater Sci Polym Ed. 2009;20(14):2129-2144.
29. Anil Kumar S, Abyaneh MK, Gosavi SW, et al. Nitrate reductase-mediated synthesis of silver nanoparticles from AgNO3. Biotechnol Lett. 2007;29(3):439-445.
30. Saifuddin N, Wong CW, Yasumira AAN. Rapid biosynthesis of silver nanoparticles using culture supernatant of bacteria with microwave irradiation. E-Journal of Chemistry. 2009;6(1):61-70.
31. Mukherjee P, Ahmad A, Mandal D, et al. Fungus-mediated synthesis of silver nanoparticles and their immobilization in the mycelial matrix: a novel biological approach to nanoparticle synthesis. Nano Lett. 2001;1(10):515-519.
32. Kim JS, Kuk E, Yu KN, et al. Antimicrobial effects of silver nanoparticles. Nanomedicine. 2007;3(1):95-101.
33. Sadeghi B, Garmaroudi FS, Hashemi M, et al. Comparison of the anti-bacterial activity on the nanosilver shapes: nanoparticles, nanorods and nanoplates. Adv Powder Technol. 2012;23(1):22-26.
34. Li P, Li J, Wu C, Wu Q, Li J. Synergistic antibacterial effects of β-lactam antibiotic combined with silver nanoparticles. Nanotechnology. 2005;16(9):1912-1917.
35. Sondi I, Salopek-Sondi B. Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. J Colloid Interface Sci. 2004;275(1):177-182.
36. Matsumura Y, Yoshikata K, Kunisaki S, Tsuchido T. Mode of bactericidal action of silver zeolite and its comparison with that of silver nitrate. Appl Environ Microbiol. 2003;69(7):4278-4281.
37. Shrivastava S, Bera T, Roy A, Singh G, Ramachandrarao P, Dash D. Characterization of enhanced antibacterial effects of novel silver nanoparticles. Nanotechnology. 2007;18(22):225103.
38. Kim KJ, Sung WS, Moon SK, Choi JS, Kim JG, Lee DG. Antifungal effect of silver nanoparticles on dermatophytes. J Microbiol Biotechnol. 2008;18(8):1482-1484.
39. Nasrollahi A, Pourshamsian Kh, Mansourkiaee P. Antifungal activity of silver nanoparticles on some of fungi. International Journal of Nano Dimension. 2011;1(3):233-239.
40. Kim KJ, Sung WS, Suh BK, et al. Antifungal activity and mode of action of silver nano-particles on Candida albicans. Biometals. 2009;22(2):235-242.
41. Sun RW, Chen R, Chung NP, Ho CM, Lin CL, Che CM. Silver nanoparticles fabricated in Hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells. Chem Commun (Camb). 2005;(40): 5059-5061.
42. Lu L, Sun RW, Chen R, et al. Silver nanoparticles inhibit hepatitis B virus replication. Antivir Ther. 2008;13(2):253-262.
43. Taylor PL, Omotoso O, Wiskel JB, Mitlin D, Burrell RE. Impact of heat on nanocrystalline silver dressings. Part II: physical properties. Biomaterials. 2005;26(35):7230-7240.
44. Baram-Pinto D, Shukla S, Perkas N, Gedanken A, Sarid R. Inhibition of herpes simplex virus type 1 infection by silver nanoparticles capped with mercaptoethane sulfonate. Bioconjug Chem. 2009;20(8):1497-1502.
45. Rogers JV, Parkinson CV, Choi YW, Speshock JL, Hussain SM. A preliminary assessment of silver nanoparticle inhibition of monkeypox virus plaque formation. Nanoscale Res Lett. 2008;3(4):129-133.
46. Taylor PL, Ussher AL, Burrell RE. Impact of heat on nanocrystalline silver dressings. Part I: chemical and biological properties. Biomaterials. 2005;26(35):7221-7229.
