Sexual function and male cancer

Translational Andrology and Urology

Volumn 2, Issue 1, 2013, Pages 74-81

  Incrocci, Luca ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Erectile dysfunction; Male cancer; Quality of life; Radiotherapy; Sexual dysfunction; Sexual function(ing)

Indexed keywords

EID: 84901189430     PISSN: 22234683     EISSN: 22234691     Source Type: Journal    
DOI: 10.3978/j.issn.2223-4683.2013.03.02     Document Type: Review

References (88)

1. Siegel R, DeSantis C, Virgo K, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin 2012;62:220-41.
2. Addis ME, Mahalik JR. Men, masculinity, and the context of help-seeking. Am Psych 2003;58:5-14.
3. Rosen RC, Riley A, Wagner G, et al. The International Index of Erectile Function (IIEF). A multidimensional scale for assessment of erectile dysfunction. Urology 1997;49:822-30.
4. Rosen RC, Cappelleri JC, Smith MD, et al. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999;11:319-26.
5. Montorsi F, Adaikan G, Becher E, et al. Summary of the recommendations on sexual dysfunctions in men. J Sex Med. 2010;7:3572-88.
6. Incrocci L, Slob AK, Levendag PC. Sexual (dys)function after radiotherapy for prostate cancer: a review. Int J Radiat Oncol Biol Phys 2002;52:681-93.
7. Incrocci L, Slob AK. Incidence, etiology, and therapy for erectile dysfunction after external beam radiotherapy for prostate cancer. Urology 2002;60:1-7.
8. Incrocci L. Sexual function after external-beam radiotherapy for prostate cancer: What do we know? Crit Rev Oncol Hematol 2006;57:165-73.
9. Zelefsky MJ, Eid JF. Elucidating the etiology of erectile dysfunction after definitive therapy for prostatic cancer. Int J Radiat Oncol Biol Phys 1998;40:129-33.
10. DiBiase SJ, Wallner K, Tralins K, et al. Brachytherapy radiation doses to the neurovascular bundles. Int J Radiat Oncol Biol Phys 2000;46:1301-7.
11. Merrick GS, Butler WM, Dorsey AT, et al. A comparison of radiation dose to the neurovascular bundles in men with and without prostate brachytherapy-induced erectile dysfunction. Int J Radiat Oncol Biol Phys 2000;48:1069-74.
12. Merrick GS, Wallner K, Butler WM, et al. A comparison of radiation dose to the bulb of the penis in men with and without prostate brachytherapy-induced erectile dysfunction. Int J Radiat Oncol Biol Phys 2001;50:597-604.
13. Merrick GS, Butler WM, Wallner KE, et al. The importance of radiation doses to the penile bulb vs. crura in the development of postbrachytherapy erectile dysfunction. Int J Radiat Oncol Biol Phys 2002;54:1055-62.
14. Merrick GS, Butler WM, Wallner KE, et al. Erectile function after prostate brachytherapy. Int J Radiat Oncol Biol Phys 2005;62:437-47.
15. Fisch BM, Pickett B, Weinberg V, et al. Dose of radiation received by the bulb of the penis correlates with risk of impotence after three-dimensional conformal radiotherapy for prostate cancer. Urology 2001;57:955-9.
16. Kiteley RA, Lee WR, deGuzman AF, et al. Radiation dose to the neurovascular bundles or penile bulb does not predict erectile dysfunction after prostate brachytherapy. Brachytherapy 2002;1:90-4.
17. Selek U, Cheung R, Lii M, et al. Erectile dysfunction and radiation dose to penile base structures: a lack of correlation. In J Radiat Oncol Biol Phys 2004;59:1039-46.
18. Roach M, Winter K, Michalski JM, et al. Penile bulb dose and impotence after three-dimensional conformal radiotherapy for prostate cancer on RTOG 9406: findings from a prospective, multi-institutional, phase I/II dose-escalation study. Int J Radiat Oncol Biol Phys 2004;60:1351-6.
19. Wernicke AG, Valicenti R, Dieva K, et al. Radiation dose delivered to the proximal penis as a predictor of the risk of erectile dysfunction after three-dimensional conformal radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 2004;60:1357-63.
20. Wright JL, Newhouse JH, Laguna JL, et al. Localization of neurovascular bundles on pelvic CT and evaluation of radiation dose to structures putatively involved in erectile dysfunction after prostate brachytherapy. Int J Radiat Oncol Biol Phys 2004;59:426-35.
