Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase

Mechanisms of Ageing and Development

Volumn 138, Issue 1, 2014, Pages 53-58

  Zhao, Wei ^a,b   Fang, Bing Xiong ^a,b   Niu, Yu Jie ^a,b   Liu, Yi Na ^a,b   Liu, Bin ^a,b   Peng, Qi ^a,b   Li, Jiang Bin ^a   Wasko, Brian M ^c   Delaney, Joseph R ^c   Kennedy, Brian K ^a,d   Suh, Yousin ^a,e   Zhou, Zhong Jun ^a,f   Kaeberlein, Matt ^a,c   Liu, Xin Guang ^a,b  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b Key Laboratory for Medical Molecular Diagnostics of Guangdong Province   (China)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Buck Institute for Research on Aging   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Lifespan; Mitochondrial superoxide dismutase; Nar1

Indexed keywords

ACONITATE HYDRATASE; IRON SULFUR PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; PARAQUAT; PROTEIN NAR1P; UNCLASSIFIED DRUG; HERBICIDE; HYDROGENASE; IRON HYDROGENASE; NAR1 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SUPEROXIDE DISMUTASE;

ARTICLE; CELL DIVISION; CELL PROTECTION; CONTROLLED STUDY; DIPLOIDY; ENZYME ACTIVITY; HAPLOIDY; HAPLOINSUFFICIENCY; HETEROZYGOSITY; LIFESPAN; NAR1 GENE; NONHUMAN; OXIDATIVE STRESS; PHYSICAL SENSITIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; ANIMAL; CYTOSOL; DEFICIENCY; METABOLISM; MITOCHONDRION; PHYSIOLOGY; TIME; ULTRASTRUCTURE;

BACTERIA (MICROORGANISMS); CAENORHABDITIS ELEGANS; SACCHAROMYCES CEREVISIAE;

ANIMALS; CYTOSOL; HERBICIDES; HYDROGENASE; IRON-SULFUR PROTEINS; MITOCHONDRIA; OXIDATIVE STRESS; PARAQUAT; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 84901039710     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2014.01.007     Document Type: Article

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