Brn4 and TH synergistically promote the differentiation of neural stem cells into dopaminergic neurons

Neuroscience Letters

Volumn 571, Issue , 2014, Pages 23-28

  Tan, Xuefeng ^a   Zhang, Lei ^a   Zhu, Huixia ^a   Qin, Jianbing ^a   Tian, Meiling ^a   Dong, Chuanming ^a   Li, Haoming ^a   Jin, Guohua ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Brn 4; Dopaminergic neuron; Neural stem cells; Parkinson's disease; Tyrosine hydroxylase

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRN4; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; DOPAMINE; NERVE PROTEIN; POU3F4 PROTEIN, RAT; TRANSCRIPTION FACTOR POU;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; IMAGE PROCESSING; IMMUNOCYTOCHEMISTRY; NEURAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; TRANSGENE; WESTERN BLOTTING; ANIMAL; CYTOLOGY; EMBRYONIC STEM CELL; GENETICS; MESENCEPHALON; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL SURVIVAL; DOPAMINE; DOPAMINERGIC NEURONS; EMBRYONIC STEM CELLS; MESENCEPHALON; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; POU DOMAIN FACTORS; RATS, SPRAGUE-DAWLEY; TRANSGENES; TYROSINE 3-MONOOXYGENASE;

EID: 84901047161     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.04.019     Document Type: Article

References (20)

1. Sundberg M., Bogetofte H., Lawson T., Jansson J., Smith G., Astradsson A., Moore M., Osborn T., Cooper O., Spealman R., Hallett P., Isacson O. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells 2013, 31:1548-1562.
2. Song L., Liu P., Han C., Liu Y., Zou W., Piao H., Wang Y., Liu J. A novel approach to facilitate dopaminergic neuron generation from stem-cells: the combination of genetic modification and signaling factors within a three-dimensional perfusion microbioreactor. Med. Hypotheses 2013, 80:407-410.
3. Martinat C., Bacci J.J., Leete T., Kim J., Vanti W.B., Newman A.H., Cha J.H., Gether U., Wang H., Abeliovich A. Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:2874-2879.
4. Kang U.J., Lee W.Y., Chang J.W. Gene therapy for Parkinson's disease: determining the genes necessary for optimal dopamine replacement in rat models. Hum. Cell 2001, 14:39-48.
5. Andersson E.K., Irvin D.K., Ahlsio J., Parmar M. Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells. Exp. Cell Res. 2007, 313:1172-1180.
6. Le Moine C., Young W.S. RHS2, a POU domain-containing gene, and its expression in developing and adult rat. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:3285-3289.
7. Shi J., Jin G., Zhu H., Tian M., Zhang X., Qin J., Tan X. The role of Brn-4 in the regulation of neural stem cell differentiation into neurons. Neurosci. Res. 2010, 67:8-17.
8. Tan X.F., Qin J.B., Jin G.H., Tian M.L., Li H.M., Zhu H.X., Zhang X.H., Shi J.H., Huang Z. Effects of Brn-4 on the neuronal differentiation of neural stem cells derived from rat midbrain. Cell Biol. Int. 2010, 34:877-882.
9. Wagner J., Akerud P., Castro D.S., Holm P.C., Canals J.M., Snyder E.Y., Perlmann T., Arenas E. Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes. Nat. Biotechnol. 1999, 17:653-659.
10. Vescovi A.L., Snyder E.Y. Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo. Brain Pathol. 1999, 9:569-598.
11. Geeta R., Ramnath R.L., Rao H.S., Chandra V. One year survival and significant reversal of motor deficits in Parkinsonian rats transplanted with hESC derived dopaminergic neurons. Biochem. Biophys. Res. Commun. 2008, 373:258-264.
12. Wang W., Sun M., Li H., Wang W., Yan M. The delivery of tyrosine hydroxylase accelerates the neurorestoration of Macaca Rhesus model of Parkinson's disease provided by Neurturin. Neurosci. Lett. 2012, 524:10-15.
13. Zhou Y., Sun M., Li H., Yan M., He Z., Wang W., Wang W., Lu S. Recovery of behavioral symptoms in hemi-parkinsonian rhesus monkeys through combined gene and stem cell therapy. Cytotherapy 2013, 15:467-480.
14. Vierbuchen T., Ostermeier A., Pang Z.P., Kokubu Y., Sudhof T.C., Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010, 463:1035-1041.
15. Zhang X., Jin G., Wang L., Hu W., Tian M., Qin J., Huang H. Brn-4 is upregulated in the deafferented hippocampus and promotes neuronal differentiation of neural progenitors in vitro. Hippocampus 2009, 19:176-186.
16. Tan X., Zhang L., Qin J., Tian M., Zhu H., Dong C., Zhao H., Jin G. Transplantation of neural stem cells co-transfected with Nurr1 and Brn4 for treatment of Parkinsonian rats. Int. J. Dev. Neurosci. 2013, 31:82-87.
17. Yasuhara T., Shingo T., Date I. Glial cell line-derived neurotrophic factor (GDNF) therapy for Parkinson's disease. Acta Med. Okayama 2007, 61:51-56.
18. Piltonen M., Bespalov M.M., Ervasti D., Matilainen T., Sidorova Y.A., Rauvala H., Saarma M., Männistö P.T. Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons. Exp. Neurol. 2009, 219:499-506.
19. Wang S., Ren P., Guan Y., Zou C., Fu L., Zhang Y. Inducible regulation of GDNF expression in human neural stem cells. Sci. China Life Sci. 2013, 56:32-39.
20. Lei Z., Jiang Y., Li T., Zhu J., Zeng S. Signaling of glial cell line-derived neurotrophic factor and its receptor GFRα1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease. J. Neuropathol. Exp. Neurol. 2011, 70:736-747.