Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 12, 2014, Pages 3220-3226

  Yan, Zi Hong ^a   Wu, Hai Qiu ^a   Chen, Wen Xue ^a   Wu, Yan ^b   Piao, Hu Ri ^b   He, Qiu Qin ^a   Chen, Fen Er ^a   De Clercq, Erik ^c   Pannecouque, Christophe ^c  

^a FUDAN UNIVERSITY   (China)

^b YANBIAN UNIVERSITY   (China)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral activity; Diarylpyrimidine; HIV 1; NNRTIs; SAR

Indexed keywords

4 [[4 [(3 BROMOPHENYL)CHLOROMETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(4 BROMOPHENYL)CHLOROMETHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(4 BROMOPHENYL)CHLOROMETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 [4 (TERT BUTYL)PHENYL] 1 HYDROXYETHYL] 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [BROMO(4 TOLYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [BROMO(PHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [CHLORO(3 CHLOROPHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [CHLORO(3 FLUOROPHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [CHLORO(4 CHLOROPHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [CHLORO(4 FLUOROPHENYL)METHYL] 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [CHLORO(4 FLUOROPHENYL)METHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [CHLORO(4 FLUOROPHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [CHLORO(4 METHOXYPHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [CHLORO(4 TOLYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [CHLORO(NAPHTHALEN 1 YL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [CHLORO(PHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [[4 (TERT BUTYL)PHENYL]CHLOROMETHYL] 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [[4 (TERT BUTYL)PHENYL]CHLOROMETHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [[4 (TERT BUTYL)PHENYL]CHLOROMETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; DELAVIRDINE; DIARYLPYRIMIDINE DERIVATIVE; EFAVIRENZ; ETRAVIRINE; LAMIVUDINE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE; 4-((4-((3-BROMOPHENYL)CHLOROMETHYL)PYRIMIDIN-2-YL)AMINO)BENZONITRILE; 4-((4-(CHLORO(3-CHLOROPHENYL)METHYL)PYRIMIDIN-2-YL)AMINO)BENZONITRILE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZAMIDE DERIVATIVE; NITRILE; REVERSE TRANSCRIPTASE, HUMAN IMMUNODEFICIENCY VIRUS 1; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CHEMICAL BOND; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HALOGEN BOND; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; WILD TYPE; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; PATHOLOGY; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SYNTHESIS; TUMOR CELL CULTURE; VIROLOGY; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; BENZAMIDES; CELL SURVIVAL; CELLS, CULTURED; DRUG DESIGN; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; NITRILES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VIRUS REPLICATION;

EID: 84901237372     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.03.020     Document Type: Article

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