Aberrant epigenetic modification in murine brain tissues of offspring from preimplantation genetic diagnosis blastomere biopsies

Biology of Reproduction

Volumn 89, Issue 5, 2013, Pages

  Zhao, Hong Cui ^a,b   Zhao, Yue ^a,c   Li, Min ^a,c   Yan, Jie ^a,b   Li, Li ^a   Li, Rong ^a,b   Liu, Ping ^a,b   Yu, Yang ^a,c   Qiao, Jie ^a,b,c  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology   (China)

Author keywords

Assisted reproductive technology; Behavior; Blastocoel formation; Blastomere biopsy; Compaction; Developmental biology; Epigenetics; Methylation; Preimplantation genetic diagnosis; Rodents (rats, mice, guinea pigs, voles)

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; MESSENGER RNA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH RATE; BLASTOCYST; BLASTOMA; BRAIN TISSUE; CLIMBING; CONCEPTION; CONTROLLED STUDY; DNA MODIFICATION; EMBRYO; EMBRYO DEVELOPMENT; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENOME; H19 GENE; IGF2 GENE; MALE; METHYLATION; MORRIS WATER MAZE TEST; MOUSE; NONHUMAN; PREIMPLANTATION GENETIC DIAGNOSIS; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; PROGENY; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SNRPN GENE; TUMOR BIOPSY;

ASSISTED REPRODUCTIVE TECHNOLOGY; BEHAVIOR; BLASTOCOEL FORMATION; BLASTOMERE BIOPSY; COMPACTION; DEVELOPMENTAL BIOLOGY; EPIGENETICS; GUINEA PIGS; METHYLATION; MICE; PREIMPLANTATION GENETIC DIAGNOSIS; RODENTS (RATS; VOLES);

ANIMALS; BEHAVIOR, ANIMAL; BLASTOMERES; BRAIN; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; EPIGENESIS, GENETIC; FEMALE; MALE; MICE; MICE, INBRED ICR; PREGNANCY; PREIMPLANTATION DIAGNOSIS; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 84901060672     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.113.109926     Document Type: Article

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