Purinergic signaling via P2Y receptors up-mediates IL-6 production by liver macrophages/Kupffer cells

Journal of Toxicological Sciences

Volumn 39, Issue 3, 2014, Pages 413-423

  Ishimaru, Makiko ^a   Yusuke, Negishi ^a   Tsukimoto, Mitsutoshi ^a   Harada, Hitoshi ^b   Takenouchi, Takato ^c   Kitani, Hiroshi ^c   Kojima, Shuji ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b Suzyka University of Medical Science   (Japan)

^c NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

Author keywords

Hepatitis; IL 6 production; Kupffer cells; P2Y receptors; Purinergic signaling

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALKALINE PHOSPHATASE; APYRASE; ECTO 5' NUCLEOTIDASE; INTERLEUKIN 6; MRS 2211; PURINERGIC P2 RECEPTOR ANTAGONIST; PURINERGIC P2Y RECEPTOR; SURAMIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; IMMUNOBLOTTING; KUPFFER CELL; MACROPHAGE; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; AZO COMPOUNDS; CELLS, CULTURED; DRUG DISCOVERY; HEPATITIS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; KUPFFER CELLS; LIPOPOLYSACCHARIDES; LIVER; MACROPHAGES; MICE, INBRED C57BL; MOLECULAR TARGETED THERAPY; PURINERGIC P2Y RECEPTOR AGONISTS; PURINERGIC P2Y RECEPTOR ANTAGONISTS; PYRIDOXAL PHOSPHATE; RECEPTORS, PURINERGIC P2Y; SIGNAL TRANSDUCTION; SURAMIN; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84901359142     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.39.413     Document Type: Article

References (41)

