Blocking NMDA receptors delays death in rats with acute liver failure by dual protective mechanisms in kidney and brain

NeuroMolecular Medicine

Volumn 16, Issue 2, 2014, Pages 360-375

  Cauli, Omar ^a,h   González Usano, Alba ^a   Cabrera Pastor, Andrea ^a   Gimenez Garzó, Carla ^a   López Larrubia, Pilar ^b   Ruiz Sauri, Amparo ^c   Hernández Rabaza, Vicente ^a   Duszczyk, Malgorzata ^d   Malek, Michal ^d   Lazarewicz, Jerzy W ^d   Carratalá, Arturo ^e   Urios, Amparo ^f   Miguel, Alfonso ^g   Torregrosa, Isidro ^g   Carda, Carmen ^c   Montoliu, Carmina ^f   Felipo, Vicente ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

^d MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^e University Hospital   (Spain)

^f INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

^g HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^h UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Acute liver failure; Blood flow; Glomerular filtration rate; Hyperammonemia; Intracranial pressure; NMDA receptor; Tubular injury

Indexed keywords

ALANINE AMINOTRANSFERASE; AMMONIA; ASPARTATE AMINOTRANSFERASE; BICARBONATE; CREATININE; DIZOCILPINE; GLUTAMINE; LACTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POTASSIUM; SODIUM; UREA; AMINO ACID RECEPTOR BLOCKING AGENT; DIZOCILPINE MALEATE; GALACTOSAMINE; INULIN; LACTIC ACID DERIVATIVE;

ACUTE LIVER FAILURE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMMONIA BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BICARBONATE BLOOD LEVEL; BLOOD BRAIN BARRIER; BLOOD PRESSURE; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN LEVEL; BRAIN PROTECTION; BRAIN TEMPERATURE; CONTROLLED STUDY; CREATININE CLEARANCE; DEATH; DISEASE COURSE; GLOMERULUS FILTRATION RATE; IN VIVO STUDY; INTRACRANIAL PRESSURE; INULIN CLEARANCE; KIDNEY TUBULE DAMAGE; MALE; MEMBRANE PERMEABILITY; MUSCLE LEVEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RENAL PROTECTION; SODIUM BLOOD LEVEL; UREA BLOOD LEVEL; URINE LEVEL; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; BODY TEMPERATURE; BRAIN; BRAIN CIRCULATION; CHEMICALLY INDUCED; COMPLICATION; DIAGNOSTIC USE; DRUG EFFECTS; DRUG SCREENING; HEPATIC ENCEPHALOPATHY; HYPERAMMONEMIA; INTRACRANIAL HYPERTENSION; KIDNEY; LIVER FAILURE; LIVER REGENERATION; METABOLISM; PATHOLOGY; TIME; TOXICITY; WISTAR RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BODY TEMPERATURE; BRAIN; BRAIN EDEMA; CEREBROVASCULAR CIRCULATION; DISEASE PROGRESSION; DIZOCILPINE MALEATE; DRUG EVALUATION, PRECLINICAL; EXCITATORY AMINO ACID ANTAGONISTS; GALACTOSAMINE; GLOMERULAR FILTRATION RATE; HEPATIC ENCEPHALOPATHY; HYPERAMMONEMIA; INTRACRANIAL HYPERTENSION; INULIN; KIDNEY; LACTATES; LIVER FAILURE; LIVER REGENERATION; MALE; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS;

EID: 84901330976     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-013-8283-5     Document Type: Article

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