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Volumn 75, Issue 12, 2014, Pages 920-928

Peripheral biomarkers revisited: Integrative profiling of peripheral samples for psychiatric research

Author keywords

Biomarker; diagnostic support; functional assay; omics; peripheral sample; tailor made therapy

Indexed keywords

BIOLOGICAL MARKER; PROTEIN; PROTEOME; TRANSCRIPTOME;

EID: 84901304269     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.09.035     Document Type: Review
Times cited : (67)

References (86)
  • 1
    • 12144287672 scopus 로고    scopus 로고
    • Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions
    • J.Z. Li, M.P. Vawter, D.M. Walsh, H. Tomita, S.J. Evans, and P.V. Choudary et al. Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions Hum Mol Genet 13 2004 609 616
    • (2004) Hum Mol Genet , vol.13 , pp. 609-616
    • Li, J.Z.1    Vawter, M.P.2    Walsh, D.M.3    Tomita, H.4    Evans, S.J.5    Choudary, P.V.6
  • 2
    • 35848939420 scopus 로고    scopus 로고
    • Increased levels of glutamate in brains from patients with mood disorders
    • K. Hashimoto, A. Sawa, and M. Iyo Increased levels of glutamate in brains from patients with mood disorders Biol Psychiatry 62 2007 1310 1316
    • (2007) Biol Psychiatry , vol.62 , pp. 1310-1316
    • Hashimoto, K.1    Sawa, A.2    Iyo, M.3
  • 3
    • 79958260092 scopus 로고    scopus 로고
    • The human brain in a dish: The promise of iPSC-derived neurons
    • R. Dolmetsch, and D.H. Geschwind The human brain in a dish: The promise of iPSC-derived neurons Cell 145 2011 831 834
    • (2011) Cell , vol.145 , pp. 831-834
    • Dolmetsch, R.1    Geschwind, D.H.2
  • 5
    • 84863980709 scopus 로고    scopus 로고
    • Genetic architectures of psychiatric disorders: The emerging picture and its implications
    • P.F. Sullivan, M.J. Daly, and M. O'Donovan Genetic architectures of psychiatric disorders: The emerging picture and its implications Nat Rev Genet 13 2012 537 551
    • (2012) Nat Rev Genet , vol.13 , pp. 537-551
    • Sullivan, P.F.1    Daly, M.J.2    O'Donovan, M.3
  • 9
    • 84861227432 scopus 로고    scopus 로고
    • Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain
    • D.G. Hernandez, M.A. Nalls, M. Moore, S. Chong, A. Dillman, and D. Trabzuni et al. Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain Neurobiol Dis 47 2012 20 28
    • (2012) Neurobiol Dis , vol.47 , pp. 20-28
    • Hernandez, D.G.1    Nalls, M.A.2    Moore, M.3    Chong, S.4    Dillman, A.5    Trabzuni, D.6
  • 10
    • 81555207759 scopus 로고    scopus 로고
    • Gene expression studies in autism: Moving from the genome to the transcriptome and beyond
    • I. Voineagu Gene expression studies in autism: Moving from the genome to the transcriptome and beyond Neurobiol Dis 45 2012 69 75
    • (2012) Neurobiol Dis , vol.45 , pp. 69-75
    • Voineagu, I.1
  • 11
    • 84862210732 scopus 로고    scopus 로고
    • Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
    • M.N. Davies, M. Volta, R. Pidsley, K. Lunnon, A. Dixit, and S. Lovestone et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood Genome Biol 13 2012 R43
    • (2012) Genome Biol , vol.13 , pp. 43
    • Davies, M.N.1    Volta, M.2    Pidsley, R.3    Lunnon, K.4    Dixit, A.5    Lovestone, S.6
  • 13
    • 27344436234 scopus 로고    scopus 로고
    • Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia
    • S.J. Glatt, I.P. Everall, W.S. Kremen, J. Corbeil, R. Sasik, and N. Khanlou et al. Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia Proc Natl Acad Sci U S A 102 2005 15533 15538
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15533-15538
    • Glatt, S.J.1    Everall, I.P.2    Kremen, W.S.3    Corbeil, J.4    Sasik, R.5    Khanlou, N.6
