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Volumn 51, Issue 2, 2014, Pages 102-111

Direct Oral Anticoagulants and Bleeding Risk (in Comparison to Vitamin K Antagonists and Heparins), and the Treatment of Bleeding

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; BLOOD CLOTTING FACTOR 10A; DABIGATRAN; EDOXABAN; HEPARIN DERIVATIVE; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; RIVAROXABAN; WARFARIN;

EID: 84901364162     PISSN: 00371963     EISSN: 15328686     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2014.02.002     Document Type: Article
Times cited : (20)

References (71)
  • 1
    • 34447306023 scopus 로고    scopus 로고
    • Bleeding complications with warfarin use-a prevalent adverse effect resulting in regulatory action
    • Wysowski D.K., Nourjah P., Swartz L. Bleeding complications with warfarin use-a prevalent adverse effect resulting in regulatory action. Arch Intern Med 2007, 167:1414-1419.
    • (2007) Arch Intern Med , vol.167 , pp. 1414-1419
    • Wysowski, D.K.1    Nourjah, P.2    Swartz, L.3
  • 2
    • 33645828603 scopus 로고    scopus 로고
    • Translating the results of randomized trials into clinical practice-the challenge of warfarin candidacy among hospitalized elderly patients with atrial fibrillation
    • Hylek E.M., Dantonio J., EvansMolina C., Shea C., Henault L.E., Regan S. Translating the results of randomized trials into clinical practice-the challenge of warfarin candidacy among hospitalized elderly patients with atrial fibrillation. Stroke 2006, 37:1075-1078.
    • (2006) Stroke , vol.37 , pp. 1075-1078
    • Hylek, E.M.1    Dantonio, J.2    EvansMolina, C.3    Shea, C.4    Henault, L.E.5    Regan, S.6
  • 3
    • 84878301696 scopus 로고    scopus 로고
    • Decision making for oral anticoagulants in atrial fibrillation: the ATA-AF study
    • Gussoni G., Di Pasquale G., Vescovo G., et al. Decision making for oral anticoagulants in atrial fibrillation: the ATA-AF study. Eur J Intern Med 2013, 24:324-332.
    • (2013) Eur J Intern Med , vol.24 , pp. 324-332
    • Gussoni, G.1    Di Pasquale, G.2    Vescovo, G.3
  • 4
    • 33747599590 scopus 로고    scopus 로고
    • Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    • Eikelboom J.W., Mehta S.R., Anand S.S., Xie C., Fox K.A., Yusuf S. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 2006, 114:774-782.
    • (2006) Circulation , vol.114 , pp. 774-782
    • Eikelboom, J.W.1    Mehta, S.R.2    Anand, S.S.3    Xie, C.4    Fox, K.A.5    Yusuf, S.6
  • 5
    • 33947575142 scopus 로고    scopus 로고
    • Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes-an analysis from the ACUITY trial
    • Manoukian S.V., Feit F., Mehran R., et al. Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes-an analysis from the ACUITY trial. J Am Coll Cardiol 2007, 49:1362-1368.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1362-1368
    • Manoukian, S.V.1    Feit, F.2    Mehran, R.3
  • 6
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly S.J., Ezekowitz M.D., Yusuf S., et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009, 361:1139-1151.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 7
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • Patel M.R., Mahaffey K.W., Garg J., et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011, 365:883-891.
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 8
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • Granger C.B., Alexander J.H., McMurray J.J., et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011, 365:981-992.
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.3
  • 9
    • 84888362796 scopus 로고    scopus 로고
    • Edoxaban versus warfarin in patients with atrial fibrillation
    • Giugliano R.P., Ruff C.T., Braunwald E., et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2013, 369:2093-2104.
    • (2013) N Engl J Med , vol.369 , pp. 2093-2104
    • Giugliano, R.P.1    Ruff, C.T.2    Braunwald, E.3
  • 10
    • 79952301326 scopus 로고    scopus 로고
    • Apixaban in patients with atrial fibrillation
    • Connolly S.J., Eikelboom J., Joyner C., et al. Apixaban in patients with atrial fibrillation. N Engl J Med 2011, 364:806-817.
    • (2011) N Engl J Med , vol.364 , pp. 806-817
    • Connolly, S.J.1    Eikelboom, J.2    Joyner, C.3
  • 11
    • 23044505564 scopus 로고    scopus 로고
    • Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients
    • Schulman S., Kearon C. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost 2005, 3:692-694.
