Cerebral cortex hyperthyroidism of newborn Mct8-deficient mice transiently suppressed by Lat2 inactivation

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Núñez, Bárbara ^a   Martínez De Mena, Raquel ^a   Obregon, Maria Jesus ^a   Font Llitjós, Mariona ^b,c   Nunes, Virginia ^b,c,d   Palacín, Manuel ^c,e   Dumitrescu, Alexandra M ^f   Morte, Beatriz ^a,c   Bernal, Juan ^a,c  

^a CSIC   (Spain)

^b BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

^e INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^f UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; LIOTHYRONINE; MONOCARBOXYLATE TRANSPORTER 8; PROTEIN LAT2; THYROXINE; UNCLASSIFIED DRUG; CARRIER PROTEIN; CD98 ANTIGEN; SLC16A2 PROTEIN, MOUSE; SLC7A8 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; CEREBRAL CORTEX HYPERTHYROIDISM; CHOROID PLEXUS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE TARGETING; HYPERTHYROIDISM; LIOTHYRONINE BLOOD LEVEL; MALE; MOUSE; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN FUNCTION; THYROXINE BLOOD LEVEL; WILD TYPE; ANIMAL; GENETICS; METABOLISM;

AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD98 LIGHT CHAINS; CEREBRAL CORTEX; FEMALE; HYPERTHYROIDISM; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; TRIIODOTHYRONINE;

EID: 84901283686     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096915     Document Type: Article

References (33)

1. Visser WE, Friesema EC, Jansen J, Visser TJ (2008) Thyroid hormone transport in and out of cells. Trends Endocrinol Metab 19: 50-56. (Pubitemid 351317898)
2. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, et al. (2003) Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 278: 40128-40135. (Pubitemid 37248580)
3. Kinne A, Kleinau G, Hoefig CS, Gruters A, Kohrle J, et al. (2010) Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8. J Biol Chem 285: 28054-28063.
4. Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S (2004) A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 74: 168-175. (Pubitemid 38085248)
5. Friesema EC, Grueters A, Biebermann H, Krude H, von Moers A, et al. (2004) Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet 364: 1435-1437. (Pubitemid 39370719)
6. Schwartz CE, May MM, Carpenter NJ, Rogers RC, Martin J, et al. (2005) Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene. Am J Hum Genet 77: 41-53. (Pubitemid 40848035)
7. Bernal J (2007) Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab 3: 249-259.
8. Contempre B, Jauniaux E, Calvo R, Jurkovic D, Campbell S, et al. (1993) Detection of thyroid hormones in human embryonic cavities during the first trimester of pregnancy. J Clin Endocrinol Metab 77: 1719-1722. (Pubitemid 24000941)
9. Nucera C, Muzzi P, Tiveron C, Farsetti A, La Regina F, et al. (2010) Maternal thyroid hormones are transcriptionally active during embryo-foetal development: results from a novel transgenic mouse model. J Cell Mol Med 14: 2417-2435.
10. Dumitrescu AM, Liao XH, Weiss RE, Millen K, Refetoff S (2006) Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology 147: 4036-4043. (Pubitemid 44268357)
11. Trajkovic M, Visser TJ, Mittag J, Horn S, Lukas J, et al. (2007) Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8. J Clin Invest 117: 627-635. (Pubitemid 46348521)
12. Wirth EK, Roth S, Blechschmidt C, Holter SM, Becker L, et al. (2009) Neuronal 3′,3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. J Neurosci 29: 9439-9449.
13. Ceballos A, Belinchon MM, Sanchez-Mendoza E, Grijota-Martinez C, Dumitrescu AM, et al. (2009) Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,39-triiodo-L-thyronine. Endocrinology 150: 2491-2496.
14. Morte B, Ceballos A, Diez D, Grijota-Martinez C, Dumitrescu AM, et al. (2010) Thyroid hormone-regulated mouse cerebral cortex genes are differentially dependent on the source of the hormone: a study in monocarboxylate transporter-8- and deiodinase-2-deficient mice. Endocrinology 151: 2381-2387.
15. Roberts LM, Woodford K, Zhou M, Black DS, Haggerty JE, et al. (2008) Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. Endocrinology 149: 6251-6261.
16. Mayerl S, Visser TJ, Darras VM, Horn S, Heuer H (2012) Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain. Endocrinology 153: 1528-1537.
17. Tohyama K, Kusuhara H, Sugiyama Y (2004) Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology 145: 4384-4391. (Pubitemid 39120588)
18. Bernal J (2011) Thyroid hormone transport in developing brain. Curr Opin Endocrinol Diabetes Obes 18: 295-299.
19. Freitas BC, Gereben B, Castillo M, Kallo I, Zeold A, et al. (2010) Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. J Clin Invest 120: 2206-2217.
20. Guadano-Ferraz A, Obregon MJ, St Germain DL, Bernal J (1997) The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain. Proc Natl Acad Sci U S A 94: 10391-10396. (Pubitemid 27407052)
21. Heuer H, Visser TJ (2012) The pathophysiological consequences of thyroid hormone transporter deficiencies: Insights from mouse models. Biochim Biophys Acta.
22. Braun D, Kinne A, Brauer AU, Sapin R, Klein MO, et al. (2010) Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells. Glia 59: 463-471.
23. Ferrara AM, Liao XH, Gil-Ibanez P, Marcinkowski T, Bernal J, et al. (2013) Changes in Thyroid Status During Perinatal Development of MCT8-Deficient Male Mice. Endocrinology 154: 2533-2541.
24. Font-Llitjós M, Espino M, others Manuscript in preparation.
25. Morreale de Escobar G, Pastor R, Obregon MJ, Escobar del Rey F (1985) Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. Endocrinology 117: 1890-1900. (Pubitemid 16200779)
26. Bernal J, Guadano-Ferraz A (2002) Analysis of thyroid hormone-dependent genes in the brain by in situ hybridization. Methods Mol Biol 202: 71-90.
27. Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, et al. (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 28: 264-278.
28. Zavacki AM, Ying H, Christoffolete MA, Aerts G, So E, et al. (2005) Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse. Endocrinology 146: 1568-1575. (Pubitemid 40289348)
29. Mayerl S, Darras VM, Müller J, Buder K, Bauer R, et al. (2014) Mct8/Oatp1c1 inactivation causes thyroid hormone deficiency in the mouse brain. J Clin Invest In Press.
30. Braun D, Wirth EK, Wohlgemuth F, Reix N, Klein MO, et al. (2011) Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8. Biochem J 439: 249-255.
31. Saunders NR, Knott GW, Dziegielewska KM (2000) Barriers in the immature brain. Cell Mol Neurobiol 20: 29-40. (Pubitemid 30090914)
32. Grijota-Martinez C, Diez D, Morreale de Escobar G, Bernal J, Morte B (2011) Lack of action of exogenously administered T3 on the fetal rat brain despite expression of the monocarboxylate transporter 8. Endocrinology 152: 1713-1721.
33. Muller J, Mayerl S, Visser TJ, Darras VM, Boelen A, et al. (2014) Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency. Endocrinology 155: 315-325.