  • 14
    • 0033659799 scopus 로고    scopus 로고
    • Cytokine and growth factor involvement in schizophrenia - Support for the developmental model
    • H. Nawa, M. Takahashi, and P.H. Patterson Cytokine and growth factor involvement in schizophrenia - support for the developmental model Mol Psychiatry 5 2000 594 603
    • (2000) Mol Psychiatry , vol.5 , pp. 594-603
    • Nawa, H.1    Takahashi, M.2    Patterson, P.H.3
  • 15
    • 70349794451 scopus 로고    scopus 로고
    • Immune proteins in brain development and synaptic plasticity
    • L.M. Boulanger Immune proteins in brain development and synaptic plasticity Neuron 64 2009 93 109
    • (2009) Neuron , vol.64 , pp. 93-109
    • Boulanger, L.M.1
  • 17
    • 41149152337 scopus 로고    scopus 로고
    • Glutamate mediates platelet activation through the AMPA receptor
    • C.N. Morrell, H. Sun, M. Ikeda, J.C. Beique, A.M. Swaim, and E. Mason et al. Glutamate mediates platelet activation through the AMPA receptor J Exp Med 205 2008 575 584
    • (2008) J Exp Med , vol.205 , pp. 575-584
    • Morrell, C.N.1    Sun, H.2    Ikeda, M.3    Beique, J.C.4    Swaim, A.M.5    Mason, E.6
  • 19
    • 0036430378 scopus 로고    scopus 로고
    • State-dependent alterations in mitochondrial complex i activity in platelets: A potential peripheral marker for schizophrenia
    • N. Dror, E. Klein, R. Karry, A. Sheinkman, Z. Kirsh, and M. Mazor et al. State-dependent alterations in mitochondrial complex I activity in platelets: A potential peripheral marker for schizophrenia Mol Psychiatry 7 2002 995 1001
    • (2002) Mol Psychiatry , vol.7 , pp. 995-1001
    • Dror, N.1    Klein, E.2    Karry, R.3    Sheinkman, A.4    Kirsh, Z.5    Mazor, M.6
  • 20
    • 33748592281 scopus 로고    scopus 로고
    • Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells
    • J.F. Padin, M.A. Rodriguez, E. Dominguez, I.G. Dopeso-Reyes, M. Buceta, and E. Cano et al. Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells Neuropharmacology 51 2006 923 932
    • (2006) Neuropharmacology , vol.51 , pp. 923-932
    • Padin, J.F.1    Rodriguez, M.A.2    Dominguez, E.3    Dopeso-Reyes, I.G.4    Buceta, M.5    Cano, E.6
  • 21
    • 79960096964 scopus 로고    scopus 로고
    • Exosomes: Secreted vesicles and intercellular communications
    • C. Thery Exosomes: Secreted vesicles and intercellular communications F1000 Biol Rep 3 2011 15
    • (2011) F1000 Biol Rep , vol.3 , pp. 15
    • Thery, C.1
  • 22
    • 0016907086 scopus 로고
    • Long-term lymphoid cell lines in the study of human genetics
    • P.R. Glade, and N.G. Beratis Long-term lymphoid cell lines in the study of human genetics Prog Med Genet 1 1976 1 48
    • (1976) Prog Med Genet , vol.1 , pp. 1-48
    • Glade, P.R.1    Beratis, N.G.2
  • 23
    • 33644905599 scopus 로고    scopus 로고
    • Epstein-Barr virus-induced transformation of B cells for the diagnosis of genetic metabolic disorders - Enumerative conditions for cryopreservation
    • A.S. Mello, M.G. Burin, K. Michellin, M. Viapiana, R. Giugliani, J.C. Coelho, and M.E. Bauer Epstein-Barr virus-induced transformation of B cells for the diagnosis of genetic metabolic disorders - enumerative conditions for cryopreservation Cell Prolif 39 2006 29 36
    • (2006) Cell Prolif , vol.39 , pp. 29-36
    • Mello, A.S.1    Burin, M.G.2    Michellin, K.3    Viapiana, M.4    Giugliani, R.5    Coelho, J.C.6    Bauer, M.E.7
  • 24
    • 61949186636 scopus 로고    scopus 로고
    • Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder
    • A. Hayashi, T. Kasahara, M. Kametani, T. Toyota, T. Yoshikawa, and T. Kato Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder Int J Neuropsychopharmacol 12 2009 33 43
