In vitro, ex vivo, and in vivo evaluation of the effect of saturated fat acid chain length on the transdermal behavior of ibuprofen-loaded microemulsions

Journal of Pharmaceutical Sciences

Volumn 103, Issue 6, 2014, Pages 1680-1691

  Ren, Qiuyue ^a   Deng, Chunli ^a   Meng, Lin ^a   Chen, Yanzuo ^a   Chen, Liangcen ^a   Sha, Xianyi ^a   Fang, Xiaoling ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

co surfactant; emulsion; oil phase; permeability; surfactant; transdermal drug delivery system

Indexed keywords

CREMOPHOR; DIETHYLENE GLYCOL MONOETHYL ETHER; IBUPROFEN; LONG CHAIN FATTY ACID; MEDIUM CHAIN FATTY ACID; SHORT CHAIN FATTY ACID; EMULSION; FATTY ACID; NONSTEROID ANTIINFLAMMATORY AGENT;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG CYTOTOXICITY; DRUG PENETRATION; DRUG RETENTION; DRUG SOLUBILITY; DRUG STABILITY; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROEMULSION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; RAT; SKIN IRRITATION TEST; SKIN PERMEABILITY; SKIN TEST; TRANSDERMAL DRUG ADMINISTRATION; VISCOSITY; ZETA POTENTIAL; CELL LINE; CHEMISTRY; CONFOCAL MICROSCOPY; EMULSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SKIN; TRANSMISSION ELECTRON MICROSCOPY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EMULSIONS; FATTY ACIDS; HUMANS; IBUPROFEN; IN VITRO TECHNIQUES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; SKIN;

EID: 84901252586     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23958     Document Type: Article

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