1. Al-Tuwaijri, A., Akdamar, K. and Di luzio, N.R. (1981): Modification of galactosamine-induced liver injury in rats by reticuloendothelial system stimulation or depression. Heptology, 1, 107-113.
2. Abbracchio, M.P., Burnstock, G., Boeynaems, L.M., Oeynaems, J.M., Barnard, E.A., Boyer, J.L., Kenndy, C., Knight, G.E., Fumagalli, M., Gachet, C., Jacobson, K.A. and Weisman, G.A. (2006): International Union of Pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol. Rev., 58, 281-341.
3. Ayata, C.K., Ganal, S.C., Hockenjos, B., Willim, K., Vieira, R.P., Grimm, M., Robaye, B., Boeynaems, J.M., Di Virgilio, F., Pellegatti, P., Diefenbach, A., Idzko, M. and Hasselblatt, P. (2012): Purinergic P2Y2 receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury. Gastroenterol., 143, 1620-1629. e4.
4. Barton, B.E. and Jakcson, J.V. (1992): Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model. Infect. Immun., 61, 1496-1499.
5. Beldi, G., Wu, Y., Sun, X., Imai, M., Enjyoji, K., Csizmadia, E., Candinas, D., Erb, L. and Robson, S.C. (2008): Regulated catalysis of extracellular nucleotides by vascular CD39/ENTPD1 is required for liver regeneration. Gastroenterol., 135, 1751-1760.
6. Beldi, G., Banz, Y., Kroemer, A., Sun, X., Wu, Y., Graubardt, N., Rellstab, A., Nowak, M., Enjyoji, K., Li, X., Junger, W.G., Candinas, D., Simon, C. and Robson, S.C. (2010): Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice. Hepatol., 51, 1702-1711.
7. Blazka, M.E., Wilmer, J.L., Holladay, S.D., Wilson, R.E. and Luster, M.I. (1995): Role of pro-inflammatory cytokines in acetaminophen hepatotoxicity. Toxicol. Appl. Pharmcol., 133, 43-52.
8. Burnstock, G. (1997): The past, present and future of purine nucleotides as signalling molecules. Neuropharmacology, 36, 1127-1139.
9. Communi, D., Govaerts, C., Parmentier, M. and Boeynaems, J.M. (1997): Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J. Biol. Chem., 272, 31969-31973.
10. Corriden, R. and Insel, P.A. (2010): Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci. Signal., 3, re1.
11. Czaja, M.J., Xu, J. and Alt, E. (1995): Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor. Gastroenterology, 108, 1849-1854.
12. Feder, L.S., Todaro, J.A. and Laskin, D.L. (1992): Characterization of interleukin-1 and interleukin-6 production by hepatic endothelial cells and macrophages. J. Leuco. Biol., 53, 126-132.
13. Fitz, J.G. (2007): Regulation of cellular ATP release. Trans. Am. Clin. Climatol. Assoc., 118, 199-208.
14. Hart, M.L., Gorzolla, L.C., Schittenhelm, J., Robson, S.C. and Eltzschig, H.K. (2010): SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning. J. Immunol., 184, 4017-4024.
15. Hisadome, K., Koyama, T., Kimura, C., Droogmans, G., Ito, Y. and Oike, M. (2002): Volume-regulated anion channels serve as an auto/paracrine nucleotide release pathway in aortic endothelial cells. J. Gen. Physiol., 119, 511-520.
16. Ishimaru, M., Tsukimoto, M., Harada, H. and Kojima, S. (2013): Involvement of P2Y11 receptor in IFN-γ-induced IL-6 production in human keratinocytes. Eur. J. Pharmacol., 703, 67-73.
17. Kitani, H., Takenouchi, T., Sato, M., Yoshioka, M. and Yamanaka, N. (2011): A simple and efficient method to isolate macrophages from mixed primary cultures of adult liver cells. J. Vis. Exp., 51.
18. Kawano, A., Tsukimoto, M., Mori, D., Noguchi, H., Harada, H., Takenouch, T., Kitani, H. and Kojima, S. (2012): Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages. Biochem. Biophys. Res. Commun., 420, 102-107.
19. Kolios, G., Valatas, V. and Kouroumalis, E. (2006): Role of Kupffer cells in the pathogenesis of liver disease. World J. Gastroenterol., 12, 7413-7420.
20. Laskin, D.L. and Pilaro, A.M. (1986): Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation. Toxicol. Appl. Pharmacol., 86, 216-226.
21. Laskin, D.L., Robertson, F.M., Pilaro, A.M. and Laskin, J.D. (1988): Activation of liver macrophages following phenobarbital treatment of rats. Hepatology, 8, 1051-1056.
22. Marteau, F., Le Poul, E., Communi, D., Communi, D., Labouret, C., Savi, P., Boeynaems, J.M. and Gonzalez, N.S. (2003): Pharmacological characterization of the human P2Y13 receptor. Mol. Pharmacol., 64, 104-112.
23. McCloskey, T.W., Todaro, J.A. and Laskin, D.L. (1992): Lipopolysaccharide treatment of rats alters antigen expression and oxidative metabolism in hepatic macrophages and endothelial cells. Hepatology, 16, 191-203.
24. Mule, J.J., Custer, M.C., Travis, W.D. and Rosenberg, S.A. (1992): Cellular mechanisms of the anti-tumor activity of recombinant IL-6 in mice. J. Immunol., 148, 2622-2629.
25. Ohshima, Y., Tsukimoto, M., Takenouchi, T., Harada, H., Suzuki, A., Sato, M., Kitani, H. and Kojima, S. (2010): Gamma-Irradiation induces P2X(7) receptor-dependent ATP release from B16 melanoma cells. Biochim. Biophys. Acta, 1800, 40-46.
26. Pellegatti, P., Falzoni, S., Pinton, P., Rizzuto, R. and Di Virgilio, R.F. (2005): A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion. Mol. Biol. Cell., 16, 3659-3665.
27. Pankratov, Y., Lalo, U., Verkhratsky, A. and North, R.A. (2006): Vesicular release of ATP at centyral synapses. Pflugers Arch., 452, 589-597.
28. Pilaro, A.M. and Laskin, D.L. (1986): Accumulation of activated mononuclear phagocytes in the liver following lipopolysaccharide treatment of rats. J. Leukoc. Biol., 40, 39-41.
29. Ramsay, A.J., Husband, A.J., Ramshaw, I.A., Bao S., Matthaei, K.I., Koehler, G. and Kopt, M. (1994): The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science, 264, 561-563.
30. Ruzek, M.C., Miller, A.H., Opal, S.M., Pearce, B.D. and Biron, C.A. (1997): Characterization of early cytokine responses and an interleukin (IL)-6-dependent pathway of endogenous glucocorticoid induction during murine cytomegalovirus infection. J. Exp. Med., 185, 1185-1192.
31. Sakaki, H., Tsukimoto, M., Harada, H., Moriyama, Y. and Kojima, S. (2013a): Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor. PLOS ONE 8, e59778.
32. Sakaki, H., Fijiwaki, T., Tsukimoto, M., Kawano, A., Harada, H. and Kojima, S. (2013b): P2X4receptor regulates P2X7 receptor-dependent IL-1β and IL-18 release in mouse bone marrow-derived dendritic cells. Biochem. Biophys. Res. Commun., 432, 406-411.
33. Sawada, K., Echigo, N., Juge, N., Miyaji, T., Otsuka, M., Omote, H., Yamamoto, A. and Moriyama, Y. (2008): Identification of a vesicular nucleotide transporter. Proc. Natl. Acad. Sci. USA, 105, 5683-5686.
34. Shiratori, Y., Tanaka, M., Hai, K., Kawase, T., Shiina, S. and Sugimoto, T. (1990): Role of endotoxin-responsive macrophages in hepatic injury. Hepatology, 11, 183-192.
35. Sprague, R.S., Ellsworth, M.L., Stephenson, A.H., Kleinhenz, M.E. and Lonigro, A.L. (1998): Deformation-induced ATP release from red blood cells requires CFTR activity. Am. J. Physiol.,275, 1726-1732.
36. Stenger, R.J., Petrelli, M., McPath, D.C.P., Segel, A., Williamson, J.N. and Johnson, E.A. (1969): Modification of carbon tetrachrolide hepatotoxicity by prior loading of the reticuloendothelial system with carbon particles. Am. J. Pathol., 57, 689-697.
37. Stout, C.E., Costantin, J.L., Naus, C.C. and Charles, A.C. (2002): Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. J. Biol. Chem., 277, 10482-10488.
38. Sun, X., Imai, M., Nowak-Machen, M., Guckelberger, O., Enjyoji, K., Wu, Y., Khalpey, Z., Berberat, P., Munasighe, J. and Robson, S.C. (2011): Liver damage and systemic inflammatory responses are exacerbated by the genetic deletion of CD39 in total hepatic ischemia. Purinergic. Signal., 7, 427-434.
39. Vaughn, B.P., Robson, S.C. and Burnstock, G. (2012): Pathological roles of purinergic signaling in the liver. J. Hepatol., 57, 916-920.
40. Xing, Z., Braciak, T., Jordana, M., Croitoru, K., Graham, F.L. and Gauldie, J. (1994): Adenovirus-mediated cytokine gene transfer at tissue sites: overexpression of IL-6 induces lymphocytic hyperplasia in the lung. J. Immunol., 153, 4059-4069.
41. Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X.F. and Achong, M.K. (1998): IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J. Clin. Invest., 101, 311-320.