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Volumn 240, Issue , 2014, Pages 1-8

Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: A comprehensive review of the literature

Author keywords

Adulterant; Cocaine; Heroin; Speedball; Xylazine

Indexed keywords

ACTIVATED CARBON; ATROPINE; COCAINE; DIAMORPHINE; ENOXAPARIN; ETOMIDATE; FLUCLOXACILLIN; INSULIN; LAXATIVE; LIDOCAINE; LORAZEPAM; METOCLOPRAMIDE; METOPROLOL SUCCINATE; MIDAZOLAM; NALOXONE; ORCIPRENALINE; OXYGEN; PROPOFOL; RANITIDINE; RECREATIONAL DRUG; THIAMINE; VECURONIUM; XYLAZINE; HYPNOTIC SEDATIVE AGENT;

EID: 84901200350     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2014.03.015     Document Type: Review
Times cited : (138)

References (52)
  • 1
    • 0038015110 scopus 로고    scopus 로고
    • A reported case involving impaired driving following self-administration of xylazine
    • Stillwell M.E. A reported case involving impaired driving following self-administration of xylazine. Forensic Sci. Int. 2003, 134(1):25-28.
    • (2003) Forensic Sci. Int. , vol.134 , Issue.1 , pp. 25-28
    • Stillwell, M.E.1
  • 2
    • 85168049379 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration, Animal & Veterinary, Animal Drugs@FDA .
    • U.S. Food and Drug Administration, Animal & Veterinary, Animal Drugs@FDA . http://www.accessdata.fda.gov/scripts/animaldrugsatfda/.
  • 3
    • 0034995962 scopus 로고    scopus 로고
    • Severe intoxication with the veterinary tranquilizer xylazine in humans
    • Hoffmann U., Meister C.M., Golle K., Zschiesche M. Severe intoxication with the veterinary tranquilizer xylazine in humans. J. Anal. Toxicol. 2001, 25:245-249.
    • (2001) J. Anal. Toxicol. , vol.25 , pp. 245-249
    • Hoffmann, U.1    Meister, C.M.2    Golle, K.3    Zschiesche, M.4
  • 4
    • 33646873455 scopus 로고    scopus 로고
    • Systemic toxicity after an ocular exposure to xylazine hydrochloride
    • Vélez L.I., Shepherd G., Mills L.D., Rivera W. Systemic toxicity after an ocular exposure to xylazine hydrochloride. J. Emerg. Med. 2006, 30(4):407-410.
    • (2006) J. Emerg. Med. , vol.30 , Issue.4 , pp. 407-410
    • Vélez, L.I.1    Shepherd, G.2    Mills, L.D.3    Rivera, W.4
  • 7
    • 0024228652 scopus 로고
    • Xylazine-a review of its pharmacology and use in veterinary medicine
    • Greene S.A., Thurmon J.C. Xylazine-a review of its pharmacology and use in veterinary medicine. J. Vet. Pharmacol. Ther. 1988, 11(4):295-313.
    • (1988) J. Vet. Pharmacol. Ther. , vol.11 , Issue.4 , pp. 295-313
    • Greene, S.A.1    Thurmon, J.C.2
  • 8
    • 0019418289 scopus 로고
    • Human xylazine overdose: a comparative review of clonidine
    • Gallanosa A.G., Spyker D.A., Shipe J.R., Morris D.D. Human xylazine overdose: a comparative review of clonidine. Clin. Toxicol. 1981, 18(6):663-678.
    • (1981) Clin. Toxicol. , vol.18 , Issue.6 , pp. 663-678
    • Gallanosa, A.G.1    Spyker, D.A.2    Shipe, J.R.3    Morris, D.D.4
  • 11
    • 4344580518 scopus 로고
    • Chemical studies to detect residues of xylazine hydrochloride
    • Putter J., Sagner G. Chemical studies to detect residues of xylazine hydrochloride. Vet. Med. Rev. 1973, 73:145-159.
