Effects of Brn-4 on the neuronal differentiation of neural stem cells derived from rat midbrain

Cell Biology International

Volumn 34, Issue 9, 2010, Pages 877-882

  Tan, Xue Feng ^a   Qin, Jian Bing ^a   Jin, Guo Hua ^a   Tian, Mei Ling ^a   Li, Hao Ming ^a   Zhu, Hui Xia ^a   Zhang, Xin Hua ^a   Shi, Jin Hong ^a   Huang, Zhen ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Brn 4; Differentiation; Knockdown; Neural stem cell; Neuron; Overexpression

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2; PROTEIN BRN 4; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL STRUCTURE; CONTROLLED STUDY; EMBRYO; FEMALE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; IMMUNOCYTOCHEMISTRY; MESENCEPHALON; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; RAT; RNA INTERFERENCE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CLONE CELLS; FLUORESCENT ANTIBODY TECHNIQUE; LUMINESCENT PROTEINS; MESENCEPHALON; NERVE TISSUE PROTEINS; NEURONS; POU DOMAIN FACTORS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; RNA INTERFERENCE; STEM CELLS; TRANSFECTION;

RATTUS;

EID: 77957332176     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20100214     Document Type: Article

References (20)

1. Alvarez-Bolado G, Rosendeld MG, Swanson LW. Model of forebrain regionalization based on spatiotemporal patterns of POU-III homeobox gene expression, birthdates, and morphological features. J Comp Neurol 1995;355:237-95.
2. Berwick DC, Calissano M, Corness JD, Cool SJ, Latchman DS. Regulation of Brn-3a N-terminal transcriptional activity by MEK1/2-ERK1/2 signalling in neural differentiation. Brain Res 2009;1256:8-18.
3. Carpenter MK, Cui X, Hu ZY, Jackson J, Sherman S, Seiger A et al. In vitro expansion of a multipotent population of human neural progenitor cells. Exp Neurol 1999;158:265-78.
4. Castro DS, Skowronska-Krawczyk D, Armant O, Donaldson IJ, Parras C, Hunt C et al. Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev Cell 2006;11:831-44.
5. Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol 2007;3:268-73.
6. Hobert O, Westphal H. Functions of LIM-homeobox genes. Trends Genet 2000;16:75-83.
7. Hussain MA, Miller CP, Habener JF. Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells. J Biol Chem 2002;277:16028-32.
8. Jin Z, Liu L, Bian W, Chen Y, Xu G, Cheng L, Jing N. Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development. J Biol Chem 2009;284:8160-73.
9. Josephson R, Muller T, Pickel J, Okabe S, Reynolds K, Turner PA et al. POU transcription factors control expression of CNS stem cellspecific genes. Development 1998;125:3087-100.
10. Marutle A, Ohmitsu M, Nilbratt M, Greig NH, Nordberg A, Sugaya K. Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine. Proc Natl Acad Sci USA 2007;104:12506-11.
11. Mathis JM, Simmons DM, He X, Swanson LW, Rosenfeld MG. Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression. EMBO J 1992;11:2551-61.
12. McEvilly RJ, de Diaz MO, Schonemann MD, Hooshmand F, Rosenfeld MG. Transcriptional regulation of cortical neuron migration by POU domain factors. Science 2002;295:1528-32.
13. Miyagi S, Nishimoto M, Saito T, Ninomiya M, Sawamoto K, Okano H et al. The Sox2 regulatory region 2 functions as a neural stem cell specific enhancer in the telencephalon. J Biol Chem 2006;281:13374-81.
14. Pfaffl MW. A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 2001;29:2002-7.
15. Samadi DS, Saunders JC, Crenshaw EB. Mutation of the POU-domain gene Brn4/Pou3f4 affects middle-ear sound conduction in the mouse. Hear Res 2005;199:11-21.
16. Shimazaki T, Arsenijevic Y, Ryan AK, Rosenfeld MG, Weiss S. A role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiation. EMBO J 1999;18:444-56.
17. Sobol SE, Teng X, Crenshaw EB. Abnormal mesenchymal differentiation in the superior semicircular canal of brn4/pou3f4 knock-out mice. Arch Otolaryngol Head Neck Surg 2005;131:41-5.
18. Sugitani Y, Nakai S, Minowa O, Nishi M, Jishage K, Kawano H et al. Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev 2002;16(14):1760-5.
19. Tanaka S, Kamachi Y, Tanouchi A, Hamada H, Jing N, Kondoh H. Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Mol Cell Biol 2004;24:8834-46.
20. Zhang X, Jin G, Wang L, Hu W, Tian M, Qin J et al. Brn-4 is upregulated in the deafferented hippocampus and promotes neuronal differentiation of neural progenitors in vitro. Hippocampus 2009;19:176-86.