21. Macdonald AG, Keyes M, Kruk A, et al. Predictive factors for erectile dysfunction in men with prostate cancer after brachytherapy: is dose to the penile bulb important? Int J Radiat Oncol Biol Phys 2005;63:155-63.
22. Mangar SA, Sydes MR, Tucker HL, et al. Evaluating the relationship between erectile dysfunction and dose received by the penile bulb: using data from a randomised controlled trial of conformal radiotherapy in prostate cancer (MRC RT01, ISRCTN47772397). Radiother Oncol 2006;80:355-62.
23. Brown MW, Brooks JP, Albert PS, et al. An analysis of erectile function after intensity modulated radiation therapy for localized prostate carcinoma. Prostate Cancer Prostatic Dis 2007;10:189-93.
24. van der Wielen GJ, Hoogeman MS, Dohle GR, et al. Dose-volume parameters of the corpora cavernosa do not correlate with erectile dysfunction after external beam radiotherapy for prostate cancer: results from a dose-escalation trial. Int J Radiat Oncol Biol Phys 2008;71:795-800.
25. Solan AN, Cesaretti JA, Stone NN, et al. There is no correlation between erectile dysfunction and dose to penile bulb and neurovascular bundles following real-time low-dose-rate prostate brachytherapy. Int J Radiat Oncol Biol Phys 2009;73:1468-74.
26. van der Wielen GJ, Mulhall JP, Incrocci L. Erectile dysfunction after radiotherapy for prostate cancer and radiation dose to the penile structures: A critical review. Radiother Oncol 2007;84:107-13.
27. Incrocci L. Brachytherapy of prostate cancer and sexual dysfunction. UroOncology 2002;2:107-12.
28. Pilepich MV, Krall JM, Al-Sarraf M, et al. Androgen deprivation with radiation therapy compared with radiation therapy alone for locally advanced prostatic carcinoma: a randomized comparative trial of the Radiation Therapy Oncology Group. Urology 1995;45:616-23.
29. Beckendorf V, Hay M, Rozan R, et al. Changes in sexual function after radiotherapy treatment of prostate cancer. Br J Urol 1996;77:118-23.
30. Beard CJ, Propert KJ, Rieker PP, et al. Complications after treatment with external-beam irradiation in early-stage prostate cancer patients: a prospective multiinstitutional outcomes study. J Clin Oncol 1997;15:223-9.
31. Borghede G, Hedelin H. Radiotherapy of localised prostate cancer. Analysis of late treatment complications. A prospective study. Radiother Oncol 1997;43:139-46.
32. Turner SL, Adams K, Bull CA, et al. Sexual dysfunction after radical radiation therapy for prostate cancer: a prospective evaluation. Urology 1999;54:124-9.
33. van der Wielen GJ, van Putten WLJ, Incrocci L. Sexual Function After Three-Dimensional Conformal Radiotherapy for Prostate Cancer: Results from a dose-escalation trial. Int J Radiat Oncol Biol Phys 2007;68:479-84.
34. Pinkawa M, Gagel B, Piroth MD, et al. Erectile dysfunction after external beam radiotherapy for prostate cancer. Eur Urol 2009;55:227-34.
35. Martinez A, Gonzalez J, Stromberg J, et al. Conformal prostate brachytherapy: initial experience of a phase I/II dose-escalating trial. Int J Radiat Oncol Biol Phys 1995;33:1019-27.
36. Arterbery VE, Frazier A, Dalmia P, et al. Quality of life after permanent prostate implant. Semin Surg Oncol 1997;13:461-4.
37. Koutrouvelis PG. Three-dimensional stereotactic posterior ischiorectal space computerized tomography guided brachytherapy of prostate cancer: a preliminary report. J Urol 1998;159:142-5.
38. Joly F, Brune D, Couette JE, et al. Health-related quality of life and sequelae in patients treated with brachytherapy and external beam irradiation for localized prostate cancer. Ann Oncol 1998;9:751-7.
39. Sharkey J, Chovnick SD, Behar RJ, et al. Outpatient ultrasound-guided Palladium-103 brachytherapy for localized adenocarcinoma of the prostate: a preliminary report of 434 patients. Urology 1998;51:796-803.
40. Kestin LL, Martinez AA, Stromberg JS, et al. Matched-pair analysis of conformal high-dose-rate brachytherapy boost versus external-beam radiation therapy alone for locally advanced prostate cancer. J Clin Oncol 2000;18:2869-80.
41. Sánchez-Ortiz RF, Broderick GA, Rovner ES, et al. Erectile function and quality of life after interstitial radiation therapy for prostate cancer. Int J Impotence Res 2000;12:18-24.