    • (1973) Vet. Med. Rev. , vol.73 , pp. 145-159
    • Putter, J.1    Sagner, G.2
  • 12
    • 0026498204 scopus 로고
    • Characterization of metabolites of xylazine produced in vivo and in vitro by LC/MS/MS and by GC/MS
    • Mutlib A.E., Chui Y.C., Young L.M., Abbott F.S. Characterization of metabolites of xylazine produced in vivo and in vitro by LC/MS/MS and by GC/MS. Drug Metab. Dispos. 1992, 20(6):840-848.
    • (1992) Drug Metab. Dispos. , vol.20 , Issue.6 , pp. 840-848
    • Mutlib, A.E.1    Chui, Y.C.2    Young, L.M.3    Abbott, F.S.4
  • 13
    • 84878999635 scopus 로고    scopus 로고
    • Characterization of xylazine metabolism in rat liver microsomes using liquid chromatography-hybrid triple quadrupole-linear ion trap-mass spectrometry
    • Lavoie D.S., Pailleux F., Vachon P., Beaudry F. Characterization of xylazine metabolism in rat liver microsomes using liquid chromatography-hybrid triple quadrupole-linear ion trap-mass spectrometry. Biomed. Chromatogr. 2013, 27(7):882-888.
    • (2013) Biomed. Chromatogr. , vol.27 , Issue.7 , pp. 882-888
    • Lavoie, D.S.1    Pailleux, F.2    Vachon, P.3    Beaudry, F.4
  • 14
    • 84890022116 scopus 로고    scopus 로고
    • Qualitative metabolism assessment and toxicological detection of xylazine, a veterinary tranquilizer and drug of abuse, in rat and human urine using GC-MS, LC-MSn, and LC-HR-MSn
    • Meyer G.M., Maurer H.H. Qualitative metabolism assessment and toxicological detection of xylazine, a veterinary tranquilizer and drug of abuse, in rat and human urine using GC-MS, LC-MSn, and LC-HR-MSn. Anal. Bioanal. Chem. 2013, 405(30):9779-9789.
    • (2013) Anal. Bioanal. Chem. , vol.405 , Issue.30 , pp. 9779-9789
    • Meyer, G.M.1    Maurer, H.H.2
  • 15
    • 79953786633 scopus 로고    scopus 로고
    • Xylazine (veterinary sedative) use in Puerto Rico
    • Torruella R.A. Xylazine (veterinary sedative) use in Puerto Rico. Subst. Abuse Treat Prev. Policy 2011, 6:7.
    • (2011) Subst. Abuse Treat Prev. Policy , vol.6 , pp. 7
    • Torruella, R.A.1
  • 18
    • 0030476414 scopus 로고    scopus 로고
    • Fatal heroin 'overdose': a review
    • Darke S., Zador D. Fatal heroin 'overdose': a review. Addiction 1996, 91(12):1765-1772.
    • (1996) Addiction , vol.91 , Issue.12 , pp. 1765-1772
    • Darke, S.1    Zador, D.2
  • 19
    • 0142059343 scopus 로고    scopus 로고
    • Heroin, part III: the pharmacology of heroin
    • Hosztafi S. Heroin, part III: the pharmacology of heroin. Acta Pharm. Hung. 2003, 73(3):197-205.
    • (2003) Acta Pharm. Hung. , vol.73 , Issue.3 , pp. 197-205
    • Hosztafi, S.1
  • 20
    • 34249034630 scopus 로고    scopus 로고
    • Managing acute heroin overdose
    • Dixon P. Managing acute heroin overdose. Emerg. Nurse 2007, 15(2):30-35.
