Human lung epithelial cells contain Mycobacterium tuberculosis in a late endosomal vacuole and are efficiently recognized by CD8+ T Cells

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Harriff, Melanie J ^a,b   Cansler, Meghan E ^b   Toren, Katelynne Gardner ^b   Canfield, Elizabeth T ^b   Kwak, Stephen ^b   Gold, Marielle C ^a,b   Lewinsohn, David M ^a,b  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HLA ANTIGEN CLASS 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; RAB7 PROTEIN; HLA B ANTIGEN; HLA-B45 ANTIGEN; HLA-E ANTIGEN; LAMP1 PROTEIN, HUMAN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; RAB PROTEIN;

ANTIGEN EXPRESSION; ARTICLE; BACTERIAL STRAIN; CD8+ T LYMPHOCYTE; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; ENDOSOME; ENZYME LINKED IMMUNOSPOT ASSAY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; TUBERCULOSIS; CELL LINE; COCULTURE; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; IMMUNOLOGY; MICROBIOLOGY; PATHOLOGY; PRIMARY CELL CULTURE; RESPIRATORY TRACT MUCOSA;

CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; COCULTURE TECHNIQUES; ENDOSOMES; EPITHELIAL CELLS; GENE EXPRESSION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-B ANTIGENS; HUMANS; INTERFERON-GAMMA; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MYCOBACTERIUM TUBERCULOSIS; PRIMARY CELL CULTURE; RAB GTP-BINDING PROTEINS; RESPIRATORY MUCOSA; VACUOLES;

EID: 84901312544     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097515     Document Type: Article

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