Bi-functionalization of a calcium phosphate-coated titanium surface with slow-release simvastatin and metronidazole to provide antibacterial activities and pro-osteodifferentiation capabilities

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Liu, Yunsong ^a,b   Zhang, Xiao ^a   Liu, Yang ^a   Jin, Xiaoxiao ^a   Fan, Cong ^a   Ye, Hongqiang ^a   Ou, MenG'en ^a   Lv, Longwei ^a   Wu, Gang ^c   Zhou, Yongsheng ^a,b  

^a PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

^b NATIONAL ENGINEERING LABORATORY FOR DIGITAL AND MATERIAL TECHNOLOGY OF STOMATOLOGY   (China)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM PHOSPHATE; METRONIDAZOLE; SIMVASTATIN; TITANIUM; ANTIINFECTIVE AGENT; BIOMATERIAL; DELAYED RELEASE FORMULATION;

ADIPOSE DERIVED STEM CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BONE MARROW CELL; BONE MARROW MESENCHYMAL STEM CELL; CELL ADHESION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG COATING; DRUG FORMULATION; DRUG RELEASE; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; PORPHYROMONAS GINGIVALIS; PROCESS OPTIMIZATION; PROOSTEODIFFERENTIATION ACTIVITY; BONE DEVELOPMENT; CELL DIFFERENTIATION; CHEMISTRY; CULTURE TECHNIQUE; CYTOLOGY; DELAYED RELEASE FORMULATION; DISK DIFFUSION; KINETICS; MESENCHYMAL STROMA CELL; PROSTHESES AND ORTHOSES; SURFACE PROPERTY;

ANTI-BACTERIAL AGENTS; CALCIUM PHOSPHATES; CELL ADHESION; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; COATED MATERIALS, BIOCOMPATIBLE; DELAYED-ACTION PREPARATIONS; DISK DIFFUSION ANTIMICROBIAL TESTS; HUMANS; KINETICS; MESENCHYMAL STROMAL CELLS; METRONIDAZOLE; OSTEOGENESIS; PROSTHESES AND IMPLANTS; SIMVASTATIN; SURFACE PROPERTIES; TITANIUM;

EID: 84901377255     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097741     Document Type: Article

References (38)