    • (2007) Emerg. Nurse , vol.15 , Issue.2 , pp. 30-35
    • Dixon, P.1
  • 21
    • 84873088281 scopus 로고    scopus 로고
    • Epidemic of illicit drug use, mechanisms of action/addiction and stroke as a health hazard
    • Esse K., Fossati-Bellani M., Traylor A., Martin-Schild S. Epidemic of illicit drug use, mechanisms of action/addiction and stroke as a health hazard. Brain Behav. 2011, 1(1):44-54.
    • (2011) Brain Behav. , vol.1 , Issue.1 , pp. 44-54
    • Esse, K.1    Fossati-Bellani, M.2    Traylor, A.3    Martin-Schild, S.4
  • 22
    • 84901240590 scopus 로고    scopus 로고
    • Use of dexmedetomidine to facilitate non-invasive ventilation
    • Demuro J.P., Mongelli M.N., Hanna A.F. Use of dexmedetomidine to facilitate non-invasive ventilation. Int. J. Crit. Illn. Inj. Sci. 2013, 3(4):274-275.
    • (2013) Int. J. Crit. Illn. Inj. Sci. , vol.3 , Issue.4 , pp. 274-275
    • Demuro, J.P.1    Mongelli, M.N.2    Hanna, A.F.3
  • 25
    • 46549085018 scopus 로고
    • Misuse of xylazine
    • Haigh J.C. Misuse of xylazine. Can. Vet. J. 1988, 29(10):782-784.
    • (1988) Can. Vet. J. , vol.29 , Issue.10 , pp. 782-784
    • Haigh, J.C.1
  • 26
    • 0025122381 scopus 로고
    • Accidental self administration of xylazine in a veterinary nurse
    • Samanta A., Roffe C., Woods K.L. Accidental self administration of xylazine in a veterinary nurse. Postgrad. Med. J. 1990, 66:244-245.
    • (1990) Postgrad. Med. J. , vol.66 , pp. 244-245
    • Samanta, A.1    Roffe, C.2    Woods, K.L.3
  • 27
  • 29
    • 9244248601 scopus 로고    scopus 로고
    • An unusual presentation from xylazine-ketamine
    • Arican F.O., Okan T., Badak O., Guneri S. An unusual presentation from xylazine-ketamine. Vet. Hum. Toxicol. 2004, 46(6):324-325.
    • (2004) Vet. Hum. Toxicol. , vol.46 , Issue.6 , pp. 324-325
    • Arican, F.O.1    Okan, T.2    Badak, O.3    Guneri, S.4
  • 30
    • 34247342184 scopus 로고    scopus 로고
    • Solid-phase extraction and gas chromatographic-mass spectrometric determination of the veterinary drug xylazine in human blood
    • Barroso M., Gallardo E., Margalho C., Devesa N., Pimentel J., Vieira D.N. Solid-phase extraction and gas chromatographic-mass spectrometric determination of the veterinary drug xylazine in human blood. J. Anal. Toxicol. 2007, 31(3):165-169.
    • (2007) J. Anal. Toxicol. , vol.31 , Issue.3 , pp. 165-169
    • Barroso, M.1    Gallardo, E.2    Margalho, C.3    Devesa, N.4    Pimentel, J.5    Vieira, D.N.6
  • 32
    • 84886085700 scopus 로고    scopus 로고
    • Case report of accidental poisoning with the tranquilizer xylazine and the anesthetic ketamine confirmed by qualitative and quantitative toxicological analysis using GC-MS and LC-MS
    • Meyer G.M., Meyer M.R., Mischo B., Schofer O., Maurer H.H. Case report of accidental poisoning with the tranquilizer xylazine and the anesthetic ketamine confirmed by qualitative and quantitative toxicological analysis using GC-MS and LC-MS. Drug Test. Anal. 2013, 5(9-10):785-789.
