ADHD diagnosis may influence the association between polymorphisms in nicotinic acetylcholine receptor genes and tobacco smoking

NeuroMolecular Medicine

Volumn 16, Issue 2, 2014, Pages 389-397

  Polina, Evelise R ^a   Rovaris, Diego L ^a   De Azeredo, Lucas A ^a   Mota, Nina R ^a   Vitola, Eduardo S ^b   Silva, Katiane L ^b   Guimarães Da Silva, Paula O ^b   Picon, Felipe A ^b   Belmonte De Abreu, Paulo ^a,b   Rohde, Luis A ^a,b   Grevet, Eugenio H ^a,b   Bau, Claiton H D ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Addiction; Attention; Comorbidity; Genetics; Hyperactivity; Nicotine

Indexed keywords

ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; CHRNA3 GENE; CHRNA5 GENE; CHRNB4 GENE; CONTROLLED STUDY; FEMALE; GENE CLUSTER; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HEALTH STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECEPTOR GENE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; ALLELE; BRAZIL; CASE CONTROL STUDY; EPIDEMIOLOGY; ETHNOLOGY; EUROPE; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; NUCLEOTIDE SEQUENCE; RISK; YOUNG ADULT;

CHRNA5 PROTEIN, HUMAN; CHRNB4 PROTEIN, HUMAN; NERVE PROTEIN; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR SUBUNIT ALPHA3;

ADULT; ALLELES; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAZIL; CASE-CONTROL STUDIES; DNA MUTATIONAL ANALYSIS; EUROPE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, NICOTINIC; RISK; SMOKING; YOUNG ADULT;

EID: 84901334533     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-013-8286-2     Document Type: Article

