Effects of vehicles and enhancers on transdermal delivery of melatonin

International Journal of Pharmaceutics

Volumn 212, Issue 1, 2001, Pages 63-71

  Oh, Han Joon ^a   Oh, Yu Kyoung ^b   Kim, Chong Kook ^a  

^a Seoul National University   (South Korea)

^b CHA University   (South Korea)

Author keywords

Enhancer; Fatty acid; Melatonin; Transdermal delivery; Vehicle

Indexed keywords

ALCOHOL; BUFFER; DRUG VEHICLE; FATTY ACID; LAURIC ACID; MACROGOL 400; MELATONIN; OLEIC ACID; PROPYLENE GLYCOL;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG PENETRATION; DRUG SOLUBILITY; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN PERMEABILITY;

ANIMALS; ETHANOL; FATTY ACIDS; FEMALE; MELATONIN; MICE; MICE, INBRED HRS; PERMEABILITY; SKIN; SOLUBILITY; VEHICLES;

EID: 0035808395     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00598-6     Document Type: Article

References (29)

1. Contributions of drug solubilization, partitioning, barrier disruption, and solvent permeation to the enhancement of skin permeation of various compounds with fatty acids and amine
2. Intranasal absorption of melatonin in vivo bioavailability study
3. Transmucosal, oral controlled-release, and transdermal drug administration in human subjects: A crossover study with melatonin
4. Prospects of the clinical utilization of melatonin
5. Effect of vehicles on yohimbine permeation across excised hairless mouse skin
6. In vitro percutaneous penetration through hairless rat skin: Influence of temperature, vehicle and penetration enhancers
7. Effect of sustained nocturnal transbuccal melatonin administration on sleep and temperature in elderly insomniacs
8. The absolute bioavailability of oral melatonin
9. Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: A human study in vivo
10. Water-based versus alcohol-based benzoyl peroxide preparations in the treatment of acne vulgaris
11. The effects of ethanol on the transports of β-estradiol and other permeants in hairless mouse skin: II. A new quantitative approach
12. Effect of various vehicles on ketoprofen permeation across excised hairless mouse skin
13. Melatonin replacement therapy of elderly insomniacs
14. Optimization of a vehicle mixture for the transdermal delivery of MT using artificial neural networks and response surface method
15. Transdermal delivery of dideoxynucleoside-type anti-HIV drugs. 2. The effect of vehicle and enhancer on skin permeation
16. Effect of Tween 20 on the penetration of ketoprofen through excised rat skin
17. Effect of fatty acids and urea on the penetration of ketoprofen through rat skin
18. Solvent mediated alteration of the stratum corneum
19. Melatonin: An antioxidant protects against cyclosporine-induced nephrotoxicity
20. Pharmacokinetics of melatonin in man: First pass hepatic metabolism
21. Skin permeation enhancement of tegafur by ethanol/panasate 800 or ethanol/water binary vehicle and combined effect of fatty acids and fatty alcohols
22. Preliminary evaluation of transdermal delivery of melatonin in human subjects
23. Relationship between lipophilicity and skin permeability of various drugs from an ethanol/water/lauric acid system
24. Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: A phase II study
25. Pharmacokinetics of melatonin in man after intravenous infusion and bolus injection
26. Enhancing effects of unsaturated fatty acids with various structures on the permeation of indomethacin through rat skin
27. Lateral chain packing in lipids and membrane
28. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag