Cardiac-targeted transgenic mutant mitochondrial enzymes: mtDNA defects, antiretroviral toxicity and cardiomyopathy

Cardiovascular Toxicology

Volumn 8, Issue 2, 2008, Pages 57-69

  Kohler, James J ^a   Hosseini, Seyed H ^a   Green, Elgin ^a   Hoying Brandt, Amy ^a   Cucoranu, Ioan ^a   Haase, Chad P ^a   Russ, Rodney ^a   Srivastava, Jaya ^a   Ivey, Kristopher ^a   Ludaway, Tomika ^a   Kapoor, Victor ^a   Abuin, Allison ^a   Shapoval, Alexsey ^a   Santoianni, Robert ^a   Saada, Ann ^b   Elpeleg, Orly ^b   Lewis, William ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Cardiomyopathy; mtDNA; Murine model; NRTI; Toxicity

Indexed keywords

ANTIRETROVIRUS AGENT; MITOCHONDRIAL ENZYME; PYRIMIDINE DERIVATIVE; DNA DIRECTED DNA POLYMERASE; MITOCHONDRIAL DNA; POLG PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE; THYMIDINE KINASE; THYMIDINE KINASE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; GENE MUTATION; HISTOCHEMISTRY; HISTOPATHOLOGY; MITOCHONDRIAL DNA DISORDER; MORPHOMETRICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ANIMAL; CONGESTIVE CARDIOMYOPATHY; DRUG EFFECT; ECHOGRAPHY; ENZYMOLOGY; GENETICS; HEART LEFT VENTRICLE HYPERTROPHY; HEART MITOCHONDRION; HEART MUSCLE CELL; HUMAN; METABOLISM; POINT MUTATION; TRANSGENIC MOUSE; ULTRASTRUCTURE;

MURINAE;

ANIMALS; ANTI-RETROVIRAL AGENTS; CARDIOMYOPATHIES; CARDIOMYOPATHY, DILATED; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; ELECTRON TRANSPORT COMPLEX I; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MICE; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; POINT MUTATION; SUCCINATE DEHYDROGENASE; THYMIDINE KINASE;

EID: 51449101904     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12012-008-9015-1     Document Type: Article

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