Association of Pro12Ala (rs1801282) variant of PPAR gamma with Rheumatoid Arthritis in a Pakistani population

Rheumatology International

Volumn 34, Issue 5, 2014, Pages 699-703

  Jalil, Syed Fazal ^a   Ahmed, Iltaf ^a   Gauhar, Zeeshan ^a   Ahmed, Mushtaq ^b   Malik, Javaid M ^c   John, Peter ^a   Bhatti, Attya ^a  

^a NATIONAL UNIVERSITY OF SCIENCES AND TECHNOLOGY   (Pakistan)

^b Military Hospital Rawalpindi   (Pakistan)

^c Rahmat Noor Clinic Arthritis Research Center Rawalpindi   (Pakistan)

Author keywords

Association studies; Polymorphism; PPARG; Pro12Ala; Rheumatoid Arthritis

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADULT; ALLELE; ARTICLE; CODING; CONTROLLED STUDY; DISEASE DURATION; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PAKISTAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; ARTHRITIS, RHEUMATOID; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PHENOTYPE; RISK; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PAKISTAN; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PPAR GAMMA; RISK FACTORS;

EID: 84901294006     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-013-2768-2     Document Type: Article

References (26)

1. Seldin MF, Amos CI, Ward R, Gregersen PK (1999) The genetics evolution and the assault on Rheumatoid Arthritis. Arthritis Rheum 42:1071-1079 (Pubitemid 29268942)
2. MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Kaprio J et al (2000) Characterizing the quantitative genetic contribution to Rheumatoid Arthritis using data from twins. Arthritis Rheum 43:30-37 (Pubitemid 30368210)
3. Firestein GS (2003) Evolving concepts of Rheumatoid Arthritis. Nature 423:356-361
4. Kersten S, Desvergne B, Wahli W (2000) Roles of PPARs in health and disease. Nature 405:421-424 (Pubitemid 30367411)
5. Hara K, Okada T, Tobe K, Yasuda K, Mori Y, Kadowaki T et al (2000) The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun 271:212-216
6. Frederiksen L, Brødbaek K, Fenger M, Jørgensen T, Borch-Johnsen K et al (2002) Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. J Clin Endocrinol Metab 87:3989-3992 (Pubitemid 34879559)
7. Su CG, Wen X, Bailey ST, Jiang W, Rangwala SM, Keilbaugh SA et al (1999) A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. J Clin Invest 104:383-389 (Pubitemid 29534322)
8. Desreumaux P, Dubuquoy L, Nutten S, Peuchmaur M, Englaro W, Schoonjans K et al (2001) Attenuation of colon inflammation through activation of the retinoid X receptor (RXR)/peroxisome proliferators- activated receptor gamma (PPAR-gamma) heterodimer. A basis for new therapeutic strategies. J Exp Med 193:827-838 (Pubitemid 32524532)
9. Gupta RA, Dubois RN (2002) Controversy: PPAR gamma as a target for treatment of colorectal cancer. Am J Physiol Gastrointest Liver Physiol 283:266-269
10. Debril MB, Renaud JP, Fajas L, Auwerx J (2001) The pleitropic functions of peroxisome proliferator5 activated receptor gamma. J Mol Med 79:30-47 (Pubitemid 32250021)
11. Neuschwander-Tetri BA, Brunt EM, Wehmeier KR, Oliver D, Bacon BR (2003) Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR5gamma ligand rosiglitazone. Hepatology 38:1008-1017 (Pubitemid 37221684)
12. Lewis JD, Lichtenstein GR, Deren JJ, Sands BE, Hanauer SB, Katz JA et al (2008) Rosiglitazone for active ulcerative colitis: a randomized placebo-controlled trial. Gastroenterology 134:688-695 (Pubitemid 351312727)
13. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of Rheumatoid Arthritis. Arthritis Rheum 31:315-324 (Pubitemid 18091653)
14. Yamauchi T, Kamon J, Waki H, Murakami K, Motojima K, Komeda K et al (2001) The mechanisms by which both heterozygous peroxisome proliferator- activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem 276(44):41245-41254
15. Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ et al (2006) International union of pharmacology. Peroxisome proliferator-activated receptors. Pharmacol Rev 58(4):726-741 (Pubitemid 44833742)
16. Stumvoll M, Haring H (2002) The peroxisome proliferator-activated receptor gamma2 Pro12Ala polymorphism. Diabetes 51:2341-2347 (Pubitemid 34827380)
17. Doney AS, Fischer B, Cecil JE, Boylan K, McGuigan FE, Ralston SH et al (2004) Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes. Diabetologia 47:555-558 (Pubitemid 38491254)
18. Al-Shali KZ, House AA, Hanley AJ, Khan HM, Harris SB, Zinman B et al (2004) Genetic variation in PPARG encoding peroxisome proliferator-activated receptor gamma associated with carotid atherosclerosis. Stroke 35:2036-2040 (Pubitemid 39129555)
19. Temelkova-Kurktschiev T, Hanefeld M, Chinetti G, Zawadzki C, Haulon S, Kubaszek A, Koehler C et al (2004) Ala12Ala genotype of the peroxisome proliferator 5 activated receptor gamma2 protects against atherosclerosis. J Clin Endocrinol Metab 89:4238-4242 (Pubitemid 39244418)
20. Herrmann SM, Ringel J, Wang JG, Staessen JA, Brand E et al (2002) Peroxisome proliferator activated receptor gamma polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes: the Berlin Diabetes Mellitus (BeDiaM) study. Diabetes 51:2653-2657 (Pubitemid 34827420)
21. Wu Z, Lou Y, Jin W, Liu Y, Lu L, Lu G (2012) The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma-2 gene (PPARγ2) is associated with increased risk of coronary artery disease: a meta-analysis. PLoS ONE 7(12):e53105
22. Pan XF, Song XB, Wang LL, Li LX, Ying BW (2009) Association of the Pro12Ala polymorphism in peroxisome proliferators activated receptor-gamma gene with Rheumatoid Arthritis in Sichuan Province of China. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26(1):87-90
23. Klotz L, Schmidt S, Heun R, Klockgether T, Kölsch H (2009) Association of the PPARγ gene polymorphism Pro12Ala with delayed onset of multiple sclerosis. Neurosci Lett 449:81-83
24. El-Sohemy A, Cornelis MC, Park YW, Bae SC (2006) Catalase and PPARgamma2 genotype and risk of Rheumatoid Arthritis in Koreans. Rheumatol Int 26(5):388-392
25. Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, Kuusisto J, Laakso M et al (1998) A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20:284-287 (Pubitemid 28507675)
26. Masugi J, Tamori Y, Mori H, Koike T, Kasuga M et al (2000) Inhibitory effect of a prolineto-alanine substitution at codon 12 of peroxisome proliferator-activated receptor gamma on thiazolidinedione-induced adipogenesis. Biochem Biophys Res Commun 268:178-182 (Pubitemid 30116630)