    • (2005) J Thromb Haemost , vol.3 , pp. 692-694
    • Schulman, S.1    Kearon, C.2
  • 12
    • 79958126202 scopus 로고    scopus 로고
    • Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial
    • Eikelboom J.W., Wallentin L., Connolly S.J., et al. Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial. Circulation 2011, 123:2363-2372.
    • (2011) Circulation , vol.123 , pp. 2363-2372
    • Eikelboom, J.W.1    Wallentin, L.2    Connolly, S.J.3
  • 13
    • 78650114177 scopus 로고    scopus 로고
    • Dabigatran and warfarin in vitamin K antagonist-naive and -experienced cohorts with atrial fibrillation
    • Ezekowitz M.D., Wallentin L., Connolly S.J., et al. Dabigatran and warfarin in vitamin K antagonist-naive and -experienced cohorts with atrial fibrillation. Circulation 2010, 122:2246-2253.
    • (2010) Circulation , vol.122 , pp. 2246-2253
    • Ezekowitz, M.D.1    Wallentin, L.2    Connolly, S.J.3
  • 14
    • 80955182268 scopus 로고    scopus 로고
    • Risks for stroke, bleeding, and death in patients with atrial fibrillation receiving dabigatran or warfarin in relation to the CHADS2 score: a subgroup analysis of the RE-LY trial
    • W204
    • Oldgren J., Alings M., Darius H., et al. Risks for stroke, bleeding, and death in patients with atrial fibrillation receiving dabigatran or warfarin in relation to the CHADS2 score: a subgroup analysis of the RE-LY trial. Ann Intern Med 2011, 155:660-667. W204.
    • (2011) Ann Intern Med , vol.155 , pp. 660-667
    • Oldgren, J.1    Alings, M.2    Darius, H.3
  • 15
    • 77956977472 scopus 로고    scopus 로고
    • Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial
    • Wallentin L., Yusuf S., Ezekowitz M.D., et al. Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. Lancet 2010, 376:975-983.
    • (2010) Lancet , vol.376 , pp. 975-983
    • Wallentin, L.1    Yusuf, S.2    Ezekowitz, M.D.3
  • 16
    • 84878535107 scopus 로고    scopus 로고
    • Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation
    • Wallentin L., Lopes R.D., Hanna M., et al. Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation. Circulation 2013, 127:2166-2176.
    • (2013) Circulation , vol.127 , pp. 2166-2176
    • Wallentin, L.1    Lopes, R.D.2    Hanna, M.3
  • 17
    • 77955872745 scopus 로고    scopus 로고
    • A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey
    • 1093-10
    • Pisters R., Lane D.A., Nieuwlaat R., de Vos C.B., Crijns H.J., Lip G.Y. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest 2010, 138. 1093-10.
    • (2010) Chest , vol.138
    • Pisters, R.1    Lane, D.A.2    Nieuwlaat, R.3    de Vos, C.B.4    Crijns, H.J.5    Lip, G.Y.6
  • 18
    • 80052094564 scopus 로고    scopus 로고
    • A new risk scheme to predict warfarin-associated hemorrhage. The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) study
    • Fang M.C., Go A.S., Chang Y., et al. A new risk scheme to predict warfarin-associated hemorrhage. The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) study. J Am Coll Cardiol 2011, 58:395-401.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 395-401
    • Fang, M.C.1    Go, A.S.2    Chang, Y.3
  • 19
    • 0041807872 scopus 로고    scopus 로고
    • Predictors of warfarin use among Ohio medicaid patients with new-onset nonvalvular atrial fibrillation
    • 1705-1
    • Johnston J.A., Cluxton R.J., Heaton P.C., Guo J.J., Moomaw C.J., Eckman M.H. Predictors of warfarin use among Ohio medicaid patients with new-onset nonvalvular atrial fibrillation. Arch Intern Med 2003, 163. 1705-1.
    • (2003) Arch Intern Med , vol.163
    • Johnston, J.A.1    Cluxton, R.J.2    Heaton, P.C.3    Guo, J.J.4    Moomaw, C.J.5    Eckman, M.H.6
  • 20
    • 80054071757 scopus 로고    scopus 로고
    • Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment
    • Fox K.A., Piccini J.P., Wojdyla D., et al. Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment. Eur Heart J 2011, 32:2387-2394.
