Natural compounds boldine and menthol are antagonists of human 5-HT3 receptors: Implications for treating gastrointestinal disorders

Neurogastroenterology and Motility

Volumn 26, Issue 6, 2014, Pages 810-820

  Walstab, J ^a   Wohlfarth, C ^a   Hovius, R ^b   Schmitteckert, S ^a   Roth R ^a   Lasitschka, F ^a   Wink, M ^a   Bonisch H ^c   Niesler, B ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b EPFL   (Switzerland)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Aequorin; Irritable bowel syndrome; Ligand gated ion channel; Natural compound

Indexed keywords

BOLDINE; CALCIUM; LIGAND GATED ION CHANNEL; MENTHOL; MESSENGER RNA; RADIOLIGAND; RECOMBINANT RECEPTOR; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN 3A RECEPTOR; SEROTONIN 3B RECEPTOR; APORPHINE DERIVATIVE;

ARTICLE; CHEMOTHERAPY INDUCED NAUSEA AND VOMITING; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIGESTIVE SYSTEM FUNCTION DISORDER; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; GASTROINTESTINAL SYMPTOM; GENE EXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE EPITHELIUM; IRRITABLE COLON; LAMINA PROPRIA; LIGAND BINDING; LUMINESCENCE; MEMBRANE POTENTIAL; MYENTERIC PLEXUS; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; STEREOCHEMISTRY; DRUG EFFECTS; GASTROINTESTINAL DISEASES;

APORPHINES; GASTROINTESTINAL DISEASES; HEK293 CELLS; HUMANS; MENTHOL; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS;

EID: 84901388890     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12334     Document Type: Article

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