    • (2009) Int J Neuropsychopharmacol , vol.12 , pp. 33-43
    • Hayashi, A.1    Kasahara, T.2    Kametani, M.3    Toyota, T.4    Yoshikawa, T.5    Kato, T.6
  • 25
    • 34247582298 scopus 로고    scopus 로고
    • Neuregulin1-induced cell migration is impaired in schizophrenia: Association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms
    • Y. Sei, R. Ren-Patterson, Z. Li, E.M. Tunbridge, M.F. Egan, B.S. Kolachana, and D.R. Weinberger Neuregulin1-induced cell migration is impaired in schizophrenia: Association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms Mol Psychiatry 12 2007 946 957
    • (2007) Mol Psychiatry , vol.12 , pp. 946-957
    • Sei, Y.1    Ren-Patterson, R.2    Li, Z.3    Tunbridge, E.M.4    Egan, M.F.5    Kolachana, B.S.6    Weinberger, D.R.7
  • 26
    • 0030292998 scopus 로고    scopus 로고
    • Cultured skin fibroblasts as a cell model for investigating schizophrenia
    • S.P. Mahadik, and S. Mukherjee Cultured skin fibroblasts as a cell model for investigating schizophrenia J Psychiatr Res 30 1996 421 439
    • (1996) J Psychiatr Res , vol.30 , pp. 421-439
    • Mahadik, S.P.1    Mukherjee, S.2
  • 27
    • 0025933086 scopus 로고
    • Changes in serine metabolism by a serum factor present in a group of episodic psychotic patients
    • D. Fekkes, L. Pepplinkhuizen, and J. Bruinvels Changes in serine metabolism by a serum factor present in a group of episodic psychotic patients Biol Psychiatry 30 1991 966 972
    • (1991) Biol Psychiatry , vol.30 , pp. 966-972
    • Fekkes, D.1    Pepplinkhuizen, L.2    Bruinvels, J.3
  • 28
    • 0022400685 scopus 로고
    • Peripheral models for the study of neurotransmitter receptors in man
    • S.M. Stahl Peripheral models for the study of neurotransmitter receptors in man Psychopharmacol Bull 21 1985 663 671
    • (1985) Psychopharmacol Bull , vol.21 , pp. 663-671
    • Stahl, S.M.1
  • 29
    • 0028345161 scopus 로고
    • Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
    • Q. Chen, and B.N. Ames Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells Proc Natl Acad Sci U S A 91 1994 4130 4134
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 4130-4134
    • Chen, Q.1    Ames, B.N.2
  • 32
    • 84882884517 scopus 로고    scopus 로고
    • Charting a dynamic DNA methylation landscape of the human genome
    • M.J. Ziller, H. Gu, F. Muller, J. Donaghey, L.T. Tsai, and O. Kohlbacher et al. Charting a dynamic DNA methylation landscape of the human genome Nature 500 2013 477 481
    • (2013) Nature , vol.500 , pp. 477-481
    • Ziller, M.J.1    Gu, H.2    Muller, F.3    Donaghey, J.4    Tsai, L.T.5    Kohlbacher, O.6
  • 33
    • 34249275353 scopus 로고    scopus 로고
    • Phenotypic plasticity and the epigenetics of human disease
    • A.P. Feinberg Phenotypic plasticity and the epigenetics of human disease Nature 447 2007 433 440
    • (2007) Nature , vol.447 , pp. 433-440
    • Feinberg, A.P.1
  • 35
    • 77953469917 scopus 로고    scopus 로고
    • Epigenetics as a unifying principle in the aetiology of complex traits and diseases
    • A. Petronis Epigenetics as a unifying principle in the aetiology of complex traits and diseases Nature 465 2010 721 727
    • (2010) Nature , vol.465 , pp. 721-727
    • Petronis, A.1
  • 36
    • 84880598197 scopus 로고    scopus 로고
    • DNA methylation in schizophrenia: Progress and challenges of epigenetic studies
    • M. Nishioka, M. Bundo, K. Kasai, and K. Iwamoto DNA methylation in schizophrenia: Progress and challenges of epigenetic studies Genome Med 4 2012 96
    • (2012) Genome Med , vol.4 , pp. 96
    • Nishioka, M.1    Bundo, M.2    Kasai, K.3    Iwamoto, K.4
  • 37
