Exogenous High-Mobility Group Box 1 Inhibits Apoptosis and Promotes the Proliferation of Lewis Cells via RAGE/TLR4-Dependent Signal Pathways

Scandinavian Journal of Immunology

Volumn 79, Issue 6, 2014, Pages 386-394

  Xu, X ^a,b   Zhu, H ^c   Wang, T ^a,b   Sun, Y ^a,b   Ni, P ^a,b   Liu, Y ^a   Tian, S ^a,b   Amoah Barnie, P ^a,b   Shen, H ^d   Xu, W ^a   Xu, H ^a,b   Su, Z ^a,b  

^a The Fourth People's Hospital of Zhenjiang   (China)

^b JIANGSU UNIVERSITY   (China)

^c AFFILIATED HOSPITAL OF JIANGSU UNIVERSITY   (China)

^d AFFILIATED PEOPLE S HOSPITAL OF JIANGSU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; BALANCED SALT SOLUTION; HIGH MOBILITY GROUP B1 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; TOLL LIKE RECEPTOR 4;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; IN VITRO STUDY; INTRACELLULAR SIGNALING; LUNG CANCER; LUNG CANCER CELL LINE; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HMGB1 PROTEIN; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84901193586     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/sji.12174     Document Type: Article

References (24)

1. Kang R, Tang D, Schapiro NE et al. The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics. Oncogene 2014;33:567-77.
2. Kawahara K, Biswas KK, Unoshima M et al. C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells. Cardiovasc Pathol 2008;17:129-38.
3. Tang D, Kang R, Cheh CW et al. HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene 2010;29:5299-310.
4. Candido J, Hagemann T. Cancer-related inflammation. J Clin Immunol 2013;33 (Suppl. 1):S79-84.
5. Tang D, Billiar TR, Lotze MT. A Janus tale of two active high mobility group box 1 (HMGB1) redox states. Mol Med 2012;18:1360-2.
6. Wang LL, Meng QH, Jiao Y et al. High-mobility group boxes mediate cell proliferation and radiosensitivity via retinoblastoma-interaction-dependent and -independent mechanisms. Cancer Biother Radiopharm 2012;27:329-35.
7. Sims GP, Rowe DC, Rietdijk ST, Herbst R, Coyle AJ. HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol 2010;28:367-88.
8. Nogueira-Machado JA, Volpe CM, Veloso CA, Chaves MM. HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation. Expert Opin Ther Targets 2011;15:1023-35.
9. Wang FP, Li L, Li J, Wang JY, Wang LY, Jiang W. High mobility group box-1 promotes the proliferation and migration of hepatic stellate cells via TLR4-dependent signal pathways of PI3K/Akt and JNK. PLoS One 2013;8:e64373.
10. Datta R. Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis. J Biol Chem 1997;272:20317-20.
11. Ohta T. Requirement of the caspase-3/CPP32 protease cascade for apoptotic death following cytokine deprivation in hematopoietic cells. J Biol Chem 1997;272:23111-6.
12. Adefolaju GA, Theron KE, Hosie MJ. Effects of HIV protease, nucleoside/non-nucleoside reverse transcriptase inhibitors on Bax, Bcl-2 and apoptosis in two cervical cell lines. Biomed Pharmacother 2014;68:241-51.
13. Asavarut P, Zhao H, Gu J, Ma D. The role of HMGB1 in inflammation-mediated organ injury. Acta Anaesthesiol Taiwan 2013;51:28-33.
14. Jube S, Rivera ZS, Bianchi ME et al. Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma. Cancer Res 2012;72:3290-301.
15. Banerjee S, de Freitas A, Friggeri A, Zmijewski JW, Liu G, Abraham E. Intracellular HMGB1 negatively regulates efferocytosis. J Immunol 2011;187:4686-94.
16. Volp K, Brezniceanu ML, Bosser S et al. Increased expression of high mobility group box 1 (HMGB1) is associated with an elevated level of the antiapoptotic c-IAP2 protein in human colon carcinomas. Gut 2006;55:234-42.
17. Chen J, Xi B, Zhao Y, Yu Y, Zhang J, Wang C. High-mobility group protein B1 (HMGB1) is a novel biomarker for human ovarian cancer. Gynecol Oncol 2012;126:109-17.
18. Zhang Y, Cheng Y, Ren X et al. NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response. Oncogene 2012;31:1055-64.
19. Tang D, Kang R, Zeh HJ 3rd, Lotze MT. High-mobility group box 1 and cancer. Biochim Biophys Acta 2010;1799:131-40.
20. Gwak GY, Moon TG, Lee DH, Yoo BC. Glycyrrhizin attenuates HMGB1-induced hepatocyte apoptosis by inhibiting the p38-dependent mitochondrial pathway. World J Gastroenterol 2012;18:679-84.
21. Ding HS, Yang J, Chen P et al. The HMGB1-TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis. Gene 2013;527:389-93.
22. Luo Y, Li SJ, Yang J, Qiu YZ, Chen FP. HMGB1 induces an inflammatory response in endothelial cells via the RAGE-dependent endoplasmic reticulum stress pathway. Biochem Biophys Res Commun 2013;438:732-8.
23. Munshi A, Ramesh R. Mitogen-activated protein kinases and their role in radiation response. Genes Cancer 2013;4:401-8.
24. Oh YJ, Youn JH, Min HJ et al. CKD712, (S)-1-(alpha-naphthylmethyl)-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C. Int Immunopharmacol 2011;11:1160-5.