Hypochlorite-induced structural modifications enhance the chaperone activity of human ?2-macroglobulin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 20, 2014, Pages

  Wyatt, Amy R ^a,b   Kumita, Janet R ^a   Mifsud, Richard W ^a   Gooden, Cherrie A ^b   Wilson, Mark R ^b   Dobson, Christopher M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; AMYLOID BETA PROTEIN[1-42]; CHAPERONE; CITRATE SYNTHASE; CREATINE KINASE; DIMER; FIBRINOGEN; HYPOCHLORITE; LIPOPROTEIN RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN; TETRAMER;

ARTICLE; CELL SURFACE; DISSOCIATION; ENZYME DENATURATION; HEAT; HEAT STRESS; HUMAN; HUMAN CELL; HYDROPHOBICITY; INNATE IMMUNITY; MACROPHAGE; MOLECULAR WEIGHT; NEUROTOXICITY; NORMAL HUMAN; NUCLEOPHILICITY; OXIDATIVE STRESS; PLASMA; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY;

CLEARANCE; INFLAMMATION; MOLECULAR CHAPERONE; PROTEIN FOLDING;

ALPHA-MACROGLOBULINS; ANIMALS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYPOCHLOROUS ACID; IMMUNITY, INNATE; INFLAMMATION; MICE; MOLECULAR CHAPERONES; OXIDANTS; OXYGEN; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; SURFACE PROPERTIES; THERMODYNAMICS;

EID: 84901052763     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1403379111     Document Type: Article

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