Determination of tissue levels of a neuroprotectant drug: The cell permeable JNK inhibitor peptide

Journal of Pharmacological and Toxicological Methods

Volumn 70, Issue 1, 2014, Pages 55-61

  Davoli, Enrico ^a   Sclip, Alessandra ^a   Cecchi, Matteo ^a   Cimini, Sara ^a   Carrà, Andrea ^a   Salmona, Mario ^a   Borsello, Tiziana ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Cell permeable peptide; D JNKI1; In vivo sensitive analytic method; Mass spectrometry; Neurons; Pharmacokinetics

Indexed keywords

PEPTIDE D JNKI1; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; D-JNKI-1; NEUROPROTECTIVE AGENT; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CELL LYSATE; CELL MEMBRANE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG TISSUE LEVEL; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MOUSE; NERVE CELL; NONHUMAN; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CELL MEMBRANE PERMEABILITY; DRUG EFFECTS; KIDNEY; LIVER; METABOLISM; NEWBORN;

ANIMALS; ANIMALS, NEWBORN; BLOOD-BRAIN BARRIER; BRAIN; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; KIDNEY; LIVER; MICE; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDES;

EID: 84901218334     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2014.04.001     Document Type: Article

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