42. Sharkey J, Chovnick SD, Behar RJ, et al. Minimally invasive treatment for localized adenocarcinoma of the prostate: review of 1048 patients treated with ultrasound-guided Palladium-103 brachytherapy. J Endourol 2000;14:343-50.
43. Zelefsky MJ, Hollister T, Raben A, et al. Five-year biochemical outcome and toxicity with transperineal CT-planned permanent I-125 prostate implantation for patients with localized prostate cancer. Int J Radiat Oncol Biol Phys 2000;47:1261-6.
44. Potters L, Torre T, Fearn PA, et al. Potency after permanent prostate brachytherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 2001;50:1235-42.
45. Stock RG, Kao J, Stone NN. Penile erectile function after permanent radioactive seed implantation for treatment of prostate cancer. J Urol 2001;165:436-9.
46. Little FA, Howard GC. Sexual function following radical radiotherapy for bladder cancer. Radiother Oncol 1998;49:157-61.
47. Fokdal L, Høyer M, Meldgaard P, et al. Long-term bladder, colorectal, and sexual functions after radical radiotherapy for urinary bladder cancer. Radiother Oncol 2004;72:139-45.
48. Månsson A, Caruso A, Capovilla E, et al. Quality of life after radical cystectomy and orthotopic bladder substitution: A comparison between Italian and Swedish men. BJU Int 2000;85:26-31.
49. Bjerre BD, Johansen C, Steven K. Sexological problems after cystectomy: bladder substitution compared with ileal conduit diversion. Scand J Urol Nephrol 1998;32:187-93.
50. Misra S, Chaturvedi A, Misra NC. Penile carcinoma: a challenge for the developing world. Lancet Oncol 2004;5:240-7.
51. Windahl T, Skeppner E, Andersson SO, et al. Sexual function and satisfaction in men after laser treatment for penile carcinoma. J Urol 2004;172:648-51.
52. Opjordsmoen S, Wahere H, Aass N, et al. Sexuality in patients treated for penile cancer: Patients' experience and doctors' judgment. Br J Urol 1994;73:554-60.
53. Che M, Tamboli P, Ro J, et al. Bilateral testicular germ cell tumours: Twenty-year experience at M.D. Anderson Cancer Center. Cancer 2002;95:1228-33.
54. Huyghe E, Matsuda T, Thonneau P. Increasing incidence of testicular cancer worldwide: a review. J Urol 2003;170:5-11.
55. van Basten JP, Schrafford Koops H, Sleijfer DT, et al. Current concepts about testicular cancer. Eur J Surg Oncol 1997;23:354-60.
56. Schover LR, Gonzales M, von Eschenbach AC. Sexual and marital relationships after radiotherapy for seminoma. Urology 1986;27:117-23.
57. Jonker-Pool G, van Basten JP, Hoekstra HJ, et al. Sexual functioning after treatment for testicular cancer. Cancer 1997;80:454-64.
58. Tinkler SD, Howard GC, Kerr GR. Sexual morbidity following radiotherapy for germ cell tumors of the testis. Radiother Oncol 1992;25: 207-12.
59. Caffo O, Amichetti M. Evaluation of sexual life after orchidectomy followed by radiotherapy for early-stage seminoma of the testis. BJU Int 1999;83:462-8.
60. Incrocci L, Hop WC, Wijnmaalen A, et al. Treatment outcome, body image, and sexual functioning after orchiectomy and radiotherapy for stage I-II testicular seminoma. Int J Radiat Oncol Biol Phys 2002;53:1165-73.
61. Arai Y, Kawakita M, Okada Y, et al. Sexuality and fertility in long-term survivors of testicular cancer. J Clin Oncol 1997;15:1444-8.
62. Nazareth I, Lewin J, King M. Sexual dysfunction after treatment for testicular cancer. A systematic review. J Psychosom Res 2001;51:735-43.
63. van Basten JP, Jonker-Pool G, van Driel MF, et al. Sexual functioning after multimodality treatment for disseminated nonseminomatous testicular germ cell tumor. J Urol 1997;158:1411-6.
64. Gritz ER, Wellisch DK, Wang HJ, et al. Long-term effects of testicular cancer on sexual functioning in married couples. Cancer 1989;64:1560-7.
65. Incrocci L, Bosch JL, Slob AK. Testicular prostheses: body image and sexual functioning. BJU Int 1999;84:1043-5.
66. Adshead J, Khoubehi B, Wood J, et al. Testicular implants and patient satisfaction: a questionnaire-based study of men after orchidectomy for testicular cancer. BJU Int 2001;88:559-62.
67. Lynch MJ, Pryor JP. Testicular prostheses: the patient's perception. Br J Urol 1992;70:420-2.
