Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Alsiary, Rawiah ^a   Brüning Richardson, Anke ^b   Bond, Jacquelyn ^a   Morrison, Ewan E ^a   Wilkinson, Nafisa ^c   Bell, Sandra M ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c LEEDS TEACHING HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABNORMAL SPINDLE LIKE MICROCEPHALY ASSOCIATED PROTEIN; CYTOPLASM PROTEIN; MICROCEPHALIN; UNCLASSIFIED DRUG; ASPM PROTEIN, HUMAN; MCPH1 PROTEIN, HUMAN; MESSENGER RNA; NERVE PROTEIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER GRADING; CANCER GROWTH; CANCER STAGING; CANCER TISSUE; COHORT ANALYSIS; CORRELATION ANALYSIS; CYTOPLASM; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MAJOR CLINICAL STUDY; OVARY CARCINOMA; PROTEIN EXPRESSION; TUMOR INVASION; GENE EXPRESSION REGULATION; GENETICS; LYMPH NODE METASTASIS; METABOLISM; MIDDLE AGED; OVARY TUMOR; YOUNG ADULT;

ADULT; AGED; COHORT STUDIES; CYTOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM INVASIVENESS; NERVE TISSUE PROTEINS; OVARIAN NEOPLASMS; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84901377246     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097059     Document Type: Article

References (45)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, et al. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide.
2. IARC Cancer base No. 10 [Internet] Lyon, France: International Agency for Research on Cancer, 2010. Available: http://globocan.iarc.fr.
3. Auersperg N, Wong AS, Choi KC, Kang SK, Leung PC (2001) Ovarian surface epithelium: biology, endocrinology and pathology. Endocr Rev 22(2): 255-88. (Pubitemid 32458162)
4. Despierre E, Lambrechts D, Neven P, Amant F, Lambrechts S, et al. (2010) The molecular genetic basis of ovarian cancer and its roadmap towards a better treatment. Gynecol Oncol 117(2): 358-65.
5. Jackson AP, Eastwood H, Bell SM, Adu J, Toomes C, et al. (2002) Identification of microcephalin, a protein implicated in determining the size of the human brain. Am J Hum Genet 71(1): 136-42. (Pubitemid 34734714)
6. Bond J, Roberts E, Mochida GH, Hampshire DJ, Scott S, et al. (2002) ASPM is a major determinant of cerebral cortical size. Nat Genet 32(2): 316-20.
7. Nicholas A, Khurshid M, Désir J, Carvalho OP, Cox JJ, et al. (2010) WDR62 is associated with the spindle pole and is mutated in human microcephaly. Nat Genet 42: 1010-4.
8. Bond J, Roberts E, Springell K, Lizarraga SB, Scott S, et al. (2005) A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. Nat Genet 37(4): 353-5.
9. Guernsey D, Jiang H, Hussin J, Arnold M, Bouyakdan K, et al. (2010) Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4. Am J Hum Genet 87: 40-51.
10. Kumar A, Girimaji SC, Duvvari MR, Blanton SH (2009) Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly. Am J Hum Genet 84(2): 286-90.
11. Sir J, Barr A, Nicholas AK, Carvalho OP, Khurshid M, et al. (2011) A primary microcephaly protein complex forms a ring around parental centrioles. Nat Genet 43: 1147-53.
12. Hussain M, Baig S, Neumann S, Faroog M, Ahmad I, et al. (2012) A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function. Am J Hum Genet 90: 871-8.
13. Genin A, Desir J, Lambert N, Biervliet M, Van Der Aa N, et al. (2012) Kinetochore KMN network gene CASC5 mutated in primary microcephaly. Hum Mol Genet 21: 5306-17.
14. Aicardi J (1998) Malformations of the central nervous system. In: Diseases of the nervous system in childhood. London: Mac Keith Press: pp 90-1.
15. Lin SY, Rai R, Li K, Xu ZX, Elledge SJ (2005) BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc Natl Acad Sci U S A 102(42): 15105-9. (Pubitemid 41513342)
16. Rai R, Dai H, Multani AS, Li K, Chin K, et al. (2006) BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell 10(2): 145-57. (Pubitemid 44175904)
17. Trimborn M, Bell SM, Felix C, Rashid Y, Jafri H, et al. (2004) Mutations in microcephalin cause aberrant regulation of chromosome condensation. Am J Hum Genet 75(2): 261-6. (Pubitemid 38943869)
18. Lin SY, Elledge SJ (2003) Multiple tumor suppressor pathways negatively regulate telomerase. Cell 113(7): 881-9.
19. do Carmo Avides M, Tavares A, Glover DM (2001) Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes. Nature Cell Biol 3: 421-4.
20. Ponting CP (2006) A novel domain suggests a ciliary function for ASPM, a brain size determining gene. Bioinformatics 22: 1031-5.
