Brain edema in acute liver failure

Indian Journal of Gastroenterology

Volumn 22, Issue SUPPL. 2, 2003, Pages

  Butterworth, R F ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Astrocytes; Hypothermia; L ornithine L aspartate

Indexed keywords

AMMONIA; AQUAPORIN 4; BRANCHED CHAIN AMINO ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; GLUTAMINE; LACTULOSE; MANNITOL; NEOMYCIN; ORNITHINE ASPARTATE; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1;

BRAIN EDEMA; CLINICAL TRIAL; CONFERENCE PAPER; DRUG EFFECT; GENE EXPRESSION; HUMAN; INDUCED HYPOTHERMIA; INTRACRANIAL HYPERTENSION; LIVER FAILURE; NEUROCHEMISTRY; NEUROPATHOLOGY; NONHUMAN; OSMOSIS;

AMMONIA; ANIMALS; ASTROCYTES; BRAIN EDEMA; DIPEPTIDES; HUMANS; HYPOTHERMIA, INDUCED; INTRACRANIAL PRESSURE; LIVER FAILURE, ACUTE;

EID: 1442338658     PISSN: 02548860     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (15)

1. Swain M, Butterworth RF, Blei AT. Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats. Hepatology 1992;15:449-53.
2. Swain MS, Bergeron M, Audet R, Blei AT, Butterworth RF. Monitoring of neurotransmitter amino acids by means of an indwelling cisterna magna catheter. A comparison of two rodent models of fulminant hepatic failure. Hepatology 1992;16:1028-35.
3. Clemmensen JO, Larsen FS, Kondrup J, Hansen BA, Ott P. Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology 1999;29:648-53.
4. Dejong CH, Deutz NE, Soeters PB. Cerebral cortex ammonia and glutamine metabolism in two rat models of chronic liver insufficiency-induced hyperammonemia: influence of pair-feeding. J Neurochem 1993;60:1047-57.
5. Bates TE, Williams SR, Kauppinen RA, Godian DG. Observation of cerebral metabolites in an animal model of acute liver failure in vivo: 1H and 31P nuclear magnetic resonance study. J Neurochem 1989;53:102-10.
6. Deutz NEP, Dejong CHC, Soeters PB. Interorgan ammonia and glutamine exchange during liver failure. In: Record C, Al-Mardini H, Eds. Advances in Hepatic Encephalopathy and Metabolism in Liver Disease. Ipswich Book Co. 1997: p. 87-99.
7. Cordoba J, Blei AT. Brain edema and hepatic encephalopathy. Semin Liver Dis 1996;16:271-80.
8. Knecht K, Michalak A, Rose C, Rothstein JD, Butterworth RF. Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure. Neurosci Lett 1997;229:201-3.
9. Desjardins P, Chan H, Bélanger M, Butterworth RF. Loss of expression of glial fibrillary acidic protein (GFAP) in astrocytes predicts brain edema in experimental acute liver failure (Abstract). Hepatology 2000;32(Suppl 1):298A.
10. Margulies, Thompson RC, Demetriou AA. Aquaporin-4 water channel is up-regulated in the brain in fulminant hepatic failure (Abstract). Hepatology 1999;30:395A.
11. Michalak A, Rose C, Butterworth J, Butterworth RF. Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure. Hepatology 1996;24:908-13.
12. Traber P, DalCanto M, Granger D, Blei AT. Effect of body temperature on brain edema and encephalopathy in the rat after hepatic devascularization. Gastroenterology 1989;96:888-91.
13. Rose C, Michalak A, Pannunzio M, Chatauret N, Rambaldi A, Butterworth RF. Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Hepatology 2000;31:872-7.
14. Jalan R, Olde Damink SWM, Deutz NEP, Lee A, Hayes PC. Moderate hypothermia for uncontrolled intracranial hypertension in acute liver failure. Lancet 1999;354:1164-8.
15. Rose C, Michalak A, Rama Rao KV, Quack G, Kircheis G, Butterworth, RF. L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure. Hepatology 1999;30:636-40.