Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo

Biochemical Pharmacology

Volumn 83, Issue 9, 2012, Pages 1278-1289

  Zhang, Chris Zhiyi ^a,b   Zhang, Haitao ^c   Yun, Jingping ^a   Chen, George Gong ^b   Lai, Paul Bo San ^b  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bak; Dihydroartemisinin; Hepatocellular carcinoma; Mcl 1

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN B; CYTOCHROME C; DIHYDROARTEMISININ; PROTEIN BAK; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN P21; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTEMISIA ANNUA; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MEMBRANE DEPOLARIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ARTEMISININS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CYTOCHROMES C; DRUG SCREENING ASSAYS, ANTITUMOR; GENES, P53; HUMANS; LIVER NEOPLASMS; MICE; MITOCHONDRIAL MEMBRANES; PROTO-ONCOGENE PROTEINS C-BCL-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84862804101     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.02.002     Document Type: Article

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