References (55)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington: American Psychiatric Press.
2. Aubin, H. J., Rollema, H., Svensson, T. H., & Winterer, G. (2012). Smoking, quitting, and psychiatric disease: A review. Neuroscience and Biobehavioral Reviews, 36(1), 271-284.
3. Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2005). Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics, 21(2), 263-265.
4. Bidwell, L. C., Garrett, M. E., McClernon, F. J., Fuemmeler, B. F., Williams, R. B., Ashley-Koch, A. E., et al. (2012). A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults. Nicotine and Tobacco Research, 14(2), 229-233.
5. Bierut, L. J., Stitzel, J. A., Wang, J. C., Hinrichs, A. L., Grucza, R. A., Xuei, X., et al. (2008). Variants in nicotinic receptors and risk for nicotine dependence. American Journal of Psychiatry, 165(9), 1163-1171.
6. Broms, U., Wedenoja, J., Largeau, M. R., Korhonen, T., Pitkaniemi, J., Keskitalo-Vuokko, K., et al. (2012). Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. Nicotine and Tobacco Research, 14(6), 720-733.
7. Bukstein, O. G. (2012). Attention deficit hyperactivity disorder and substance use disorders. Current Topics in Behavioral Neurosciences, 9, 145-172.
8. Chen, X., Chen, J., Williamson, V. S., An, S. S., Hettema, J. M., Aggen, S. H., et al. (2009). Variants in nicotinic acetylcholine receptors α5 and α3 increase risks to nicotine dependence. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 150B(7), 926-933.
9. David, S. P., Hamidovic, A., Chen, G. K., Bergen, A. W., Wessel, J., Kasberger, J. L., et al. (2012). Genome-wide meta-analyses of smoking behaviors in African Americans. Translational Psychiatry, 2, e119.
10. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2002). Structured clinical interview for DSM-IV-TR axis I disorders, research version, patient edition (SCID-I/P). New York: Biometrics Research.
11. Freathy, R. M., Ring, S. M., Shields, B., Galobardes, B., Knight, B., Weedon, M. N., et al. (2009). A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Human Molecular Genetics, 18(15), 2922-2927.
12. Furberg, H., Kim, Y., Dackor, J., Boerwinkle, E., Franceschini, N., Ardissino, D., et al. (2010). Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nature Genetics, 42(5), 441-447.
13. Glass, K., & Flory, K. (2010). Why does ADHD confer risk for cigarette smoking? A review of psychosocial mechanisms. Clinical Child and Family Psychology Review, 13(3), 291-313.
14. Gotti, C., & Clementi, F. (2004). Neuronal nicotinic receptors: From structure to pathology. Progress in Neurobiology, 74(6), 363-396.
15. Gotti, C., Clementi, F., Fornari, A., Gaimarri, A., Guiducci, S., Manfredi, I., et al. (2009). Structural and functional diversity of native brain neuronal nicotinic receptors. Biochemical Pharmacology, 78(7), 703-711.
16. Gould, T.J., Leach, P.T. (2013). Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning. Neurobiology of Learning and Memory, doi: 10.1016/j.nlm.2013.08.004.
17. Grevet, E. H., Bau, C. H., Salgado, C. A., Ficher, A., Victor, M. M., Garcia, C., et al. (2005). Interrater reliability for diagnosis in adults of attention deficit hyperactivity disorder and oppositional defiant disorder using K-SADS-E. Arquivos de Neuro-Psiquiatria, 63(2A), 307-310.
18. Grucza, R. A., Wang, J. C., Stitzel, J. A., Hinrichs, A. L., Saccone, S. F., Saccone, N. L., et al. (2008). A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Biological Psychiatry, 64(11), 922-929.
19. Heatherton, T. F., Kozlowski, L. T., Frecker, R. C., & Fagerstrom, K. O. (1991). The Fagerstrom test for nicotine dependence: A revision of the Fagerstrom tolerance Questionnaire. British Journal of Addiction, 86(9), 1119-1127.
20. Hindorff, L. A., MacArthur, J., Morales, J., Junkins, H. A., Hall, P. N., Klemm, A. K., & Manolio, T. A. (2013, May). A catalog of published genome-wide association studies. www.genome.gov/gwastudies. Accessed 9 May 2013.
21. Hutchison, K. E., Stallings, M., McGeary, J., & Bryan, A. (2004). Population stratification in the candidate gene study: Fatal threat or red herring? Psychological Bulletin, 130(1), 66-79.
22. Kalil, K. L., Bau, C. H., Grevet, E. H., Sousa, N. O., Garcia, C. R., Victor, M. M., et al. (2008). Smoking is associated with lower performance in WAIS-R Block Design scores in adults with ADHD. Nicotine and Tobacco Research, 10(4), 683-688.
23. Kapoor, M., Wang, J. C., Bertelsen, S., Bucholz, K., Budde, J. P., Hinrichs, A., et al. (2012). Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. PLoS One, 7(3), e33513.
24. Kessler, R. C., Adler, L., Ames, M., Demler, O., Faraone, S., Hiripi, E., et al. (2005). The World Health Organization adult ADHD Self-Report Scale (ASRS): A short screening scale for use in the general population. Psychological Medicine, 35(2), 245-256.
25. Lahiri, D. K., & Nurnberger, J. I, Jr. (1991). A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Research, 19(19), 5444.
26. Lee, C. T., Fuemmeler, B. F., McClernon, F. J., Ashley-Koch, A., & Kollins, S. H. (2013). Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood. Addictive Behaviors, 38(11), 2683-2689.
27. Liu, J. Z., Tozzi, F., Waterworth, D. M., Pillai, S. G., Muglia, P., Middleton, L., et al. (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nature Genetics, 42(5), 436-440.
28. Marques-Vidal, P., Kutalik, Z., Paccaud, F., Bergmann, S., Waeber, G., Vollenweider, P., et al. (2011). Variant within the promoter region of the CHRNA3 gene associated with FTN dependence is not related to self-reported willingness to quit smoking. Nicotine and Tobacco Research, 13(9), 833-839.