47. Lara HH, Ayala-Nuñez NV, Ixtepan-Turrent L, Rodriguez-Padilla C. Mode of antiviral action of silver nanoparticles against HIV-1. J Nanobiotechnology. 2010;8:1.
48. Nadworny PL, Wang J, Tredget EE, Burrell RE. Anti-inflammatory activity of nanocrystalline silver in a porcine contact dermatitis model. Nanomedicine. 2008;4(3):241-251.
49. Shin SH, Ye MK. The effect of nano-silver on allergic rhinitis model in mice. Clin Exp Otorhinolaryngol. 2012;5(4):222-227.
50. Castillo PM, Herrera JL, Fernandez-Montesinos R, et al. Tiopronin monolayer-protected silver nanoparticles modulate IL-6 secretion mediated by Toll-like receptor ligands. Nanomedicine (Lond). 2008;3(5): 627-635.
51. Chaloupka K, Malam Y, Seifalian AM. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends Biotechnol. 2010;28(11):580-588.
52. Huang Y, Li X, Liao Z, et al. A randomized comparative trial between Acticoat and SD-Ag in the treatment of residual burn wounds, including safety analysis. Burns. 2007;33(2):161-166.
53. Chen J, Han CM, Lin XW, Tang ZJ, Su SJ. [Effect of silver nanoparticle dressing on second degree burn wound]. Zhonghua Wai Ke Za Zhi. 2006;44(1):50-52. Chinese.
54. Lu S, Gao W, Gu HY. Construction, application and biosafety of silver nanocrystalline chitosan wound dressing. Burns. 2008;34(5): 623-628.
55. Grunkemeier GL, Jin RY, Starr A. Prosthetic heart valves: Objective Performance Criteria versus randomized clinical trial. Ann Thorac Surg. 2006;82(3):776-780.
56. Jamieson WR, Fradet GJ, Abel JG, et al. Seven-year results with the St Jude Medical Silzone mechanical prosthesis. J Thorac Cardiovasc Surg. 2009;137(5):1109-1115. e2.
57. Andara M, Agarwal A, Scholvin D, et al. Hemocompatibility of diamondlike carbon-metal composite thin films. Diam Relat Mater. 2006;15(11-12):1941-1948.
58. Ghanbari H, Viatge H, Kidane AG, Burriesci G, Tavakoli M, Seifalian AM. Polymeric heart valves: new materials, emerging hopes. Trends Biotechnol. 2009;27(6):359-367.
59. Fu J, Ji J, Fan D, Shen J. Construction of antibacterial multilayer films containing nanosilver via layer-by-layer assembly of heparin and chitosan-silver ions complex. J Biomed Mater Res A. 2006;79(3): 665-674.
60. Lackner P, Beer R, Broessner G, et al. Efficacy of silver nanoparticles-impregnated external ventricular drain catheters in patients with acute occlusive hydrocephalus. Neurocrit Care. 2008;8(3):360-365.
61. Alt V, Bechert T, Steinrücke P, et al. An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement. Biomaterials. 2004;25(18):4383-4391.
62. Morley KS, Webb PB, Tokareva NV, et al. Synthesis and characterisation of advanced UHMWPE/silver nanocomposites for biomedical applications. Eur Polym J. 2007;43(2):307-314.
63. Yoshida K, Tanagawa M, Matsumoto S, Yamada T, Atsuta M. Antibacterial activity of resin composites with silver-containing materials. Eur J Oral Sci. 1999;107(4):290-296.
64. Yamamoto K, Ohashi S, Aono M, Kokubo T, Yamada I, Yamauchi J. Antibacterial activity of silver ions implanted in SiO2 filler on oral streptococci. Dent Mater. 1996;12(4):227-229.
65. Magalhães APR, Santos LB, Lopes LG, et al. Nanosilver application in dental cements. ISRN Nanotechnology. 2012;2012:1-6.
66. Ahn SJ, Lee SJ, Kook JK, Lim BS. Experimental antimicrobial orthodontic adhesives using nanofillers and silver nanoparticles. Dent Mater. 2009;25(2):206-213.