    • (2013) Drug Test. Anal. , vol.5 , Issue.9-10 , pp. 785-789
    • Meyer, G.M.1    Meyer, M.R.2    Mischo, B.3    Schofer, O.4    Maurer, H.H.5
  • 33
    • 41149147156 scopus 로고    scopus 로고
    • Concurrent detection of heroin, fentanyl, and xylazine in seven drug-related deaths reported from the Philadelphia Medical Examiner's Office
    • Wong S.C., Curtis J.A., Wingert W.E. Concurrent detection of heroin, fentanyl, and xylazine in seven drug-related deaths reported from the Philadelphia Medical Examiner's Office. J. Forensic Sci. 2008, 53(2):495-498.
    • (2008) J. Forensic Sci. , vol.53 , Issue.2 , pp. 495-498
    • Wong, S.C.1    Curtis, J.A.2    Wingert, W.E.3
  • 34
    • 85168047539 scopus 로고    scopus 로고
    • Nine xylazine related deaths in Puerto Rico, oral presentation (K44)
    • American Academy of Forensic Sciences
    • Chavez C., Sanabria D., Ruiz K. Nine xylazine related deaths in Puerto Rico, oral presentation (K44). Forensic Toxicology Proceedings 2002-2011 2009, 77 pp. American Academy of Forensic Sciences.
    • (2009) Forensic Toxicology Proceedings 2002-2011
    • Chavez, C.1    Sanabria, D.2    Ruiz, K.3
  • 35
    • 0021891496 scopus 로고
    • Xylazine in human tissues and fluids in a case of fatal drug abuse
    • Poklis A., Mackell M.A., Case M. Xylazine in human tissues and fluids in a case of fatal drug abuse. J. Anal. Toxicol. 1985, 9:234-236.
    • (1985) J. Anal. Toxicol. , vol.9 , pp. 234-236
    • Poklis, A.1    Mackell, M.A.2    Case, M.3
  • 37
    • 0031917007 scopus 로고    scopus 로고
    • Xylazine toxicity-literature review and report of two cases
    • Mittleman R.E., Hearn W.L., Hime G.W. Xylazine toxicity-literature review and report of two cases. J. Forensic Sci. 1998, 43:400-402.
    • (1998) J. Forensic Sci. , vol.43 , pp. 400-402
    • Mittleman, R.E.1    Hearn, W.L.2    Hime, G.W.3
  • 39
    • 84863779471 scopus 로고    scopus 로고
    • The emerging of xylazine as a new drug of abuse and its health consequences among drug users in Puerto Rico
    • Reyes J.C., Negrón J.L., Colón H.M., Padilla A.M., Millán M.Y., Matos T.D., Robles R.R. The emerging of xylazine as a new drug of abuse and its health consequences among drug users in Puerto Rico. J. Urban Health 2012, 89(3):519-526.
    • (2012) J. Urban Health , vol.89 , Issue.3 , pp. 519-526
    • Reyes, J.C.1    Negrón, J.L.2    Colón, H.M.3    Padilla, A.M.4    Millán, M.Y.5    Matos, T.D.6    Robles, R.R.7
  • 42
    • 14144253824 scopus 로고    scopus 로고
    • Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments
    • Kreek M.J., Bart G., Lilly C., LaForge K.S., Nielsen D.A. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol. Rev. 2005, 57(1):1-26.
    • (2005) Pharmacol. Rev. , vol.57 , Issue.1 , pp. 1-26
    • Kreek, M.J.1    Bart, G.2    Lilly, C.3    LaForge, K.S.4    Nielsen, D.A.5
  • 43
    • 84885933596 scopus 로고    scopus 로고
    • Elevated norepinephrine may be a unifying etiological factor in the abuse of a broad range of substances: alcohol, nicotine, Marijuana, Heroin, Cocaine, and Caffeine
    • Fitzgerald P.J. Elevated norepinephrine may be a unifying etiological factor in the abuse of a broad range of substances: alcohol, nicotine, Marijuana, Heroin, Cocaine, and Caffeine. Subst. Abuse 2013, 13(7):171-183.