    • 81855183787 scopus 로고    scopus 로고
    • Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    • E.L. Dempster, R. Pidsley, L.C. Schalkwyk, S. Owens, A. Georgiades, and F. Kane et al. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder Hum Mol Genet 20 2011 4786 4796
    • (2011) Hum Mol Genet , vol.20 , pp. 4786-4796
    • Dempster, E.L.1    Pidsley, R.2    Schalkwyk, L.C.3    Owens, S.4    Georgiades, A.5    Kane, F.6
  • 38
    • 84862776228 scopus 로고    scopus 로고
    • A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder
    • Z. Kaminsky, M. Tochigi, P. Jia, M. Pal, J. Mill, and A. Kwan et al. A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder Mol Psychiatry 17 2012 728 740
    • (2012) Mol Psychiatry , vol.17 , pp. 728-740
    • Kaminsky, Z.1    Tochigi, M.2    Jia, P.3    Pal, M.4    Mill, J.5    Kwan, A.6
  • 39
    • 84861775810 scopus 로고    scopus 로고
    • Epigenetic aberrations in leukocytes of patients with schizophrenia: Association of global DNA methylation with antipsychotic drug treatment and disease onset
    • P.A. Melas, M. Rogdaki, U. Osby, M. Schalling, C. Lavebratt, and T.J. Ekstrom Epigenetic aberrations in leukocytes of patients with schizophrenia: Association of global DNA methylation with antipsychotic drug treatment and disease onset FASEB J 26 2012 2712 2718
    • (2012) FASEB J , vol.26 , pp. 2712-2718
    • Melas, P.A.1    Rogdaki, M.2    Osby, U.3    Schalling, M.4    Lavebratt, C.5    Ekstrom, T.J.6
  • 40
    • 34548130797 scopus 로고    scopus 로고
    • Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: A potential link between epigenetics and schizophrenia
    • M. Shimabukuro, T. Sasaki, A. Imamura, T. Tsujita, C. Fuke, and T. Umekage et al. Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: A potential link between epigenetics and schizophrenia J Psychiatr Res 41 2007 1042 1046
    • (2007) J Psychiatr Res , vol.41 , pp. 1042-1046
    • Shimabukuro, M.1    Sasaki, T.2    Imamura, A.3    Tsujita, T.4    Fuke, C.5    Umekage, T.6
  • 42
    • 33749257338 scopus 로고    scopus 로고
    • Reproducibility of microarray studies: Concordance of current analysis methods
    • M.T. Wayland, and S. Bahn Reproducibility of microarray studies: Concordance of current analysis methods Prog Brain Res 158 2006 109 125
    • (2006) Prog Brain Res , vol.158 , pp. 109-125
    • Wayland, M.T.1    Bahn, S.2
  • 43
    • 33745698337 scopus 로고    scopus 로고
    • Critical appraisal of DNA microarrays in psychiatric genomics
    • K. Mirnics, P. Levitt, and D.A. Lewis Critical appraisal of DNA microarrays in psychiatric genomics Biol Psychiatry 60 2006 163 176
    • (2006) Biol Psychiatry , vol.60 , pp. 163-176
    • Mirnics, K.1    Levitt, P.2    Lewis, D.A.3
  • 44
    • 81955161247 scopus 로고    scopus 로고
    • The first decade and beyond of transcriptional profiling in schizophrenia
    • P.A. Sequeira, M.V. Martin, and M.P. Vawter The first decade and beyond of transcriptional profiling in schizophrenia Neurobiol Dis 45 2012 23 36
    • (2012) Neurobiol Dis , vol.45 , pp. 23-36
    • Sequeira, P.A.1    Martin, M.V.2    Vawter, M.P.3
  • 45
    • 12944277034 scopus 로고    scopus 로고
    • Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: A preliminary report
    • M.T. Tsuang, N. Nossova, T. Yager, M.M. Tsuang, S.C. Guo, and K.G. Shyu et al. Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: A preliminary report Am J Med Genet B Neuropsychiatr Genet 133B 2005 1 5
    • (2005) Am J Med Genet B Neuropsychiatr Genet , vol.133 B , pp. 1-5
    • Tsuang, M.T.1    Nossova, N.2    Yager, T.3    Tsuang, M.M.4    Guo, S.C.5    Shyu, K.G.6
  • 46
    • 77952674096 scopus 로고    scopus 로고
    • Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures
    • M. Takahashi, H. Hayashi, Y. Watanabe, K. Sawamura, N. Fukui, and J. Watanabe et al. Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures Schizophr Res 119 2010 210 218
    • (2010) Schizophr Res , vol.119 , pp. 210-218
    • Takahashi, M.1    Hayashi, H.2    Watanabe, Y.3    Sawamura, K.4    Fukui, N.5    Watanabe, J.6
  • 47
    • 43049142299 scopus 로고    scopus 로고
    • Verification of proposed peripheral biomarkers in mononuclear cells of individuals with schizophrenia
    • Y. Yao, J. Schroder, and H. Karlsson Verification of proposed peripheral biomarkers in mononuclear cells of individuals with schizophrenia J Psychiatr Res 42 2008 639 643
    • (2008) J Psychiatr Res , vol.42 , pp. 639-643
    • Yao, Y.1    Schroder, J.2    Karlsson, H.3
  • 48
    • 80054850997 scopus 로고    scopus 로고
    • Similarities and differences in peripheral blood gene-expression signatures of individuals with schizophrenia and their first-degree biological relatives
    • S.J. Glatt, W.S. Stone, N. Nossova, C.C. Liew, L.J. Seidman, and M.T. Tsuang Similarities and differences in peripheral blood gene-expression signatures of individuals with schizophrenia and their first-degree biological relatives Am J Med Genet B Neuropsychiatr Genet 156B 2011 869 887
    • (2011) Am J Med Genet B Neuropsychiatr Genet , vol.156 B , pp. 869-887
    • Glatt, S.J.1    Stone, W.S.2    Nossova, N.3    Liew, C.C.4    Seidman, L.J.5    Tsuang, M.T.6
  • 49
    • 1642483063 scopus 로고    scopus 로고
    • Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree
    • M.P. Vawter, E. Ferran, B. Galke, K. Cooper, W.E. Bunney, and W. Byerley Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree Schizophr Res 67 2004 41 52
    • (2004) Schizophr Res , vol.67 , pp. 41-52
    • Vawter, M.P.1    Ferran, E.2    Galke, B.3    Cooper, K.4    Bunney, W.E.5    Byerley, W.6
  • 52
    • 58549113372 scopus 로고    scopus 로고
    • Assessment of circadian function in fibroblasts of patients with bipolar disorder
    • S. Yang, H.P. Van Dongen, K. Wang, W. Berrettini, and M. Bucan Assessment of circadian function in fibroblasts of patients with bipolar disorder Mol Psychiatry 14 2009 143 155
    • (2009) Mol Psychiatry , vol.14 , pp. 143-155
    • Yang, S.1    Van Dongen, H.P.2    Wang, K.3    Berrettini, W.4    Bucan, M.5
  • 53
    • 56449084674 scopus 로고    scopus 로고
    • Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues
    • J.T. Huang, L. Wang, S. Prabakaran, M. Wengenroth, H.E. Lockstone, and D. Koethe et al. Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues Mol Psychiatry 13 2008 1118 1128
    • (2008) Mol Psychiatry , vol.13 , pp. 1118-1128
    • Huang, J.T.1    Wang, L.2    Prabakaran, S.3    Wengenroth, M.4    Lockstone, H.E.5    Koethe, D.6
  • 54
    • 78650446303 scopus 로고    scopus 로고
    • Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival
    • M. Herberth, D. Koethe, Y. Levin, E. Schwarz, N.D. Krzyszton, and S. Schoeffmann et al. Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival Proteomics 11 2011 94 105
    • (2011) Proteomics , vol.11 , pp. 94-105
    • Herberth, M.1    Koethe, D.2    Levin, Y.3    Schwarz, E.4    Krzyszton, N.D.5    Schoeffmann, S.6
  • 55
    • 77958496632 scopus 로고    scopus 로고
    • Global proteomic profiling reveals altered proteomic signature in schizophrenia serum
    • Y. Levin, L. Wang, E. Schwarz, D. Koethe, F.M. Leweke, and S. Bahn Global proteomic profiling reveals altered proteomic signature in schizophrenia serum Mol Psychiatry 15 2010 1088 1100
    • (2010) Mol Psychiatry , vol.15 , pp. 1088-1100
    • Levin, Y.1    Wang, L.2    Schwarz, E.3    Koethe, D.4    Leweke, F.M.5    Bahn, S.6
