Long-term exposure of mice to nucleoside analogues disrupts mitochondrial DNA maintenance in cortical neurons

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Zhang, Yulin ^a   Song, Fengli ^a   Gao, Ziyun ^b   Ding, Wei ^a   Qiao, Luxin ^a   Yang, Sufang ^a   Chen, Xi ^c   Jin, Ronghua ^a   Chen, Dexi ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b NANCHANG UNIVERSITY   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DIDANOSINE; LAMIVUDINE; MITOCHONDRIAL DNA; NUCLEOSIDE ANALOG; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; ZIDOVUDINE; ANTIMETABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BRAIN CORTEX; BRAIN MITOCHONDRION; BRAIN TISSUE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; EMBRYO; GENE DELETION; GLIA CELL; LASER CAPTURE MICRODISSECTION; LIVER MITOCHONDRION; MITOCHONDRIAL TOXICITY; MOUSE; MUSCLE MITOCHONDRION; MUSCLE TISSUE; NERVE CELL; NEUROTOXICITY; NONHUMAN; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TREATMENT DURATION; BRAIN CELL; CARDIOMYOPATHY; CELL CULTURE; CELL DISRUPTION; CELL GROWTH; CELL SURVIVAL; CELL VIABILITY; DNA ISOLATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; LACTIC ACIDOSIS; LIPOATROPHY; LONG TERM EXPOSURE; MYOPATHY; POLYNEUROPATHY; VIRUS REPLICATION; ANIMAL; CYTOLOGY; DRUG EFFECTS; LIVER; METABOLISM; MITOCHONDRION; SKELETAL MUSCLE;

MUS;

ANIMALS; ANTIMETABOLITES; CELLS, CULTURED; CEREBRAL CORTEX; DIDANOSINE; DNA, MITOCHONDRIAL; LAMIVUDINE; LIVER; MICE; MITOCHONDRIA; MUSCLE, SKELETAL; NEURONS; STAVUDINE; ZIDOVUDINE;

EID: 84901201411     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0085637     Document Type: Article

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