    • (2011) Eur Heart J , vol.32 , pp. 2387-2394
    • Fox, K.A.1    Piccini, J.P.2    Wojdyla, D.3
  • 21
    • 79960955075 scopus 로고    scopus 로고
    • The use of dabigatran in elderly patients
    • Legrand M., Mateo J., Aribaud A., et al. The use of dabigatran in elderly patients. Arch Intern Med 2011, 171:1285-1286.
    • (2011) Arch Intern Med , vol.171 , pp. 1285-1286
    • Legrand, M.1    Mateo, J.2    Aribaud, A.3
  • 22
    • 84865815830 scopus 로고    scopus 로고
    • Life-threatening bleeding in four patients with an unusual excessive response to dabigatran: implications for emergency surgery and resuscitation
    • Lillo-Le Louet A., Wolf M., Soufir L., et al. Life-threatening bleeding in four patients with an unusual excessive response to dabigatran: implications for emergency surgery and resuscitation. Thromb Haemost 2012, 108:583-585.
    • (2012) Thromb Haemost , vol.108 , pp. 583-585
    • Lillo-Le Louet, A.1    Wolf, M.2    Soufir, L.3
  • 23
    • 84859549864 scopus 로고    scopus 로고
    • Clinical challenges in a patient with dabigatran-induced fatal hemorrhage
    • Cano E.L., Miyares M.A. Clinical challenges in a patient with dabigatran-induced fatal hemorrhage. Am J Geriatr Pharmacother 2012, 10:160-163.
    • (2012) Am J Geriatr Pharmacother , vol.10 , pp. 160-163
    • Cano, E.L.1    Miyares, M.A.2
  • 24
    • 84860746568 scopus 로고    scopus 로고
    • Neurosurgical complications of direct thrombin inhibitors-catastrophic hemorrhage after mild traumatic brain injury in a patient receiving dabigatran
    • Garber S.T., Sivakumar W., Schmidt R.H. Neurosurgical complications of direct thrombin inhibitors-catastrophic hemorrhage after mild traumatic brain injury in a patient receiving dabigatran. J Neurosurg 2012, 116:1093-1096.
    • (2012) J Neurosurg , vol.116 , pp. 1093-1096
    • Garber, S.T.1    Sivakumar, W.2    Schmidt, R.H.3
  • 25
    • 84862243930 scopus 로고    scopus 로고
    • Rectal bleeding and hemostatic disorders induced by dabigatran etexilate in 2 elderly patients
    • Bene J., Said W., Rannou M., Deheul S., Coupe P., Gautier S. Rectal bleeding and hemostatic disorders induced by dabigatran etexilate in 2 elderly patients. Ann Pharmacother 2012, 46:e14.
    • (2012) Ann Pharmacother , vol.46
    • Bene, J.1    Said, W.2    Rannou, M.3    Deheul, S.4    Coupe, P.5    Gautier, S.6
  • 26
    • 84859703006 scopus 로고    scopus 로고
    • Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment
    • Wychowski M.K., Kouides P.A. Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment. Ann Pharmacother 2012, 46:e1.
    • (2012) Ann Pharmacother , vol.46
    • Wychowski, M.K.1    Kouides, P.A.2
  • 27
    • 84867847882 scopus 로고    scopus 로고
    • Diffuse alveolar hemorrhage associated with dabigatran
    • Yokoi K., Isoda K., Kimura T., Adachi T. Diffuse alveolar hemorrhage associated with dabigatran. Intern Med 2012, 51:2667-2668.
    • (2012) Intern Med , vol.51 , pp. 2667-2668
    • Yokoi, K.1    Isoda, K.2    Kimura, T.3    Adachi, T.4
  • 28
    • 84875780959 scopus 로고    scopus 로고
    • Dabigatran and postmarketing reports of bleeding
    • Southworth M.R., Reichman M.E., Unger E.F. Dabigatran and postmarketing reports of bleeding. N Engl J Med 2013, 368:1272-1274.
    • (2013) N Engl J Med , vol.368 , pp. 1272-1274
    • Southworth, M.R.1    Reichman, M.E.2    Unger, E.F.3
  • 29
    • 84901298099 scopus 로고    scopus 로고
    • US Food and Drug Adminstration.