  • 58
    • 0019522428 scopus 로고
    • The human platelet as a model for the glutamatergic neuron: Platelet uptake of L-glutamate
    • R.M. Mangano, and R. Schwarcz The human platelet as a model for the glutamatergic neuron: Platelet uptake of L-glutamate J Neurochem 36 1981 1067 1076
    • (1981) J Neurochem , vol.36 , pp. 1067-1076
    • Mangano, R.M.1    Schwarcz, R.2
  • 59
    • 60949090134 scopus 로고    scopus 로고
    • A flow-cytometric method to investigate glutamate-receptor-sensitivity in whole blood platelets - Results from healthy controls and patients with schizophrenia
    • P.C. Baier, J.M. Koch, M. Seeck-Hirschner, K. Ohlmeyer, S. Wilms, J.B. Aldenhoff, and D. Hinze-Selch A flow-cytometric method to investigate glutamate-receptor-sensitivity in whole blood platelets - results from healthy controls and patients with schizophrenia J Psychiatr Res 43 2009 585 591
    • (2009) J Psychiatr Res , vol.43 , pp. 585-591
    • Baier, P.C.1    Koch, J.M.2    Seeck-Hirschner, M.3    Ohlmeyer, K.4    Wilms, S.5    Aldenhoff, J.B.6    Hinze-Selch, D.7
  • 61
    • 77956647414 scopus 로고    scopus 로고
    • Disturbed synaptic connectivity in schizophrenia: Convergence of genetic risk factors during neurodevelopment
    • A. Hayashi-Takagi, and A. Sawa Disturbed synaptic connectivity in schizophrenia: Convergence of genetic risk factors during neurodevelopment Brain Res Bull 83 2010 140 146
    • (2010) Brain Res Bull , vol.83 , pp. 140-146
    • Hayashi-Takagi, A.1    Sawa, A.2
  • 62
    • 0037317444 scopus 로고    scopus 로고
    • Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia
    • M.C. Ryan, P. Collins, and J.H. Thakore Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia Am J Psychiatry 160 2003 284 289
    • (2003) Am J Psychiatry , vol.160 , pp. 284-289
    • Ryan, M.C.1    Collins, P.2    Thakore, J.H.3
  • 63
    • 0026467216 scopus 로고
    • Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Assessment with xenon 133 single-photon emission computed tomography and the Tower of London
    • N.C. Andreasen, K. Rezai, R. Alliger, V.W. Swayze 2nd, M. Flaum, and P. Kirchner et al. Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Assessment with xenon 133 single-photon emission computed tomography and the Tower of London Arch Gen Psychiatry 49 1992 943 958
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 943-958
    • Andreasen, N.C.1    Rezai, K.2    Alliger, R.3    Swayze II, V.W.4    Flaum, M.5    Kirchner, P.6
  • 64
    • 30744443492 scopus 로고    scopus 로고
    • Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: A systematic review and meta-analysis
    • R.G. Steen, R.M. Hamer, and J.A. Lieberman Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: A systematic review and meta-analysis Neuropsychopharmacology 30 2005 1949 1962
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1949-1962
    • Steen, R.G.1    Hamer, R.M.2    Lieberman, J.A.3
  • 65
    • 2942604863 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in schizophrenia: Evidence for compromised brain metabolism and oxidative stress
    • 643
    • S. Prabakaran, J.E. Swatton, M.M. Ryan, S.J. Huffaker, J.T. Huang, and J.L. Griffin et al. Mitochondrial dysfunction in schizophrenia: Evidence for compromised brain metabolism and oxidative stress Mol Psychiatry 9 2004 684 697 643
    • (2004) Mol Psychiatry , vol.9 , pp. 684-697
    • Prabakaran, S.1    Swatton, J.E.2    Ryan, M.M.3    Huffaker, S.J.4    Huang, J.T.5    Griffin, J.L.6
  • 67
    • 0024473920 scopus 로고
    • Accumulation of diacylgylcerol in platelet phosphoinositide turnover in schizophrenia: A biological marker of good prognosis?
