메뉴 건너뛰기




Volumn 9, Issue 5, 2014, Pages

Suppression of Akt-mTOR pathway - A novel component of oncogene induced DNA damage response barrier in breast tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN E; DNA; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

EID: 84901045092     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097076     Document Type: Article
Times cited : (11)

References (30)
  • 3
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • DOI 10.1126/science.1140735
    • Halazonetis TD, Gorgoulis VG, Bartek J (2008) An oncogene-induced DNA damage model for cancer development. Science 319: 1352-1355. (Pubitemid 351354863)
    • (2008) Science , vol.319 , Issue.5868 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 4
    • 33751293168 scopus 로고    scopus 로고
    • Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis
    • DOI 10.1158/0008-5472.CAN-06-2178
    • Tort F, Bartkova J, Sehested M, Orntoft T, Lukas J, et al. (2006) Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis. Cancer Res 66: 10258-10263. (Pubitemid 44799741)
    • (2006) Cancer Research , vol.66 , Issue.21 , pp. 10258-10263
    • Tort, F.1    Bartkova, J.2    Sehested, M.3    Oorntoft, T.4    Lukas, J.5    Bartek, J.6
  • 5
    • 70349438994 scopus 로고    scopus 로고
    • Tumour suppression by p53: A role for the DNA damage response?
    • Meek DW (2009) Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer 9: 714-723.
    • (2009) Nat Rev Cancer , vol.9 , pp. 714-723
    • Meek, D.W.1
  • 7
    • 0025763647 scopus 로고
    • Morphological expression of cell transformation induced by c-Ha-ras oncogene in human breast epithelial cells
    • Russo J, Tait L, Russo IH (1991) Morphological expression of cell transformation induced by c-Ha-ras oncogene in human breast epithelial cells. J Cell Sci 99 (Pt 2): 453-463. (Pubitemid 21925032)
    • (1991) Journal of Cell Science , vol.99 , Issue.2 , pp. 453-463
    • Russo, J.1    Tait, L.2    Russo, I.H.3
  • 10
    • 67651177535 scopus 로고    scopus 로고
    • Image analysis algorithms for immunohistochemical assessment of cell death events and fibrosis in tissue sections
    • Krajewska M, Smith LH, Rong J, Huang X, Hyer ML, et al. (2009) Image analysis algorithms for immunohistochemical assessment of cell death events and fibrosis in tissue sections. J Histochem Cytochem 57: 649-663.
    • (2009) J Histochem Cytochem , vol.57 , pp. 649-663
    • Krajewska, M.1    Smith, L.H.2    Rong, J.3    Huang, X.4    Hyer, M.L.5
  • 11
    • 2342593373 scopus 로고    scopus 로고
    • Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer
    • DOI 10.1158/0008-5472.CAN-03-3672
    • Akli S, Zheng PJ, Multani AS, Wingate HF, Pathak S, et al. (2004) Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer. Cancer Res 64: 3198-3208. (Pubitemid 38581423)
    • (2004) Cancer Research , vol.64 , Issue.9 , pp. 3198-3208
    • Akli, S.1    Zheng, P.-J.2    Multani, A.S.3    Wingate, H.F.4    Pathak, S.5    Zhang, N.6    Tucker, S.L.7    Chang, S.8    Keyomarsi, K.9
  • 12
    • 79551519970 scopus 로고    scopus 로고
    • In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines
    • Fiebiger W, Olszewski U, Ulsperger E, Geissler K, Hamilton G (2011) In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines. Clin Transl Oncol 13: 43-49.
    • (2011) Clin Transl Oncol , vol.13 , pp. 43-49
    • Fiebiger, W.1    Olszewski, U.2    Ulsperger, E.3    Geissler, K.4    Hamilton, G.5
  • 14
    • 34547619944 scopus 로고    scopus 로고
    • Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway
    • DOI 10.1158/0008-5472.CAN-07-0599
    • Akli S, Van Pelt CS, Bui T, Multani AS, Chang S, et al. (2007) Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res 67: 7212-7222. (Pubitemid 47206549)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7212-7222
    • Akli, S.1    Van Pelt, C.S.2    Bui, T.3    Multani, A.S.4    Chang, S.5    Johnson, D.6    Tucker, S.7    Keyomarsi, K.8
  • 16
    • 42949165854 scopus 로고    scopus 로고
    • PKBalpha/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival
    • DOI 10.1016/j.molcel.2008.02.024, PII S1097276508001718
    • Bozulic L, Surucu B, Hynx D, Hemmings BA (2008) PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell 30: 203-213. (Pubitemid 351626686)