    • US Food and Drug Adminstration. http://mini-sentinel.org.
  • 30
    • 84878292470 scopus 로고    scopus 로고
    • Efficacy and safety of dabigatran etexilate and warfarin in "real-world" patients with atrial fibrillation: a prospective nationwide cohort study
    • Larsen T.B., Rasmussen L.H., Skjoth F., et al. Efficacy and safety of dabigatran etexilate and warfarin in "real-world" patients with atrial fibrillation: a prospective nationwide cohort study. J Am Coll Cardiol 2013, 61:2264-2273.
    • (2013) J Am Coll Cardiol , vol.61 , pp. 2264-2273
    • Larsen, T.B.1    Rasmussen, L.H.2    Skjoth, F.3
  • 31
    • 84878451205 scopus 로고    scopus 로고
    • Dabigatran use in Danish atrial fibrillation patients in 2011: a nationwide study
    • Sorensen R., Gislason G., Torp-Pedersen C., et al. Dabigatran use in Danish atrial fibrillation patients in 2011: a nationwide study. BMJ Open 2013, 3:e002758.
    • (2013) BMJ Open , vol.3
    • Sorensen, R.1    Gislason, G.2    Torp-Pedersen, C.3
  • 32
    • 71849117615 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    • Schulman S., Kearon C., Kakkar A.K., et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009, 361:2342-2352.
    • (2009) N Engl J Med , vol.361 , pp. 2342-2352
    • Schulman, S.1    Kearon, C.2    Kakkar, A.K.3
  • 33
    • 84885618705 scopus 로고    scopus 로고
    • Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism
    • Buller H.R., Decousus H., Grosso M.A., et al. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med 2013, 369:1406-1415.
    • (2013) N Engl J Med , vol.369 , pp. 1406-1415
    • Buller, H.R.1    Decousus, H.2    Grosso, M.A.3
  • 34
    • 78650619315 scopus 로고    scopus 로고
    • Oral rivaroxaban for symptomatic venous thromboembolism
    • 2499-51
    • Bauersachs R., Berkowitz S.D., Brenner B., et al. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010, 363. 2499-51.
    • (2010) N Engl J Med , vol.363
    • Bauersachs, R.1    Berkowitz, S.D.2    Brenner, B.3
  • 35
    • 84859385808 scopus 로고    scopus 로고
    • Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
    • Buller H.R., Prins M.H., Lensin A.W., et al. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 2012, 366:1287-1297.
    • (2012) N Engl J Med , vol.366 , pp. 1287-1297
    • Buller, H.R.1    Prins, M.H.2    Lensin, A.W.3
  • 36
    • 84880327613 scopus 로고    scopus 로고
    • Oral apixaban for the treatment of acute venous thromboembolism
    • Agnelli G., Buller H.R., Cohen A., et al. Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med 2013, 369:799-808.
    • (2013) N Engl J Med , vol.369 , pp. 799-808
    • Agnelli, G.1    Buller, H.R.2    Cohen, A.3
  • 37
    • 84874003257 scopus 로고    scopus 로고
    • Extended use of dabigatran, warfarin, or placebo in venous thromboembolism
    • Schulman S., Kearon C., Kakkar A.K., et al. Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. N Engl J Med 2013, 368:709-718.
    • (2013) N Engl J Med , vol.368 , pp. 709-718
    • Schulman, S.1    Kearon, C.2    Kakkar, A.K.3
  • 38
    • 84873596181 scopus 로고    scopus 로고
    • Apixaban for extended treatment of venous thromboembolism
    • Agnelli G., Buller H.R., Cohen A., et al. Apixaban for extended treatment of venous thromboembolism. N Engl J Med 2013, 368:699-708.
    • (2013) N Engl J Med , vol.368 , pp. 699-708
    • Agnelli, G.1    Buller, H.R.2    Cohen, A.3
  • 39
    • 84870517411 scopus 로고    scopus 로고
    • Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review
    • Adam S.S., McDuffie J.R., Ortel T.L., Williams J.W. Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review. Ann Intern Med 2012, 157:796-807.
    • (2012) Ann Intern Med , vol.157 , pp. 796-807
    • Adam, S.S.1    McDuffie, J.R.2    Ortel, T.L.3    Williams, J.W.4
  • 40
    • 84869236631 scopus 로고    scopus 로고
    • Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature
    • Dentali F., Riva N., Crowther M., Turpie A.G., Lip G.Y., Ageno W. Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature. Circulation 2012, 126:2381-2391.