67. Haes AJ, Van Duyne RP. A nanoscale optical blosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles. J Am Chem Soc. 2002;124(35):10596-10604.
68. Zhou W, Ma Y, Yang H, Ding Y, Luo X. A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma. Int J Nanomedicine. 2011;6:381-386.
69. Loo C, Lowery A, Halas N, West J, Drezek R. Immunotargeted nanoshells for integrated cancer imaging and therapy. Nano Lett. 2005;5(4):709-711.
70. Haes AJ, Hall WP, Chang L, Klein WL, Van Duyne RP. A localized surface plasmon resonance biosensor: first steps toward an assay for Alzheimer's disease. Nano Lett. 2004;4(6):1029-1034.
71. Liu J, Zhao Y, Guo Q, et al. TAT-modified nanosilver for combating multidrug-resistant cancer. Biomaterials. 2012;33(26):6155-6161.
72. Skirtach AG, Antipov AA, Shchukin DG, Sukhorukov GB. Remote activation of capsules containing Ag nanoparticles and IR dye by laser light. Langmuir. 2004;20(17):6988-6992.
73. Etheridge ML, Campbell SA, Erdman AG, Haynes CL, Wolf SM, McCullough J. The big picture on nanomedicine: the state of investigational and approved nanomedicine products. Nanomedicine. 2013;9(1):1-14.
74. Shin SH, Ye MK, Kim HS, Kang HS. The effects of nano-silver on the proliferation and cytokine expression by peripheral blood mononuclear cells. Int Immunopharmacol. 2007;7(13):1813-1818.
75. Park S, Lee YK, Jung M, et al. Cellular toxicity of various inhalable metal nanoparticles on human alveolar epithelial cells. Inhal Toxicol. 2007;19 Suppl 1:59-65.
76. Soto K, Garza KM, Murr LE. Cytotoxic effects of aggregated nanomaterials. Acta Biomater. 2007;3(3):351-358.
77. Hussain SM, Javorina AK, Schrand AM, Duhart HM, Ali SF, Schlager JJ. The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion. Toxicol Sci. 2006;92(2): 456-463.
78. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro. 2005;19(7):975-983.
79. McAuliffe ME, Perry MJ. Are nanoparticles potential male reproductive toxicants? A literature review. Nanotoxicology. 2007;1(3): 204-210.
80. Kone BC, Kaleta M, Gullans SR. Silver ion (Ag+)-induced increases in cell membrane K+ and Na+ permeability in the renal proximal tubule: reversal by thiol reagents. J Membr Biol. 1988;102(1):11-19.
81. Carlson C, Hussain SM, Schrand AM, et al. Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. J Phys Chem B. 2008;112(43):13608-13619.
82. Hsin YH, Chen CF, Huang S, Shih TS, Lai PS, Chueh PJ. The apoptotic effect of nanosilver is mediated by a ROS-and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicol Lett. 2008;179(3):130-139.
83. Takenaka S, Karg E, Roth C, et al. Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environ Health Perspect. 2001;109 Suppl 4:547-551.
84. Kim YS, Kim JS, Cho HS, et al. Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. Inhal Toxicol. 2008;20(6):575-583.
85. Lee KJ, Nallathamby PD, Browning LM, Osgood CJ, Xu XH. In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos. ACS Nano. 2007;1(2):133-143.
86. Lansdown AB. Critical observations on the neurotoxicity of silver. Crit Rev Toxicol. 2007;37(3):237-250.
87. Ji JH, Jung JH, Kim SS, et al. Twenty-eight-day inhalation toxicity study of silver nanoparticles in Sprague-Dawley rats. Inhal Toxicol. 2007;19(10):857-871.
88. DiVincenzo GD, Giordano CJ, Schriever LS. Biologic monitoring of workers exposed to silver. Int Arch Occup Environ Health. 1985;56(3):207-215.