Chemical constituents and their acetyl cholinesterase inhibitory and antioxidant activities from leaves of Acanthopanax henryi: Potential complementary source against Alzheimer's disease

Archives of Pharmacal Research

Volumn 37, Issue 5, 2014, Pages 606-616

  Zhang, Xiao Dan ^a   Liu, Xiang Qian ^b   Kim, Yang Hee ^a   Whang, Wan Kyunn ^a  

^a Chung Ang University   (South Korea)

^b HUNAN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Acanthopanax henryi; Biological activities; Chemical constituents; HPLC UV

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); ACANTHOPANAX HENRYI EXTRACT; ACETYLCHOLINESTERASE; ALLOPURINOL; ASCORBIC ACID; FLAVONOID; PLANT EXTRACT; QUERCETIN; QUINIC ACID; SUPEROXIDE; TROLOX C; UNCLASSIFIED DRUG; 2,2'-AZINO-DI-(3-ETHYLBENZOTHIAZOLINE)-6-SULFONIC ACID; 2,2-DIPHENYL-1-PICRYLHYDRAZYL; 4,5-DICAFFEOYL QUINIC ACID; ANTIOXIDANT; BENZOTHIAZOLE DERIVATIVE; BIPHENYL DERIVATIVE; CHOLINESTERASE INHIBITOR; PICRIC ACID; SULFONIC ACID DERIVATIVE;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ACANTHOPANAX; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; HUMAN; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; PHYTOTHERAPY; PLANT LEAF; ULTRAVIOLET SPECTROPHOTOMETRY;

ACANTHOPANAX; ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANTIOXIDANTS; BENZOTHIAZOLES; BIPHENYL COMPOUNDS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; PHYTOTHERAPY; PICRATES; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; QUERCETIN; QUINIC ACID; SPECTROPHOTOMETRY, ULTRAVIOLET; SULFONIC ACIDS;

EID: 84901240361     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0252-x     Document Type: Article

References (30)