68. Bonnel C, Parc YR, Pocard M, et al. Effects of preoperative radiotherapy for primary resectable rectal adenocarcinoma on male sexual and urinary function. Dis Colon Rectum 2002;45:934-9.
69. Marijnen CA, van de Velde CJ, Putter H, et al. Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer. Report of a multicenter randomized trial. J Clin Oncol 2005;23:1847-58.
70. Nesbakken A, Nygaard K, Bull-Njaa T, et al. Bladder and sexual dysfunction after mesorectal excision for rectal cancer. Br J Surg 2000;87:206-10.
71. Pocard M, Zinzindohoue F, Haab F, et al. A prospective study of sexual and urinary function before and after total mesorectal excision with autonomic nerve preservation for rectal cancer. Surgery 2002;131:368-72.
72. Maas CP, Moriya Y, Steup WH, et al. Radical and nerve-preserving surgery for rectal cancer in The Netherlands: a prospective study on morbidity and functional outcome. Br J Surg 1998;85:92-7.
73. Arai Y, Aoki Y, Okubo K, et al. Impact of interventional therapy for benign prostatic hyperplasia on quality of life and sexual function: a prospective study. J Urol 2000;164:1206-11.
74. Pierce LJ, Whittington R, Hanno PM, et al. Pharmacologic erection with intracavernosal injection for men with sexual dysfunction following irradiation: a preliminary report. Int J Radiat Oncol Biol Phys 1991;21:1311-4.
75. Dubocq FM, Bianco FJ Jr, Maralani SJ, et al. Outcome analysis of penile implant surgery after external beam radiation for prostate cancer. J Urol 1997;158:1787-90.
76. Zelefsky MJ, McKee AB, Lee H, et al. Efficacy of oral sildenafil in patients with erectile dysfunction after radiotherapy for carcinoma of the prostate. Urology 1999;53:775-8.
77. Kedia S, Zippe CD, Agarwal A, et al. Treatment of erectile dysfunction with sildenafil citrate (Viagra) after radiation therapy for prostate cancer. Urology 1999;54:308-12.
78. Valicenti RK, Choi E, Chen C, et al. Sildenafil citrate effectively reverses sexual dysfunction induced by three-dimensional conformal radiation therapy. Urology 2001;57:769-73.
79. Weber DC, Bieri S, Kurtz JM, et al. Prospective pilot study of sildenafil for treatment of postradiotherapy erectile dysfunction in patients with prostate cancer. J Clin Oncol 1999;17:3444-9.
80. Ohebshalom M, Parker M, Guhring P, et al. The efficacy of sildenafil citrate following radiation therapy for prostate cancer: temporal considerations. J Urol 2005;174:258-62.
81. Incrocci L, Koper PC, Hop WC, et al. Sildenafil citrate (Viagra) and erectile dysfunction following external-beam radiotherapy for prostate cancer. A randomized, double-blind, placebo-controlled, cross-over study. Int J Radiat Oncol Biol Phys 2001;51:1190-5.
82. Incrocci L, Hop WC, Slob AK. Efficacy of sildenafil in an open-label study as a continuation of a double-blind study in the treatment of erectile dysfunction after radiotherapy of prostate cancer. Urology 2003;62:116-20.
83. Incrocci L, Slagter C, Slob AK, et al. A randomized, double-blind, placebo-controlled, cross-over study to assess the efficacy of tadalafil (Cialis) in the treatment of erectile dysfunction following three-dimensional conformal external-beam radiotherapy for prostatic carcinoma. Int J Radiat Oncol Biol Phys 2006;66:439-44.
84. Incrocci L, Slob AK, Hop WC. Tadalafil (Cialis) and erectile dysfunction after radiotherapy for prostate cancer: an open-label extension of a blinded trial. Urology 2007;70:1190-3.
85. Ricardi U, Gontero P, Ciammella P, et al. Efficacy and safety of tadalafil 20 mg on demand vs. tadalafil 5 mg once-a-day in the treatment of post-radiotherapy erectile dysfunction in prostate cancer men: a randomized phase II trial. J Sex Med 2010;7:2851-9.
86. Watkins Bruner D, James JL, Bryan CJ, et al. Randomized, double-blinded, placebo-controlled crossover trial of treating erectile dysfunction with sildenafil after radiotherapy and short-term androgen deprivation therapy: results of RTOG 0215. J Sex Med 2011;8:1228-38.
87. Incrocci L. Talking about sex to oncologists and cancer to sexologists. J Sex Med 2011;8:3251-3.
88. Sadovsky R, Basson R, Krychman M, et al. Cancer and sexual problems. J Sex Med 2010;7:349-73.