    • (2008) Molecular Cell , vol.30 , Issue.2 , pp. 203-213
    • Bozulic, L.1    Surucu, B.2    Hynx, D.3    Hemmings, B.A.4
  • 17
    • 77749233738 scopus 로고    scopus 로고
    • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
    • Alexander A, Cai SL, Kim J, Nanez A, Sahin M, et al. (2010) ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A 107: 4153-4158.
    • (2010) Proc Natl Acad Sci U S a , vol.107 , pp. 4153-4158
    • Alexander, A.1    Cai, S.L.2    Kim, J.3    Nanez, A.4    Sahin, M.5
  • 18
    • 0034576494 scopus 로고    scopus 로고
    • The many substrates and functions of ATM
    • Kastan MB, Lim DS (2000) The many substrates and functions of ATM. Nat Rev Mol Cell Biol 1: 179-186.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 179-186
    • Kastan, M.B.1    Lim, D.S.2
  • 19
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman AR (2002) Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108: 171-182.
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 21
  • 22
    • 71749090715 scopus 로고    scopus 로고
    • Variants in DNA double-strand break repair genes and breast cancer susceptibility
    • Kuschel B, Auranen A, McBride S, Novik KL, Antoniou A, et al. (2002) Variants in DNA double-strand break repair genes and breast cancer susceptibility. Hum Mol Genet 11: 1399-1407.
    • (2002) Hum Mol Genet , vol.11 , pp. 1399-1407
    • Kuschel, B.1    Auranen, A.2    McBride, S.3    Novik, K.L.4    Antoniou, A.5
  • 25
    • 53049104973 scopus 로고    scopus 로고
    • Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
    • Concannon P, Haile RW, Borresen-Dale AL, Rosenstein BS, Gatti RA, et al. (2008) Variants in the ATM gene associated with a reduced risk of contralateral breast cancer. Cancer Res 68: 6486-6491.
    • (2008) Cancer Res , vol.68 , pp. 6486-6491
    • Concannon, P.1    Haile, R.W.2    Borresen-Dale, A.L.3    Rosenstein, B.S.4    Gatti, R.A.5
  • 26
    • 56649086648 scopus 로고    scopus 로고
    • Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene
    • Bartkova J, Tommiska J, Oplustilova L, Aaltonen K, Tamminen A, et al. (2008) Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Mol Oncol 2: 296-316.
    • (2008) Mol Oncol , vol.2 , pp. 296-316
    • Bartkova, J.1    Tommiska, J.2    Oplustilova, L.3    Aaltonen, K.4    Tamminen, A.5
  • 27
    • 80655147072 scopus 로고    scopus 로고
    • Constitutive expression of gamma-H2AX has prognostic relevance in triple negative breast cancer
    • Nagelkerke A, van Kuijk SJ, Sweep FC, Nagtegaal ID, Hoogerbrugge N, et al. (2011) Constitutive expression of gamma-H2AX has prognostic relevance in triple negative breast cancer. Radiother Oncol 101: 39-45.
    • (2011) Radiother Oncol , vol.101 , pp. 39-45
    • Nagelkerke, A.1    Van Kuijk, S.J.2    Sweep, F.C.3    Nagtegaal, I.D.4    Hoogerbrugge, N.5
  • 28
    • 65649106134 scopus 로고    scopus 로고
    • Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: Biomarkers of progression
    • Kim SH, Miller FR, Tait L, Zheng J, Novak RF (2009) Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: biomarkers of progression. Int J Cancer 124: 2813-2828.
    • (2009) Int J Cancer , vol.124 , pp. 2813-2828
    • Kim, S.H.1    Miller, F.R.2    Tait, L.3    Zheng, J.4    Novak, R.F.5
  • 29
    • 77950114803 scopus 로고    scopus 로고
    • Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines
    • Kadota M, Yang HH, Gomez B, Sato M, Clifford RJ, et al. (2010) Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines. PLoS One 5: e9201.
    • (2010) PLoS One , vol.5
    • Kadota, M.1    Yang, H.H.2    Gomez, B.3    Sato, M.4    Clifford, R.J.5
  • 30
    • 84863260492 scopus 로고    scopus 로고
    • Differential expression of key signaling proteins in MCF10 cell lines, a human breast cancer progression model
    • So JY, Lee HJ, Kramata P, Minden A, Suh N (2012) Differential expression of key signaling proteins in MCF10 cell lines, a human breast cancer progression model. Molecular and Cellular Pharmacology 4: 31-40.
    • (2012) Molecular and Cellular Pharmacology , vol.4 , pp. 31-40
    • So, J.Y.1    Lee, H.J.2    Kramata, P.3    Minden, A.4    Suh, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.