Soluble Aβ oligomer-induced synaptopathy: C-Jun N-terminal kinase's role

Journal of Molecular Cell Biology

Volumn 5, Issue 4, 2013, Pages 277-279

  Sclip, Alessandra ^a   Arnaboldi, Andrea ^a   Colombo, Isabella ^a   Veglianese, Pietro ^a   Colombo, Laura ^a   Messa, Massimo ^a   Mancini, Simona ^a   Cimini, Sara ^a   Morelli, Federica ^a   Antoniou, Xanthi ^a   Welker, Egbert ^b   Salmona, Mario ^a   Borsello, Tiziana ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; GLUTAMATE RECEPTOR; OLIGOMER; STRESS ACTIVATED PROTEIN KINASE;

ALZHEIMER DISEASE; ALZHEIMER DISEASE SYNAPTOPATHY; LETTER; MOLECULAR MECHANICS; POSTSYNAPTIC DENSITY; PROMOTER REGION; SYNAPTIC TRANSMISSION;

EID: 84881598173     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjt015     Document Type: Letter

References (9)

1. Arispe, N., Rojas, E., and Pollard, H.B. (1993). Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum. Proc. Natl Acad. Sci. USA 90, 567-571. (Pubitemid 23028904)
2. Chapman, P.F., White, G.L., Jones, M.W., et al. (1999). Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat. Neurosci. 2, 271-276. (Pubitemid 30491299)
3. D'Amelio, M., Cavallucci, V., Middei, S., et al. (2011). Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease. Nat. Neurosci. 14, 69-76.
4. Lashuel, H.A., Hartley, D., Petre, B.M., et al. (2002). Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature 418, 291. (Pubitemid 34790672)
5. Li, Z., Jo, J., Jia, J.M., et al. (2010). Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization. Cell 141, 859-871.
6. Selkoe, D.J. (2002). Alzheimer's disease is a synaptic failure. Science 298, 789-791. (Pubitemid 35231524)
7. Sivanesan, S., Tan, A., and Rajadas, J. (2013). Pathogenesis of abeta oligomers in synaptic failure. Curr. Alzheimer Res. 10, 316-323.
8. Tackenberg, C., Ghori, A., and Brandt, R. (2009). Thin, stubby or mushroom: spine pathology in Alzheimer's disease. Curr. Alzheimer Res. 6, 261-268.
9. Walsh, D.M., Klyubin, I., Fadeeva, J.V., et al. (2002). Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539. (Pubitemid 34288854)