Prospective pilot study of sildenafil for treatment of postradiotherapy erectile dysfunction in patients with prostate cancer

Journal of Clinical Oncology

Volumn 17, Issue 11, 1999, Pages 3444-3449

  Weber, Damien C ^a   Bieri, Sabine ^a   Kurtz, John M ^a   Miralbell, Raymond ^a  

^a SAN GIOVANNI HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GOSERELIN; SILDENAFIL;

ADULT; AGED; ARTICLE; CANCER HORMONE THERAPY; CANCER RADIOTHERAPY; CLINICAL ARTICLE; DRUG EFFECT; DYSPEPSIA; ERECTILE DYSFUNCTION; FLUSHING; HEADACHE; HUMAN; MALE; PENIS ERECTION; PRIAPISM; PRIORITY JOURNAL; PROSTATE CANCER; RADIATION INJURY; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032701092     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1999.17.11.3444     Document Type: Article

References (20)

1. Robinson JW, Dufour MS, Fung TS: Erectile functioning of men treated for prostate carcinoma. Cancer 79:538-544, 1997
2. Fransson P, Widmark A: Self-assessed sexual function after pelvic irradiation for prostate cancer. Cancer 78:1066-1078, 1996
3. Chinn DM, Holland J, Crownover RL, et al: Potency following high-dose three-dimensional conformal radiotherapy and the impact of major urologic surgical procedures in patients treated for prostate cancer. Int J Radiat Oncol Biol Phys 33:15-22, 1995
4. Zinreich ES, Derogatis LR, Herpst J, et al: Pre and posttreatment evaluation of sexual function in patients with adenocarcinoma of the prostate. Int J Radiat Oncol Biol Phys 19:729-732, 1990
5. Talcott JA, Rieker P, Clark JA, et al: Patient-reported symptoms after primary therapy for early prostate cancer: Results of a prospective cohort study. J Clin Oncol 16:275-283, 1998
6. Helgason AR, Fredrikson M, Adolfsson J, et al: Decreased sexual capacity after external radiation therapy for prostate cancer impairs quality of life. Int J Radiat Oncol Biol Phys 32:33-39, 1995
7. Carter AJ, Ballard SA, Naylor AM: Effect of the selective phosphodiesterase type 5 inhibitor sildenafil on erectile dysfunction in the anesthetized dog. J Urol 160:242-246, 1998
8. Ballard SA, Gingell CJ, Tang K, et al: Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activity of cyclic nucleotide phosphodiesterase isozymes. J Urol 159:2164-2171, 1998
9. Goldstein I, Lue TF, Padman-Nathan H, et al: Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 338:1397-1404, 1998
10. Zelefsky MJ, McKee AB, Lee H, et al: Efficacy of oral sildenafil in patients with erectile dysfunction after radiotherapy for carcinoma of the prostate. Urology 53:775-778, 1999
11. Rosen RC, Riley A, Gorm W, et al: The international index of erectile function (IIEF): A multidimentional scale for assessment of erectile dysfunction. Urology 49:822-830, 1997
12. Buyse ME, Staquet MJ, Sylvester RJ: Cancer Clinical Trials Methods and Practice. Oxford, United Kingdom, Oxford, University Press, 1984
13. Zelefsky MJ, Eid JF: Elucidating the etiology of erectile dysfunction after definitive therapy for prostatic cancer. Int J Radiat Oncol Biol Phys 40:129-133, 1998
14. Boolell M, Allen MJ, Ballard SA, et al: Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 8:47-52, 1996
15. Bolla M, Gonzalez D, Warde P, et al: Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin. N Engl J Med 337:295-300, 1997
16. Bieri S, Miralbell R, Rohner S, et al: Influence of transurethral resection on sexual dysfunction in patients with prostate cancer. Br J Urol 78:537-541, 1996
17. Aass N, Fossa SD, Dahl AA, et al: Occurrence of anxiety and depression in cancer patients. Tidsskr Nor Laegeforen 118:696-703, 1998
18. Beck JG, Bozman AW; Gender differences in sexual desire: The effects of anger and anxiety. Arch Sex Behav 24:595-612, 1995
19. Utiger RD: A pill for impotence. N Engl J Med 338:1458-1459, 1998 (editorial)
20. Feenstra J, van Dri-Perik RJ, Lacle CF, et al: Acute myocardial infarction associated with sildenafil. Lancet 352:957-958, 1998