21. Rhoads A, Kenguele H (2005) Expression of IQ-motif genes in human cells and ASPM domain structure. Ethn Dis 15(4 Suppl 5): S5-88-91.
22. Higgins J, Midgley C, Bergh A-M, Bell SM, Askham JM, et al. (2010) Human ASPM participates in spindle organisation, cleavage furrow orientation and cytokinesis. BMC Cell Biology 11:85.
23. Fish JL, Kosodo Y, Enard W, Paabo S, Huttner WB (2006) Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. Proc Natl Acad Sci U S A 103(27): 10438-43. (Pubitemid 44051185)
24. Zhong X, Liu L, Zhao A, Pfeifer GP, Xu X (2005) The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein. Cell Cycle 4(9): 1227-9. (Pubitemid 41365393)
25. Bond J, Woods CG (2006) Cytoskeletal genes regulating brain size. Curr Opin Cell Biol 18(1): 95-101. (Pubitemid 43107614)
26. Kouprina N, Pavlicek A, Collins NK, Nakano M, Noskov VN, et al. (2005) The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein. Hum Mol Genet 14(15): 2155-65. (Pubitemid 41418015)
27. Paramasivam M, Chang YJ, LoTurco JJ (2007) ASPM and citron kinase co-localize to the midbody ring during cytokinesis. Cell Cycle 6(13): 1605-12. (Pubitemid 47327947)
28. Richardson J, Shaaban AM, Kamal M, Alisary R, Walker C, et al. (2010) Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation. Breast Cancer Research and Treatment 127(3): 639-648.
29. Bhattacharya N, Mukherjee N, Singh RK, Sinha S, Alam N, et al. (2013) Frequent alterations of MCPH1 and ATM are associated with primary breast carcinoma: clinical and prognostic implications. Ann Surg Oncol 20(3): S424-32.
30. Jo YH, Kim HO, Lee J, Lee SS, Cho CH, et al. (2013) MCPH1 protein expression and polymorphisms are associated with risk of breast cancer. Gene 517(2): 184-90.
31. Venkatesh T, Nagashri MN, Swamy SS, Mohiyuddin SM, Gopinath KS, et al. (2013) Primary microcephaly gene MCPH1 shows signatures of tumour suppressors and is regulated by miR-27 in oral squamous cell carcinoma. PLoS One 8(3): e54643.
32. Hagemann C, Anacker J, Gerngras S, Kuhnel S, Said HM, et al. (2008) Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, microcephaly associated) in human malignant gliomas. Oncol Rep 20(2): 301-8.
33. Bikeye SN, Colin C, Marie Y, Vampouille R, Ravassard P, et al. (2010) ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target. Cancer Cell Int 10: 1.
34. Drozdov I, Bornschein J, Wex T, Valeyev NV, Tsoka S, et al. (2012) Functional and topological properties in hepatocellular carcinoma transcriptome. PLoS One 7(4): e35510.
35. Wang WY, Hsu CC, Wang TY, Li CR, Hou YC, et al (2013) A gene expression signature of epithelial tubulogenesis and a role for ASPM in pancreatic tumour progression. Gastroenterology 145(5): 1110-20.
36. Bruning-Richardson A, Bond J, Alsiary R, Richardson J, Cairns DA, et al. (2011) ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival. Br J Cancer 104(10): 1602-10.
37. Hermanek P (2001) Why TNM system for staging of gynecologic tumors? CME Journal of Gynecologic Oncology 2(6): 267-9.
38. Ellis IO, Abd El-Rehim DM, Ball G, Pinder SE, Rakha E, et al. (2005) High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses. Int J Cancer 116(3): 340-50.
39. Allred DC, Clark GM, Elledge R, Fuqua SA, Brown RW, et al. (1993) Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst 85(3): 200-6. (Pubitemid 23046895)
40. Bremnes RM, Veve R, Gabrielson E, Hirsch FR, Baron A, et al. (2002) High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. Journal of Clinical Oncology 20(10): 2417-28. (Pubitemid 34525727)
41. Rodriguez JA, Au WW, Henderson BR (2004) Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain. Exp Cell Res 293(1): 14-21. (Pubitemid 38064410)
42. Wu X, Mondal G, Wang X, Wu J, Yang L, et al. (2009) Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair. Cancer Res 69: 5531-36.
43. Gavvovidis I, Rost I, Trimborn M, Kaiser FJ, Purps J, et al. (2012) A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells. PLoS One 7(8): e40387.
44. Peyre M, Commo F, Dantas-Barbosa C, Andreiuolo F, Puget S, et al. (2010) Portrait of ependymoma recurrence in children: biomarkers of tumor progression identified by dual-color microarray-based gene expression analysis. PLoS One 24:5(9): e12932.
45. Köbel M, Kalloger SE, Boyd N, McKinney S, Mehl E, et al. (2008) Ovarian carcinoma subtypes are different diseases: implications for biomarker studies. PLoS Med 5(12): e232.