    • (2012) Circulation , vol.126 , pp. 2381-2391
    • Dentali, F.1    Riva, N.2    Crowther, M.3    Turpie, A.G.4    Lip, G.Y.5    Ageno, W.6
  • 41
    • 84863981277 scopus 로고    scopus 로고
    • Meta-analysis of efficacy and safety of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus warfarin in patients with atrial fibrillation
    • Miller C.S., Grandi S.M., Shimony A., Filion K.B., Eisenberg M.J. Meta-analysis of efficacy and safety of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus warfarin in patients with atrial fibrillation. Am J Cardiol 2012, 110:453-456.
    • (2012) Am J Cardiol , vol.110 , pp. 453-456
    • Miller, C.S.1    Grandi, S.M.2    Shimony, A.3    Filion, K.B.4    Eisenberg, M.J.5
  • 42
    • 84862778535 scopus 로고    scopus 로고
    • Survival benefit of new anticoagulants compared with warfarin in patients with atrial fibrillation: a meta-analysis
    • Liu T., Korantzopoulos P., Li L., Li G. Survival benefit of new anticoagulants compared with warfarin in patients with atrial fibrillation: a meta-analysis. Int J Cardiol 2012, 156:96-97.
    • (2012) Int J Cardiol , vol.156 , pp. 96-97
    • Liu, T.1    Korantzopoulos, P.2    Li, L.3    Li, G.4
  • 43
    • 84869838484 scopus 로고    scopus 로고
    • Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: direct and adjusted indirect meta-analysis of randomised controlled trials
    • Fox B.D., Kahn S.R., Langleben D., Eisenberg M.J., Shimony A. Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: direct and adjusted indirect meta-analysis of randomised controlled trials. BMJ 2012, 345:e7498.
    • (2012) BMJ , vol.345
    • Fox, B.D.1    Kahn, S.R.2    Langleben, D.3    Eisenberg, M.J.4    Shimony, A.5
  • 44
    • 84880785759 scopus 로고    scopus 로고
    • Gastrointestinal bleeding with the new oral anticoagulants-defining the issues and the management strategies
    • Desai J., Kolb J.M., Weitz J.I., Aisenberg J. Gastrointestinal bleeding with the new oral anticoagulants-defining the issues and the management strategies. Thromb Haemost 2013, 110:205-212.
    • (2013) Thromb Haemost , vol.110 , pp. 205-212
    • Desai, J.1    Kolb, J.M.2    Weitz, J.I.3    Aisenberg, J.4
  • 45
    • 80052413972 scopus 로고    scopus 로고
    • Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents
    • Levi M., Eerenberg E., Kamphuisen P.W. Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents. J Thromb Haemost 2011, 9:1705-1712.
    • (2011) J Thromb Haemost , vol.9 , pp. 1705-1712
    • Levi, M.1    Eerenberg, E.2    Kamphuisen, P.W.3
  • 46
    • 80155206426 scopus 로고    scopus 로고
    • Questions and answers on the use of dabigatran and perspectives on the use of other new oral anticoagulants in patients with atrial fibrillation. A consensus document of the Italian Federation of Thrombosis Centers (FCSA)
    • Pengo V., Crippa L., Falanga A., et al. Questions and answers on the use of dabigatran and perspectives on the use of other new oral anticoagulants in patients with atrial fibrillation. A consensus document of the Italian Federation of Thrombosis Centers (FCSA). Thromb Haemost 2011, 106:868-876.
    • (2011) Thromb Haemost , vol.106 , pp. 868-876
    • Pengo, V.1    Crippa, L.2    Falanga, A.3
  • 47
    • 84867240886 scopus 로고    scopus 로고
    • New direct oral anticoagulants-current therapeutic options and treatment recommendations for bleeding complications
    • Miesbach W., Seifried E. New direct oral anticoagulants-current therapeutic options and treatment recommendations for bleeding complications. Thromb Haemost 2012, 108:625-632.
    • (2012) Thromb Haemost , vol.108 , pp. 625-632
    • Miesbach, W.1    Seifried, E.2
  • 48
    • 84880280696 scopus 로고    scopus 로고
    • EHRA practical guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary
    • Heidbuchel H., Verhamme P., Alings M., et al. EHRA practical guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary. Eur Heart J 2013, 34:2094-2106.
    • (2013) Eur Heart J , vol.34 , pp. 2094-2106
    • Heidbuchel, H.1    Verhamme, P.2    Alings, M.3
  • 49
    • 84880571372 scopus 로고    scopus 로고
    • Management of major bleeding complications and emergency surgery in patients on long-term treatment with direct oral anticoagulants, thrombin or factor-Xa inhibitors: proposals of the working group on perioperative haemostasis (GIHP)-March. 2013
    • Pernod G., Albaladejo P., Godier A., et al. Management of major bleeding complications and emergency surgery in patients on long-term treatment with direct oral anticoagulants, thrombin or factor-Xa inhibitors: proposals of the working group on perioperative haemostasis (GIHP)-March. 2013. Arch Cardiovasc Dis 2013, 106:382-393.
    • (2013) Arch Cardiovasc Dis , vol.106 , pp. 382-393
    • Pernod, G.1    Albaladejo, P.2    Godier, A.3
  • 50
    • 84875000370 scopus 로고    scopus 로고
    • Clinical management of rivaroxaban-treated patients
    • Palareti G., Ageno W., Ferrari A., et al. Clinical management of rivaroxaban-treated patients. Expert Opin Pharmacother 2013, 14:655-667.
    • (2013) Expert Opin Pharmacother , vol.14 , pp. 655-667
    • Palareti, G.1    Ageno, W.2    Ferrari, A.3
  • 51
    • 84878460192 scopus 로고    scopus 로고
    • A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa
    • Lu G., DeGuzman F.R., Hollenbach S.J., et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med 2013, 19:446-451.
    • (2013) Nat Med , vol.19 , pp. 446-451
    • Lu, G.1    DeGuzman, F.R.2    Hollenbach, S.J.3
  • 52
    • 84879548455 scopus 로고    scopus 로고
    • A specific antidote for dabigatran: functional and structural characterization
    • Schiele F., van Ryn J., Canada K., et al. A specific antidote for dabigatran: functional and structural characterization. Blood 2013, 121:3554-3562.
    • (2013) Blood , vol.121 , pp. 3554-3562
    • Schiele, F.1    van Ryn, J.2    Canada, K.3
  • 53
    • 84857015053 scopus 로고    scopus 로고
    • Laboratory testing of anticoagulants: the present and the future
    • Favaloro E.J., Lippi G., Koutts J. Laboratory testing of anticoagulants: the present and the future. Pathology (Phila) 2011, 43:682-692.
    • (2011) Pathology (Phila) , vol.43 , pp. 682-692
    • Favaloro, E.J.1    Lippi, G.2    Koutts, J.3
  • 54
    • 84880972950 scopus 로고    scopus 로고
    • The laboratory and the direct oral anticoagulants
    • Tripodi A. The laboratory and the direct oral anticoagulants. Blood 2013, 121:4032-4035.
    • (2013) Blood , vol.121 , pp. 4032-4035
    • Tripodi, A.1
  • 55
    • 84901381956 scopus 로고    scopus 로고
    • Direct oral anticoagulants: interference with laboratory tests and mechanisms of action
    • xx-xx
    • Tsakiris D.A. Direct oral anticoagulants: interference with laboratory tests and mechanisms of action. Semin Hematol 2014, 51. xx-xx.
    • (2014) Semin Hematol , vol.51
    • Tsakiris, D.A.1
  • 56
    • 0024361281 scopus 로고
    • Bleeding in outpatients treated with warfarin: relation to the prothrombin time and important remediable lesions
    • Landefeld C.S., Rosenblatt M.W., Goldman L. Bleeding in outpatients treated with warfarin: relation to the prothrombin time and important remediable lesions. Am J Med 1989, 87:153-159.
    • (1989) Am J Med , vol.87 , pp. 153-159
    • Landefeld, C.S.1    Rosenblatt, M.W.2    Goldman, L.3
  • 57
    • 77949421739 scopus 로고    scopus 로고
    • Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study
    • Stangier J., Rathgen K., Stahle H., Mazur D. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet 2010, 49:259-268.