    • H. Kaiya, A. Nishida, A. Imai, S. Nakashima, and Y. Nozawa Accumulation of diacylgylcerol in platelet phosphoinositide turnover in schizophrenia: A biological marker of good prognosis? Biol Psychiatry 26 1989 669 676
    • (1989) Biol Psychiatry , vol.26 , pp. 669-676
    • Kaiya, H.1    Nishida, A.2    Imai, A.3    Nakashima, S.4    Nozawa, Y.5
  • 68
    • 0037108020 scopus 로고    scopus 로고
    • Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites
    • J. Yao, J.A. Stanley, R.D. Reddy, M.S. Keshavan, and J.W. Pettegrew Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites Biol Psychiatry 52 2002 823 830
    • (2002) Biol Psychiatry , vol.52 , pp. 823-830
    • Yao, J.1    Stanley, J.A.2    Reddy, R.D.3    Keshavan, M.S.4    Pettegrew, J.W.5
  • 69
    • 55949089964 scopus 로고    scopus 로고
    • High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides
    • E. Schwarz, S. Prabakaran, P. Whitfield, H. Major, F.M. Leweke, and D. Koethe et al. High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides J Proteome Res 7 2008 4266 4277
    • (2008) J Proteome Res , vol.7 , pp. 4266-4277
    • Schwarz, E.1    Prabakaran, S.2    Whitfield, P.3    Major, H.4    Leweke, F.M.5    Koethe, D.6
  • 71
    • 35349006914 scopus 로고    scopus 로고
    • Omega-3 DHA and EPA for cognition, behavior, and mood: Clinical findings and structural-functional synergies with cell membrane phospholipids
    • P.M. Kidd Omega-3 DHA and EPA for cognition, behavior, and mood: Clinical findings and structural-functional synergies with cell membrane phospholipids Altern Med Rev 12 2007 207 227
    • (2007) Altern Med Rev , vol.12 , pp. 207-227
    • Kidd, P.M.1
  • 72
    • 0036140127 scopus 로고    scopus 로고
    • A dose-ranging exploratory study of the effects of ethyl- eicosapentaenoate in patients with persistent schizophrenic symptoms
    • E-E Multicentre Study Group
    • M. Peet, D.F. Horrobin E-E Multicentre Study Group A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms J Psychiatr Res 36 2002 7 18
    • (2002) J Psychiatr Res , vol.36 , pp. 7-18
    • Peet, M.1    Horrobin, D.F.2
  • 75
    • 1442264399 scopus 로고    scopus 로고
    • Apoptotic proteins in the temporal cortex in schizophrenia: High Bax/Bcl-2 ratio without caspase-3 activation
    • L.F. Jarskog, E.S. Selinger, J.A. Lieberman, and J.H. Gilmore Apoptotic proteins in the temporal cortex in schizophrenia: High Bax/Bcl-2 ratio without caspase-3 activation Am J Psychiatry 161 2004 109 115
    • (2004) Am J Psychiatry , vol.161 , pp. 109-115
    • Jarskog, L.F.1    Selinger, E.S.2    Lieberman, J.A.3    Gilmore, J.H.4
  • 76
    • 46249104490 scopus 로고    scopus 로고
    • Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: The SzGene database
    • N.C. Allen, S. Bagade, M.B. McQueen, J.P. Ioannidis, F.K. Kavvoura, and M.J. Khoury et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: The SzGene database Nat Genet 40 2008 827 834
    • (2008) Nat Genet , vol.40 , pp. 827-834
    • Allen, N.C.1    Bagade, S.2    McQueen, M.B.3    Ioannidis, J.P.4    Kavvoura, F.K.5    Khoury, M.J.6
  • 77
    • 41849119908 scopus 로고    scopus 로고