1. Aliev, G. 2011. Oxidative stress induced-metabolic imbalance, mitochondrial failure, and cellular hypoperfusion as primary pathogenetic factors for the development of Alzheimer disease which can be used as a alternate and successful drug treatment strategy: past, present and future. CNS & Neurological Disorders: Drug Targets 10: 147-148.
2. Arnao, M.B., A. Cano, and M. Acosta. 2001. The hydrophilic and lipophilic contribution to total antioxidant activity. Food Chemistry 73: 239-244. (Pubitemid 32280257)
3. Ellman, G.L., K.D. Courtney, V. Andres Jr, and R.M. Feather-Stone. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology 7: 88-95.
4. Feng, Y., and X. Wang. 2012. Antioxidant therapies for Alzheimer's disease. Oxidative Medicine and Cellular Longevity 2012: 472932.
5. Fu, J., J. Yuan, N. Zhang, B. Gao, G. Fu, Y. Tu, and Y. Zhang. 2012. Anti-diabetic activities of Acanthopanax senticosus polysaccharide (ASP) in combination with metformin. International Journal of Biological Macromolecules 50: 619-623.
6. Hatano, T., R. Edamatsu, M. Hiramatsu, A. Mori, Y. Fujita, T. Yasuhara, T. Yoshida, and T. Okuda. 1989. Effects of the interaction of tannins with co-existing substances. VI. Effects of tannins and related polyphenols on superoxide anion radical, and on 1,1-diphenyl-2-picrylhydrazyl radical. Chemical and Pharmaceutical Bulletin 37: 2016-2021.
7. Heinze, M., D. Andreae, and R. Grohmann. 2002. Rivastigmin and impaired motor function. Pharmacopsychiatry 35: 79-80. (Pubitemid 34293239)
8. Hu, X., W. Zhang, and Q. Zhu. 1999. Zhong Hua Ben Cao. Shang Hai: Shanghai science and Technology Press.
9. Huang, L.Z., B.K. Huang, J. Liang, C.J. Zheng, T. Han, Q.Y. Zhang, and L.P. Qin. 2011. Antifatigue activity of the liposoluble fraction from Acanthopanax senticosus. Phytotherapy Research 25: 940-943.
10. Hwang, Y.C., I.K. Jeong, K.J. Ahn, and H.Y. Chung. 2009. The effects of Acanthopanax senticosus extract on bone turnover and bone mineral density in Korean postmenopausal women. Journal of Bone and Mineral Metabolism 27: 584-590.
11. Kiem, P.V., X.F. Cai, C.V. Minh, J.J. Lee, and Y.H. Kim. 2004. Kaurane-type diterpene glycoside from the stem bark of Acanthopanax trifoliatus. Planta Medica 70: 282-284. (Pubitemid 38445202)
12. Kim, J.A., S.B. Song, S.Y. Yang, and Y.H. Kim. 2011. Components from the steamed leaves of Acanthopanax koreanum and their effects on PPAR activity in HepG2 cells. Natural Products Communications 6: 1233-1236.
13. Lovell, M.A., and W.R. Markesbery. 2007. Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease. Nucleic Acids Research 35: 7497-7504.
14. Melzer, D. 1998. New drug treatment for Alzheimer's disease: lessons for healthcare policy. British Medical Journal 316: 762-764. (Pubitemid 28121082)
15. Mishra, S., and K. Palanivelu. 2008. The effect of curcumin (turmeric) on Alzheimer's disease: An overview. Annals of Indian Academy of Neurology 11: 13-19. (Pubitemid 351550812)
16. Nhiem, N.X., K.C. Kim, A.D. Kim, J.W. Hyun, H.K. Kang, P. Van Kiem, C. Van Minh, V.K. Thu, B.H. Tai, J.A. Kim, and Y.H. Kim. 2011. Phenylpropanoids from the leaves of Acanthopanax koreanum and their antioxidant activity. Journal of Asian Natural Products Research 13: 56-61.
17. Park, S.Y., S.Y. Chang, O.J. Oh, C.S. Yook, and T. Nohara. 2002. nor-Oleanene type triterpene glycosides from the leaves of Acanthopanax japonicus. Phytochemistry 59: 379-384. (Pubitemid 34202553)
18. Perry, G., A.D. Cash, and M.A. Smith. 2002. Alzheimer Disease and Oxidative Stress. Journal of Biomedicine and Biotechnology 2: 120-123. (Pubitemid 44204507)
19. Perry, L. 1980. Medicinal plants of east & southeast Asia attributed properties and uses. Cambridge: The MTT Press.
20. Pratico, D., C.M. Clark, V.M. Lee, J.Q. Trojanowski, J. Rokach, and G.A. Fitzgerald. 2000. Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity. Annals of Neurology 48: 809-812.
21. Racchi, M., M. Mazzucchelli, E. Porrello, C. Lanni, and S. Govoni. 2004. Acetylcholinesterase inhibitors: novel activities of old molecules. Pharmacological Research 50: 441-451. (Pubitemid 39089089)
22. Schulz, V. 2003. Ginkgo extract or cholinesterase inhibitors in patients with dementia: what clinical trials and guidelines fail to consider. Phytomedicine 10(Suppl 4): 74-79. (Pubitemid 36597162)
23. Sithisarn, P., and S. Jarikasem. 2009. Antioxidant activity of Acanthopanax trifoliatus. Medical Principles and Practice 18: 393-398.
24. Small, G.W., P.V. Rabins, P.P. Barry, N.S. Buckholtz, S.T. Dekosky, S.H. Ferris, S.I. Finkel, L.P. Gwyther, Z.S. Khachaturian, B.D. Lebowitz, T.D. Mcrae, J.C. Morris, F. Oakley, L.S. Schneider, J.E. Streim, T. Sunderland, L.A. Teri, and L.E. Tune. 1997. Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society. JAMA 278: 1363-1371. (Pubitemid 27449698)
25. Sriraksa, N., J. Wattanathorn, S. Muchimapura, S. Tiamkao, K. Brown, and K. Chaisiwamongkol. 2012. Cognitive-enhancing effect of quercetin in a rat model of Parkinson's disease induced by 6-hydroxydopamine. Evidence-Based Complementary and Alternative Medicine 2012: 823206.
26. Yang, E.J., J.Y. Moon, J.S. Lee, J. Koh, N.H. Lee, and C.G. Hyun. 2010. Acanthopanax koreanum fruit waste inhibits lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. Journal of Biomedicine and Biotechnology 2010: 715739.
27. Yang, J.Y., K.S. Lee, M.K. Kim, S.K. Moon, M.K. Kang, B.H. Park, J.S. Kim, and J.W. Park. 2004. Effect of Acanthopanax senticosus on lipoprotein lipase in 3T3-L1 adipocytes. Phytotherapy Research 18: 160-163.
28. Yokozawa, T., C.P. Chen, E. Dong, T. Tanaka, G.I. Nonaka, and I. Nishioka. 1998. Study on the inhibitory effect of tannins and flavonoids against the 1,1-diphenyl-2 picrylhydrazyl radical. Biochemical Pharmacology 56: 213-222. (Pubitemid 28479829)
29. Yook, C.S., X.Q. Liu, S.Y. Chang, S.Y. Park, and T. Nohara. 2002. Lupane-triterpene glycosides from the leaves of Acanthopanax gracilistylus. Chemical and Pharmaceutical Bulletin 50: 1383-1385. (Pubitemid 41702043)
30. Zhou, H., J. Xing, S. Liu, F. Song, Z. Cai, Z. Pi, and Z. Liu. 2012. Screening and determination for potential alpha-glucosidase inhibitors from leaves of Acanthopanax senticosus harms by using UF-LC/MS and ESI-MS(n). Phytochemical Analysis 23: 315-323.