    • (2010) Clin Pharmacokinet , vol.49 , pp. 259-268
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Mazur, D.4
  • 58
  • 59
    • 84857759555 scopus 로고    scopus 로고
    • Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding
    • Warkentin T.E., Margetts P., Connolly S.J., Lamy A., Ricci C., Eikelboom J.W. Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding. Blood 2012, 119:2172-2174.
    • (2012) Blood , vol.119 , pp. 2172-2174
    • Warkentin, T.E.1    Margetts, P.2    Connolly, S.J.3    Lamy, A.4    Ricci, C.5    Eikelboom, J.W.6
  • 60
    • 84875926001 scopus 로고    scopus 로고
    • Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease
    • Khadzhynov D., Wagner F., Formella S., et al. Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease. Thromb Haemost 2013, 109:596-605.
    • (2013) Thromb Haemost , vol.109 , pp. 596-605
    • Khadzhynov, D.1    Wagner, F.2    Formella, S.3
  • 61
    • 84655176578 scopus 로고    scopus 로고
    • Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model
    • Godier A., Miclot A., Le Bonniec B., et al. Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model. Anesthesiology 2012, 116:94-102.
    • (2012) Anesthesiology , vol.116 , pp. 94-102
    • Godier, A.1    Miclot, A.2    Le Bonniec, B.3
  • 62
    • 84856631805 scopus 로고    scopus 로고
    • Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents
    • Fukuda T., Honda Y., Kamisato C., Morishima Y., Shibano T. Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents. Thromb Haemost 2012, 107:253-259.
    • (2012) Thromb Haemost , vol.107 , pp. 253-259
    • Fukuda, T.1    Honda, Y.2    Kamisato, C.3    Morishima, Y.4    Shibano, T.5
  • 63
    • 84856214360 scopus 로고    scopus 로고
    • Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran
    • Zhou W., Schwarting S., Illanes S., et al. Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran. Stroke 2011, 42:3594-3599.
    • (2011) Stroke , vol.42 , pp. 3594-3599
    • Zhou, W.1    Schwarting, S.2    Illanes, S.3
  • 64
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects
    • Eerenberg E.S., Kamphuisen P.W., Sijpkens M.K., Meijers J.C., Buller H.R., Levi M. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 2011, 124:1573-1579.
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3    Meijers, J.C.4    Buller, H.R.5    Levi, M.6
  • 65
    • 34547436844 scopus 로고    scopus 로고
    • Coagulation factor concentrates: past, present, and future
    • Key N.S., Negrier C. Coagulation factor concentrates: past, present, and future. Lancet 2007, 370:439-448.
    • (2007) Lancet , vol.370 , pp. 439-448
    • Key, N.S.1    Negrier, C.2
  • 66
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers
    • Marlu R., Hodaj E., Paris A., Albaladejo P., Crackowski J.L., Pernod G. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers. Thromb Haemost 2012, 108:217-224.
    • (2012) Thromb Haemost , vol.108 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3    Albaladejo, P.4    Crackowski, J.L.5    Pernod, G.6
  • 68
    • 78049498149 scopus 로고    scopus 로고
    • Safety of recombinant activated factor VII in randomized clinical trials
    • 1791-80
    • Levi M., Levy J.H., Andersen H.F., Truloff D. Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 2010, 363. 1791-80.
    • (2010) N Engl J Med , vol.363
    • Levi, M.1    Levy, J.H.2    Andersen, H.F.3    Truloff, D.4
  • 69
    • 77954717667 scopus 로고    scopus 로고
    • Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial
    • Shakur H., Roberts R., Bautista R., et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010, 376:23-32.
    • (2010) Lancet , vol.376 , pp. 23-32
    • Shakur, H.1    Roberts, R.2    Bautista, R.3
  • 70
    • 62449131258 scopus 로고    scopus 로고
    • Stroke risk in atrial fibrillation patients on warfarin. Predictive ability of risk stratification schemes for primary and secondary prevention
    • Poli D., Antonucci E., Grifoni E., Abbate R., Gensini G.F., Prisco D. Stroke risk in atrial fibrillation patients on warfarin. Predictive ability of risk stratification schemes for primary and secondary prevention. Thromb Haemost 2009, 101:367-372.
    • (2009) Thromb Haemost , vol.101 , pp. 367-372
    • Poli, D.1    Antonucci, E.2    Grifoni, E.3    Abbate, R.4    Gensini, G.F.5    Prisco, D.6


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