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Volumn 8, Issue 1, 2014, Pages 79-84

Ethanol extract of cirsium japonicum attenuates hepatic lipid accumulation via AMPK activation in human HepG2 cells

Author keywords

AMP activated protein kinase; Cirsium japonicum; Fatty acid oxidation; Nonalcoholic fatty liver disease

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; BETA ACTIN; CARNITINE PALMITOYLTRANSFERASE I; CHOLESTEROL; CIRSIUM JAPONICUM EXTRACT; COMPLEMENTARY DNA; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84901363757     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1698     Document Type: Article
Times cited : (28)

References (22)
  • 1
    • 84898439031 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Molecular mechanisms for the hepatic steatosis
    • Koo SH: Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis. Clin Mol Hepatol 19: 210-215, 2013.
    • (2013) Clin Mol Hepatol , vol.19 , pp. 210-215
    • Koo, S.H.1
  • 2
    • 48649110854 scopus 로고    scopus 로고
    • The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
    • Gentile CL and Pagliassotti MJ: The role of fatty acids in the development and progression of nonalcoholic fatty liver disease. J Nutr Biochem 19: 567-576, 2008.
    • (2008) J Nutr Biochem , vol.19 , pp. 567-576
    • Gentile, C.L.1    Pagliassotti, M.J.2
  • 3
    • 40749106081 scopus 로고    scopus 로고
    • Obesity: A review of pathogenesis and management strategies
    • Kaila B and Raman M: Obesity: a review of pathogenesis and management strategies. Can J Gastroenterol 22: 61-68, 2008.
    • (2008) Can J Gastroenterol , vol.22 , pp. 61-68
    • Kaila, B.1    Raman, M.2
  • 4
    • 34547491854 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease
    • Angulo P: Obesity and nonalcoholic fatty liver disease. Nutr Rev 65: S57-S63, 2007.
    • (2007) Nutr Rev , vol.65
    • Angulo, P.1
  • 5
    • 39149104311 scopus 로고    scopus 로고
    • Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis
    • Marra F, Gastaldelli A, Svegliati Baroni G, Tell G and Tiribelli C: Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis. Trends Mol Med 4: 72-81, 2008.
    • (2008) Trends Mol Med , vol.4 , pp. 72-81
    • Marra, F.1    Gastaldelli, A.2    Baroni, G.S.3    Tell, G.4    Tiribelli, C.5
  • 6
    • 34247863931 scopus 로고    scopus 로고
    • Abnormal lipid and glucose metabolism in obesity: Implications for nonalcoholic fatty liver disease
    • Parekh S and Anania FA: Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease. Gastroenterology 132: 2191-2207, 2007.
    • (2007) Gastroenterology , vol.132 , pp. 2191-2207
    • Parekh, S.1    Anania, F.A.2
  • 8
    • 65949090538 scopus 로고    scopus 로고
    • Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes
    • Ricchi M, Odoardi MR, Carulli L, et al: Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol 24: 830-840, 2009.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 830-840
    • Ricchi, M.1    Odoardi, M.R.2    Carulli, L.3
  • 9
    • 13344285343 scopus 로고    scopus 로고
    • Mammalian AMP-activated protein kinase subfamily
    • Stapleton D, Mitchelhill KI, Gao G, et al: Mammalian AMP-activated protein kinase subfamily. J Biol Chem 271: 611-614, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 611-614
    • Stapleton, D.1    Mitchelhill, K.I.2    Gao, G.3
  • 10
    • 39049105534 scopus 로고    scopus 로고
    • AMP activated protein kinase: A next generation target for total metabolic control
    • Misra P: AMP activated protein kinase: a next generation target for total metabolic control. Expert Opin Ther Targets 12: 91-100, 2008.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 91-100
    • Misra, P.1
  • 11
    • 36849061190 scopus 로고    scopus 로고
    • Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders
    • Viollet B, Mounier R, Leclerc J, Yazigi A, Foretz M and Andreelli F: Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders. Diabetes Metab 33: 395-402, 2007.
    • (2007) Diabetes Metab , vol.33 , pp. 395-402
    • Viollet, B.1    Mounier, R.2    Leclerc, J.3    Yazigi, A.4    Foretz, M.5    Andreelli, F.6
  • 13
    • 0842291449 scopus 로고    scopus 로고
    • Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats
    • Park JC, Hur JM, Park JG, Kim SC, Park JR, Choi SH and Choi JW: Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats. Phytother Res 18: 19-24, 2004.
    • (2004) Phytother Res , vol.18 , pp. 19-24
    • Park, J.C.1    Hur, J.M.2    Park, J.G.3    Kim, S.C.4    Park, J.R.5    Choi, S.H.6    Choi, J.W.7
  • 15
    • 4344582117 scopus 로고    scopus 로고
    • Epidemiology of nonalcoholic fatty liver
    • Ruhl CE and Everhart JE: Epidemiology of nonalcoholic fatty liver. Clin Liver Dis 8: 501-519, 2004.
    • (2004) Clin Liver Dis , vol.8 , pp. 501-519
    • Ruhl, C.E.1    Everhart, J.E.2
  • 16
    • 79955993481 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase and adiponectin during development of hepatic steatosis in high-fat diet-induced obesity in rats
    • Ha SK, Kim J and Chae C: Role of AMP-activated protein kinase and adiponectin during development of hepatic steatosis in high-fat diet-induced obesity in rats. J Comp Pathol 145: 88-94, 2011.
    • (2011) J Comp Pathol , vol.145 , pp. 88-94
    • Ha, S.K.1    Kim, J.2    Chae, C.3
  • 18
    • 33745196745 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase in the liver: A new strategy for the management of metabolic hepatic disorders
    • Viollet B, Foretz M, Guigas B, et al: Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol 574: 41-53, 2006.
    • (2006) J Physiol , vol.574 , pp. 41-53
    • Viollet, B.1    Foretz, M.2    Guigas, B.3
  • 19
    • 29244436681 scopus 로고    scopus 로고
    • AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1
    • Lee WJ, Kim M, Park HS, et al: AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. Biochem Biophys Res Commun 340: 291-295, 2006.
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 291-295
    • Lee, W.J.1    Kim, M.2    Park, H.S.3
  • 20
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z, et al: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127: 1109-1122, 2006.
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 21
    • 84883154801 scopus 로고    scopus 로고
    • Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway
    • Wang ZQ, Zhang XH, Yu Y, et al: Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway. Metabolism 62: 1239-1249, 2013.
    • (2013) Metabolism , vol.62 , pp. 1239-1249
    • Wang, Z.Q.1    Zhang, X.H.2    Yu, Y.3
  • 22
    • 84875700893 scopus 로고    scopus 로고
    • Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway
    • Quan HY, Kim do Y, Kim SJ, Jo HK, Kim GW and Chung SH: Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway. Biochem Pharmacol 85: 1330-1340, 2013.
    • (2013) Biochem Pharmacol , vol.85 , pp. 1330-1340
    • Quan, H.Y.1    Kim, Y.2    Kim, S.J.3    Jo, H.K.4    Kim, G.W.5    Chung, S.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.