1. Goodman SB, Yao Z, Keeney M, Yang F (2013) The future of biologic coatings for orthopaedic implants. Biomaterials 34(13): 3174-3183.
2. Huang Z, Newcomb CJ, Zhou Y, Lei YP, Bringas P, et al. (2013) The role of bioactive nanofibers in enamel regeneration mediated through integrin signals acting upon C/EBPalpha and c-Jun. Biomaterials 34(13): 3303-3314.
3. Yang XF, Chen Y, Yang F, He FM, Zhao SF (2009) Enhanced initial adhesion of osteoblast-like cells on an anatase-structured titania surface formed by H2O2/HCl solution and heat treatment. Dent mater 25(4): 473-480.
4. Liu Y, Wu G, de Groot K (2010) Biomimetic coatings for bone tissue engineering of critical-sized defects. J R Soc Interface 7 Suppl 5: S631-647.
5. Wu G, Liu Y, Iizuka T, Hunziker EB (2010) Biomimetic coating of organic polymers with a protein-functionalized layer of calcium phosphate: the surface properties of the carrier influence neither the coating characteristics nor the incorporation mechanism or release kinetics of the protein. Tissue Eng Part C Methods 16(6): 1255-1265.
6. Liu Y, Huse RO, de Groot K, Buser D, Hunziker EB (2007) Delivery mode and efficacy of BMP-2 in association with implants. J Dent Res 86(1): 84-89.
7. Saran N, Zhang R, Turcotte RE (2011) Osteogenic protein-1 delivered by hydroxyapatite-coated implants improves bone ingrowth in extracortical bone bridging. Clin Orthop Relat Res 469(5): 1470-1478.
8. He J, Huang T, Gan L, Zhou Z, Jiang B, et al. (2012) Collagen-infiltrated porous hydroxyapatite coating and its osteogenic properties: in vitro and in vivo study. J Biomed Mater Res A 100(7): 1706-1715.
9. Wu G, Liu Y, Iizuka T, Hunziker EB (2010) The effect of a slow mode of BMP-2 delivery on the inflammatory response provoked by bone-defect-filling polymeric scaffolds. Biomaterials 31(29): 7485-7493.
10. Peter B, Pioletti DP, Laib S, Bujoli B, Pilet P, et al. (2005) Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration. Bone 36(1): 52-60. (Pubitemid 40128274)
11. Zhou Y, Ni Y, Liu Y, Zeng B, Xu Y, et al. (2010) The role of simvastatin in the osteogenesis of injectable tissue-engineered bone based on human adiposederived stromal cells and platelet-rich plasma. Biomaterials 31(20): 5325-5335.
12. Mundy G, Garrett R, Harris S, Chan J, Chen D, et al. (1999) Stimulation of bone formation in vitro and in rodents by statins. Science 286(5446): 1946-1949. (Pubitemid 129515901)
13. Kunishima H, Chiba J, Saito M, Honda Y, Kaku M (2013) Antimicrobial susceptibilities of Clostridium difficile isolated in Japan. J Infect Chemother 19(2): 360-362.
14. Boyanova L, Vladimir D, Gergova G, Dragomir I, Petrov D, et al. (2004) Anaerobic microbiology in 198 cases of pleural empyema: a Bulgarian study. Anaerobe 10(5): 261-267. (Pubitemid 39221786)
15. Yang F, Zhao SF, Zhang F, He FM, Yang GL (2011) Simvastatin-loaded porous implant surfaces stimulate preosteoblasts differentiation: an in vitro study. Oral Surg Oral Med Oral pathol Oral Radiol Endod 111(5): 551-556.
16. Yardimci C, Ozaltin N (2010) Simultaneous determination of ezetimibe and simvastatin in pharmaceutical preparations by MEKC. J Chromatogr Sci 48(2): 95-99.
17. Tavakoli N, Varshosaz J, Dorkoosh F, Zargarzadeh MR (2007) Development and validation of a simple HPLC method for simultaneous in vitro determination of amoxicillin and metronidazole at single wavelength. J Pharm Biomed Anal 43(1): 325-329. (Pubitemid 44856177)
18. Pelaez T, Cercenado E, Alcala L, Marin M, Martin-Lopez A, et al. (2008) Metronidazole resistance in Clostridium difficile is heterogeneous. J Clin Microbiol 46(9): 3028-3032.
19. LeGeros RZ (2002) Properties of osteoconductive biomaterials: calcium phosphates. Clin Orthop Relat Res 395: 81-98.
20. Sun L, Berndt CC, Khor KA, Cheang HN, Gross KA (2002) Surface characteristics and dissolution behavior of plasma-sprayed hydroxyapatite coating. J Biomed Mater Res 62(2): 228-236. (Pubitemid 34988500)
21. Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret GY (2007) Effects of statins on bone mineral density: a meta-analysis of clinical studies. Bone 40(6): 1581-1587. (Pubitemid 46779004)
22. Pauly S, Luttosch F, Morawski M, Haas NP, Schmidmaier G, et al. (2009) Simvastatin locally applied from a biodegradable coating of osteosynthetic implants improves fracture healing comparable to BMP-2 application. Bone 45(3): 505-511.
23. Gristina AG (1987) Biomaterial-centered infection: microbial adhesion versus tissue integration. Science 237(4822): 1588-1595.
24. Leitsch D, Kolarich D, Binder M, Stadlmann J, Altmann F, et al. (2009) Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance. Mol Microbiol 72(2): 518-536.
25. van der Wouden EJ, Thijs JC, Kusters JG, van Zwet AA, Kleibeuker JH (2001) Mechanism and clinical significance of metronidazole resistance in Helicobacter pylori. Scand J Gastroenterol Suppl (234): 10-14. (Pubitemid 33070906)
26. Nolan R, Kemmoona M, Polyzois I, Claffey N (2014) The influence of prophylactic antibiotic administration on post-operative morbidity in dental implant surgery. A prospective double blind randomized controlled clinical trial. Clin Oral Implants Res 25(2): 252-259.
27. Hickok NJ, Shapiro IM (2012) Immobilized antibiotics to prevent orthopaedic implant infections. Adv Drug Deliv Rev 64(12): 1165-1176.
28. Mankin HJ, Doppelt S, Tomford W (1983) Clinical experience with allograft implantation. The first ten years. Clin Orthop Relat Res 174: 69-86. (Pubitemid 13122175)
29. Gaines ST (1988) Infection in bone allografts. Incidence, nature, and treatment. J Bone Joint Surg Am 70(9): 1430-1431.
30. Endres M, Hutmacher DW, Salgado AJ, Kaps C, Ringe J, et al. (2003) Osteogenic induction of human bone marrow-derived mesenchymal progenitor cells in novel synthetic polymer-hydrogel matrices. Tissue Eng 9(4): 689-702. (Pubitemid 37048111)
31. Liu Y, Wang L, Kikuiri T, Akiyama K, Chen C, et al. (2011) Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFNgamma and TNF-alpha. Nat Med 17(12): 1594-1601.
32. Kang JM, Han M, Park IS, Jung Y, Kim SH (2012) Adhesion and differentiation of adipose-derived stem cells on a substrate with immobilized fibroblast growth factor. Acta Biomater 8(5): 1759-1767.
33. Liu Y, Zhou Y, Feng H, Ma GE, Ni Y (2008) Injectable tissue-engineered bone composed of human adipose-derived stromal cells and platelet-rich plasma. Biomaterials 29(23): 3338-3345.
34. Liu Y, Zhao Y, Zhang X, Chen T, Zhao X, et al. (2013) Flow cytometric cell sorting and in vitro pre-osteoinduction are not requirements for in vivo bone formation by human adipose-derived stromal cells. PLOS One 8(2): e56002.
35. Zhang W, Yang N, Shi X (2008) Regulation of mesenchymal stem cell osteogenic differentiation by glucocorticoid-induced leucine zipper (GILZ). J Biol Chem 283: 4723-4729.
36. Herberg S, Shi X, Johnson MH, Hamrick MW, Isales CM, et al. (2013) Stromal cell-derived factor-1beta mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells. PLOS One 8(3): e58207.
37. Akiyama K, You YO, Yamaza T, Chen C, Tang L, et al. (2012) Characterization of bone marrow derived mesenchymal stem cells in suspension. Stem Cell Res Ther 3(5): 40.
38. Zhou W, Han C, Song Y, Yan X, Li D, et al. (2010) The performance of bone marrow mesenchymal stem cell-implant complexes prepared by cell sheet engineering techniques. Biomaterials 31(12): 3212-3221.