Radiation dose delivered to the proximal penis as a predictor of the risk of erectile dysfunction after three-dimensional conformal radiotherapy for localized prostate cancer

International Journal of Radiation Oncology Biology Physics

Volumn 60, Issue 5, 2004, Pages 1357-1363

  Wernicke, A Gabriella ^a   Valicenti, Richard ^a,b   DiEva, Kelly ^a   Houser, Christopher ^a   Pequignot, Ed ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

Erectile dysfunction; Penile bulb; Prostate cancer; Three dimensional conformal radiotherapy

Indexed keywords

EJACULATORY DIFFICULTY (EJ); ERECTILE DYSFUNCTION; QUALITY OF LIFE;

BIOLOGICAL ORGANS; ONCOLOGY; PATIENT TREATMENT; RADIOTHERAPY; TUMORS;

DOSIMETRY;

ADULT; AGED; ARTICLE; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED RADIOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSIMETRY; EJACULATION; EJACULATION DISORDER; ERECTILE DYSFUNCTION; FOLLOW UP; HISTOGRAM; HUMAN; LOW ENERGY RADIATION; MALE; PENIS; PREDICTION; PRIORITY JOURNAL; PROSTATE CANCER; QUALITY OF LIFE; QUESTIONNAIRE; RADIATION DOSE; RADIATION SICKNESS; RISK ASSESSMENT; SATISFACTION; SCORING SYSTEM; SEXUAL BEHAVIOR; TREATMENT PLANNING; VOLUMETRY;

AGED; AGED, 80 AND OVER; ALCOHOL DRINKING; HUMANS; IMPOTENCE; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PENILE ERECTION; PENIS; PROSTATIC NEOPLASMS; QUALITY OF LIFE; RADIOTHERAPY DOSAGE; RADIOTHERAPY, CONFORMAL; SMOKING;

EID: 10044234012     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2004.05.030     Document Type: Article

References (29)

1. E.D. Crawford, C.L. Bennett, N.N. Stone Comparison of perspectives on prostate cancer: Analyses of survey data Urology 50 1997 366
2. T. Siegel, J.W. Moul, M. Spevak The development of erectile dysfunction in men treated for prostate cancer J Urol 165 2001 430 435
3. C.J. Beard, K.J. Propert, P.P. Rieker Complications after treatment with external beam irradiation in early stage prostate cancer patients: A prospective multiinstitutional outcomes study J Clin Oncol 15 1997 223
4. J. Crook, B. Esche, N. Futter Effect of pelvic radiotherapy for prostate cancer on bowel, bladder, and sexual function: The patient's perspective Urology 47 1996 387
5. C.J. Beard, C. Lamb, L. Buswell Radiation-associated morbidity in patients undergoing small-field external beam irradiation for prostate cancer Int J Radiat Oncol Biol Phys 41 1998 257
6. C.A. Mantz, J. Nautiyal, A. Awan Potency preservation following conformal radiotherapy for localized prostate cancer: Impact on neoadjuvant androgen blockade, treatment technique, and patient-related factors Cancer Sci Am 5 1999 230
7. C.A. Mantz, P. Song, E. Farhangi Potency probability following conformal megavoltage radiotherapy using conventional doses for localized prostate cancer Int J Radiat Oncol Biol Phys 37 1997 551
8. M.J. Zelefsky, D. Cowen, Z. Fuks Long term tolerance of high dose three-dimensional conformal radiotherapy in patients with localized prostate carcinoma Cancer 85 1999 2460
9. R.T. Greenlee, T. Murray, S. Bolden Cancer statistics 2000 CA Cancer J Clin 50 2000 7
10. I. Goldstein, M.I. Feldman, P.J. Deckers Radiation-associated impotence JAMA 251 1994 903 910
11. B. Mittal A study of penile circulation before and after radiation in patients with prostate cancer and its effect on impotence Int J Radiat Oncol Biol Phys 11 1985 1121 1125
12. M.J. Zelefsky, J.F. Eid Elucidating the etiology of erectile dysfunction after definitive therapy for prostate cancer Int J Radiat Oncol Biol Phys 40 1998 129 133
13. B.M. Fisch, B. Pickett, V. Weinberg Dose of radiation received by the bulb of the penis correlates with risk of impotence after three-dimensional conformal radiotherapy for prostate cancer Urology 57 2001 955 959
14. S. Carrier, H. Hricak, S. Lee Radiation-induced decrease in nitric oxide synthase-containing nerves in the rat penis Radiology 195 1995 95 99
15. B. Pickett, B.M. Fisch, V. Weinberg Dose to the bulb of the penis is associated with the risk of impotence following radiotherapy for prostate cancer Int J Radiat Oncol Biol Phys 45 1999 263
16. J.P. Mulhall, P. Yonover, A. Sethi Radiation exposure to the corporeal bodies during 3-dimensional conformal radiation therapy for prostate cancer J Urol 167 2002 539 542
17. J.P. Mulhall, P. Yonover Correlation of radiation dose and impotence risk after three-dimensional conformal radiotherapy for prostate Urology 58 2001 828
18. M.P. O'Leary, F.J. Fowler, W.R. Lenderking A brief male sexual function inventory for urology Adult Urology 46 1995 697 705
19. K.E. Wallner, G.S. Merrick, M.L. Benson Penile bulb imaging Int J Radiat Oncol Biol Phys 52 2002 928 933
20. G.S. Merrick, W.M. Butler, K.E. Wallner The importance of radiation doses to the penile bulb vs. crura in the development of postbrachytherapy erectile dysfunction Int J Radiat Oncol Biol Phys 54 2002 1055 1062
21. M.D. Incrocci, A.K. Slob, P.C. Levendag Sexual (dys)function after radiotherapy for prostate cancer: A review Int J Radiat Oncol Biol Phys 52 2002 681 693
22. S.L. Parker, T. Tong, S. Bolden Cancer statistics CA Cancer J Clin 54 1996 5 27
23. K.A. McCammon, P. Kolm, B. Main Comparative quality-of-life analysis after radical prostatectomy or external beam radiation for localized prostate cancer Urology 54 1999 509 516
24. U.S. Ofman Sexual quality of life in men with prostate cancer Cancer 75 1995 1949 1953
25. A.R. Helgason, M. Fredrikson, J. Adolfsson Decreased sexual capacity after external radiation therapy for prostate cancer impairs quality of life Int J Radiat Oncol Biol Phys 32 1995 33 39
26. M.V. Pilepich, J.M. Krall, M. Al-Sharraf Androgen deprivation with radiation therapy compared with radiation therapy alone for locally advanced prostatic carcinoma: A randomized comparative trial of the Radiation Therapy Oncology Group Urology 45 1995 616623
27. V. Beckendorf, M. Hay, R. Rozan Changes in sexual function after radiotherapy treatment of prostate cancer Br J Urol 77 1996 118 123
28. I. Goldstein, M.I. Feldman, P.J. Deckers Radiation-associated impotence A clinical study of its mechanism JAMA 251 1984 903 910
29. L.E. Neese, L.R. Schover, E.A. Klein Finding help for sexual problems after prostate cancer treatment: A phone survey of men's and women's perspectives Psychooncology 12 2003 463 473