29. Martin-Soelch, C. (2013). Neuroadaptive changes associated with smoking: Structural and functional neural changes in nicotine dependence. Brain Sciences, 3, 159-176.
30. Mayhew, K. P., Flay, B. R., & Mott, J. A. (2000). Stages in the development of adolescent smoking. Drug and Alcohol Dependence, 59(Suppl 1), S61-S81.
31. McClernon, F. J., Fuemmeler, B. F., Kollins, S. H., Kail, M. E., & Ashley-Koch, A. E. (2008). Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults. Nicotine and Tobacco Research, 10(1), 117-127.
32. McClernon, F. J., & Kollins, S. H. (2008). ADHD and smoking: From genes to brain to behavior. Annals of the New York Academy of Sciences, 1141, 131-147.
33. Mercadante, M. T., Asbahar, F., Rosário, M. C., Ayres, A. M., Karman, L., Ferrari, M. C., et al. (1995). K-SADS, entrevista semi-estruturada para diagnóstico em psiquiatria da infância, versão epidemiológica. São Paulo: FMUSP.
34. Mihailescu, S., & Drucker-Colin, R. (2000). Nicotine, brain nicotinic receptors, and neuropsychiatric disorders. Archives of Medical Research, 31(2), 131-144.
35. Mitchell, J.T., McIntyre, E.M., McClernon, F.J., Kollins, S.H. (2013). Smoking motivation in adults with attention-deficit/hyperactivity disorder using the Wisconsin inventory of smoking dependence motives. Nicotine and Tobacco Research, doi: 10.1093/ntr/ntt144.
36. Morisano, D., Bacher, I., Audrain-McGovern, J., & George, T. P. (2009). Mechanisms underlying the comorbidity of tobacco use in mental health and addictive disorders. Canadian Journal of Psychiatry, 54(6), 356-367.
37. Potter, A. S., Newhouse, P. A., & Bucci, D. J. (2006). Central nicotinic cholinergic systems: A role in the cognitive dysfunction in attention-deficit/hyperactivity disorder? Behavioural Brain Research, 175(2), 201-211.
38. Saccone, N. L., Saccone, S. F., Hinrichs, A. L., Stitzel, J. A., Duan, W., Pergadia, M. L., et al. (2009a). Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 150B(4), 453-466.
39. Saccone, N. L., Wang, J. C., Breslau, N., Johnson, E. O., Hatsukami, D., Saccone, S. F., et al. (2009b). The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Research, 69(17), 6848-6856.
40. Salzano, F. M., & Bortolini, M. C. (2002). The evolution and genetics of Latin American populations. Cambridge: Cambridge University Press.
41. Santos, N. P., Ribeiro-Rodrigues, E. M., Ribeiro-Dos-Santos, A. K., Pereira, R., Gusmao, L., Amorim, A., et al. (2010). Assessing individual interethnic admixture and population substructure using a 48-insertion-deletion (INSEL) ancestry-informative marker (AIM) panel. Human Mutation, 31(2), 184-190.
42. Sarginson, J. E., Killen, J. D., Lazzeroni, L. C., Fortmann, S. P., Ryan, H. S., Schatzberg, A. F., et al. (2011). Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 156B(3), 275-284.
43. Schlaepfer, I. R., Hoft, N. R., Collins, A. C., Corley, R. P., Hewitt, J. K., Hopfer, C. J., et al. (2008). The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. Biological Psychiatry, 63(11), 1039-1046.
44. Sherva, R., Kranzler, H. R., Yu, Y., Logue, M. W., Poling, J., Arias, A. J., et al. (2010). Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. Neuropsychopharmacology, 35(9), 1921-1931.
45. Sousa, N. O., Grevet, E. H., Salgado, C. A., Silva, K. L., Victor, M. M., Karam, R. G., et al. (2011). Smoking and ADHD: An evaluation of self medication and behavioral disinhibition models based on comorbidity and personality patterns. Journal of Psychiatric Research, 45(6), 829-834.
46. Stevens, V. L., Bierut, L. J., Talbot, J. T., Wang, J. C., Sun, J., Hinrichs, A. L., et al. (2008). Nicotinic receptor gene variants influence susceptibility to heavy smoking. Cancer Epidemiol Biomarkers and Prevention, 17(12), 3517-3525.
47. Thorgeirsson, T. E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K. P., et al. (2008). A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature, 452(7187), 638-642.
48. Thorgeirsson, T. E., Gudbjartsson, D. F., Surakka, I., Vink, J. M., Amin, N., Geller, F., et al. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature Genetics, 42(5), 448-453.
49. Van Voorhees, E., McClernon, F. J., Fuemmeler, B., English, J., Holdaway, A., Hallyburton, M., et al. (2012). An examination of differences in variables maintaining smoking behavior in adult smokers with and without attention-deficit/hyperactivity disorder. Addiction Research and Theory, 20(1), 72-81.
50. Volkow, N. D., Wang, G. J., Newcorn, J., Telang, F., Solanto, M. V., Fowler, J. S., et al. (2007). Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/ hyperactivity disorder. Archives of General Psychiatry, 64(8), 932-940.
51. Wang, J. C., Grucza, R., Cruchaga, C., Hinrichs, A. L., Bertelsen, S., Budde, J. P., et al. (2009). Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Molecular Psychiatry, 14(5), 501-510.
52. Wang, G. J., Volkow, N. D., Wigal, T., Kollins, S. H., Newcorn, J. H., Telang, F., et al. (2013). Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder. PLoS One, 8(5), e63023.
53. Weiss, R. B., Baker, T. B., Cannon, D. S., von Niederhausern, A., Dunn, D. M., Matsunami, N., et al. (2008). A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genetics, 4(7), e1000125.
54. Wellman, R. J., DiFranza, J. R., Savageau, J. A., & Dussault, G. F. (2004). Short term patterns of early smoking acquisition. Tobacco Control, 13(3), 251-257.
55. Zembrzuski, V. M., Callegari-Jacques, S. M., & Hutz, M. H. (2006). Application of an African ancestry index as a genomic control approach in a Brazilian population. Annals of Human Genetics, 70(Pt 6), 822-828.