    • Cancer incidence in patients with schizophrenia and their first-degree relatives - A meta-analysis
    • V.S. Catts, S.V. Catts, B.I. O'Toole, and A.D. Frost Cancer incidence in patients with schizophrenia and their first-degree relatives - a meta-analysis Acta Psychiatr Scand 117 2008 323 336
    • (2008) Acta Psychiatr Scand , vol.117 , pp. 323-336
    • Catts, V.S.1    Catts, S.V.2    O'Toole, B.I.3    Frost, A.D.4
  • 78
    • 0027953993 scopus 로고
    • Abnormal growth of cultured skin fibroblasts associated with poor premorbid history in schizophrenic patients
    • S. Mukherjee, S.P. Mahadik, D.B. Schnur, H. Laev, and R. Reddy Abnormal growth of cultured skin fibroblasts associated with poor premorbid history in schizophrenic patients Schizophr Res 13 1994 233 237
    • (1994) Schizophr Res , vol.13 , pp. 233-237
    • Mukherjee, S.1    Mahadik, S.P.2    Schnur, D.B.3    Laev, H.4    Reddy, R.5
  • 80
  • 81
    • 0012284588 scopus 로고    scopus 로고
    • Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia
    • S.G. Schwab, J. Hallmayer, J. Freimann, B. Lerer, M. Albus, and M. Borrmann-Hassenbach et al. Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia Am J Med Genet 114 2002 315 320
    • (2002) Am J Med Genet , vol.114 , pp. 315-320
    • Schwab, S.G.1    Hallmayer, J.2    Freimann, J.3    Lerer, B.4    Albus, M.5    Borrmann-Hassenbach, M.6
  • 83
    • 40949107708 scopus 로고    scopus 로고
    • Inflammatory cytokine alterations in schizophrenia: A systematic quantitative review
    • S. Potvin, E. Stip, A.A. Sepehry, A. Gendron, R. Bah, and E. Kouassi Inflammatory cytokine alterations in schizophrenia: A systematic quantitative review Biol Psychiatry 63 2008 801 808
    • (2008) Biol Psychiatry , vol.63 , pp. 801-808
    • Potvin, S.1    Stip, E.2    Sepehry, A.A.3    Gendron, A.4    Bah, R.5    Kouassi, E.6
  • 84
    • 80355143546 scopus 로고    scopus 로고
    • Microglial cell origin and phenotypes in health and disease
    • K. Saijo, and C.K. Glass Microglial cell origin and phenotypes in health and disease Nat Rev Immunol 11 2011 775 787
    • (2011) Nat Rev Immunol , vol.11 , pp. 775-787
    • Saijo, K.1    Glass, C.K.2
  • 85
    • 77955207800 scopus 로고    scopus 로고
    • Validation of a blood-based laboratory test to aid in the confirmation of a diagnosis of schizophrenia
    • E. Schwarz, R. Izmailov, M. Spain, A. Barnes, J.P. Mapes, and P.C. Guest et al. Validation of a blood-based laboratory test to aid in the confirmation of a diagnosis of schizophrenia Biomark Insights 5 2010 39 47
    • (2010) Biomark Insights , vol.5 , pp. 39-47
    • Schwarz, E.1    Izmailov, R.2    Spain, M.3    Barnes, A.4    Mapes, J.P.5    Guest, P.C.6
  • 86
    • 84858055742 scopus 로고    scopus 로고
    • Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients
    • E. Schwarz, P.C. Guest, J. Steiner, B. Bogerts, and S. Bahn Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients Transl Psychiatry 2 2012 e82
    • (2012) Transl Psychiatry , vol.2 , pp. 82
    • Schwarz, E.1    Guest, P.C.2    Steiner, J.3    Bogerts, B.4    Bahn, S.5


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