    • (2013) Subst. Abuse , vol.13 , Issue.7 , pp. 171-183
    • Fitzgerald, P.J.1
  • 44
    • 0017553206 scopus 로고
    • Xylazine-morphine sequence to obtain analgesia in the horse and dog
    • Huska G.R. Xylazine-morphine sequence to obtain analgesia in the horse and dog. Can. Vet. J. 1977, 18(11):317.
    • (1977) Can. Vet. J. , vol.18 , Issue.11 , pp. 317
    • Huska, G.R.1
  • 45
    • 1842588616 scopus 로고    scopus 로고
    • Influence of morphine sulfate on the halothane sparing effect of xylazine hydrochloride in horses
    • Bennett R.C., Steffey E.P., Kollias-Baker C., Sams R. Influence of morphine sulfate on the halothane sparing effect of xylazine hydrochloride in horses. Am. J. Vet. Res. 2004, 65(4):519-526.
    • (2004) Am. J. Vet. Res. , vol.65 , Issue.4 , pp. 519-526
    • Bennett, R.C.1    Steffey, E.P.2    Kollias-Baker, C.3    Sams, R.4
  • 46
    • 0028901144 scopus 로고
    • Cardiovascular effects of epidurally administered morphine and a xylazine-morphine combination in isoflurane-anesthetized dogs
    • Keegan R.D., Greene S.A., Weil A.B. Cardiovascular effects of epidurally administered morphine and a xylazine-morphine combination in isoflurane-anesthetized dogs. Am. J. Vet. Res. 1995, 56(4):496-500.
    • (1995) Am. J. Vet. Res. , vol.56 , Issue.4 , pp. 496-500
    • Keegan, R.D.1    Greene, S.A.2    Weil, A.B.3
  • 47
    • 0003549757 scopus 로고    scopus 로고
    • District of Columbia, Washington, 60 pp.
    • Levine B. Principles of Forensic Toxicology 2010, 247-248. District of Columbia, Washington, 60 pp. 3rd ed.
    • (2010) Principles of Forensic Toxicology , pp. 247-248
    • Levine, B.1
  • 48
    • 0037221068 scopus 로고    scopus 로고
    • Understanding polydrug use: review of heroin and cocaine co-use
    • Leri F., Bruneau J., Stewart J. Understanding polydrug use: review of heroin and cocaine co-use. Addiction 2003, 98(1):7-22.
    • (2003) Addiction , vol.98 , Issue.1 , pp. 7-22
    • Leri, F.1    Bruneau, J.2    Stewart, J.3
  • 49
    • 84862205740 scopus 로고    scopus 로고
    • Drug interactions between common illicit drugs and prescription therapies
    • Lindsey W.T., Stewart D., Childress D. Drug interactions between common illicit drugs and prescription therapies. Am. J. Drug Alcohol Abuse 2012, 38(4):334-343.
    • (2012) Am. J. Drug Alcohol Abuse , vol.38 , Issue.4 , pp. 334-343
    • Lindsey, W.T.1    Stewart, D.2    Childress, D.3
  • 50
    • 0023833138 scopus 로고
    • Effect of cocaine on xylazine analgesic activity
    • Leonhardt J.H., Freire A.C. Effect of cocaine on xylazine analgesic activity. Braz. J. Med. Biol. Res. 1988, 21(1):103-105.
    • (1988) Braz. J. Med. Biol. Res. , vol.21 , Issue.1 , pp. 103-105
    • Leonhardt, J.H.1    Freire, A.C.2
  • 51
    • 35348864322 scopus 로고    scopus 로고
    • Crack-heroin speedball injection and its implications for vein care: qualitative study
    • Rhodes T., Briggs D., Kimber J., Jones S., Holloway G. Crack-heroin speedball injection and its implications for vein care: qualitative study. Addiction 2007, 102(11):1782-1790.
    • (2007) Addiction , vol.102 , Issue.11 , pp. 1782-1790
    • Rhodes, T.1    Briggs, D.2    Kimber, J.3    Jones, S.4    Holloway, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.