Unexpected extensive lysine acetylation in the trump-card antibiotic producer Streptomyces roseosporus revealed by proteome-wide profiling

Journal of Proteomics

Volumn 106, Issue , 2014, Pages 260-269

  Liao, Guojian ^a   Xie, Longxiang ^a   Li, Xin ^b   Cheng, Zhongyi ^b,c   Xie, Jianping ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b Jingjie PTM Biolabs (Hangzhou) Co Ltd   (China)

^c TONGJI UNIVERSITY   (China)

Author keywords

Daptomycin; Lysine acetylation; PTM; Regulation; Secondary metabolism; Streptomyces

Indexed keywords

ANTIBIOTIC AGENT; DAPTOMYCIN; HYDROXAMIC ACID; LYSINE; LYSINE DERIVATIVE; N ACETYLLYSINE; NONRIBOSOMAL PEPTIDE SYNTHETASE; PHOSPHINIC ACID DERIVATIVE; PROTEOME; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; PEPTIDE; PHOSPHORIC ACID; PROTEIN;

ACETYLATION; AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY AFFINITY; ARTICLE; BACTERIAL STRAIN; CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; GENE EXPRESSION; GENE ONTOLOGY; LYSINE ACETYLATION; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEOMICS; STREPTOMYCES; STREPTOMYCES ROSEOSPORUS; TANDEM MASS SPECTROMETRY; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; FACTUAL DATABASE; GENE EXPRESSION REGULATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; PROCEDURES; PROTEIN MOTIF;

ACETYLATION; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, LIQUID; DAPTOMYCIN; DATABASES, FACTUAL; GENE EXPRESSION REGULATION, BACTERIAL; LYSINE; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHORIC ACIDS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; PROTEOME; PROTEOMICS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STREPTOMYCES; TANDEM MASS SPECTROMETRY;

EID: 84901217765     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2014.04.017     Document Type: Article

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